MycoData

Crude polysaccharides (MPS) from soybean residue fermented with Morchella esculenta were extracted and purified by DEAE Sephadex A-50 chromatography and Sephadex G-100 size-exclusion chromatography in sequence. Three main fractions MP-1, MP-3 and MP-4 were obtained during the purification steps..

OncologyImmune supportLiver supportSkin & hydration

High relevance

Turkey Tail · 2017 · Journal Article · International journal of biological macromolecules

Quorum sensing molecule-farnesol increased the production and biological activities of extracellular polysaccharide from Trametes versicolor.

A novel strategy of exposing 2-day-old mycelia cultures to 0.8mM farnesol was developed to stimulate extracellular polysaccharide (EPS) production in Trametes versicolor submerged cultures..

OncologyImmune supportMetabolic health

High relevance

Enoki · 2017 · Journal Article · International journal of medicinal mushrooms

Structural Characteristics of the Novel Polysaccharide FVPA1 from Winter Culinary-Medicinal Mushroom, Flammulina velutipes (Agaricomycetes), Capable of Enhancing Natural Killer Cell Activity against K562 Tumor Cells.

FVPA1, a novel polysaccharide, has been isolated from fruiting bodies of the culinary-medicinal mushroom Flammulina velutipes, a historically popular, widely cultivated and consumed functional food with an attractive taste, beneficial nutraceutical properties such as antitumor and immunomodulatory effects, and a….

OncologyImmune supportEnergy & fatigue

High relevance

Maitake · 2017 · Journal Article · Apoptosis: an international journal on programmed cell death

The induction of apoptosis and autophagy in human hepatoma SMMC-7721 cells by combined treatment with vitamin C and polysaccharides extracted from Grifola frondosa.

Polysaccharides extracted from the mushroom Grifola frondosa (GFP) are a potential anticancer agent. The objective of this study was to investigate the effect of GFP and vitamin C (VC) alone and in combination on the viability of human hepatocarcinoma SMMC-7721 and HepG2 cells..

OncologyImmune supportLiver support

High relevance

Mesima · 2017 · Journal Article · International journal of medicinal mushrooms

Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) and IL-23 Induced by Polysaccharide of the Black Hoof Medicinal Mushroom, Phellinus linteus (Agaricomycetes).

Matrix metalloproteinase-9 (MMP-9) has diverse roles associated with cell growth, migration, invasion, and angiogenesis. Tissue inhibitor of metalloproteinase-1 (TIMP-1) is known to inhibit MMP-9 by complexing with it at a 1:1 ratio..

OncologyImmune supportLiver supportRespiratory

High relevance

Chaga · 2017 · Journal Article · Natural product communications

Triterpenes with Anti-invasive Activity from Sclerotia of Inonotus obliquus.

The methanolic extract [inhibition (%): 61.2±3.8 (p<0.01) at 100 μg/mL] and its EtOAc-soluble fraction [inhibition (%): 82.5±1.7 (p<0.01) at 100 μg/mL1 from the sclerotia of Inonotus obliquus collected in Japan significantly inhibited invasion of human fibrosarcoma HT1080 cells through matrigel-coated filters..

OncologyRespiratory

High relevance

Shiitake · 2016 · Journal Article · International immunopharmacology

Activation of the NRF2-ARE signalling pathway by the Lentinula edodes polysaccharose LNT alleviates ROS-mediated cisplatin nephrotoxicity.

The nephrotoxicity of cisplatin (cis-DDP) limits its general clinical applications. Lentinan (LNT), a dextran extracted from the mushroom Lentinula edodes, has been shown to have multiple pharmacological activities..

OncologyImmune supportEnergy & fatigue

High relevance

Almond Mushroom · 2016 · Journal Article · International journal of oncology

Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells.

Agaricus blazei (A. blazei) is a mushroom with many biological effects and active ingredients.

OncologyEnergy & fatigue

High relevance

Shiitake · 2016 · Journal Article · Cancer immunology, immunotherapy: CII

Age-associated impairment of antitumor immunity in carcinoma-bearing mice and restoration by oral administration of Lentinula edodes mycelia extract.

Because cancer is associated with aging, immunological features in the aged should be considered in anticancer immunotherapy. In this study, we investigated antitumor immunity in aged mice using a CT26 colon carcinoma model..

