MycoData

Mesima · 2019 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Phellinus linteus Grown on Germinated Brown Rice Inhibits IgE-Mediated Allergic Activity through the Suppression of FcεRI-Dependent Signaling Pathway In Vitro and In Vivo.

Phellinus linteus (PL) has been used as a traditional herbal medicine owing to its immune regulatory activity. Previous studies reported that PL grown on germinated brown rice (PBR) exerted immunomodulatory, anticancer, and anti-inflammatory activities..

Turkey Tail · 2019 · Journal Article · International journal of biological macromolecules

Polysaccharopeptide from Trametes versicolor blocks inflammatory osteoarthritis pain-morphine tolerance effects via activating cannabinoid type 2 receptor.

Analgesia with opioids such as morphine is an effective clinical strategy for the treatment of cancer pain and chronic inflammatory pain. However, long-term use of morphine can cause morphine tolerance (MT), which limits the clinical application of opioids..

OncologyImmune supportMetabolic healthGut & microbiome

Enoki · 2019 · Journal Article · International journal of biological macromolecules

Preparation and in vitro absorption studies of a novel polysaccharide‑iron (III) complex from Flammulina velutipes.

Iron is essential in fundamental bioactivities, so it makes sense to improve the efficiency of iron on epithelial transport. In this work, a novel polysaccharide‑iron(III) complex (FVP-Fe(III)) was prepared from Flammulina velutipes with a specific structure..

OncologyImmune supportMetabolic health

Maitake · 2019 · Research Article · BioMed research international

Structural Elucidation and Immune-Enhancing Effects of Novel Polysaccharide from Grifola frondosa.

Beta-glucan (β-glucan) is a macromolecule structure where glucose unit has bonded through β-glycosidic bond at 1 and 3 positions. It is well known as a natural immunomodulator without exhibiting any side effects via enhancing immunity..

OncologyEnergy & fatigueMetabolic healthLiver support

Niu-Chang-Chih · 2019 · Research Article · Molecules (Basel, Switzerland)

The Effects of Ergosta-7,9(11),22-trien-3β-ol from Antrodia camphorata on the Biochemical Profile and Exercise Performance of Mice.

Antrodia camphorata (AC) is a rare and unique mushroom that is difficult to cultivate. Previous studies have demonstrated the bioactivity of the compound Ergosta-7,9(11),22-trien-3β-ol (EK100) from AC in submerged culture..

OncologyImmune supportEnergy & fatigueLiver support

Chaga · 2019 · Journal Article · International journal of biological macromolecules

The polysaccharide from Inonotus obliquus protects mice from Toxoplasma gondii-induced liver injury.

The study aimed to explore the protective effects and mechanism of Inonotus obliquus polysaccharide (IOP) on liver injury caused by Toxoplasma gondii (T. gondii) infection in mice..

Turkey Tail · 2019 · Research Article · International journal of molecular sciences

Use of the Secreted Proteome of Trametes versicolor for Controlling the Cereal Pathogen Fusarium langsethiae.

Fusarium langsethiae is amongst the most recently discovered pathogens of small grains cereals. F.

Shiitake · 2019 · Research Article · Frontiers in microbiology

Variations in Nuclear Number and Size in Vegetative Hyphae of the Edible Mushroom Lentinula edodes.

In basidiomycete fungi, the number of nuclei and their ploidy level per nucleus can vary tremendously among species; however, within species, nuclear number and ploidy levels are traditionally considered fixed in their vegetative hyphae..

Mesima · 2018 · Research Article · Oncotarget

A lethal synergy induced by phellinus linteus and camptothecin11 in colon cancer cells.

Side effects of anti-cancer drugs are always challenging for effective cancer treatments. The polysaccharides extracted from Phellinus linteus (PLGL) have been widely used in treating cancers.

OncologyCognition & nervesEnergy & fatigue

Almond Mushroom · 2018 · Journal Article · Nutritional neuroscience

Agaricus blazei extract attenuates rotenone-induced apoptosis through its mitochondrial protective and antioxidant properties in SH-SY5Y neuroblastoma cells.

The present study was aimed to find out the effect of Agaricus blazei mushroom extract against rotenone-induced cellular model. SH-SY5Y neuroblastoma cells are divided into four experimental groups (control, rotenone (100 nM), A.

