MycoData

The limitations of traditional extraction methods in terms of efficiency and environmental sustainability have highlighted the urgent need for advancements in extraction technology..

Immune supportEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Enhancement of grindability and physicochemical properties of Ganoderma lucidum through steam explosion and its impact on quality characteristics of wheat dough

Steam explosion (SE) was applied to enhance the grinding performance and physicochemical properties of Ganoderma lucidum (GL), and the effects of steam-exploded Ganoderma lucidum powders (SGL) on quality characteristics of wheat dough were investigated..

Immune supportEnergy & fatigueSkin & hydration

High relevance

King Oyster · 2025 · Research Article · Antioxidants (Basel, Switzerland)

Enhancing the Nutritional and Health-Related Properties of Taralli Through the Use of Pleurotus eryngii: Focus on Antioxidant and Anti-Inflammatory Properties.

In this study, a portion of whole durum wheat semolina was replaced with Pleurotus eryngii powder (PeP) at concentrations of 5% and 10% (w/w) to produce two taralli variants, TPE5 and TPE10. The impact of PeP on the technological, chemical, physical, and sensory properties of taralli was evaluated..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Enhancing the physicochemical and textural properties of goat milk yogurt using Cordyceps militaris polysaccharide and polymerized whey protein composite hydrogels

This study investigated the physicochemical and textural improvement of goat milk yogurt using composite hydrogels prepared from polymerized whey protein (PWP, 10 %, w/v) and Cordyceps militaris polysaccharides (CMP, 0–6 %, w/v)..

Immune support

High relevance

Yellow Morel · 2025 · Research Article · Journal of food science

Evaluating the antioxidant, anti-inflammatory, and neuroprotective potential of fruiting body and mycelium extracts from edible yellow morel (Morchella esculenta L. Pers.).

SCOPE: This study aimed to assess the antioxidant, anti-inflammatory, and acetylcholinesterase activities of fruiting bodies (FB) and mycelium (M) extracts of Morchella esculenta L. collected from various regions of Pakistan..

Immune supportCognition & nerves

High relevance

Enoki · 2025 · Journal Article · Food chemistry

Exploring the effect of pH-shifting on the gel properties and interaction of heat-induced Flammulina velutipes polysaccharide-porcine myofibrillar protein for improving the quality of Flammulina velutipes-pork patties.

This study primarily investigated the impact of pH-shifting on the gel properties of Flammulina velutipes polysaccharide (FVP)-porcine myofibrillar protein (MPs) gels, aiming to improve the quality of Flammulina velutipes-pork patties..

Immune support

High relevance

Reishi · 2025 · Review · International journal of biological macromolecules

Extraction, purification, structural characterization, biological activity, mechanism of action and application of polysaccharides from Ganoderma lucidum: A review.

Ganoderma lucidum is a traditional tonic medicine in China, known as the "fairy grass" and "spiritual grass". It contains various chemical components, such as polysaccharides, triterpenoids, alkaloids, nucleosides, sterols, and acid compounds, which have the effects of tonifying qi and calming the mind, stopping cough….

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Enoki · 2025 · Research Article · Journal of dental sciences

Flammulina velutipes polysaccharides exhibit potent antioxidant and anti-pyroptotic properties in diabetes-associated periodontitis: A preliminary in vitro study.

BACKGROUND/PURPOSE: Diabetes-associated periodontitis (DAP) is a complicated illness characterized by elevated oxidative stress and a pro-inflammatory response. There is a bidirectional relationship between diabetes and periodontitis..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Enoki · 2025 · Journal Article · International journal of biological macromolecules

Flammulina velutipes protein-Flammulina velutipes soluble polysaccharide-tea polyphenols particles stabilized Pickering emulsions for the delivery of β-carotene.

The delivery vehicles based on protein-polysaccharide-polyphenol are promising methods to encapsulate bioactive components with the aim of improving their solubility and bioavailability..

Immune supportLiver support

High relevance

Cordyceps · 2025 · Journal Article · Journal of agricultural and food chemistry

Functional Characterization of a β-1,3-Glucanosyltransferase CmGel4 in Cordyceps militaris Using a Precise CRISPR-Cas9 Genome-Editing System.

