MycoData

Immune supportCognition & nervesLiver support

Lion's Mane · 2021 · Journal Article · International journal of medicinal mushrooms

Liver and Brain Protective Effect of Sulfated Polysaccharides from Residue of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), on D-Galactose-Induced Aging Mice.

This work describes the preparation of sulfated Hericium erinaceus residue polysaccharides (SHRPs) and investigates their antioxidant and antiaging effects on D-galactose-induced aging mice. The results indicated that the degree of SO42- substitution was 0.47 ± 0.22 for SHRPs..

Reishi · 2021 · Research Article · Molecules (Basel, Switzerland)

Postharvest Drying Techniques Regulate Secondary Metabolites and Anti-Neuroinflammatory Activities of Ganoderma lucidum.

Ganoderma lucidum extract is a potent traditional remedy for curing various ailments. Drying is the most important postharvest step during the processing of Ganoderma lucidum.

Reishi · 2021 · Journal Article · Journal of ethnopharmacology

Prophylactic effects of sporoderm-removed Ganoderma lucidum spores in a rat model of streptozotocin-induced sporadic Alzheimer's disease.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum, Lingzhi), also known as "immortality mushroom" has been broadly used to improve health and longevity for thousands of years in Asia.

Chaga · 2021 · Journal Article · International journal of medicinal mushrooms

Protective Effects of Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), Extract on β-Amyloid-Induced Neurotoxicity in PC12 Cells and Aging Rats: In Vitro and In Vivo Studies.

Modulation of β-amyloid (Aβ)-induced neurotoxicity has emerged as a possible therapeutic approach to ameliorate the onset and progression of Alzheimer's disease. The present study aimed to evaluate the protective effect of Inonotus obliquus extracts (IOEs) on Aβ-induced neurotoxicity in cultured rat pheochromocytoma….

Reishi · 2021 · Journal Article · Journal of medicinal food

Self-Medication with Ganoderma lucidum ("Reishi") to Combat Parkinson's Disease Symptoms: A Single Case Study.

Parkinson's disease (PD) is a prevalent neurodegenerative disease for which only symptomatic treatments, mainly focused on motor symptoms. In contrast, conventional pharmacological treatments do not address cognitive impairment and emotional dysfunction..

OncologyCognition & nervesGut & microbiome

Cordyceps · 2021 · Research Article · Molecules (Basel, Switzerland)

Virtual Screening for Biomimetic Anti-Cancer Peptides from Cordyceps militaris Putative Pepsinized Peptidome and Validation on Colon Cancer Cell Line.

Colorectal cancer is one of the leading causes of cancer-related death in Thailand and many other countries. The standard practice for curing this cancer is surgery with an adjuvant chemotherapy treatment.

Cognition & nervesEnergy & fatigue

Lion's Mane · 2026 · Preprint · journal metadata

A randomized, double□blind, placebo□controlled study evaluating the impact of Hericium erinaceus (Lion’s Mane) on cognitive performance and subjective wellbeing

Hericium erinaceus (Lion’s Mane) is a functional mushroom with a long history of culinary and traditional use, as well as potential neurotrophic and mood□modulating properties. Evidence for its effects on cognitive performance under real□world conditions, however, remains limited..

Lion's Mane · 2026 · Preprint · journal metadata

Evaluating the Neurotrophic Mechanisms of Hericium erinaceus in Mood Regulation: Emerging Evidence and Translational Barriers

Background: The limitations of current monoaminergic antidepressants in treating major depressive disorder (MDD) have driven exploratory interest in neurotrophic compounds..

Lion's Mane · 2025 · Preprint · journal metadata

Calm Under Challenge: Immune Balancing and Stress Quenching Effects of Hericium erinaceus Mycelium in Human Immune Cells

Hericium erinaceus is a medicinal mushroom valued for its neuroprotective, immunomodulatory, and antioxidant activities. While many extracts and bioactive compounds from both mycelium and fruit bodies have been characterized, the mechanisms driving their effects are not fully understood..

