MycoData

Zhu Ling · 2023 · Research Support, Non U.S. Gov'T · Organic letters

S-o-(p-Methoxyphenylethynyl)benzyl (SMPEB) Glycosides for Catalytic Glycosylation and Their Application in the Synthesis of Polyporus Umbellatus Polysaccharides.

We herein reported a new type of S-o-(p-methoxyphenylethynyl)benzyl donor for a highly efficient glycosylation method. The donor was activated by 10% Tf2O and underwent glycosylation with various acceptors to provide the corresponding glycosides in excellent yield..

Reishi · 2023 · Retracted Publication · Scientific reports

The effect of Ganoderma lucidum polysaccharide extract on sensitizing prostate cancer cells to flutamide and docetaxel: an in vitro study.

Ganoderma lucidum polysaccharide is the most widely used complementary therapy in cancer. The present study aims to investigate the possible interaction between Ganoderma lucidum polysaccharide and Docetaxel (a chemotherapy drug) and the first-line medication for prostate cancer treatment (Flutamide) and sensitizing….

Oyster Mushroom · 2023 · Case Reports · The journal of allergy and clinical immunology. Global

Trehalose phosphorylase as a novel potential allergen in a case of allergic reaction due to oyster mushroom (Pleurotus ostreatus) ingestion.

To our knowledge, we present the first case report of allergic reaction from oyster mushroom ingestion, which was confirmed by an oral food challenge test. Trehalose phosphorylase was identified as a novel potential allergen by IgE immunoblotting and mass spectrometry..

OncologyImmune supportLiver supportRespiratory

Agarikon · 2022 · Research Support, Non U.S. Gov'T · Anti-cancer agents in medicinal chemistry

Anti-oxidant and Anticancerous Effect of Fomitopsis officinalis (Vill. ex Fr. Bond. et Sing) Mushroom on Hepatocellular Carcinoma Cells In Vitro through NF-kB Pathway.

BACKGROUND: Fomitopsis officinalis (Vill. ex Fr.

Immune supportLiver support

Niu-Chang-Chih · 2022 · Research Support, Non U.S. Gov'T · Journal of cellular and molecular medicine

Antrodia camphorata polysaccharide improves inflammatory response in liver injury via the ROS/TLR4/NF-κB signal.

Antrodia Camphorata Polysaccharide (ACP) refers to a kind of polysaccharide extracted from the natural porous fungus Antrodia camphorata. This study investigated the mechanism of action of ACP in protecting the liver..

Shiitake · 2022 · Research Support, Non U.S. Gov'T · mSystems

Cultivating Lentinula edodes on Substrate Containing Composted Sawdust Affects the Expression of Carbohydrate and Aromatic Amino Acid Metabolism-Related Genes.

In mushroom cultivation, composting the substrate can make the nutrients more easily absorbed by hyphae due to the degradation of lignin, cellulose, and other organic matter..

Cordyceps · 2022 · Research Support, Non U.S. Gov'T · Scientific reports

Effects of Cordyceps militaris fermentation products on reproductive development in juvenile male mice.

Cordyceps militaris (CM) is a popular medicinal fungus; however, few studies have focused on its impact on the male reproductive system. We evaluated the effects of CM fermentation products on the reproductive development of juvenile male (JM) mice..

OncologyImmune supportMetabolic healthLiver support

Chaga · 2022 · Brief Report · Current research in pharmacology and drug discovery

Inonotus obliquus aqueous extract prevents histopathological alterations in liver induced by environmental toxicant Microcystin.

Environmental toxicants like microcystins are known to adversely impact liver physiology and lead to the increased risk for abnormal liver function and even liver carcinoma..

OncologyImmune supportRespiratory

Almond Mushroom · 2022 · Case Reports · Case reports in gastroenterology

Interstitial Lung Disease Associated with Agaricus blazei Murill in a Patient with Pancreatic Ductal Adenocarcinoma Receiving Gemcitabine-Based Therapy.

A male in his sixties with locally advanced pancreatic ductal adenocarcinoma (PDAC) was administered gemcitabine plus nab-paclitaxel therapy. Computed tomography (CT) scans after five courses revealed nonspecific interstitial pneumonitis in addition to PDAC aggravation..

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2022 · Research Support, Non U.S. Gov'T · Frontiers in endocrinology

Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora.