OncologyImmune supportGut & microbiome

High relevance

Niu-Chang-Chih · 2016 · Journal Article · Antiviral therapy

Anti-herpes simplex virus activities of bioactive extracts from Antrodia camphorata mycelia.

BACKGROUND: Antrodia camphorata, a traditional Chinese medicine, is widely used in the treatment of liver diseases and cancers. Anti-inflammatory properties have also been described.

OncologyImmune supportLiver supportRespiratory

High relevance

Maitake · 2016 · Journal Article · International journal of food science & technology

Antioxidant and antitumour activities of exopolysaccharide from liquid‐cultured Grifola frondosa by chemical modification

Grifola frondosa is a popular edible mushroom for its tasty flavour and can be used as a dietary supplement for its functional substances. In this study, an exopolysaccharide (EPS), purified from the submerged culture of G..

OncologyImmune supportEnergy & fatigue

High relevance

Enoki · 2016 · Journal Article · Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]

Antitumor and Antioxidant Properties of Water-Soluble Polysaccharides from Submerged Mycelium of Flammulina velutipes.

The aim of the study was to evaluate antitumor and antioxidant properties of water-soluble polysaccharides from submerged myceliumn of Flammulina velutipes grown under optimized conditions..

OncologyImmune supportMetabolic health

High relevance

Niu-Chang-Chih · 2016 · Research Article · Frontiers in pharmacology

Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells.

Antrodia camphorata is a Taiwanese-specific fungus which has been used clinically to treat hypertension, immune- and liver-related diseases and cancer; however, it has never been studied in type 2 diabetes mellitus (T2DM). Hyperglycemia in T2DM causes endoplasmic reticulum (ER) stress, leading to β-cell dysfunction..

OncologyImmune supportMetabolic healthLiver support

High relevance

Shiitake · 2016 · Research Article · SpringerPlus

Biosynthesis of Se-methyl-seleno-l-cysteine in Basidiomycetes fungus Lentinula edodes (Berk.) Pegler.

BACKGROUND: The aim of the current study was to investigate whether the Basidiomycetes fungus Lentinula edodes can biosynthesize Se-methyl-seleno-l-cysteine, a seleno-amino acid with strong anticancer activity, and to optimize the culture conditions for its biosynthesis..

Oncology

High relevance

Chaga · 2016 · Journal Article · Journal of natural medicines

Chemical constituents from Inonotus obliquus and their antitumor activities.

Four new lanostane-type triterpenes (inonotusanes D-G, 1-4), including a 24,25,26,27-tetranorlanostane, together with 11 known compounds (5-15), including 7 lanostane derivatives, 2 steroids and 2 aromatic compounds, were isolated from the sclerotia of Inonotus obliquus..

Oncology

High relevance

Maitake · 2016 · Research Article · Experimental biology and medicine (Maywood, N.J.)

Cold-water extracts of Grifola frondosa and its purified active fraction inhibit hepatocellular carcinoma in vitro and in vivo.

Mushrooms are used in traditional Chinese medicine to treat a variety of diseases. Grifola frondosa (GF) is an edible mushroom indigenous to many Asian countries with a large fruiting body characterized by overlapping caps..

OncologyLiver support

High relevance

Chaga · 2016 · Journal Article · Molecular medicine reports

Effects of polysaccharides isolated from Inonotus obliquus against hydrogen peroxide-induced oxidative damage in RINm5F pancreatic β-cells.

The purpose of the present study was to elucidate the cytoprotective effects of polysaccharides isolated from Inonotus obliquus. The polysaccharides were extracted from the fruiting body of I.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Lion's Mane · 2016 · Research Article · BMC complementary and alternative medicine

High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity.

BACKGROUND: Hericium erinaceus (HE) is a well-known mushroom in traditional Chinese food and medicine. HE extracts from the fruiting body and mycelia not only exhibit immunomodulatory, antimutagenic and antitumor activity but also have neuroprotective properties..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Turkey Tail · 2016 · Research Article · Molecules (Basel, Switzerland)

In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden).

Two ergostanes, 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (1) and 5α-ergost-7,22-dien-3β-ol (2), and a lanostane, 3β-hydroxylanostan-8,24-diene-21-oic acid (trametenolic acid) (3), were isolated from an n-hexane extract prepared from the fruiting body of Trametes versicolor (Bres. Rivarden)..