Lion's Mane · 2025 · Preprint · journal metadata

Metabolic Profiling and Substrate Utilization of Hericium erinaceus (Lion’s Mane) Mycelia Isolate Using Biolog Phenotype Microarray

Abstract Hericium erinaceus, has long been recognized in traditional Chinese medicine for its extensive health benefits. H.

OncologyImmune supportCognition & nervesGut & microbiome

Shiitake · 2025 · Preprint · journal metadata

Oral Lentinula edodes mycelia extract enhances the antitumor effect of radiotherapy via gut-associated activation of dendritic and cytotoxic T cells

Abstract Oral administration of Lentinula edodes mycelia extract (L.E.M.) has been shown to stimulate systemic T cell–mediated antitumor immunity and inhibit tumor growth in mice, suggesting its potential to modulate host immune responses. However, the route of this systemic antitumor effect remains unclear..

OncologyImmune supportCognition & nervesGut & microbiome

Reishi · 2024 · Preprint · journal metadata

Bioactive compounds and nanoparticles in Ganoderma lucidum: New perspectives on health benefits

The unique medicinal properties of Ganoderma lucidum have led to a growing demand for it as an essential source of dietary supplements in the food sector. The wide array of therapeutic and pharmacological effects of G.

Lion's Mane · 2024 · Preprint · journal metadata

Identification and partial reconstitution of the biosynthetic pathway of bioactive meroterpenoids from Hericium erinaceus (Lion’s Mane mushroom)

ABSTRACT Hericium erinaceus (Lion’s Mane mushroom) is widely consumed for its numerous reported benefits for brain health. A growing body of evidence suggests that these benefits are likely attributable to aromatics contained in its fruiting bodies, including the meroterpenoids hericenones..

Reishi · 2024 · Preprint · journal metadata

Investigating the neuroprotective mechanism of Ganoderma lucidum in glaucoma treatment through network pharmacology and molecular docking analysis

Abstract Ganoderma lucidum(GL), a medicinal fungus belonging to the polyporaceae family, has been extensively utilized in the treatment of glaucoma. To elucidate the underlying mechanisms of GL in glaucoma therapy, network pharmacology methods were employed for screening its active compounds, potential targets, and….

Immune supportCognition & nervesRespiratory

Cordyceps · 2024 · Preprint · journal metadata

The Preventive Potential of the Mycelial Submerged Culture of Ophiocordyceps sinensis against Neurodegenerative Diseases and Its Possible Active Compounds

The pharmacological effects of the fruiting body of Ophiocordyceps sinensis (Os) exerted antioxidant, anti-virus, and immunomodulatory, whereas the anti-inflammatory effects and active components of Os mycelial submerged culture (OMSC) are not known..

Snow Fungus · 2024 · Preprint · journal metadata

Tremella fuciformis polysaccharides alleviate early brain injury in experimental subarachnoid hemorrhage by inhibiting the KDR-mediated P38 MAPK/NF-κB pathway

Abstract Background Subarachnoid hemorrhage is associated with high mortality and morbidity rates. In its early stages, the substantial influx of blood into the subarachnoid space triggers excessive activation of microglial cells, which markedly contributes to early brain injury, a pivotal determinant of poor….

OncologyImmune supportCognition & nervesGut & microbiome

Almond Mushroom · 2020 · Review · Nutrients

Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies.

Since the 1980s, medicinal effects have been documented in scientific studies with the related Basidiomycota mushrooms Agaricus blazei Murill (AbM), Hericium erinaceus (HE) and Grifola frondosa (GF) from Brazilian and Eastern traditional medicine..

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2019 · Review · Critical reviews in food science and nutrition

Recent developments in Hericium erinaceus polysaccharides: extraction, purification, structural characteristics and biological activities.

Hericium erinaceus (H. erinaceus), an edible mushroom with medicinal value, has a long history of usage in China and other oriental countries.

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2019 · Review · International journal of molecular sciences

Therapeutic Potential of Hericium erinaceus for Depressive Disorder.

Depression is a common and severe neuropsychiatric disorder that is one of the leading causes of global disease burden. Although various anti-depressants are currently available, their efficacies are barely adequate and many have side effects..

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2017 · Review · International journal of biological macromolecules

Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom: A review.

