MycoData

OncologyImmune supportLiver support

Almond Mushroom · 2024 · Journal Article · Tissue & cell

Citrus reticulata peel extract mitigates oxidative stress and liver injury induced by abamectin in rats.

The prevalent use of abamectin (ABM) has latterly raised safety attention as it has different toxicities to non-target living organisms. Citrus fruits are widely renowned for their nutritional and health-promoting qualities, and their peels are full of phenolic constituents..

Cordyceps · 2024 · Journal Article · Reproduction (Cambridge, England)

Cordycepin suppresses steroidogenic acute regulatory protein expression by reducing SP1 in human granulosa-lutein cells.

IN BRIEF: Cordycepin (COR), a compound derived from Cordyceps, is recognized as an adenosine analog with numerous beneficial effects on human health. However, its impact on steroidogenic acute regulatory protein (STAR) expression in ovarian granulosa cells is not well understood..

Almond Mushroom · 2024 · Journal Article · European journal of nuclear medicine and molecular imaging

Development of probes for radiotheranostics with albumin binding moiety to increase the therapeutic effects of astatine-211 (211At).

PURPOSE: We have developed probes for multiradionuclides radiotheranostics using RGD peptide ([67Ga]Ga-DOTA-c[RGDf(4-I)K] ([67Ga]1) and Ga-DOTA-[211At]c[RGDf(4-At)K] ([211At]2)) for clinical applications..

Almond Mushroom · 2024 · Research Article · Frontiers in immunology

Dysregulated FGFR3 signaling alters the immune landscape in bladder cancer and presents therapeutic possibilities in an agent-based model.

Bladder cancer is an increasingly prevalent global disease that continues to cause morbidity and mortality despite recent advances in treatment. Immune checkpoint inhibitors (ICI) and fibroblast growth factor receptor (FGFR)-targeted therapeutics have had modest success in bladder cancer when used as monotherapy..

Almond Mushroom · 2024 · Journal Article · Bulletin of mathematical biology

Forecasting and Predicting Stochastic Agent-Based Model Data with Biologically-Informed Neural Networks.

Collective migration is an important component of many biological processes, including wound healing, tumorigenesis, and embryo development. Spatial agent-based models (ABMs) are often used to model collective migration, but it is challenging to thoroughly predict these models' behavior throughout parameter space due….

OncologySkin & hydration

OncologyImmune supportCognition & nerves

Almond Mushroom · 2024 · Research Article · Scientific reports

In silico study of heterogeneous tumour-derived organoid response to CAR T-cell therapy.

Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapy for treating cancers. This method consists in modifying the patients' T-cells to directly target antigen-presenting cancer cells.

Almond Mushroom · 2024 · Research Article · APL bioengineering

Integrating mechanism-based T cell phenotypes into a model of tumor-immune cell interactions.

Interactions between cancer cells and immune cells in the tumor microenvironment influence tumor growth and can contribute to the response to cancer immunotherapies. It is difficult to gain mechanistic insights into the effects of cell-cell interactions in tumors using a purely experimental approach..

Nameko · 2024 · Journal Article · Biological trace element research

Levels and Health Risk Assessment of Inorganic Arsenic, Methylmercury, and Heavy Metals in Edible Mushrooms Collected from Online Supermarket in China.

Chromium (Cr), total arsenic (As), inorganic arsenic (iAs), cadmium (Cd), mercury (Hg), methylmercury (MeHg), and lead (Pb) were analyzed in in Agaricus blazei, Tricholoma matsutake, Pholiota nameko, agrocybe aegirit, Boletus edulis, Auricularia auricula, and Lentinus edodes collected from online supermarket in China….

OncologyImmune supportMetabolic health

Oyster Mushroom · 2024 · Research Article · Molecules (Basel, Switzerland)

Pleurotus sajor-caju (Fr.) Singer β-1,3-Glucanoligosaccharide (Ps-GOS) Suppresses RANKL-Induced Osteoclast Differentiation and Function in Pre-Osteoclastic RAW 264.7 Cells by Inhibiting the RANK/NFκB/cFOS/NFATc1 Signalling Pathway.

Edible grey oyster mushroom, Pleurotus sajor-caju, β (1,3), (1,6) glucan possesses a wide range of biological activities, including anti-inflammation, anti-microorganism and antioxidant. However, its biological activity is limited by low water solubility resulting from its high molecular weight..

OncologyImmune supportMetabolic healthGut & microbiome

Agarikon · 2024 · Research Article · Frontiers in pharmacology

Proteomic study of medicinal mushroom extracts reveals antitumor mechanisms in an advanced colon cancer animal model via ribosomal biogenesis, translation, and metabolic pathways.