Almond Mushroom · 2018 · Journal Article · Biological trace element research

Agaricus blazei Murill Polysaccharides Protect Against Cadmium-Induced Oxidative Stress and Inflammatory Damage in Chicken Spleens.

Agaricus blazei Murill polysaccharide (ABP) has exhibited antioxidant and immunoregulatory activity. The aim of this study was to investigate the effect of ABP on cadmium (Cd)-induced antioxidant functions and inflammatory damage in chicken spleens..

Mesima · 2018 · Journal Article · Journal of microbiology and biotechnology

Anti-Pigmentation Effects of Eight Phellinus linteus-Fermented Traditional Crude Herbal Extracts on Brown Guinea Pigs of Ultraviolet B-Induced Hyperpigmentation.

We have previously found that mycelia culture broth of eight kinds of traditional herbal extracts fermented with Phellinus linteus (previously named as 8-HsPLCB) not only inhibited melanin and tyrosinase activity, but also reduced the contents of melanogenesis-related proteins, including tyrosinase and….

OncologySkin & hydration

OncologyImmune supportLiver support

Niu-Chang-Chih · 2018 · Research Article · Frontiers in pharmacology

Antrodia camphorata Mycelia Exert Anti-liver Cancer Effects and Inhibit STAT3 Signaling in vitro and in vivo.

Hepatocellular carcinoma (HCC), the major form of primary liver cancer, is a common cause of cancer-related death worldwide. Signal transducer and activator of transcription 3 (STAT3) signaling is constantly activated in HCC and has been proposed as a chemotherapeutic target for HCC..

OncologyImmune supportCognition & nerves

Enoki · 2018 · Journal Article · International journal of biological macromolecules

Cognitive-enhancing effect of polysaccharides from Flammulina velutipes on Alzheimer's disease by compatibilizing with ginsenosides.

This study was performed to evaluate the cognitive-enhancing effect Flammulina velutipes polysaccharides (FVP) by compatibilizing with ginsenosides on D-galactose-induced Alzheimer's disease (AD) rats..

OncologyImmune supportEnergy & fatigueRespiratory

Enoki · 2018 · Research Article · Asian-Australasian journal of animal sciences

Effect of golden needle mushroom (Flammulina velutipes) stem waste on laying performance, calcium utilization, immune response and serum immunity at early phase of production.

OBJECTIVE: This experiment was conducted to evaluate the effects of golden needle mushroom (Flammulina velutipes) stem waste (FVW), on organic eggs production, calcium utilization, antibody response, serum immunoglobulin, and serum cytokine concentration at early phase of production in laying hens..

OncologyImmune supportSkin & hydration

Yellow Morel · 2018 · Journal Article · Food & function

Effect of polysaccharide FMP-1 from Morchella esculenta on melanogenesis in B16F10 cells and zebrafish.

Polysaccharides from Morchella esculenta are known to exhibit diverse bioactivities, while an anti-melanogenesis effect has been barely addressed. Herein, the anti-melanogenesis activity of a heteropolysaccharide from M.

Almond Mushroom · 2018 · Journal Article · Biological trace element research

Effects of Agaricus blazei Murill Polysaccharide on Cadmium Poisoning on the MDA5 Signaling Pathway and Antioxidant Function of Chicken Peripheral Blood Lymphocytes.

This experimental study investigated the effect of Agaricus blazei Murill polysaccharide (ABP) on cadmium (Cd) poisoning on the melanoma differentiation-associated gene 5 (MDA5) signaling pathway and antioxidant function of peripheral blood lymphocytes (PBLs) in chickens..

OncologyEnergy & fatigueMetabolic health

Niu-Chang-Chih · 2018 · Research Article · The Journal of veterinary medical science

Effects of Antrodia camphorata and Panax ginseng supplementation on anti-fatigue properties in mice

Antrodia camphorata and Panax ginseng are well-known medicinal plants in Taiwan folk and traditional Chinese medicine, which have been reported for multifunctional bioactivities..

OncologyImmune supportEnergy & fatigueMetabolic health

Maitake · 2018 · Journal Article · Journal of food science

Enzymatic Modification of Rice Bran Polysaccharides by Enzymes from Grifola Frondosa: Natural Killer Cell Cytotoxicity and Antioxidant Activity.

UNLABELLED: Rice bran polysaccharides (RBPSs) are the major active constituents of rice bran (RB). In this study, we utilized intracellular enzymes from Grifola frondosa to modify RBPSs, which were extracted from RB using ultrasound..