Hericium erinaceus (Bull.) Pers., also known as Yamabushitake, Houtou and Lion's Mane, is capable of fortifying the spleen and nourishing the stomach, tranquilizing the mind, and fighting cancer. Over the past decade, it has been demonstrated that H..

Cognition & nervesMetabolic healthGut & microbiomeLiver support

Yellow Morel · 2026 · Journal Article · Food Research International

A novel Fucose-specific lectin from Morchella esculenta modulates gut-liver Axis to alleviate non-alcoholic fatty liver disease

Morchella esculenta is an underexplored source of lectins with diverse bioactivities. In this study, a novel fucose-specific lectin (MEP5) was isolated from M.

Cognition & nervesMetabolic healthGut & microbiomeLiver support

Yellow Morel · 2026 · Journal Article · Food research international (Ottawa, Ont.)

A novel Fucose-specific lectin from Morchella esculenta modulates gut-liver Axis to alleviate non-alcoholic fatty liver disease.

Morchella esculenta is an underexplored source of lectins with diverse bioactivities. In this study, a novel fucose-specific lectin (MEP5) was isolated from M.

Immune supportCognition & nervesMetabolic healthGut & microbiome

Lion's Mane · 2026 · Journal Article · Journal of food science

Exploring the Prebiotic Effects of Composite Fungal Polysaccharides From Hericium erinaceus and Lyophyllum decastes on Gut Microbiota and Metabolism.

Fungal polysaccharides have attracted considerable scholarly interest due to their potential as prebiotics, with the ability to modulate gut microbiota and enhance host health..

Reishi · 2026 · Research Article · Pharmaceutical biology

Fermented Moringa oleifera leaves and Ganoderma lucidum mixtures ameliorate cognitive deficits in scopolamine-induced dementia rats by enhancing brain antioxidant and cholinergic functions.

CONTEXT: Moringa oleifera Lam. (Moringaceae) and Ganoderma lucidum (Curtis) P.

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Ganoderma lucidum Triterpenoids Suppress Adipogenesis and Obesity via PRKCQ Activation: An Integrated In Vivo, In Vitro, and Systems Pharmacology Study.

Ganoderma lucidum triterpenoids (GLTs) exhibit potential anti-obesity activity. However, their mechanism remains unclear.

Cognition & nervesEnergy & fatigue

Cordyceps · 2026 · Journal Article · Analytical and bioanalytical chemistry

Identification of geographical origins of Ophiocordyceps sinensis (Berk.) via machine learning-assisted surface-enhanced Raman spectroscopy.

Ophiocordyceps sinensis (Berk.) is a functional food with health. O.

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2026 · Journal Article · Journal of biotechnology

Morphological and molecular characterization of Mexican Hericium erinaceus strains.

Hericium erinaceus is an edible and medicinal fungus recognized for its antimicrobial, antioxidant, anticancer, neuroprotective, and immunomodulatory properties. Despite its biological and biotechnological relevance, reports of this species in Mexico remain limited, with only one previous molecularly confirmed record….

OncologyImmune supportCognition & nervesGut & microbiome

Shiitake · 2026 · Research Article · Scientific reports

Oral Lentinula edodes mycelia extract enhances the antitumor effect of radiotherapy via gut-associated activation of dendritic and cytotoxic T cells.

Oral administration of Lentinula edodes mycelia extract (L.E.M.) has been shown to stimulate systemic T cell-mediated antitumor immunity and inhibit tumor growth in mice, suggesting its potential to modulate host immune responses. However, the route of this systemic antitumor effect remains unclear..

Lion's Mane · 2026 · Journal Article · International journal of clinical pharmacology and therapeutics

Peripheral nerve regeneration and synergistic pharmacology using Hericium erinaceus, lithium, and vitamin B12: The triple neuromodulatory axis hypothesis.

BACKGROUND: Peripheral nerve injuries (PNI) frequently result in incomplete functional recovery, creating a significant translational gap despite advances in surgical techniques. While Hericium erinaceus (H..

Lion's Mane · 2026 · Journal Article · Biological trace element research

The Chronic Metabolic Fingerprint of Canine Anxiety: Hair Trace Element Dyshomeostasis and the Dissociation of Behavioral Recovery via Hericium erinaceus.