Cordyceps militaris polysaccharides, especially β-glucans, have presented significant antitumor, hypoglycemic, and immunomodulatory activities. However, the enzymes involved in the branching formation of C.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Ganoderma lucidum polysaccharide alleviates cognitive dysfunction by inhibiting neuroinflammation via NLRP3/NF-κB signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum), a traditional Chinese medicinal herb, is commonly recommended for its potential to promote mental relaxation and alleviate memory impairment..

Immune supportCognition & nervesGut & microbiome

High relevance

Reishi · 2025 · Research Article · Biochemistry and biophysics reports

Ganoderma lucidum polysaccharide attenuates retinal ischemia-reperfusion injury by regulating microglial M1/M2 polarization, suppressing neuroinflammation and inhibiting JAK2/STAT3 pathway.

Retinal ischemia-reperfusion (RIR) injury is implicated in the pathogenesis of numerous retinal degenerative disorders, resulting in visual impairment or even blindness in millions of individuals worldwide..

Immune supportCognition & nerves

High relevance

Reishi · 2025 · Journal Article · Food Bioscience

Ganoderma lucidum polysaccharides: A comprehensive overview of pharmacological effects and future perspectives

Ganoderma lucidum polysaccharides (GLPs), derived from the medicinal mushroom Ganoderma lucidum, are recognized for their diverse pharmacological properties. This systematic review offers a detailed analysis of how the structure of GLPs influences their biological functions..

OncologyImmune supportLiver support

High relevance

Reishi · 2025 · Journal Article · Journal of pharmaceutical and biomedical analysis

Ganoderma lucidum spore oil attenuates acute liver injury by modulating lipid metabolism and gut microbiota.

The incidence of acute liver injury is increasing and poses a significant threat to human health. Ganoderma lucidum spore oil (GLSO), a lipid substance extracted from Ganoderma lucidum spore powder using supercritical CO2 technology, has been investigated for its potential to prevent acute liver injury..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Ganoderma lucidum spore oil modulates immunity in hepatoma H22-bearing mice and restricts tumor growth by inhibiting eicosanoid metabolism pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum spore oil (GLSO) is a well-known health product that is beneficial for immuno-enhancement, which stems from a medicine fungus: Ganoderma lucidum (Curtis) P. Karst.

OncologyImmune supportMetabolic healthLiver support

High relevance

Reishi · 2025 · Journal Article · Journal of advanced research

Ganoderma lucidum spore powder enhances IFN-α-mediated antiviral capacity of COVID-19 vaccine boosters revealed by single-cell multi-omics sequencing.

INTRODUCTION: Reduced vaccine efficacy may hinder stable herd immunity. Traditional natural medicinal ingredients, such as Ganoderma lucidum products, have shown potential as safe and effective adjuvants to improve vaccine efficacy..

Immune supportEnergy & fatigueRespiratory

High relevance

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Ganoderma lucidum sporoderm-broken spore powder alleviates kidney aging by modulating gut microbiota.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum), a revered medicinal mushroom in traditional Chinese medicine (TCM), has been historically documented for its anti-aging properties and nephroprotective effects..

Immune supportGut & microbiomeSkin & hydration

High relevance

Reishi · 2025 · Review · Antioxidants (Basel, Switzerland)

Ganoderma lucidum-From Ancient Remedies to Modern Applications: Chemistry, Benefits, and Safety.

Ganoderma lucidum (G. lucidum), commonly known as Reishi or Lingzhi, is a medicinal mushroom with a rich history in traditional Asian medicine.

OncologyImmune supportMetabolic healthLiver support

High relevance

Maitake · 2025 · Research Article · Foods (Basel, Switzerland)

Grifola frondosa Polysaccharide F2 Ameliorates Disordered Glucose and Lipid Metabolism in Prediabetic Mice by Modulating Bile Acids.

Prediabetes (pre-DM) is the buffer period before developing overt type 2 diabetes (T2DM), and the search for novel food agents to protect against pre-DM is in high demand..

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Review · International journal of biological macromolecules

Health benefits of Ganoderma lucidum polysaccharides: A review of potential cardiovascular protective effects.

Ganoderma lucidum polysaccharides (GLPs) are a diverse class of bioactive compounds abundantly present in the mycelia, fruiting bodies, and spores of Ganoderma lucidum (G. lucidum).

Immune supportMetabolic health

High relevance

Cordyceps · 2025 · Journal Article · International journal of medicinal mushrooms

Heat Treatment Abolishes Cytotoxicity of the Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycota) Cold-Phosphate-Buffered Saline Extract.

