MycoData

Cordyceps militaris is a commonly used medicinal mushroom containing various therapeutic effects such as anti-inflammatory, anti-allergic, and anti-cancer activities..

OncologyImmune supportRespiratory

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Cordyceps · 2018 · Journal Article · International journal of medicinal mushrooms

Effects of a Commercial Supplement of Ophiocordyceps sinensis and Ganoderma lucidum on Physiological Responses to Maximal Exercise in Healthy Young Participants.

Cordyceps sinensis (=Ophiocordyceps sinensis) and Ganoderma lucidum are 2 medicinal mushrooms that have been suggested to have the potential to enhance exercise capacity. We used a commercial supplement combining a traditional Chinese medicine and G..

Energy & fatigueRespiratory

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Agarikon · 2018 · Journal Article · Journal of natural medicines

Lanostane triterpenoids from Fomitopsis officinalis and their trypanocidal activity.

Fomitopsis officinalis is a medicinal fungus, known as 'Agarikon', and is used traditionally in the treatment of asthma and rheumatism in Mongolia. The investigation of the chemical constituents of F.

Respiratory

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King Oyster · 2017 · Journal Article · International journal of biological macromolecules

Antioxidant, antitumor and immunostimulatory activities of the polypeptide from Pleurotus eryngii mycelium.

The objective of this study was to investigate the antioxidant, antitumor and immunological activities of the polypeptide from Pleurotus eryngii mycelium (PEMP). The ability of the polypeptide to stimulate Ana-1 macrophages to englobe neutral red, secrete NO, H2O2, TNF-α, and IL-6, increase TLR2 and TLR4 expression….

OncologyImmune supportSkin & hydrationRespiratory

High relevance

Maitake · 2017 · Journal Article · Nutrition and cancer

Antitumoral Effects of D-Fraction from Grifola Frondosa (Maitake) Mushroom in Breast Cancer.

D-Fraction is protein-bound β-1,6 and β-1,3 glucans (proteoglucan) extracted from the edible and medicinal mushroom Grifola frondosa (Maitake). The antitumoral effect of D-Fraction has long been exclusively attributed to their immunostimulatory capacity..

OncologyImmune supportRespiratory

High relevance

Cordyceps · 2017 · Journal Article · Applied biochemistry and biotechnology

Functional Analysis of Ribonucleotide Reductase from Cordyceps militaris Expressed in Escherichia coli.

Cordyceps militaris produces cordycepin (3'-deoxyadenosine), which has various activities, including anti-oxidant, anti-tumoral, anti-viral, and anti-inflammatory. Ribonucleotide reductase (RNR) seems to be a candidate to produce cordycepin in C..

OncologyImmune supportMetabolic healthRespiratory

High relevance

Chaga · 2016 · Research Article · Heliyon

Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice.

AIMS: Cancer is a leading cause of morbidity and mortality worldwide; therefore, effective measures for cancer prevention and treatment are in constant demand. The extracts of Inonotus obliquus (Chaga mushroom) demonstrate potent anti-tumor activities and have been used to treat cancer in several countries; however,….

OncologyEnergy & fatigueMetabolic healthRespiratory

High relevance

King Oyster · 2016 · Journal Article · Fish physiology and biochemistry

Effects of Eryngii mushroom (Pleurotus eryngii) and Lactobacillus plantarum on growth performance, immunity and disease resistance of Pangasius catfish (Pangasius bocourti, Sauvage 1880).

This study was conducted to evaluate the effects of Eryngii mushroom, Pleurotus eryngii (PE), and Lactobacillus plantarum single or combined on growth, innate immune response and disease resistance of the Pangasius catfish, Pangasius bocourti..

Immune supportEnergy & fatigueGut & microbiomeRespiratory

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Shiitake · 2016 · Journal Article · FEMS microbiology letters

Incidence of diverse dsRNA mycoviruses in Trichoderma spp. causing green mold disease of shiitake Lentinula edodes.