Type 2 diabetes mellitus (T2DM) poses a significant risk to human health. Previous research demonstrated that Inonotus obliquus possesses good hypolipidemic, anti-inflammatory, and anti-tumor properties..

Immune supportMetabolic healthGut & microbiome

Cordyceps · 2022 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Polysaccharides from Cordyceps militaris prevent obesity in association with modulating gut microbiota and metabolites in high-fat diet-fed mice.

Improved gut microbes and nutritious metabolites have been considered as the mediators of health benefits from indigestible polysaccharides, but their role in the anti-obesity effect of polysaccharides from Cordyceps militaris (CMP) remains elusive..

Reishi · 2022 · Research Support, Non U.S. Gov'T · Biophysical chemistry

The thermodynamic and kinetic mechanisms of a Ganoderma lucidum proteoglycan inhibiting hIAPP amyloidosis.

Ganoderma lucidum is a valuable medicinal herbal which has been reported to prevent type 2 diabetes (T2D). A natural hyperbranched proteoglycan extracted from Ganoderma lucidum, namely, FYGL, has been demonstrated to inhibit the amyloidosis of human islet amyloid polypeptide (hIAPP) previously by our lab..

Immune supportEnergy & fatigueMetabolic healthLiver support

Chaga · 2022 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

Triterpenoid acids from medicinal mushroom Inonotus obliquus (Chaga) alleviate hyperuricemia and inflammation in hyperuricemic mice: Possible inhibitory effects on xanthine oxidase activity.

The purpose of this study was to explore the hypouricemic effect in hyperuricemia mice of triterpenoid acids from Inonotus obliquus (TAIO), and decipher of the underlying xanthine oxidase inhibitory mechanism. Measurement of xanthine oxidase (XO) inhibitory activity was assayed..

Immune supportGut & microbiome

King Oyster · 2022 · Research Support, Non U.S. Gov'T · Frontiers in immunology

β-1,6-Glucan From Pleurotus eryngii Modulates the Immunity and Gut Microbiota.

Polysaccharides from Pleurotus eryngii exhibit a variety of biological activities. Here, we obtained a homogeneous branched β-1,6-glucan (APEP-A-b) from the fruiting bodies of P.

Immune supportCognition & nervesEnergy & fatigueSkin & hydration

Almond Mushroom · 2021 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

Agaricus blazei polypeptide exerts a protective effect on D-galactose-induced aging mice via the Keap1/Nrf2/ARE and P53/Trim32 signaling pathways.

This experiment mainly optimized the extraction technology of Agaricus blazei polypeptide (ABp) and evaluated its protective effect on aging mice. In this study, a novel single component, the M is 3 kD, was isolated and purified from Agaricus blazei.

King Oyster · 2021 · Research Support, Non U.S. Gov'T · Scientific reports

Cultivation of Kabul Dhingri (Pleurotus eryngii) mushroom by standardizing protocols in subtropical zones of world.

The study is of great relevance with present day pandemic era where mushrooms have immunity enhancing properties and they convert agro-wastes into protein rich food..

Immune supportCognition & nerves

Cordyceps · 2021 · Research Support, Non U.S. Gov'T · Journal of immunology (Baltimore, Md.: 1950)

Distinct Responses of Thitarodes xiaojinensis β-1,3-Glucan Recognition Protein-1 and Immulectin-8 to Ophiocordyceps sinensis and Cordyceps militaris Infection.

Melanization and encapsulation are prominent defense responses against microbes detected by pattern recognition receptors of their host insects. In the ghost moth Thitarodes xiaojinensis, an activated immune system can melanize and encapsulate the fungus Cordyceps militaris However, these responses were hardly….

Cordyceps · 2021 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Homologous overexpression of genes in Cordyceps militaris improves the production of polysaccharides.

The maximum yield of EPS produced by mutant CM-pgm-H was 4.63 ± 0.23 g/L, whereas the yield of wild-type strain was 3.43 ± 0.26 g/L. In addition, the data obtained in the present study indicated that the yield of EPS produced by the engineered strain treated with the co-overexpression of phosphoglucomutase and….

Chaga · 2021 · Research Support, Non U.S. Gov'T · Frontiers in immunology

Inotodiol From Inonotus obliquus Chaga Mushroom Induces Atypical Maturation in Dendritic Cells.

Dendritic cells (DCs) have the ability to stimulate naïve T cells that coordinate subsequent adaptive response toward an inflammatory response or tolerance depending on the DC differentiation level..