Cordyceps militaris is an entomopathogenic fungus that is traditionally used in East Asian medicine. The fungus contains various bioactive compounds that have potential therapeutic applications.

OncologyImmune support

High relevance

King Oyster · 2025 · Journal Article · International journal of biological macromolecules

High internal phase Pickering emulsions stabilized by Pleurotus eryngii protein-polysaccharide conjugates.

In this work, Pleurotus eryngii protein-polysaccharide conjugates (PE-PPCs) were used as the only stabilizer for the preparation of high internal phase emulsions (HIPEs)..

Immune supportEnergy & fatigueSkin & hydration

High relevance

Shiitake · 2025 · Review · Chemistry & biodiversity

Holistic Evaluation of Shiitake mushrooms (Lentinula edodes): Unraveling Its Medicinal and Therapeutic Potentials.

Lentinula edodes (Shiitake mushroom [SM]), a Basidiomycete with extensive ethnomedicinal use, exhibits significant nutraceutical and pharmaceutical potential. This review critically discusses findings from multidisciplinary sources, including ScienceDirect, PubMed, Scopus, Web of Science, Google Scholar, and classical….

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Almond Mushroom · 2025 · Research Article · Foods (Basel, Switzerland)

Identification of a Novel Peptide from Agaricus blazei Murrill and Its Immune-Enhancing Activity by Regulation of PI3K/AKT/mTOR Signaling Pathways in RAW 264.7 Cells.

This study aimed to screen and identify a novel immune-enhancing peptide and explore the molecular mechanism. Five novel peptides were identified from Agaricus blazei Murrill (ABM), and their secondary structure components consisted of random coil (50.5%), α-helix (28.9%), β-turn (15.6%), and β-sheet (5.0%)..

Immune support

High relevance

Reishi · 2025 · Review · Current issues in molecular biology

Immunomodulatory Effects of Ganoderma lucidum Bioactive Compounds on Gut-Brain and Gut-Liver Axis Disorders.

Ganoderma lucidum (Lingzhi), a traditional medicinal mushroom, is renowned for its immunomodulatory, anti-inflammatory, and antioxidant properties, primarily attributed to its bioactive components such as polysaccharides and triterpenoids..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Almond Mushroom · 2025 · Research Article · Biomedicines

Immunomodulatory Effects of Multivitamin Complexes Containing Agaricus blazei in Patients Undergoing Curative Resection for Non-Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Multicenter Pilot Trial.

Background/Objectives: Surgical resection of non-small-cell lung cancer (NSCLC) often results in temporary suppression of natural killer cell activity (NKA), potentially increasing the risk of recurrence..

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Shiitake · 2025 · Journal Article · Biocatalysis and Agricultural Biotechnology

Immunomodulatory properties of a β-glucan-rich bioflour of Bactris gasipaes shells colonized by Lentinula edodes

Lentinula edodes β-glucans have shown potential in reducing lung injury caused by inflammation associated with severe acute respiratory syndrome (SARS). This study aimed to investigate the immunomodulatory properties related to lung inflammation, both in vitro and in vivo, of a high-β-glucan content bioflour derived….

Immune supportGut & microbiomeRespiratory

High relevance

Oyster Mushroom · 2025 · Research Article · Current research in food science

Implications of Pleurotus ostreatus solid-state bioprocessing on the nutritional composition, protein structure, and anti-hypertensive and anti-inflammatory potential of local beans (Phaseolus vulgaris L.).

Improving snacks formulation to make them more nutritionally balanced can support healthy growth and development in children. Specifically, this approach can be beneficial for preventing obesity and promoting overall metabolic health..

Immune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2025 · Journal Article · Journal of food science

Improved Functional Components and Anti-Inflammatory and Anti-Oxidant Activity of Coconut Water by Bidirectional Fermentation Using Ganoderma lucidum.

This study addresses the limited variety of coconut-based products by exploring bidirectional fermentation of coconut water with Ganoderma lucidum to enhance its value..

Immune support

High relevance

Cordyceps · 2025 · Journal Article · Sugar tech

Improvement of Cordyceps militaris Polysaccharides Production by a Sole Corn Steep Liquor Medium, and its Antioxidant Activity

The production of polysaccharides through submerged fermentation using a sole corn steep liquor (CSL) medium with Cordyceps militaris (C. militaris GDMCC 5270) has been successfully demonstrated.

