MycoData

OncologyImmune supportGut & microbiome

Lion's Mane · 2019 · Journal Article · International immunopharmacology

A unique polysaccharide from Hericium erinaceus mycelium ameliorates acetic acid-induced ulcerative colitis rats by modulating the composition of the gut microbiota, short chain fatty acids levels and GPR41/43 respectors.

Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disorder of the colonic mucosa. Risk of colorectal cancer in ulcerative colitis is increased in patients with long-standing disease compared with the general population..

OncologyImmune supportGut & microbiome

Shiitake · 2019 · Research Article · Journal of clinical biochemistry and nutrition

Activation of NF-E2 p45-related factor-2 transcription and inhibition of intestinal tumor development by AHCC, a standardized extract of cultured Lentinula edodes mycelia.

It has been reported that activation of NF-E2 p45-related factor-2 (NRF2), a transcription factor, induces a variety of antioxidant enzymes, and plays an important role in preventing carcinogenesis. AHCC is a standardized extract of cultured Lentinula edodes mycelia and it has been demonstrated to improve cancer..

Immune supportEnergy & fatigueMetabolic health

Maitake · 2019 · Journal Article · Applied biochemistry and biotechnology

Anti-Diabetic and Anti-Nephritic Activities of Grifola frondosa Mycelium Polysaccharides in Diet-Streptozotocin-Induced Diabetic Rats Via Modulation on Oxidative Stress.

Grifola frondosa is an edible fungus with a variety of potential pharmacological activities. This study investigates the hypoglycemic, anti-diabetic nephritic, and antioxidant properties of G.

Turkey Tail · 2019 · Journal Article · Natural product research

Anti-inflammatory activities of the chemical constituents isolated from Trametes versicolor.

Twenty-seven compounds including nine triterpenoids (1-9), eight sterols (10-17), two ribonucleotides (18, 19), four phenols (20-23), three glycosides (24-26), and one furan (27) were isolated from the fruiting bodies of Trametes versicolor (L.) Lloyd..

Mesima · 2019 · Journal Article · International journal of biological macromolecules

Anti-inflammatory activity of polysaccharides from Phellinus linteus by regulating the NF-κB translocation in LPS-stimulated RAW264.7 macrophages.

Inflammatory response remains one of the most common and serious complications of disease. In order to profound understanding relationship between Phellinus linteus polysaccharides (TCM) and inflammation, inflammatory cell model was constructed by LPS acting RAW264.7 cell line..

OncologyImmune supportEnergy & fatigueRespiratory

Yellow Morel · 2019 · Journal Article · International journal of biological macromolecules

Anti-inflammatory effects of Morchella esculenta polysaccharide and its derivatives in fine particulate matter-treated NR8383 cells.

Fine particulate matter (PM2.5) exposure could cause many acute and chronic respiratory diseases. In this study the protective effects of polysaccharide from Morchella esculenta (FMP-1) and its derivatives against PM2.5-induced inflammation were evaluated..

Immune supportMetabolic healthGut & microbiome

Enoki · 2019 · Journal Article · International journal of food science & technology

Characteristic of polysaccharides from Flammulina velutipes in vitro digestion under salivary, simulated gastric and small intestinal conditions and fermentation by human gut microbiota

In this study, in vitro digestion and fermentation of Flammulina velutipes ‐derived polysaccharides (FVP) were investigated. It was found that FVP mainly consisted of 48.45% glucose, 15.40% mannose, 14.60% xylose, 11.80% fucose and 9.90% galactose..

OncologyImmune supportEnergy & fatigueSkin & hydration

Enoki · 2019 · Research Article · Antioxidants (Basel, Switzerland)

Characterization and Antioxidant Activities of Yellow Strain Flammulina velutipes (Jinhua Mushroom) Polysaccharides and Their Effects on ROS Content in L929 Cell.

Yellow strain Flammulina velutipes, which is known as Jinhua mushroom in Taiwan, has become popular among customers due to its distinct texture that is utterly different from white strain F. velutipes..