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2018 · Research Article · International journal of molecular sciences

Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice.

Antidepressant-like effects of ethanolic extract of Hericium erinaceus (HE) mycelium enriched in erinacine A on depressive mice challenged by repeated restraint stress (RS) were examined. HE at 100, 200 or 400 mg/kg body weight/day was orally given to mice for four weeks..

Lion's Mane · 2018 · Journal Article · International journal of biological macromolecules

Hericium erinaceus isolectins recognize mucin-type O-glycans as tumor-associated carbohydrate antigens on the surface of K562 human leukemia cells.

In Hericium erinaceus mushroom fruiting body, two different lectin groups, HEL1 and HEL2, were identified by using peptide mass fingerprinting based on customized protein sequence databases derived from RNA-Seq data. The HEL2 group included four isoforms designated HEL2a-d..

Almond Mushroom · 2018 · Research Article · BMC complementary and alternative medicine

Hot water extract of Agaricus blazei Murrill specifically inhibits growth and induces apoptosis in human pancreatic cancer cells.

BACKGROUND: Pancreatic cancer is one of the most aggressive human malignancies. The development of a novel drug to treat pancreatic cancer is imperative, and it is thought that complementary and alternative medicine (CAM) could yield such a candidate..

Almond Mushroom · 2018 · Research Article · Oncology letters

Low-molecular-weight polysaccharides from Agaricus blazei Murrill modulate the Th1 response in cancer immunity.

To assess the effect of low-molecular-weight polysaccharides from Agaricus blazei Murrill (ABP-AW1) as an immunoadjuvant therapy for type 1 T-helper (Th1) responses in tumorigenesis, C57BL/6 mice were inoculated subcutaneously with ovalbumin (E.G7-OVA)..

Shiitake · 2018 · Research Article · International journal of molecular sciences

LP1 from Lentinula edodes C91-3 Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.

Present study aimed to elucidate the anticancer effect and the possible molecular mechanism underlying the action of Latcripin 1 (LP1), from the mushroom Lentinula edodes strain C91-3 against gastric cancer cell lines SGC-7901 and BGC-823..

OncologySkin & hydration

OncologyImmune supportRespiratory

Cordyceps · 2018 · Research Article · International journal of chronic obstructive pulmonary disease

Nucleosides isolated from Ophiocordyceps sinensis inhibit cigarette smoke extract-induced inflammation via the SIRT1-nuclear factor-κB/p65 pathway in RAW264.7 macrophages and in COPD mice.

BACKGROUND: Ophiocordyceps sinensis (C. sinensis) extracts have been found to have a therapeutic effect on patients with chronic obstructive pulmonary disease (COPD)..

OncologyImmune supportRespiratory

Yellow Morel · 2018 · Journal Article · International journal of biological macromolecules

Polysaccharide FMP-1 from Morchella esculenta attenuates cellular oxidative damage in human alveolar epithelial A549 cells through PI3K/AKT/Nrf2/HO-1 pathway.

Oxidative stress is considered to involve cell death in severe pulmonary diseases like idiopathic pulmonary fibrosis (IPF). Polysaccharide FMP-1 from Morchella esculenta can exert significant antioxidant activity.

OncologyImmune supportEnergy & fatigue

Lion's Mane · 2018 · Journal Article · Gene

Proteome analysis provides insight into the regulation of bioactive metabolites in Hericium erinaceus.

BACKGROUND: Hericium erinaceus, a famous edible mushroom, is also a well-known traditional medicinal fungus. To date, a large number of bioactive metabolites with antitumor, antibacterial, and immune-boosting effects were isolated from the free-living mycelium and fruiting body of H.

OncologyImmune supportEnergy & fatigue

Maitake · 2018 · Journal Article · International journal of biological macromolecules

Purification, characterization and immunomodulatory activity of a novel polysaccharide from Grifola frondosa.

A novel bioactive polysaccharide, GFP-22, was isolated from the fruit bodies of Grifola frondosa by anion-exchange and gel filtration chromatography. Structure of GFP-22 was investigated using gas chromatography-mass spectrometry (GC-MS), methylation, nuclear magnetic resonance (NMR), high-performance size exclusion….

Niu-Chang-Chih · 2018 · Journal Article · Fitoterapia

Reprint of: Antiproliferative activity of the Antrodia camphorata secondary metabolite 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole and analogues.