Immune supportGut & microbiome

Snow Fungus · 2021 · Research Support, Non U.S. Gov'T · Frontiers in immunology

Tremella fuciformis Polysaccharides Inhibited Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice via Foxp3+ T Cells, Gut Microbiota, and Bacterial Metabolites.

Tremella fuciformis is an edible medicinal mushroom, and its polysaccharide components are found to confer various health benefits. This study identified the protective effects of polysaccharides of Tremella fuciformis (TPs) against dextran sulfate sodium (DSS)-induced colitis in mice..

Immune supportSkin & hydration

Shiitake · 2017 · Systematic Review · International journal of dermatology

Clinical features of shiitake dermatitis: a systematic review.

Shiitake dermatitis is a rare cutaneous reaction to lentinan, a polysaccharide component in the cell walls of shiitake mushrooms (Lentinula edodes). Herein, we systematically review the case report and case series English-language literature on shiitake dermatitis, which refers to a total of 50 patients (38 males, 12….

Oyster Mushroom · 2020 · Preprint · journal metadata

Estimation of Protein and Productive Efficiency Profile of Locally Produced Oyster Mushroom (Pleurotus Ostreatus) in Broiler

Background: Pleurotus ostreatus (Oyster) is a worldwide used mushroom, known to have a wide range of nutrients. Effects of the ethanolic and aqueous extracts of Oyster and its isolated proteins on the production profiles and bio health markers in broiler birds were evaluated in the present research..

Immune supportSkin & hydration

Chaga · 2020 · Preprint · journal metadata

Genoprotective effects of Chaga mushroom ( Inonotus obliquus ) polysaccharides in UVB-exposed embryonic zebrafish ( Danio rerio ) through coordinated expression of DNA repair genes

Background Chaga mushroom (Inonotus obliquus) is one of the most promising antioxidants with incredible health-promoting effects. Chaga polysaccharides (IOP) have been reported to enhance immune response and alleviate oxidative stress during development..

Cordyceps · 2020 · Preprint · journal metadata

Homologous Overexpression of Genes in Cordyceps militaris Improves the Production of Polysaccharide

Abstract Background Cordyceps polysaccharides have been used around the globe for its bioactivity for millennia. However, the study and medicinal of Cordyceps militaris polysaccharides has been hampered by the low in natural abundances.

Cordyceps · 2020 · Preprint · journal metadata

Immune modulation of macrophage response by Cordyceps militaris extracts

Backgrounds:: Cordyceps militaris is a well-known medicinal fungus. Cordycepin, a metabolite of this fungus, has strong biological activities against leukemia, oxidative stress, aging, tumors, and inflammation.

OncologyImmune support

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2020 · Preprint · journal metadata

The Regulation Effect of Crude Polysaccharides from Cordyceps Militaris on Obesity Control and Gut Microbiota Community via High-Fat Diet-Fed Mice Model

Administration of crude polysaccharides extract from natural product is a promising gut microbiota-targeted approach to preventing obesity and associated metabolic disorders. Dietary restrictions can change the type and number of gut bacteria, which is an important factor in delaying the onset and burden of diseases..

Immune supportLiver support

Zhu Ling · 1993 · Randomized Controlled Trial · Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

[Therapeutic effect of combined therapy of Salvia miltiorrhizae and Polyporus umbellatus polysaccharide in the treatment of chronic hepatitis B].

90 patients of chronic hepatitis B with positive HBV replication markers and abnormality of ALT were randomly allocated to 3 groups. 30 cases were treated with Salvia miltiorrhizae (SM) and Polyporus Umbellatus polysaccharide (PUP) as group I, 30 cases were treated with SM solely as group II and 30 cases were treated….

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Oyster Mushroom · 2026 · Randomized Controlled Trial · Food & function

A randomised controlled study to investigate the cognitive, mood, metabolic and anti-inflammatory effects of acute oyster mushroom intervention in healthy older adults.

The Pleurotus oyster is a common edible mushroom rich in ergothioneine, a bioactive that has shown benefits to cognition in animals when administered in extract form. The OYSACO study investigated the acute effects of oyster mushroom (OM) on cognition, mood, inflammation and metabolism in healthy older adults..

Shiitake · 2026 · Research Article · Food science & nutrition

Immunomodulatory Effects of Zinc and Selenium-Enriched Lentinula edodes Extract: Biochemical Characterization and Bioactivity Relevant to Tuberculosis.