Canine anxiety is a complex welfare issue involving neuro-endocrine dysregulation. While acute stress biomarkers are widely used, the chronic metabolic consequences of anxiety remain under-investigated.

Immune supportCognition & nervesGut & microbiome

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

The Ganoderma lucidum and Rosa roxburghii Tratt Formulation Prevents Depressive-like Behaviors in Mice by Modulating Tryptophan Metabolism via the Gut-Brain Axis and Upregulating the BDNF/TrkB/PI3K/AKT Pathway.

Depression is a common mental disorder that substantially impairs patients' daily life and work. To identify natural and safe preventive options, we investigated the preventive effect and underlying mechanism of the Ganoderma lucidum and Rosa roxburghii Tratt formula (GLRRTF) on depression..

Immune supportCognition & nervesMetabolic health

Cordyceps · 2026 · Research Article · BMC microbiology

Transcriptomic and metabolomic insights into the long-term survival strategies of Ophiocordyceps sinensis following host immune perturbation.

BACKGROUND: Ophiocordyceps sinensis is a premier medicinal fungus with a unique slow-killing parasitic strategy, yet the molecular basis of its long-term persistence in host hemocoel remains elusive..

Shiitake · 2026 · Journal Article · Food chemistry

Unraveling the spatial chemical heterogeneity of Lentinula edodes: Integrative metabolomics and machine learning for cultivar and origin classification.

As a major edible mushroom, Lentinula edodes requires accurate cultivar and origin authentication. Conventional homogenate-based metabolomics obscures spatial chemical information..

Immune supportCognition & nervesGut & microbiome

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

A glucan from Ganoderma lucidum: Structural characterization and the anti-inflammatory effect on Parkinson's disease via regulating dysfunctions of intestinal microecology and inhibiting TLR4/MyD88/NF-κB signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Curtis) P. Karst (G.

Lion's Mane · 2025 · Research Article · International journal of medical sciences

A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation.

Hericium erinaceus, renowned for its pharmaceutical potential, is particularly notable for its isolated diterpenoid derivative, erinacine S. Colorectal cancer (CRC) is one of the most prevalent cancers, characterized by CSC that contribute to chemoresistance and sustained tumor growth..

OncologyCognition & nerves

Shiitake · 2025 · Research Article · Frontiers in oncology

A placebo-controlled study of the doses and efficacy of Lentinula edodes mycelia for oxaliplatin-induced peripheral neuropathy in colorectal cancer.

INTRODUCTION: Preclinical studies have demonstrated the potential of Lentinula edodes mycelium (L.E.M.) extract for managing oxaliplatin-induced peripheral neuropathy (OIPN). The efficacy and optimal dosage of L.E.M.

Immune supportCognition & nervesEnergy & fatigueGut & microbiome

Lion's Mane · 2025 · Research Article · BMB reports

Anti-inflammatory effects of Hericium erinaceus hot water extract via the JAK1/STAT3 pathway in LPS-stimulated RAW 264.7 macrophages.

Several individual bioactive compounds isolated from Hericium erinaceus exhibit various physiological and biochemical activities, including neuroprotective, neurotrophic, gastrointestinal protective, immunoregulatory, and anti-inflammatory effects. However, the specific anti-inflammatory effects of H..

OncologyImmune supportCognition & nervesLiver support

Zhu Ling · 2025 · Research Article · Computational and structural biotechnology journal

Anticancer effects and mechanisms of Pulsatilla chinensis, Bupleurum chinense and Polyporus umbellatus on human lung carcinoma and hepatoma cells.

Herbs are extensively utilized in Traditional Chinese Medicine (TCM) for lung and liver cancer treatment, but the mechanisms behind these herbs remain largely unknown. Here, high-throughput transcriptomic analysis technology was used to uncover molecular mechanisms of herbal treatment..

Reishi · 2025 · Journal Article · Organic letters

Chizhiaroterpenoids A-C: Benzofused Rearranged Lanostane-Type Triterpenoids from Ganoderma lucidum.