Enoki · 2019 · Research Article · Molecules (Basel, Switzerland)

Characterization, Antioxidant, Anti-Aging and Organ Protective Effects of Sulfated Polysaccharides from Flammulina velutipes.

As an irreversible and complex degenerative physiological process, the treatment for aging seems strategically necessary, and polysaccharides play important roles against aging owing to their abundant bioactivities..

Immune supportCognition & nerves

Cordyceps · 2019 · Research Article · Insects

Comparative Transcriptome Analysis of Thitarodes Armoricanus in Response to the Entomopathogenic Fungi Paecilomyces Hepiali and Ophiocordyceps Sinensis.

Thitarodes armoricanus is a medicinal and economically important Lepidopteran insect species. The larvae infected by Paecilomyces hepiali survive no more than four days, while those infected by Ophiocordyceps sinensis can survive for several months before mummification..

Immune supportLiver supportRespiratory

Enoki · 2019 · Research Article · Food technology and biotechnology

Development of a Transgenic Flammulina velutipes Oral Vaccine for Hepatitis B.

Orally administered fungal vaccines show promise for the prevention of infectious diseases. Edible mushrooms are deemed appropriate hosts to produce oral vaccines due to their low production cost and low risk of gene contamination..

OncologyImmune supportEnergy & fatigueMetabolic health

Enoki · 2019 · Journal Article · Journal of the science of food and agriculture

Dietary inclusion of mushroom (Flammulina velutipes) stem waste on growth performance and immune responses in growing layer hens

BACKGROUND: Medicinal mushrooms contain biologically active substances that can be used as an immune‐modulating agent in poultry. The present study aimed to investigate the effects of Flammulina velutipes mushroom waste (FVW) on performance, immune response and serum immunity in growing layer hens..

OncologyImmune supportEnergy & fatigueMetabolic health

Enoki · 2019 · Journal Article · Journal of the science of food and agriculture

Dietary inclusion of mushroom (Flammulina velutipes) stem waste on growth performance and immune responses in growing layer hens.

BACKGROUND: Medicinal mushrooms contain biologically active substances that can be used as an immune-modulating agent in poultry. The present study aimed to investigate the effects of Flammulina velutipes mushroom waste (FVW) on performance, immune response and serum immunity in growing layer hens..

Immune supportEnergy & fatigueMetabolic health

Enoki · 2019 · Research Article · Animals: an open access journal from MDPI

Dietary Inclusion of Mushroom (Flammulina velutipes) Stem Waste on Growth Performance, Antibody Response, Immune Status, and Serum Cholesterol in Broiler Chickens.

This study was carried out to investigate the effects of mushroom (Flammulina velutipes) stem waste (MW) on growth performance, antibody response, immune status, and serum cholesterol in broiler chickens..

OncologyImmune supportGut & microbiome

Lion's Mane · 2019 · Research Article · Molecules (Basel, Switzerland)

Effects of Atmospheric and Room Temperature Plasma (ARTP) Mutagenesis on Physicochemical Characteristics and Immune Activity In Vitro of Hericium erinaceus Polysaccharides.

The polysaccharide is the main active substance contained in Hericium erinaceus and is commonly used in the treatment of neurasthenia, tumors, and digestive diseases. Six intracellular polysaccharide components were obtained from H..

Enoki · 2019 · Journal Article · International journal of biological macromolecules

Effects of ultrasound-assisted extraction on antioxidant activity and bidirectional immunomodulatory activity of Flammulina velutipes polysaccharide.

In order to investigate the impacts of ultrasound-assisted extraction (UAE) on Flammulina velutipes polysaccharides (FVPs), the differences between FVPs extracted by ultrasound-assisted extraction (FVPU) and FVPs extracted by hot water extraction (FVPH) were compared in terms of yield, primary compositions, surface….

OncologyImmune supportEnergy & fatigueSkin & hydration

Turkey Tail · 2019 · Journal Article · Journal of cosmetic dermatology

Enzymatic hydrolysates obtained from Trametes versicolor polysaccharopeptides protect human skin keratinocyte against AAPH-induced oxidative stress and inflammatory.