A total of 315 fungal isolates causing green mold disease were collected from contaminated artificial logs and sawdust bags used for cultivating shiitake Lentinula edodes in Korea and were analyzed for the presence of double-stranded RNA (dsRNA)..

Gut & microbiomeRespiratory

High relevance

Cordyceps · 2013 · Review · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Advances on Cordyceps militaris constituents and pharmacological effect].

Cordyceps militaris is a parasitic fungus in a variety of lepidopteran pupae and larvae. It was reported that Cordyceps militaris has strong activity on the immuregulation, tumor, virus, infecction.

OncologyRespiratory

High relevance

Chaga · 2010 · Review · Applied microbiology and biotechnology

Chemical diversity of biologically active metabolites in the sclerotia of Inonotus obliquus and submerged culture strategies for up-regulating their production.

Inonotus obliquus (Fr.) Pilat is a white rot fungus belonging to the family Hymenochaetaceae in the Basidiomycota. In nature, this fungus rarely forms a fruiting body but usually an irregular shape of sclerotial conk called 'Chaga'.

OncologyImmune supportSkin & hydrationRespiratory

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Reishi · 2025 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Regulation of apoptosis and autophagy in hepatoblastoma cells by Ganoderma lucidum polysaccharides through Akt/mTOR pathway].

This research investigated the impact of Ganoderma lucidum polysaccharides(GLP) on hepatoblastoma HepG2 and Huh6 cell models, as well as KM mouse model with in situ transplanted tumors, so as to provide a theoretical basis for the clinical application of GLP..

OncologyImmune supportLiver supportRespiratory

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Cordyceps · 2025 · Comparative Study · Journal of pharmaceutical and biomedical analysis

Integrating 2D NMR-based metabolomics and in vitro assays to explore the potential viability of cultivated Ophiocordyceps sinensis as an alternative to the wild counterpart.

Ophiocordyceps sinensis is widely used to treat various diseases and as a health supplement. The present study comprehensively compared the metabolic differences between wild and cultivated O.

OncologyMetabolic healthRespiratory

High relevance

Reishi · 2025 · Research Support, Non U.S. Gov'T · Applied and environmental microbiology

Spermidine enhances the heat tolerance of Ganoderma lucidum by promoting mitochondrial respiration driven by fatty acid β-oxidation.

UNLABELLED: High temperature is an unavoidable environmental stress that generally exerts detrimental effects on organisms and has widespread effects on metabolism. Spermidine is an important member of the polyamines family and is involved in a range of abiotic stress responses in plants..

Energy & fatigueRespiratory

High relevance

Reishi · 2024 · Research Support, Non U.S. Gov'T · Journal of the Chinese Medical Association: JCMA

Ganoderma lucidum spore oil synergistically enhances the function of cyclophosphamide in the prevention of breast cancer metastasis.

BACKGROUND: Ganoderma lucidum ( G. lucidum ) is a traditional Chinese herbal medicine that has shown potential as an alternative adjuvant therapy for cancer patients.

OncologyImmune supportMetabolic healthRespiratory

High relevance

Reishi · 2024 · Research Support, Non U.S. Gov'T · Journal of cellular and molecular medicine

Sporoderm-broken spores of Ganoderma lucidum modulate hepatoblastoma malignancy by regulating RACK1-mediated autophagy and tumour immunity.

Hepatoblastoma (HB), a primary liver tumour, is notorious for its high metastatic potential and poor prognosis. Ganoderma lucidum, an edible mushroom species utilized in traditional Chinese medicine for addressing various tumour types, presents an intriguing avenue for HB treatment.

OncologyImmune supportLiver supportRespiratory

High relevance

Snow Fungus · 2024 · Research Support, Non U.S. Gov'T · Aging

Tremella fuciformis polysaccharides induce ferroptosis in Epstein-Barr virus-associated gastric cancer by inactivating NRF2/HO-1 signaling.