Both the traditional Chinese medicinal fungus, Antrodia camphorata, and its secondary metabolite, 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole, have been reported to possess promising anticancer activity..

OncologyImmune supportMetabolic healthLiver support

Enoki · 2018 · Journal Article · Carbohydrate polymers

Structural characteristics and bioactive properties of a novel polysaccharide from Flammulina velutipes.

A new water-soluble polysaccharide (FVP1) was extracted from Flammulina velutipes by traditional method "water extraction and alcohol precipitation" and purified by column chromatography. Physicochemical characterization showed that FVP1 was a homogeneous polysaccharide with a relative molecular weight of 54.78 kDa..

Almond Mushroom · 2018 · Journal Article · International journal of biological macromolecules

Structure and conformation of α-glucan extracted from Agaricus blazei Murill by high-speed shearing homogenization.

Agaricus blazei Murill is an edible and medicinal mushroom favored in many countries, by virtue of both its delicious taste and its potential health benefits such as its purported anticancer activity..

OncologyCognition & nerves

Lion's Mane · 2018 · Journal Article · The Journal of antibiotics

Three new cyathane diterpenes with neurotrophic activity from the liquid cultures of Hericium erinaceus.

Three new cyathane diterpenes erinacines T-V (1-3), and two known cyathane diterpenes erinacine A (4) and erinacine P (5) were isolated from the liquid cultures of Hericium erinaceus. The structures of 1-3 were determined by extensive spectroscopic analysis..

OncologyImmune supportEnergy & fatigue

Yellow Morel · 2018 · Journal Article · Microbial pathogenesis

Total flavones of fermentation broth by co-culture of Coprinus comatus and Morchella esculenta induces an anti-inflammatory effect on LPS-stimulated RAW264.7 macrophages cells via the MAPK signaling pathway.

The inflammatory cellular model of RAW264.7 cells induced by lipopolysaccharide (LPS) has always been used to investigate the effect of anti-inflammatory agents in vitro..

Turkey Tail · 2018 · Journal Article · Natural product research

Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement.

This study aimed to estimate antiradical, antioxidant (AO) and cytotoxic activities of the fungus Trametes versicolor ethanol fruiting body extract. The extract was found to effectively scavenge both O2•- and NO• (29.62 and 52.48 μg/mL, respectively)..

Mesima · 2017 · Research Article · Food science and biotechnology

Anti-allergic and anti-inflammatory activity of Phellinus linteus grown on Panax ginseng.

Panax ginseng (PG) or Phellinus linteus (PL) have been widely used as traditional medicine owing to their many biological activities, including anti-inflammatory and anti-allergic activities. Previously, our group produced PL that was grown on PG media (PGP) to enhance anti-cancer activities of PGP..

Niu-Chang-Chih · 2017 · Journal Article · Fitoterapia

Antiproliferative activity of the Antrodia camphorata secondary metabolite 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole and analogues.

Niu-Chang-Chih · 2017 · Journal Article · Journal of ethnopharmacology

Antrodia camphorata inhibits metastasis and epithelial-to-mesenchymal transition via the modulation of claudin-1 and Wnt/β-catenin signaling pathways in human colon cancer cells.

ETHNOPHARMACOLOGICAL RELEVANCE: Antrodia camphorata (AC) is a well known traditional Chinese medicinal mushroom in Taiwan, has been used to treat various diseases including cancer..

OncologyGut & microbiome

Niu-Chang-Chih · 2017 · Journal Article · Journal of agricultural and food chemistry

Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular Mechanism and Inhibitory Targets.

Antroquinonol (ANQ) is a ubiquinone derivative from the unique mushroom Antrodia camphorata, which exhibits broad-spectrum bioactivities. The effects of ANQ on cancer stem cell-like properties in colon cancer, however, remain unclear.

OncologyGut & microbiome

Niu-Chang-Chih · 2017 · Journal Article · Molecular medicine reports

Ethanol extract of Antrodia camphorata inhibits proliferation of HCT-8 human colorectal cancer cells by arresting cell cycle progression and inducing apoptosis.

Antrodia camphorata (AC) is well known in Taiwan as a traditional Chinese medicine, with a long history of use in treating cancer and inflammation. Previous studies have revealed that AC exhibits anticancer effects in various cancer cell lines..