OncologyImmune support

High relevance

Niu-Chang-Chih · 2016 · Journal Article · Journal of the science of food and agriculture

Increasing anti-Aβ-induced neurotoxicity ability of Antrodia camphorata-fermented product with deep ocean water supplementary.

BACKGROUND: Antrodia camphorata is proven to probably inhibit the neurotoxicity of amyloid β-peptide (Aβ), known as a risk factor toward the development of Alzheimer's disease..

OncologyCognition & nerves

High relevance

Niu-Chang-Chih · 2016 · Journal Article · Journal of the science of food and agriculture

Increasing anti‐Aβ‐induced neurotoxicity ability of Antrodia camphorata‐fermented product with deep ocean water supplementary

BACKGROUND: Antrodia camphorata is proven to probably inhibit the neurotoxicity of amyloid β‐peptide (Aβ), known as a risk factor toward the development of Alzheimer's disease..

OncologyCognition & nerves

High relevance

Chaga · 2016 · Journal Article · Molecular medicine reports

Polysaccharide isolated from the liquid culture broth of Inonotus obliquus suppresses invasion of B16-F10 melanoma cells via AKT/NF-κB signaling pathway.

A number of polysaccharides exhibit pharmacological activities. Polysaccharides derived from Inonotus obliquus (PLIO) appear to have various potential pharmacological properties, including anti‑tumor activity.

OncologyImmune support

High relevance

Shiitake · 2016 · Journal Article · Food & function

Proteomic analysis of intestinal tissues from mice fed with Lentinula edodes-derived polysaccharides.

Lentinula edodes-derived polysaccharides are well known for their immunomodulation and antitumor activities. However, the mechanisms of action have not been fully elucidated..

OncologyImmune supportGut & microbiome

High relevance

Maitake · 2016 · Journal Article · Food & function

Structural characterization and immunomodulatory activity of Grifola frondosa polysaccharide via toll-like receptor 4-mitogen-activated protein kinases-nuclear factor κB pathways.

We isolated a neutral polysaccharide from the fruiting body of a mushroom Grifola frondosa (GFP-A). The aim of this study was to characterize a neutral α-d-polysaccharide derived from G..

OncologyImmune support

High relevance

Lion's Mane · 2016 · Research Article · International journal of molecular sciences

The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer's Disease Mouse Model.

Hericium erinaceus, an edible and medicinal mushroom, displays various pharmacological activities in the prevention of dementia in conditions such as Parkinson's and Alzheimer's disease. The present study explored the neuroprotective effects of H..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Lion's Mane · 2014 · Review · Applied microbiology and biotechnology

Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals.

Hericium erinaceus is an important mushroom with edible values and medicinal properties. Both the mycelium and the fruiting bodies contain many bioactive compounds with drug efficacy..

OncologyImmune supportCognition & nervesGut & microbiome

High relevance

Chaga · 2013 · Review · Asian Pacific journal of cancer prevention: APJCP

Progress on understanding the anticancer mechanisms of medicinal mushroom: inonotus obliquus.

Cancer is a leading cause of death worldwide. Recently, the demand for more effective and safer therapeutic agents for the chemoprevention of human cancer has increased.

OncologyImmune supportSkin & hydrationRespiratory

High relevance

Niu-Chang-Chih · 2012 · Review · International journal of medicinal mushrooms

Review of biological and pharmacological activities of the endemic Taiwanese bitter medicinal mushroom, Antrodia camphorata (M. Zang et C. H. Su) Sh. H. Wu et al. (higher Basidiomycetes).

Antrodia camphorata is an extremely rare fungus native to the forested regions of Taiwan. It is also a traditional Chinese medicine, and Taiwanese aborigines applied it for treating liver diseases and protecting from food and drug intoxication.

OncologyImmune supportMetabolic healthLiver support

High relevance

Niu-Chang-Chih · 2011 · Review Article · Evidence-based complementary and alternative medicine: eCAM

Review of Pharmacological Effects of Antrodia camphorata and Its Bioactive Compounds.