Approximately 10% of gastric cancers are associated with Epstein-Barr virus (EBV). Tremella fuciformis polysaccharides (TFPs) are characterized by antioxidative and anti-inflammatory effects in different diseases.

OncologyImmune supportRespiratory

High relevance

Reishi · 2023 · Research Article · Journal of biomedical science

A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge.

BACKGROUND: Human enteroviruses A71 (EV-A71) and D68 (EV-D68) are the suspected causative agents of hand-foot-and-mouth disease, aseptic meningitis, encephalitis, acute flaccid myelitis, and acute flaccid paralysis in children. Until now, no cure nor mucosal vaccine existed for EV-A71 and EV-D68..

Immune supportRespiratory

High relevance

Maitake · 2023 · Journal Article · Plant foods for human nutrition (Dordrecht, Netherlands)

Anti-α-glucosidase, Anti-proliferative and Anti-enterovirus 71 Activity of Secondary Metabolites Identified from Grifola Frondosa.

Grifola frondosa, an edible and medicinal resource, is widely used as functional foods worldwide. To explore bioactive compounds against α-glucosidase, human tumor cells and enterovirus 71 (EV71), eight compounds were isolated from G.

OncologyMetabolic healthRespiratory

High relevance

Turkey Tail · 2023 · Research Article · Journal of veterinary research

Antioxidant and antimicrobial properties of an extract rich in proteins obtained from Trametes versicolor.

INTRODUCTION: Bioactive proteins and peptides generated from fruit, vegetables, meat or fish have great potential as functional food or substitutes for antibiotics. In recent years it has also been demonstrated that the fungus kingdom could be a source of these compounds..

Skin & hydrationRespiratory

High relevance

Cordyceps · 2023 · Journal Article · Journal of ethnopharmacology

Bioinformatics analysis and in vivo validation study of Ophiocordyceps sinensis (Berk.)G.H.Sungetal against lung adenocarcinoma.

ETHNOPHARMACOLOGICAL RELEVANCE: Lung adenocarcinoma (LUAD) is one of the main types of lung cancer. Ophiocordyceps sinensis has many potentially useful pharmacologic features, such as lung protection, and both anti-inflammatory and antioxidant activities..

OncologyImmune supportRespiratory

High relevance

Turkey Tail · 2023 · Research Article · Nutrients

Medicinal Mushroom Extracts from Hericium coralloides and Trametes versicolor Exert Differential Immunomodulatory Effects on Immune Cells from Older Adults In Vitro.

Medicinal mushroom extracts (MMEs) exert immunomodulatory effects on innate immunity. The present study aimed to examine the effect of medicinal mushroom components on in vitro immune cell responses to inflammatory stimuli by peripheral blood mononuclear cells (PBMCs) isolated from older adults, where immune function….

Immune supportRespiratory

High relevance

Shiitake · 2023 · Research Article · Pathogens (Basel, Switzerland)

Oral Supplementation with AHCC®, a Standardized Extract of Cultured Lentinula edodes Mycelia, Enhances Host Resistance against SARS-CoV-2 Infection.

The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted global public health safety and the economy. Multiple antiviral drugs have been developed, and some have received regulatory approval and/or authorization..

Immune supportRespiratory

High relevance

Reishi · 2023 · Journal Article · Journal of biosciences

Pathway analysis of host responses to dengue virus serotype 2 infection and inhibition of viral envelope protein by naringenin from Ganoderma lucidum.

Dengue fever cases are spiking over the last two decades. Incessant efforts are still being made to gain deeper insights on this arboviral disease and to identify bioactive antivirals..

Energy & fatigueRespiratory

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Oyster Mushroom · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

Transcriptome Analysis Revealed That Hydrogen Peroxide-Regulated Oxidative Phosphorylation Plays an Important Role in the Formation of Pleurotus ostreatus Cap Color.