Lion's Mane · 2017 · Research Article · Oncotarget

Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota.

Hericium erinaceus (HE), a traditional edible mushroom, is known as a medicine food homology to ameliorate gastrointestinal diseases. To investigate whether HE is clinically effective in alleviating inflammatory bowel disease (IBD), HE extracts (polysaccharide, alcoholic extracts and whole extracts were prepared using….

OncologyImmune supportMetabolic healthGut & microbiome

Chaga · 2017 · Research Article · International journal of biological macromolecules

Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses.

Inonotus obliquus polysaccharides (IOPs) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, AIDs, pancreatitis and other diseases. In this study, we found that IOP can act as a broad-spectrum antiviral drug against feline viruses in the in vitro experiment..

Lion's Mane · 2017 · Research Article · Frontiers in immunology

Immunomodulatory Activities of a Fungal Protein Extracted from Hericium erinaceus through Regulating the Gut Microbiota.

A single-band protein (HEP3) was isolated from Hericium erinaceus using a chemical separation combined with pharmacodynamic evaluation methods. This protein exhibited immunomodulatory activity in lipopolysaccharide-activated RAW 264.7 macrophages by decreasing the overproduction of tumor necrosis factor-α, interleukin….

Niu-Chang-Chih · 2017 · Journal Article · Journal of the science of food and agriculture

Induction of antroquinonol production by addition of hydrogen peroxide in the fermentation of Antrodia camphorata S-29.

BACKGROUND: Antroquinonol have significantly anti-tumour effects on various cancer cells. There is still lack of reports on regulation of environmental factors on antroquinonol production by Antrodia camphorata.

OncologyEnergy & fatigue

Niu-Chang-Chih · 2017 · Journal Article · Journal of the science of food and agriculture

Induction of antroquinonol production by addition of hydrogen peroxide in the fermentation of Antrodia camphorata S‐29

BACKGROUND: Antroquinonol have significantly anti‐tumour effects on various cancer cells. There is still lack of reports on regulation of environmental factors on antroquinonol production by Antrodia camphorata.

OncologyEnergy & fatigue

Chaga · 2017 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Inonotus obliquus extract induces apoptosis in the human colorectal carcinoma's HCT-116 cell line.

Because of irregular dietary habits and lifestyle in Taiwan, the incidence and mortality rate of colorectal cancer have been increasing rapidly these years. This study investigated the inhibitory activity against the proliferation of human colorectal cancer HCT-116 cells by Inonotus obliquus extracts obtained from….

OncologyEnergy & fatigue

OncologyImmune supportMetabolic healthGut & microbiome

Chaga · 2017 · Research Article · AMB Express

Inonotus obliquus polysaccharide regulates gut microbiota of chronic pancreatitis in mice.

Polysaccharide is efficient in attenuation of metabolic ailments and modulation of gut microbiota as prebiotics. The therapeutic effect of Inonotus obliquus polysaccharide (IOP) on chronic pancreatitis (CP) in mice has been validated in our previous study..

Shiitake · 2017 · Research Article · Molecular and clinical oncology

Lentinula edodes mycelia extract plus adjuvant chemotherapy for breast cancer patients: Results of a randomized study on host quality of life and immune function improvement.

Anthracycline-based chemotherapies for breast cancer are known to adversely affect patients' quality of life (QOL) and immune function. For that reason, adjuvants that improve those impairments are required..

Mesima · 2017 · Research Article · Frontiers in pharmacology

Phellinus linteus Mycelium Alleviates Myocardial Ischemia-Reperfusion Injury through Autophagic Regulation.

The incidence of myocardial ischemia-reperfusion (IR) injury is rapidly increasing around the world and this disease is a major contributor to global morbidity and mortality. It is known that regulation of programmed cell death including apoptosis and autophagy reduces the impact of myocardial IR injury..

Enoki · 2017 · Journal Article · Food and agricultural immunology

Preparation, characterization, and anti-inflammatory effect of the chelate of Flammulina velutipes polysaccharide with Zn

The optimal conditions for preparing Zn- Flammulina velutipes polysaccharide (Zn-FVP) chelate were studied by using L ₉ (3 ⁴) orthogonal test. The results showed that the optimized conditions for the chelating reaction were as follows: initial concentration of Zn (II), 6 mg/mL; ratio of purified polysaccharide (FVPp)….