INTRODUCTION: Colorectal cancer ranks as the third most common cancer in both men and women, with approximately 35% of cases being stage IV metastatic at diagnosis. Even with treatment advancements, the survival rates for these patients remain suboptimal..

Almond Mushroom · 2024 · Research Article · CPT: pharmacometrics & systems pharmacology

Quantitative systems pharmacology modeling of tumor heterogeneity in response to BH3-mimetics using virtual tumors calibrated with cell viability assays.

Both primary and acquired resistance mechanisms that involve intra-tumoral cell heterogeneity limit the use of BH3-mimetics to trigger tumor cell apoptosis. This article proposes a new quantitative systems pharmacology (QSP)-based methodology in which cell viability assays are used to calibrate virtual tumors (VTs)….

OncologyLiver supportSkin & hydration

Almond Mushroom · 2024 · Research Article · International cancer conference journal

Radiation hepatitis after postmastectomy radiation therapy for early breast cancer: difficult to differentiate from drug-induced liver injury caused by abemaciclib.

Abemaciclib (ABM) is recommended for adjuvant endocrine therapy in hormone receptor-positive, human epidermal growth factor receptor type 2-negative early breast cancer (EBC) patients at high risk of recurrence..

Almond Mushroom · 2024 · Research Article · Radiation oncology (London, England)

Spatially fractionated GRID radiation potentiates immune-mediated tumor control.

BACKGROUND: Tumor-immune interactions shape a developing tumor and its tumor immune microenvironment (TIME) resulting in either well-infiltrated, immunologically inflamed tumor beds, or immune deserts with low levels of infiltration..

OncologyImmune supportCognition & nervesEnergy & fatigue

Reishi · 2024 · Journal Article · Frontiers in nutrition

UPLC-ESI-MS/MS-based widely targeted metabolomics reveals differences in metabolite composition among four Ganoderma species.

The Chinese name "Lingzhi" refers to Ganoderma genus, which are increasingly used in the food and medical industries. Ganoderma species are often used interchangeably since the differences in their composition are not known..

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2022 · Review · International journal of medicinal mushrooms

Cordycepin as a Metabolite with Pharmacological Potential: A Review.

The pharmacological values of Cordyceps spp. are substantially associated with the existence of an extremely potent biometabolite: cordycepin.

Almond Mushroom · 2022 · Review · Cancers

Placental Mesenchymal Dysplasia and Beckwith-Wiedemann Syndrome.

Placental mesenchymal dysplasia (PMD) is characterized by placentomegaly, aneurysmally dilated chorionic plate vessels, thrombosis of the dilated vessels, and large grapelike vesicles, and is often mistaken for partial or complete hydatidiform mole with a coexisting normal fetus..

OncologyImmune supportSkin & hydration

Shiitake · 2021 · Review · Histology and histopathology

Immunology of tissue homeostasis, ovarian cancer growth and regression, and long lasting cancer immune prophylaxis - review of literature.

Data on the substantial physiological role of the immune system in the organism's ability to manage proper differentiation and function of normal tissues (tissue homeostasis), and detailed causes of the immune system's essential role for the in-vivo stimulation of cancer growth, are severely lacking..

OncologyImmune supportEnergy & fatigueRespiratory

Cordyceps · 2019 · Research Article · International journal of molecular sciences

Adenosine Induces EBV Lytic Reactivation through ADORA1 in EBV-Associated Gastric Carcinoma.

Cordyceps species are known to contain numerous bioactive compounds, including cordycepin. Extracts of Cordyceps militaris (CME) are used in diverse medicinal purposes because of their bioactive components..

King Oyster · 2017 · Journal Article · Food chemistry

Wild mushrooms and their mycelia as sources of bioactive compounds: Antioxidant, anti-inflammatory and cytotoxic properties.

Mushrooms are important sources of natural bioactive compounds. Pleurotus eryngii (DC.) Quél is recognized for its organoleptic quality and health effects, being extensively commercialized.

OncologyImmune supportEnergy & fatigueGut & microbiome

Maitake · 2010 · Research Support, Non U.S. Gov'T · Cancer immunology, immunotherapy: CII

Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity.

Bone marrow myelotoxicity is a major limitation of chemotherapy. While granulocyte colony stimulating factor (G-CSF) treatment is effective, alternative approaches to support hematopoietic recovery are sought..

OncologyImmune supportLiver support

Enoki · 2010 · Research Support, Non U.S. Gov'T · International immunopharmacology

Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma.