Pleurotus ostreatus is widely cultivated in China. H2O2, as a signaling molecule, can regulate the formation of cap color, but its regulatory pathway is still unclear, severely inhibiting the breeding of dark-colored strains.

Metabolic healthRespiratory

High relevance

Cordyceps · 2023 · Research Article · Medicine

Uncovering anti-influenza mechanism of Ophiocordyceps sinensis using network pharmacology, molecular pharmacology, and metabolomics.

Ophiocordyceps sinensis is a precious Chinese traditional herb with a long medicinal history. This study used UPLC-MS metabolomics to explore and compare the metabolic profiles of the stroma (OSBSz), sclerotium (OSBSh), and mycelium (OSBS) of O sinensis to analyze their differential metabolites and identified….

Metabolic healthRespiratory

High relevance

Niu-Chang-Chih · 2022 · Research Article · Molecules (Basel, Switzerland)

Anti-Inflammatory Constituents of Antrodia camphorata on RAW 264.7 Cells Induced by Polyinosinic-Polycytidylic Acid.

Antrodia camphorata is an endemic mushroom in Taiwan. This study was designed to screen anti-inflammatory compounds from the methanolic extract of the mycelium of A..

OncologyImmune supportRespiratory

High relevance

Turkey Tail · 2022 · Research Article · Frontiers in microbiology

Characterization of a Trametes versicolor aflatoxin B1-degrading enzyme (TV-AFB1D) and its application in the AFB1 degradation of contaminated rice in situ.

Aflatoxin B1 (AFB1) contaminates rice during harvest or storage and causes a considerable risk to human and animal health. In this study, Trametes versicolor AFB1-degrading enzyme (TV-AFB1D) gene recombinantly expressed in engineered E.

Respiratory

High relevance

Shiitake · 2022 · Research Article · BMC genomics

Chromosomal genome and population genetic analyses to reveal genetic architecture, breeding history and genes related to cadmium accumulation in Lentinula edodes.

BACKGROUND: Lentinula edodes (Berk.) is the second most productive mushroom in the world. It contains compounds effective for antiviral, antitumor, antioxidant and immune regulation.

OncologyImmune supportRespiratory

High relevance

Shiitake · 2022 · Research Article · Molecules (Basel, Switzerland)

Effect of Supplementation with the Combination of Se-Enriched Lentinula edodes Mycelium, Exogenous Enzymes, Acidifiers, Sodium Butyrate and Silicon Dioxide Nanoparticle Feed Additives on Selected Parameters in Calves.

During the initial months of calves’ lives, the young animals are exposed to bacterial and viral infections, and during this period, crucial physiological changes take place in their organisms..

Immune supportLiver supportRespiratory

High relevance

Shiitake · 2022 · Research Article · Bioengineering (Basel, Switzerland)

Enhanced Effects of Iron on Mycelial Growth, Metabolism and In Vitro Antioxidant Activity of Polysaccharides from Lentinula edodes.

The polysaccharides found in Lentinula edodes have a variety of medicinal properties, such as anti-tumor and anti-viral effects, but their content in L. edodes sporophores is very low.

OncologyImmune supportMetabolic healthRespiratory

High relevance

Lion's Mane · 2022 · Research Article · Bioresources and bioprocessing

In vitro assessment of multipotential therapeutic importance of Hericium erinaceus mushroom extracts using different solvents.

Infectious disease is one of the major threats to humans and it is the second leading cause of death worldwide. Edible mushrooms have many nutritional and medicinal values to human health..

Immune supportLiver supportRespiratory

High relevance

Shiitake · 2022 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Lentinula edodes extract increases goblet cell number and Muc2 expression in an intestinal inflammatory model of Trichinella spiralis infection.

AHCC® is a standardized extract of cultured mushroom (Lentinula edodes) mycelia with a wide variety of therapeutic effects including anti-inflammatory, antitumor and antiviral effects. Trichinellosis, a food-borne parasitic zoonosis is caused by the nematode Trichinella spp..