Immune supportSkin & hydration

High relevance

Reishi · 2025 · Journal Article · Heliyon

In vitro evaluation of antioxidant, probiotic, and antiproliferative activity of Ganoderma lucidum-extracted polysaccharides for the prevention of complication associated with gastrointestinal inflammatory diseases

Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, are associated with increased oxidative stress, chronic inflammation, and in some cases, abnormal cell proliferation, which can lead to serious complications such as cancer..

OncologyImmune supportGut & microbiome

High relevance

Maitake · 2025 · Research Article · Nutrients

In Vitro Gastrointestinal Digestion of Grifola frondosa Polysaccharides and Their Enhancement of GABA Production via Gut Microbiota Modulation.

Background: The water-soluble Grifola frondosa polysaccharides (GFPs) are the primary bioactive component of the edible and medicinal fungus Grifola frondosa. However, the digestive behavior of GFPs in the human gastrointestinal (GI) tract and their subsequent interaction with gut microbiota (GM) to exert health….

Immune supportGut & microbiome

High relevance

Almond Mushroom · 2025 · Journal Article · Biometals: an international journal on the role of metal ions in biology, biochemistry, and medicine

Influence of Agaricus blazei Murill polysaccharides on synthesis, stabilization, acute toxicity and antifungal activity of copper (II) oxide nanoparticles.

In general, nanomaterials tend to have better physical, chemical and biological properties than conventional materials. Furthermore, the polysaccharides from Agaricus blazei Murill mushroom have several pharmacological properties, in addition to low cytotoxicity and high biocompatibility..

OncologyImmune support

High relevance

Cordyceps · 2025 · Review · Foods (Basel, Switzerland)

Influence of Culture Conditions on Bioactive Compounds in Cordyceps militaris: A Comprehensive Review.

Cordyceps militaris (C. militaris) is a medicinal fungus renowned for its diverse therapeutic properties, largely attributed to bioactive compounds such as cordycepin, polysaccharides, adenosine, D-mannitol, carotenoids, and ergosterol..

Immune supportEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · Phytotherapy research: PTR

Inhibition of Hepatoblastoma by Ganoderma Lucidum Polysaccharide via the Induction of HDAC4-p16-RB Axis-Mediated Cellular Senescence.

Hepatoblastoma (HB), the most common primary malignant liver tumor in children, is characterized by high metastatic potential and poor prognosis. Ganoderma lucidum polysaccharide (GLP), the main bioactive compound of Ganoderma lucidum, has not been fully investigated for its therapeutic effects on HB..

OncologyImmune supportLiver supportSkin & hydration

High relevance

Chaga · 2025 · Research Article · Frontiers in pharmacology

Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing.

BACKGROUND: Renal fibrosis, characterized by the abnormal accumulation of extracellular matrix in renal tissue and progressive loss of kidney function, is posing a significant challenge in clinical treatment. While several therapeutic options exist, effective treatments remain limited..

Immune supportSkin & hydration

High relevance

Chaga · 2025 · Research Article · Animal microbiome

Inonotus obliquus fermentation product improves growth performance and meat quality probably through intestine and antioxidant capacity enhanced by gut microbes and metabolites regulation in rabbits.

BACKGROUND: Inonotus obliquus is a medicinal edible fungus that contains a variety of biologically active ingredients and has multiple physiological effects. When supplemented in avian diet, Inonotus obliquus has proved to be beneficial.

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Chaga · 2025 · Journal Article · International Journal of Biological Macromolecules

Inonotus obliquus polysaccharides improve hyperlipidemia with respect to lipid synthesis and intestinal flora modulation

Chronic high-fat diet can lead to fatty liver metabolism, hyperlipidemia disorders, and other diseases. Polysaccharides are natural lipid-lowering agents.

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Chaga · 2025 · Journal Article · International journal of biological macromolecules

Inonotus obliquus polysaccharides improve hyperlipidemia with respect to lipid synthesis and intestinal flora modulation.

Chronic high-fat diet can lead to fatty liver metabolism, hyperlipidemia disorders, and other diseases. Polysaccharides are natural lipid-lowering agents.

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2025 · Journal Article · Biochemical and biophysical research communications

Investigating the therapeutic potential of Ganoderma lucidum in treating optic nerve atrophy through network pharmacology and experimental validation.