The primary hypothesis of the study was that zinc and selenium supplementation through fortified cookies would enhance the immune response and improve clinical outcomes in tuberculosis patients..

Immune supportCognition & nerves

Lion's Mane · 2026 · Review · Journal of food science

Lion's Mane Mushroom: Nutritional Profile, Bioactive Compounds, Functional Properties, and Applications in Functional Food Systems.

Lion's Mane mushroom (Hericium erinaceus) holds a significant place in traditional Chinese medicine (TCM), valued for centuries for benefiting various internal organs and overall well-being..

Shiitake · 2025 · Research Article · Food chemistry: X

Dynamic analysis of quality characteristics and flavor development in yogurt fermented with Lentinula edodes polysaccharides.

This study investigated the dynamic changes in quality of yogurts containing Lentinula edode polysaccharide (LEP) and enzymatically hydrolyzed Lentinula edode polysaccharide (EH-LEP)..

Immune supportEnergy & fatigue

Shiitake · 2025 · Research Article · Foods (Basel, Switzerland)

Lentinula edodes Stalk Polysaccharide Coating Extends the Shelf-Life of Agaricus bisporus by Modulating Respiration and Energy Metabolism.

This study comprehensively evaluated the effect of a Shiitake Stalk Isolated Polysaccharide (LEP) coating on Agaricus bisporus. The study findings revealed that the application of 1.5% LEP reduced weight loss, maintained firmness and chewiness, as well as the nutritional indices of mushrooms, extended the shelf life….

Wood Ear · 2023 · Preprint · journal metadata

Association between Auricularia auricula-judae consumption and sarcopenia: A Cross-Sectional Study

Abstract Background: Several studies have shown that Auricularia auricula-judae (AAJ) can reduce inflammation and oxidative stress. Although these factors are closely involved in the pathogenesis of sarcopenia, limited research has focused on the association between AAJconsumption and sarcopenia in the general….

Immune supportEnergy & fatigueGut & microbiome

Reishi · 2023 · Preprint · journal metadata

Effect of dietary supplementation of Ganoderma lucidum residue on growth performance, immune organ index and faecal microbial community diversity in broiler chickens

Ganoderma lucidum residue (GLR) contains a variety of medicinal and nutritional components and is a potentially high quality roughage. The purpose of the experiment was to study the effects of GLR on the growth performance, immune function and intestinal flora of broilers..

OncologyImmune supportMetabolic health

Reishi · 2023 · Preprint · journal metadata

Optimization of chemical conditions for metabolites production by Ganoderma lucidum using response surface methodology and investigation of antimicrobial as well as anticancer activities

Ganoderma lucidum ( G. lucidum ) is a medical mushroom known for its tendency to produce physiologically active compounds with far-reaching effects on human health..

Shiitake · 2023 · Preprint · journal metadata

Optimization of Se- and Zn-Enriched Mycelium of Lentinula edodes (Berk.) Pegler as a Dietary Supplement with Immunostimulatory Activity

Mycelial cultures of Lentinula edodes, an edible and medicinal mushroom, have been used in our previous research to obtain selenium-containing immunomodulatory preparations..

Immune supportEnergy & fatigueMetabolic healthSkin & hydration

Chaga · 2023 · Preprint · journal metadata

Protective effect of Inonotus obliquus polysaccharide on fibroblasts after MGO-induced nonenzymatic glycation

Abstract Background Nonenzymatic glycation of fibroblasts causes functional downregulation and behavioral disorders in skin. Methods To investigate the effect of Inonotus obliquus on the nonenzymatic glycation of skin, we examined advanced glycation end product (AGE) inhibition by four extract fractions: n-butanol,….

Immune supportRespiratory

Lion's Mane · 2022 · Preprint · journal metadata

In vitro assessment of multipotential therapeutic importance of Hericium erinaceus mushroom extracts using different solvents

Abstract Infectious disease is one of the major threats to humans and it is the second leading cause of death worldwide, especially at present in which the Covid-19 and its modified variants. Edible mushrooms have many nutritional and medicinal values to human health..

Chaga · 2022 · Preprint · journal metadata

Inonotus obliquus (Fr.) Pilat (IOPE) ameliorates immune response via LKB1- Bax-Casepase-3-PARP pathways in B16-F10 cells induced low immunity BALB/c mice model

Objective: Inonotus obliquus (Fr.) Pilat extract (IOPE) is a major active carbohydrate, an important herb used in traditional medicine, the aim of this study was to investigate the immunomodulatory effects and possible underlying mechanisms of IOPE in B16-F10 cells induced low immunity mice..