Antrodia camphorata is a unique mushroom of Taiwan, which has been used as a traditional medicine for protection of diverse health-related conditions. In an effort to translate this Eastern medicine into Western-accepted therapy, a great deal of work has been carried out on A.

OncologyImmune support

High relevance

Chaga · 2010 · Review · Journal of biomedicine & biotechnology

Anti-inflammatory effects of Inonotus obliquus in colitis induced by dextran sodium sulfate.

A total of 28 male BALB/c mice (average weight 20.7 +/- 1.6 g) were divided into 4 treatment groups and fed a commercial diet (A), a commercial diet + induced colitis by dextran sodium sulfate (DSS) (B), Inonotus obliquus (IO) administration (C), and IO administration + induced colitis by DSS (D)..

OncologyImmune supportGut & microbiome

High relevance

Mesima · 2010 · Review Article · Experimental and therapeutic medicine

Medicinal mushroom Phellinus linteus as an alternative cancer therapy.

Alternative cancer treatment with nutritional/dietary supplements containing a wide variety of herbal products is on the rise in Western countries. Recent epidemiological studies have suggested that mushrooms may prevent against different types of cancers..

OncologyImmune support

High relevance

Niu-Chang-Chih · 2009 · Review · Journal of ethnopharmacology

Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases.

Niuchangchih (Antrodia camphorata (M. Zang & C.H.

OncologyImmune supportMetabolic healthLiver support

High relevance

Mesima · 2008 · Review · Current medicinal chemistry

A medicinal mushroom: Phellinus linteus.

Phellinus Linteus (Berkeley & M. A.

OncologyImmune support

High relevance

King Oyster · 2005 · Research Article · Mycosystema

Antioxidative and antitumor activities of the crude extracts of {\sl Pleurotus eryngii} var. {\sl nebrodensis}

Metadata-grounded summary: This research article indexes research on Pleurotus eryngii in Mycosystema in 2005. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

Oncology

High relevance

Maitake · 2005 · Journal Article · Oncology reports

Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa.

In innate immunity, activated natural killer (NK) cells attack and damage pathogens such as bacteria and virus without restriction by the MHC antigen. NK cells activated by IL-12 have been reported to recognize and kill tumor cells in perforin-mediated apoptosis..

OncologyImmune supportRespiratory

High relevance

Chaga · 2005 · Research Article · Mycobiology

Immunomodulatory Activity of the Water Extract from Medicinal Mushroom Inonotus obliquus.

The immunomodulatory effect of aqueous extract of Inonotus obliquus, called as Chaga, was tested on bone marrow cells from chemically immunosuppressed mice. The Chaga water extract was daily administered for 24 days to mice that had been treated with cyclophosphamide (400 mg/kg body weight), immunosuppressive….

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Turkey Tail · 2005 · Research Article · Wei sheng wu xue tong bao

The optimization of manganese peroxidase production by {\sl Trametes versicolor}

Metadata-grounded summary: This research article indexes research on Trametes versicolor in Wei sheng wu xue tong bao in 2005. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..

OncologyImmune support

High relevance

Maitake · 2004 · Journal Article · Journal of medicinal food

Administration of a polysaccharide from Grifola frondosa stimulates immune function of normal mice.

We have reported that D-Fraction, a polysaccharide extracted from the edible maitake mushroom (Grifola frondosa), activates immunocompetent cells, thereby eliciting antitumor activity..

OncologyImmune support

High relevance

Lion's Mane · 2004 · Research Article · Heilongjiang Medicine and Pharmacy

Isolation, purification and activity of polysaccharide from Hericium erinaceus

The mitotic activity of the transplantable mouse tumors, Sarcoma 37, Krebs-2, and Ehrlich carcinomas, in the ascites form, were inhibited after treatment with a mixture of vitamins C and B12 with no apparent toxic side effects..

OncologyImmune support

High relevance

King Oyster · 2004 · Research Article · Journal of Huaiyin Teachers College(Natural Science Edition)

The analysis of the fatty acid compositions in the fruitbody and the mixture barley and mycelium of pleurotus eryngii

Tumor growth and survival time were followed in rats transplanted with Morris hepatoma 5123 and previously injected with a crude homogenate of the same tumor by the intradermic or intralymphatic route. Female rats treated by the intralymphatic route showed a longer survival time and impaired tumor growth..