FVE is a documented immunomodulatory protein purified from Enoki mushroom (Flammulina velutipes) and known as an activator for human T lymphocytes. This present study was aimed to investigate the anti-tumor effect and the related mechanisms of oral administration of FVE using a murine hepatoma model..

OncologyImmune supportMetabolic healthLiver support

Maitake · 2009 · Review Article · International journal of general medicine

Synergistic potentiation of D-fraction with vitamin C as possible alternative approach for cancer therapy.

Maitake D-fraction or PDF is the bioactive extract of maitake mushroom (Grifola frondosa) and its active constituent is the protein-bound polysaccharide (proteoglucan), or more specifically known as beta-glucan..

OncologyImmune supportGut & microbiome

Maitake · 2007 · Research Support, Non U.S. Gov'T · Clinical and vaccine immunology: CVI

Enhancement of umbilical cord blood cell hematopoiesis by maitake beta-glucan is mediated by granulocyte colony-stimulating factor production.

Maitake beta-glucan (MBG) is an extract from the fruit body of the Grifola frondosa mushroom that is being widely used to treat cancer in Asia. We have previously reported that MBG enhances mouse bone marrow cell (BMC) hematopoiesis in vitro and protects BMC from doxorubicin (DOX) toxicity..

OncologyImmune supportMetabolic healthSkin & hydration

Turkey Tail · 2007 · Patent · journal metadata

STRAIN OF TURKEY TAIL MUSHROOM, EXTRACT FROM THE SAME, AND USE OF THE SAME

Disclosed is a strain of turkey tail mushroom (Trametes versicolor) having excellent biological activities (Accession number: FERM BP-10633). The strain is excellent in platelet aggregation inhibitory effect, chemokine gene expression inhibitory effect, anti-mutagenic effect, anti-tumor effect, anti-hypertensive….

Cordyceps · 2025 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Synergistic Effect of HAD-B1 and Osimertinib Against Gefitinib Resistant HCC827 Non-Small Cell Lung Cancer Cells.

In this study, we investigated the synergistic effect of co-administration of osimertinib and HAD-B1 using gefitinib-resistant non-small cell lung cancer cells, HCC827-GR. HAD-B1 is composed of 4 natural drugs, Panax Notoginseng Radix, Panax ginseng C.

OncologyRespiratory

OncologyImmune supportRespiratory

Chaga · 2025 · Research Support, Non U.S. Gov'T · Apoptosis: an international journal on programmed cell death

β-glucan nanoparticles alleviate acute asthma by suppressing ferroptosis and DNA damage in mice.

Asthma is a severe respiratory disease marked by airway inflammation, remodeling, and oxidative stress. β-Glucan (BG), a polysaccharide constituent of fungal cellular structures, exhibits potent immunomodulatory activities..

OncologyCognition & nerves

Cordyceps · 2023 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Cordycepin improved neuronal synaptic plasticity through CREB-induced NGF upregulation driven by MG-M2 polarization: a microglia-neuron symphony in AD.

PURPOSE: Microglia-neuron crosstalk is critically involved in synaptic plasticity and degeneration by releasing diverse mediators in Alzheimer's disease (AD). Therefore, determining contributors that modulate the systemic microenvironment is essential..

OncologyEnergy & fatigueMetabolic health

Cordyceps · 2023 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Cordycepin protects islet β-cells against glucotoxicity and lipotoxicity via modulating related proteins of ROS/JNK signaling pathway.

Type 2 diabetes mellitus (T2DM) is a common and multiple endocrine metabolic disease. When pancreatic β cell in case of dysfunction, the synthesis and secretion of insulin are reduced..

Cordyceps · 2023 · Research Article · Journal of cancer research and clinical oncology

Cordycepin remodels the tumor microenvironment of colorectal cancer by down-regulating the expression of PD-L1.

PURPOSE: Colorectal cancer, as a common malignant tumor, poses a serious threat to human life. Cordycepin, derived from Cordyceps militaris extract, which was established as a capable inhibitor of tumor growth.

OncologyGut & microbiome

OncologyImmune supportEnergy & fatigue

Cordyceps · 2023 · Journal Article · International immunopharmacology

Cordycepin suppresses vascular inflammation, apoptosis and oxidative stress of arterial smooth muscle cell in thoracic aortic aneurysm with VEGF inhibition.

BACKGROUND: Thoracic aortic aneurysm (TAA) is a type of common and serious vascular disease, in which inflammation, apoptosis and oxidative stress are strongly involved in the progression. Cordycepin, a bioactive compound from Cordyceps militaris, exhibits anti-inflammatory and anti-oxidative activities..