OBJECTIVE: The aim of this study is to employ network pharmacology to identify potential therapeutic targets for Ganoderma lucidum in the treatment of optic atrophy, and elucidate the underlying pharmacological mechanism. METHODS: This study is mainly divided into two parts..

OncologyImmune supportCognition & nerves

High relevance

Cordyceps · 2025 · Research Article · PloS one

Investigation of biometabolites and novel antimicrobial peptides derived from promising source Cordyceps militaris and effect of non-small cell lung cancer genes computationally.

Mushrooms are considered one of the safe and effective medications because they have great economic importance due to countless biological properties. Cordyceps militaris contains bioactive compounds with antioxidant, antimicrobial and anti-cancerous properties..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2025 · Journal Article · Food Chemistry

Investigation of the solid-state fermentation of Astragalus membranaceus residue with Cordyceps militaris: effects on phenolic profile and in vitro neuroprotective activity

We developed a Cordyceps militaris-mediated solid-state fermentation (SSF) strategy to enhance phenolic antioxidants in Astragalus membranaceus residue (AR) and confer neuroprotective effects against oxidative stress..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Cordyceps · 2025 · Journal Article · Food chemistry

Investigation of the solid-state fermentation of Astragalus membranaceus residue with Cordyceps militaris: effects on phenolic profile and in vitro neuroprotective activity.

Immune supportCognition & nervesEnergy & fatigue

High relevance

Cordyceps · 2025 · Research Article · BMC complementary medicine and therapies

Laboratory cultivated Cordyceps militaris modulates cockroach allergen-induced inflammation in keratinocytes and macrophages dual cell platforms.

BACKGROUND: Cordyceps militaris (CM) is noted for its anti-inflammatory properties and potential efficacy in treating allergic diseases. This research aimed to investigate the anti-inflammatory effect of ethanolic and aqueous extracts from laboratory-cultivated specific Cordyceps militaris on Per a 2-induced….

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Cordyceps · 2025 · Research Article · Microbiology spectrum

Light-responsive transcription factor CmOzf integrates conidiation, fruiting body development, and secondary metabolism in Cordyceps militaris.

Cordyceps militaris, an entomopathogenic fungus, produces diverse bioactive compounds. Conidial fitness and secondary metabolite levels critically influence its morphogenesis and entomopathogenicity, yet the regulatory mechanisms remain unclear..

Immune support

High relevance

Snow Fungus · 2025 · Research Article · Frontiers in fungal biology

Lignocellulose adaptation drives polysaccharide biosynthesis in Tremella fuciformis: metabolomic and proteomic insights into CAZyme regulation.

BACKGROUND/OBJECTIVES: Tremella fuciformis is an edible fungus prized for its culinary value. The polysaccharide content of T.

Immune supportMetabolic health

High relevance

Reishi · 2025 · Journal Article · International journal of medicinal mushrooms

Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Aqueous Extract Reverses Hypoxia Induced Redox Imbalance and Inflammatory Response in Rat Thymocytes.

Inflammatory diseases are associated with immune imbalances and the linkage between immune system and inflammatory mechanisms, particularly under hypoxia, is still incomprehensive..

Immune supportEnergy & fatigue

High relevance

Lion's Mane · 2025 · Review · Nutrients

Lion's Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential-A Narrative Review.

Hericium erinaceus, commonly known as lion's mane mushroom, has gained increasing scientific interest due to its rich composition of bioactive compounds and diverse health-promoting properties. This narrative review provides a comprehensive overview of the nutritional and therapeutic potential of H..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Chaga · 2025 · Journal Article · Journal of ethnopharmacology

Mechanisms of Inonotus obliquus (Fr.) Pilát polysaccharides in ameliorating lipid-induced skeletal muscle insulin resistance via PI3K/AKT and AMPK/ACC1/CPT1 signaling pathways.

ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus (Fr.) Pilát, a traditional medicinal fungi, has been used to treat diabetes in China and Russia since the 16th century..

Immune supportEnergy & fatigueMetabolic healthLiver support

High relevance

Snow Fungus · 2025 · Research Article · Microorganisms

Microbiota Involved in the Degradation of Tremella fuciformis Polysaccharide and Microbial Enzymatic Potential Revealed by Microbiome and Metagenome.

Tremella fuciformis, as a traditional edible fungus in Asian countries, is rich in polysaccharides with a variety of bioactivities. Nevertheless, its high molecular weight and complex structure have caused limitations in its application and structural analysis..

Immune supportGut & microbiome