OncologyImmune supportGut & microbiomeRespiratory

High relevance

Oyster Mushroom · 2022 · Research Article · Journal of fungi (Basel, Switzerland)

Nitric Oxide Negatively Regulates the Rapid Formation of Pleurotus ostreatus Primordia by Inhibiting the Mitochondrial aco Gene.

Nitric oxide (NO) is as a signaling molecule that participates in the regulation of plant development and in a number of physiological processes. However, the function and regulatory pathway of NO in the growth and development of edible mushrooms are still unknown..

Energy & fatigueRespiratory

High relevance

Reishi · 2022 · Research Article · Frontiers in pharmacology

Nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for Ganoderma lucidum with Marsdenia tenacissima.

Lung cancer is one of the malignant tumors with the fastest incidence rate and mortality growth and the greatest threat to human health and life. Marsdenia tenacissima is an antitumor of Chinese medicine..

OncologyRespiratory

High relevance

Mesima · 2022 · Journal Article · Molecular biology reports

Systematic evaluation of the anti-tumor effect of Phellinus linteus polysaccharide in thyroid carcinoma in vitro.

BACKGROUND: Thyroid carcinoma (TC) is the most common malignant tumor of the endocrine system. Phellinus linteus polysaccharide (PLP) physiologically acts as a suitable anti-tumor molecule..

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Enoki · 2022 · Research Article · Frontiers in nutrition

The Effect of Flammulina velutipes Polysaccharide on Immunization Analyzed by Intestinal Flora and Proteomics.

Proteomics and intestinal flora were used to determine the mechanism of immune modulatory effects of Flammulina velutipes polysaccharide on immunosuppressed mice. The results showed that compared with the model group, F..

Immune supportGut & microbiomeLiver supportRespiratory

High relevance

Turkey Tail · 2021 · Research Article · International journal of molecular sciences

Biodegradation of Chloroxylenol by Cunninghamella elegans IM 1785/21GP and Trametes versicolor IM 373: Insight into Ecotoxicity and Metabolic Pathways.

Chloroxylenol (PCMX) is applied as a preservative and disinfectant in personal care products, currently recommended for use to inactivate the SARS-CoV-2 virus. Its intensive application leads to the release of PCMX into the environment, which can have a harmful impact on aquatic and soil biotas..

Metabolic healthRespiratory

High relevance

Lion's Mane · 2021 · Journal Article · International journal of biological macromolecules

Effects of Hericium erinaceus polysaccharide on immunity and apoptosis of the main immune organs in Muscovy duck reovirus-infected ducklings.

To investigate the effects of Hericium erinaceus polysaccharide (HEP) on immunity in Muscovy duck reovirus (MDRV)-infected ducklings and explore its mechanism of action, an MDRV contact-infection model was established..

OncologyImmune supportRespiratory

High relevance

Shiitake · 2021 · Journal Article · Food & function

Protective effects of sulfated polysaccharides from Lentinula edodes on the lung and liver of MODS mice.

In this work, the effects of sulfated polysaccharides from Lentinula edodes (SPLE) on zymosan (ZYM)-induced multiple organ dysfunction syndrome (MODS) mice were investigated..

Immune supportLiver supportRespiratory

High relevance

Reishi · 2021 · Research Article · Polymers

WSG, a Glucose-Rich Polysaccharide from Ganoderma lucidum, Combined with Cisplatin Potentiates Inhibition of Lung Cancer In Vitro and In Vivo.

Lung cancer has the highest global mortality rate of any cancer. Although targeted therapeutic drugs are commercially available, the common drug resistance and insensitivity to cisplatin-based chemotherapy, a common clinical treatment for lung cancer, have prompted active research on alternative lung cancer therapies….

OncologyImmune supportMetabolic healthRespiratory

High relevance

Oyster Mushroom · 2023 · Research Article · Molecules (Basel, Switzerland)

Effect of Oyster Mushroom Addition on Improving the Sensory Properties, Nutritional Value and Increasing the Antioxidant Potential of Carp Meat Burgers.