OncologyImmune supportRespiratory

Cordyceps · 2023 · Journal Article · Microorganisms

Natural Product Cordycepin (CD) Inhibition for NRP1/CD304 Expression and Possibly SARS-CoV-2 Susceptibility Prevention on Cancers.

NRP1/CD304 is a typical membrane-bound co-receptor for the vascular endothelial cell growth factor (VEGF), semaphorin family members, and viral SARS-CoV-2. Cordycepin (CD) is a natural product or active gradient from traditional Chinese medicine (TCM) from Cordyceps militaris Link and Ophiocordyceps sinensis (Berk.)..

OncologyImmune supportGut & microbiome

Cordyceps · 2022 · Journal Article · International immunopharmacology

Cordycepin enhances anti-tumor immunity in colon cancer by inhibiting phagocytosis immune checkpoint CD47 expression.

Cordycepin, also known as 3'-deoxyadenosine, is an extract from Cordyceps militaris, which has been reported as an anti-inflammation and anti-tumor substance without toxicity. However, the pharmacological mechanism of Cordycepin on tumor immunity under its anti-tumor effect has not yet been elucidated..

Cordyceps · 2022 · Research Article · Pharmaceutical biology

Cordycepin mitigates spermatogenic and redox related expression in H2O2-exposed Leydig cells and regulates testicular oxidative apoptotic signalling in aged rats.

CONTEXT: Cordycepin (COR), from Cordyceps militaris L., (Cordycipitaceae), is a valuable agent with immense health benefits. OBJECTIVE: The protective effects of COR in ageing-associated oxidative and apoptosis events in vivo and hydrogen peroxide (H2O2)-exposed spermatogenesis gene alterations in TM3 Leydig cells was….

OncologyGut & microbiomeSkin & hydrationRespiratory

Cordyceps · 2022 · Research Article · Cell journal

Cordycepin Suppresses The Malignant Phenotypes of Colon Cancer Cells through The GSK3ß/ß-catenin/cyclin D1 Signaling Pathway.

OBJECTIVE: Cordycepin, also known as 3'-deoxyadenosine, is the main bioactive ingredient of Cordyceps militaris and possesses various pharmacological effects. This study was performed to investigate the role of cordycepin in regulating the biological behaviors of colon cancer cells and the potential mechanism behind….

OncologyImmune supportGut & microbiome

Shiitake · 2022 · Journal Article · Journal of food composition and analysis

Facile extraction of nanosized β-glucans from edible mushrooms and their antitumor activities

It has been recently reported that, β-Glucans with globular small particle size confer a higher disease resistance due to its induced strong immunomodulating activity. Herein, this work was designed to directly extract the nano β-glucans (NGs) from mushrooms using an acid-base procedure..

Reishi · 2022 · Journal Article · Journal of ethnopharmacology

Integrating network pharmacology and experimental models to investigate the efficacy of QYHJ on pancreatic cancer.

ETHNOPHARMACOLOGICAL RELEVANCE: The Qingyihuaji decoction (QYHJ) is composed of seven herbs: Scutellaria barbata D.Don (Banzhilian, HSB), Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan, GP), Oldenlandia diffusa (Willd.) Roxb. (Baihuasheshecao, HDH), Ganoderma lucidum (Leyss.

OncologyMetabolic healthRespiratory

Cordyceps · 2021 · Journal Article · Sheng wu gong cheng xue bao = Chinese journal of biotechnology

[Construction and optimization of cordycepin-producing Saccharomyces cerevisiae].

Cordycepin is the key active component of medicinal fungus Cordyceps militaris, and it shows multiple functional activities such as anti-tumor and anti-virus. Cordycepin was conventionally produced by liquid fermentation of C..

Cordyceps · 2021 · Research Article · Evidence-based complementary and alternative medicine: eCAM

A Network Pharmacology Study on the Molecular Mechanisms of FDY003 for Breast Cancer Treatment.

Herbal medicines have drawn considerable attention with regard to their potential applications in breast cancer (BC) treatment, a frequently diagnosed malignant disease, considering their anticancer efficacy with relatively less adverse effects..

Chaga · 2021 · Research Article · Molecules (Basel, Switzerland)

Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici.

Inonotus nidus-pici is a sterile conk which produces macrofungus, a neglected Central-Eastern European relative of the prized Inonotus obliquus, also known as chaga. Investigation of the methanol extract of the poroid fungus I..