Reishi · 2022 · Preprint · journal metadata

Overexpression of purine nucleoside phosphorylase increases the adenosine content in Ganoderma lucidum

Adenosine has been getting increasing attention due to its positive role in immunomodulation, anti-inflammation, and anti-cancer, etc.. The low production of Ganoderma adenosine is a bottleneck for clinical trials and commercial applications..

Reishi · 2022 · Preprint · journal metadata

Overexpression of purine nucleoside phosphorylase increases the adenosine content in Ganoderma lucidum

Background: Adenosine has been getting increasing attention due to its positive role in immunomodulation, anti-inflammation, and anti-cancer, etc.. The low production of Ganoderma adenosine is a bottleneck for clinical trials and commercial applications..

Snow Fungus · 2022 · Preprint · journal metadata

Structural analysis, in vitro antioxidant and lipid-lowering activities of purified Tremella fuciformis polysaccharide fractions

Abstract In order to study the composition, structure and physicochemical properties of Tremella fuciformis polysaccharide (TFPS), four new polysaccharide fractions (TFPS1, TFPS2, TFPS3 and TFPS4) were successfully isolated from the hot-water extracted crude polysaccharides by DEAE-52 cellulose column..

Mesima · 2021 · Preprint · journal metadata

Clinical Trial to Analyze the Effect of Oral Intake of Phellinus Linteus(Sanghuang) Extract on Immune Function: A Study Protocol for a Randomized, Double-blind Controlled Trial

Abstract Background: As Korea becomes an aging society, interest in health care has increased. In particular, there is an increasing demand for immune function improvement to prevent infectious diseases.

OncologyImmune support

Immune supportEnergy & fatigue

Shiitake · 2021 · Preprint · journal metadata

Corncob as a Substrate for the Cultivation of Lentinula Edodes

Abstract Corncob is a major agricultural waste in the world. The study aims to evaluate the effect of using corncob as a substrate for Lentinula edodes cultivation, so as to provide an economic and eco-friendly approach to transform waste biomass into high quality edible mushrooms (whose original substrate - wood - is….

Immune supportSkin & hydration

Chaga · 2021 · Published Erratum · Heliyon

Corrigendum to "Chaga mushroom (Inonotus obliquus) polysaccharides exhibit genoprotective effects in UVB-exposed embryonic zebrafish (Danio rerio) through coordinated expression of DNA repair genes" [Heliyon 7 (2) (February 2021) Article e06003].

[This corrects the article DOI: 10.1016/j.heliyon.2021.e06003.]..

Chaga · 2021 · Preprint · journal metadata

Effect of Alkali-Treated Birch Sawdust on the Lignocellulase Secretion and Exo-Polysaccharide Production by Inonotus Obliquus Under Submerged Fermentation and its Lignocellulose Degradation Patterns

Abstract The objectives of this study were to investigate the medicinal mushroom Inonotus obliquus on the production of polysaccharides and changes of extracellular lignocellulolytic enzymes during submerged fermentation using alkali-treated birch sawdust as substrate..

OncologyImmune supportSkin & hydration

Chaga · 2021 · Preprint · journal metadata

Genome Sequencing of Inonotus Obliquus Reveals Insights Into Candidate Genes Involved In Secondary Metabolite Biosynthesis

Background: Inonotus obliquus is an important edible and medicinal mushroom that was shown to have many pharmacological activities in preclinical trials, including anti-inflammatory, antitumor, immunomodulatory, and antioxidant effects..

Shiitake · 2021 · Preprint · journal metadata

Optimization of Culture Conditions in a Bioreactor for the Production of Biomass and Metabolites of the Macromycete Lentinula Edodes

Abstract Lentinula edodes is an edible mushroom known for its medicinal properties attributed to different secondary metabolites. In this article, the effect of glucose concentration, aeration and agitation on the production of biomass and intrametabolites in submerged fermentation was evaluated..

Chaga · 2021 · Preprint · journal metadata

Potential Target Screening and Molecular Docking of Newly Isolated Compound From Inonotus Obliquus

Compound (1-(4-hydroxyphenyl)-3-methoxypropan-1-one) is a newly isolated compound from Inonotus obliquus. In this paper, four target protein prediction methods were used to search the potential targets of compounds.