The growing interest in functional food makes looking for new possibilities of enriching products with health-promoting ingredients necessary. One raw material with a very high potential for the food industry is the oyster mushroom (Pleurotus ostreatus), which has a strong antioxidant, antiviral, and anticancer….

OncologyGut & microbiomeRespiratory

High relevance

Oyster Mushroom · 2023 · Journal Article · Molecular biology reports

Identification and morpho-molecular characterization of low spore strain in oyster mushroom.

BACKGROUND: Sporocarps of oyster mushroom liberate enormous spores and cause allergic reactions to workers involved in its cultivation. These spore-related allergies include stiffness or pain in the forearms, limbs, itchy throat, grogginess, and respiratory problems and are major problems during oyster mushroom….

Respiratory

High relevance

Cordyceps · 2021 · Journal Article · Journal of ethnopharmacology

Toxicological safety evaluation of the cultivated Chinese cordyceps.

ETHNOPHARMACOLOGICAL RELEVANCE: The Chinese cordyceps, a parasitic Thitarodes insect-Ophiocordyceps sinensis fungus complex in the Qinghai-Tibet Plateau, is one of the most valuable traditional Chinese medicines and health food for ameliorating conditions associated with aging and for treating fatigue, night sweats,….

Energy & fatigueMetabolic healthLiver supportRespiratory

High relevance

Cordyceps · 2016 · Research Article · Experimental and therapeutic medicine

Separation of cordycepin from Cordyceps militaris fermentation supernatant using preparative HPLC and evaluation of its antibacterial activity as an NAD+-dependent DNA ligase inhibitor.

Cordycepin exhibits various bio-activities, including anticancer, antibacterial, antiviral and immune regulation activities, and is a significant focus of research. However, the preparation of high-purity cordycepin remains challenging..

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Maitake · 2018 · Review · Discovery medicine

Grifola frondosa polysaccharide: a review of antitumor and other biological activity studies in China.

Grifola frondosa, a species of Basidiomycotina, is an edible medicinal mushroom with a large fruiting body characterized by overlapping caps. The β-glucan is the major biologically active component in G.

OncologyImmune supportMetabolic healthRespiratory

High relevance

King Oyster · 2004 · Review · Shi yong jun xue bao (Online)

Advances in the research of Pleurotus eryngii

Macrophages were prepared from the lung, peritoneal cavity and blood of normal, unstimulated rats from a number of strains. The macrophages were purified by adherence, and characterized via surface markers, enzyme activity and phagocytic capacity, and subsequently tested for activity in cultures of mitogen-stimulated….

Immune supportRespiratory

High relevance

King Oyster · 2003 · Review · Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society

[Hypersensitivity pneumonitis induced by Pleurotus eryngii spores--a case report].

A 52-year-old man was hospitalized because of recurrent fever, dyspnea and cough in February 2002. He had worked in a Eringi (Pleurotus eryngii) mushroom factory since 1996.

Immune supportRespiratory

High relevance

Cordyceps · 2026 · Review · Phytotherapy research: PTR

Biologically Active Ingredients and Underlying Mechanisms of Cordyceps in Treating Respiratory Diseases: A Comprehensive Review With Future Perspectives.

The incidence of respiratory diseases is increasing worldwide and imposes a significant health burden. Due to the complex etiology and diverse inducements of these diseases, existing therapies often struggle to control disease progression and reduce recurrence rates..

Immune supportRespiratory

High relevance

Cordyceps · 2025 · Review · Current pharmaceutical design

Immunopharmacological Insights into Cordyceps spp.: Harnessing Therapeutic Potential for Sepsis.

Cordyceps spp. (CS), a well-known medicinal mushroom that belongs to Tibetan medicine and is predominantly found in the high altitudes in the Himalayas.

Immune supportCognition & nervesLiver supportRespiratory