OncologyImmune supportCognition & nervesSkin & hydration

Cordyceps · 2021 · Journal Article · American journal of cancer research

Cordycepin inhibits the proliferation of malignant peripheral nerve sheath tumor cells through the p53/Sp1/tubulin pathway.

Neurofibromatosis type 1 (NF1) is one of the most common hereditary neurocutaneous disorders. In addition to skin pigmentation and cutaneous neurofibroma, some patients developed the plexiform neurofibroma since birth..

OncologyImmune supportEnergy & fatigue

Cordyceps · 2021 · Research Article · Antioxidants (Basel, Switzerland)

Ergosta-7,9(11),22-trien-3β-ol Attenuates Inflammatory Responses via Inhibiting MAPK/AP-1 Induced IL-6/JAK/STAT Pathways and Activating Nrf2/HO-1 Signaling in LPS-Stimulated Macrophage-like Cells.

Chronic inflammation induces autoimmune disorders and chronic diseases. Several natural products activate nuclear factor erythroid 2-related factor 2 (Nrf2) signaling, attenuating inflammatory responses..

OncologyEnergy & fatigueMetabolic healthGut & microbiome

Cordyceps · 2021 · Journal Article · RSC advances

In silico and in vitro design of cordycepin encapsulation in liposomes for colon cancer treatment.

Cordycepin or 3'-deoxyadenosine is an interesting anti-cancer drug candidate that is found in abundance in the fungus Cordyceps militaris. It inhibits cellular growth of many cancers including lung carcinoma, melanoma, bladder cancer, and colon cancer by inducing apoptosis, anti-proliferation, anti-metastasis and by….

OncologyImmune supportRespiratory

Shiitake · 2019 · Research Support, Non U.S. Gov'T · Progress in molecular biology and translational science

Mushroom polysaccharide lentinan for treating different types of cancers: A review of 12 years clinical studies in China.

Lentinula edodes has been used to improve general health for thousands of years in Asia. It is the second largest cultivated and the most popular edible mushroom in the world known as "Xianggu" in China and "Shiitake" in Japan.

Mesima · 2005 · Research Article · Mycobiology

Development of Species-specific Primers for Rapid Detection of Phellinus linteus and P. baumii.

Genus Phellinus taxonomically belongs to Aphyllophorales and some species of this genus have been used as a medicinal ingredients and Indian folk medicines. Especially, P..

OncologyImmune supportMetabolic healthLiver support

Reishi · 2005 · Journal Article · Mushroom Science and Biotechnology

Development of the method for efficient disruption and rapid extraction on the β-1,3-glucan determination from the mycelium of Ganoderma lucidum

Metadata-grounded summary: This journal article indexes research on Ganoderma lucidum in Mushroom Science and Biotechnology in 2005. MycoData maps the paper to oncology, immune support, metabolic health, liver support based on its title, species context, article metadata, and study classification..

Niu-Chang-Chih · 2005 · Journal Article · Transactions of the Meeting in Hokkaido Branch of the Japanese Forest Society

Effect of Antrodia camphorata (Japanese name Benikusunokitake) in Basidiomycota on the growth of tumor cells

Metadata-grounded summary: This journal article indexes research on Antrodia camphorata in Transactions of the Meeting in Hokkaido Branch of the Japanese Forest Society in 2005. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

OncologyCognition & nervesLiver support

Niu-Chang-Chih · 2004 · Journal Article · Food chemistry

Antioxidant properties of methanolic extracts from two kinds of Antrodia camphorata mycelia.

Metadata-grounded summary: This journal article indexes research on Antrodia camphorata in Food chemistry in 2004. MycoData maps the paper to oncology, cognition & nerves, liver support based on its title, species context, article metadata, and study classification..

OncologyCognition & nervesLiver support

Niu-Chang-Chih · 2004 · Journal Article · Transactions of the Meeting in Hokkaido Branch of the Japanese Forest Society

Antrodia camphorata (Japanese name Benikusunokitake) in Basidiomycota

Metadata-grounded summary: This journal article indexes research on Antrodia camphorata in Transactions of the Meeting in Hokkaido Branch of the Japanese Forest Society in 2004. MycoData maps the paper to oncology, cognition & nerves, liver support based on its title, species context, article metadata, and study classification..

Turkey Tail · 2004 · Journal Article · Asian Pacific Confederation of Chemical Engineering congress program and abstracts

Decolorization of Dye Solutions by a Ceramic Membrane Bioreactor using Trametes Versicolor KCTC 16781

Metadata-grounded summary: This journal article indexes research on Trametes versicolor in Asian Pacific Confederation of Chemical Engineering congress program and abstracts in 2004. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..