Chizhiaroterpenoids A-C (1-3), three unprecedented skeletal benzofused lanostane-type triterpenoids with unprecedented 6/6/6/6/6 (1), 6/6/6/6/7 (2), and 6/6/6/5/6 (3) ring systems, were isolated from Ganoderma lucidum. Their biosynthetic pathways were proposed..

Lion's Mane · 2025 · Journal Article · Food Bioscience

Dynamic analysis of terpenoids in Hericium erinaceus liquid-fermented mycelium by non-targeted metabolomics and their mechanisms against Helicobacter pylori-associated gastritis

Biosynthetic functional food ingredients represent an innovative strategy within the food industry. The fruiting bodies of Hericium erinaceus have traditionally been utilized as an adjunctive treatment for gastric ulcers.

Immune supportCognition & nervesGut & microbiomeSkin & hydration

Reishi · 2025 · Journal Article · Die Naturwissenschaften

Effects of Ganoderma lucidum polysaccharide on learning and memory impairment and intestinal flora in mice with D-galactose-induced aging.

Learning and memory impairment is one of the main manifestations of cognitive impairment. Gut flora can affect cognitive function and behavior through the gut-brain axis.

Immune supportCognition & nervesEnergy & fatigue

Shiitake · 2025 · Journal Article · Neuroscience

Ergothioneine-rich Lentinula edodes mushroom extract restores mitochondrial functions in senescent HT22 cells.

A decline in mitochondrial functions associated with ageing is the key factor of free radical generation which contributes to age-related pathologies. Protecting healthy functional mitochondrial networks with antioxidants is critical in promoting healthy ageing..

Reishi · 2025 · Journal Article · Neurochemical research

Evaluation of the Potential Anticonvulsant and Neuroprotective Effects of Ganoderma Lucidum Extract in an Animal Model of Pentylenetetrazol-Induced Seizures.

Ganoderma lucidum extract (GLE) has neuro-therapeutic and anticonvulsant effects. This study aimed to evaluate the potential neuroprotective and antioxidant effects of ethanolic extract on pentylenetetrazol-induced brain damage in male Wistar rats and to analyze behavioral manifestations in vivo..

Immune supportCognition & nervesEnergy & fatigue

Reishi · 2025 · Journal Article · Mycopathologia

Exopolysaccharides of Ganoderma lucidum Activate the NLRP3 Inflammasome, Modulating Phagocytes and the Response of Mice to Infection with Cryptococcus neoformans.

Interleucin-1β (IL-1β) is a pivotal cytokine in pro-inflammatory response induction, and it is regarded as protective in various diseases. IL-1β secretion is mainly associated with activation of the inflammasome complex, which normally is tightly regulated, depending on two signals for significant activity..

OncologyImmune supportCognition & nervesRespiratory

Agarikon · 2025 · Research Article · Frontiers in pharmacology

Exploration of the role of Fomitopsis officinalis Ames in the treatment of gastric cancer using network pharmacology, molecular docking, and in vitro experiments.

BACKGROUND: Gastric cancer (GC) is one of the most common malignant tumors worldwide, with approximately one million people diagnosed with gastric cancer each year..

OncologyImmune supportCognition & nervesEnergy & fatigue

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Ganoderma lucidum low molecular weight polysaccharide promotes the repair of spinal cord injury through anti-inflammatory and antioxidant

Oxidative stress after spinal cord injury (SCI) significantly promotes neuronal apoptosis. The imbalance of flora leads to the destruction of the intestinal barrier, so that pro-inflammatory cytokines enter the blood and further aggravate neuroinflammation..

OncologyImmune supportCognition & nervesEnergy & fatigue

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Ganoderma lucidum low molecular weight polysaccharide promotes the repair of spinal cord injury through anti-inflammatory and antioxidant.

Immune supportCognition & nervesMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Ganoderma lucidum triterpenes ameliorate age-related cognitive impairment via regulating Eubacterium lentum-mediated serine metabolism.

BACKGROUND: Natural aging of the brain is commonly accompanied by a decline in cognitive ability, which is driven by oxidative stress, inflammation, and metabolic dysregulation. These pathological processes are further exacerbated by gut microbiota dysbiosis..