OncologyLiver support

High relevance

Maitake · 2003 · Journal Article · Journal of medicinal food

Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients.

Maitake D-Fraction, extracted from maitake mushroom, has been reported to exert its antitumor effect in tumor-bearing mice by enhancing the immune system through activation of macrophages, T cells, and natural killer (NK) cells..

OncologyImmune supportLiver supportRespiratory

High relevance

Maitake · 2002 · Journal Article · Japanese journal of pharmacology

A Polysaccharide, Extract From Grifola frondosa, Induces Th-1 Dominant Responses in Carcinoma-Bearing BALB/c Mice

A polysaccharide, designated as the D-fraction, extracted from maitake (Grifola frondosa), was reported to have anti-tumor effects by activating macrophages and T cells in C3H/HeN mice in which a Th-1 dominant response was established..

OncologyImmune support

High relevance

Maitake · 2002 · Journal Article · Biological & pharmaceutical bulletin

Effect of Maitake (Grifola frondosa) D-Fraction on the Control of the T Lymph Node Th-1/Th-2 Proportion

We have already reported that the D-Fraction, a beta-glucan extracted from the fruiting body of the maitake mushroom (Grifola frondosa), activates cellular immunity and expresses anti-tumor effects..

OncologyImmune support

High relevance

Maitake · 2002 · Journal Article · Biological & pharmaceutical bulletin

Effects of D-Fraction, a Polysaccharide from Grifola frondosa on Tumor Growth Involve Activation of NK Cells

Natural killer (NK) cells are directly cytotoxic for tumor cells and play a primary role in regulating immune responses. We monitored levels of NK cell cytotoxic activity in cancer patients receiving D-Fraction extracted from maitake mushrooms (Grifola frondosa)..

OncologyImmune support

High relevance

Lion's Mane · 2001 · Journal Article · The Kaohsiung journal of medical sciences

Antimutagenicity of extracts of Hericium erinaceus.

Hericium erinaceus is valuable in the diet and in medical treatment. It contains water-soluble polysaccharides that have been found to enhance immunity and which show anti-artificial pulmonary metastatic tumor effects..

OncologyImmune supportRespiratory

High relevance

Maitake · 2001 · Journal Article · Cancer letters

Effects of maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis.

We have reported that D-Fraction extracted from maitake (Grifola frondosa), activates immune competent cells, and indicates anti-tumor activities. The D-Fraction was observed to induce angiogenesis in vivo and to enhance the proliferation capability and migration capability of human vascular endothelial cell in vitro..

OncologyImmune support

High relevance

Maitake · 2001 · Journal Article · Journal of experimental & clinical cancer research: CR

Nitric oxide-mediated antitumor activity induced by the extract from Grifola frondosa (Maitake mushroom) in a macrophage cell line, RAW264.7.

We have investigated D-fraction (MDF) extracted from Grifola frondosa (Maitake mushroom) on the inducible nitric oxide synthase (iNOS)-mediated nitric oxide (NO) production in RAW264.7 (RAW) cells, a murine monocyte/macrophage cell line, with special reference to antitumor activity of MDF against human….

OncologyImmune supportLiver support

High relevance

Maitake · 2000 · Journal Article · Japanese journal of pharmacology

Effects of maitake (Grifola frondosa) polysaccharide on collagen-induced arthritis in mice.

We recently reported the anti-hepatitis effect of a polysaccharide, designated as the D-fraction, extracted from maitake. Its effect includes immuno-regulating activities.

OncologyImmune supportGut & microbiomeLiver support

High relevance

Enoki · 1997 · Journal Article · Edible Fungi of China

Effects of light quality on the growth and development of the fruitbody of Flammulina velutipes (Fr.) Sing.

The patient is a 17-year-old female. She was suffering from dwarfism, irregular menstruation and obesity.

OncologyCognition & nerves

High relevance

Enoki · 1997 · Journal Article · Nong ye sheng wu ji shu xue bao = Journal of agricultural biotechnology

Transformation of foreign DNA into protoplasts from Flammulina velutipes

Fifty-six male and 14 female leprosy patients, aged 11-62, were studied for cell-mediated immunity (CMI) and histocompatibility antigens. Healthy blood donors were used as normal controls.

OncologyImmune support