BACKGROUND: Polysaccharopeptides (PSPs) extracted from Trametes versicolor show antitumor, anti-inflammatory, and immunomodulation effects. According to our previous report, the enzymatic hydrolysates obtained from T versicolor PSPs by 80 U/mL β-1,3-D-glucanase (PSPs-EH80) did not change the functional groups of PSPs….

Immune supportCognition & nerves

Niu-Chang-Chih · 2019 · Journal Article · Food & function

Ergostatrien-7,9(11),22-trien-3β-ol from Antrodia camphorata ameliorates ischemic stroke brain injury via downregulation of p65NF-κ-B and caspase 3, and activation of Akt/GSK3/catenin-associated neurogenesis.

Antrodia camphorata is a well-known traditional Chinese mushroom used as a functional food and nutraceutical in Taiwan and China. The aim of this study was to explore the protective effects and mechanism(s) of the ethyl acetate crude extract of A..

Maitake · 2019 · Journal Article · Mycoscience

Expression of tyrosinase genes associated with fruiting body formation and pigmentation in Grifola frondosa

Chemical and physical properties (including ultraviolet spectrum) of a brown pigment isolated from Grifola frondosa fruiting bodies were almost identical to those of fungal melanin. From the full genome sequence of G..

Maitake · 2019 · Journal Article · Journal of agricultural and food chemistry

Functions of a Glucan Synthase Gene GFGLS in Mycelial Growth and Polysaccharide Production of Grifola frondosa.

Glucan synthase (GLS) gene is known to be involved in the fungal biosynthesis of cell wall, differentiation, and growth. In the present study, a glucan synthase gene (GFGLS) in the edible mushroom Grifola frondosa with a full sequence of 5927 bp encoding a total of 1781 amino acids was cloned and characterized for the….

Zhu Ling · 2019 · Research Article · Nutrients

GPP (Composition of Ganoderma Lucidum Poly-saccharides and Polyporus Umbellatus Poly-saccharides) Enhances Innate Immune Function in Mice.

Modern research has found that Ganoderma lucidum polysaccharides (GLP) and Polyporus umbellatus polysaccharides (PUP) mainly exhibit immunoregulation. However, the immune function of a polysaccharide composition consisting of GLP and PUP has not been studied..

Maitake · 2019 · Journal Article · Bioscience, biotechnology, and biochemistry

Grifola frondosa extract and ergosterol reduce allergic reactions in an allergy mouse model by suppressing the degranulation of mast cells.

The increasing number of patients suffering from allergic diseases is a global health problem. Grifola frondosa is an edible mushroom consumed as a health food in Asia, and has recently been reported to have anti-allergic effects.

Immune supportMetabolic healthGut & microbiomeLiver support

Maitake · 2019 · Journal Article · Food & function

Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats.

The purpose of this study was to assess the potential effects of polysaccharides from edible mushroom Grifola frondosa (GFP) on lipid metabolic disorders and gut microbiota dysbiosis, and elucidate their possible regulatory mechanisms on lipid and cholesterol metabolism in high-fat diet (HFD)-exacerbated….

Immune supportEnergy & fatigueMetabolic healthLiver support

Yellow Morel · 2019 · Research Article · Oxidative medicine and cellular longevity

Hepatoprotective Effects of Morchella esculenta against Alcohol-Induced Acute Liver Injury in the C57BL/6 Mouse Related to Nrf-2 and NF-κB Signaling.

This study investigated the hepatoprotective effects of Morchella esculenta fruit body (ME) and the underlying mechanisms in mice with alcohol-induced acute liver injury. Systematic analysis revealed that ME contained 21 types of fatty acid, 17 types of amino acid, and 12 types of mineral..

Immune supportCognition & nerves

Lion's Mane · 2019 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?

Epidemiological data indicate that subjects affected by obesity have an increased risk of developing mood disorders. The relationship between obesity and mood disorders is bidirectional..

Immune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2019 · Research Article · Nutrients

Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging.

Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, implicated in both poor quality of life and negative health outcomes. One central question surrounding frailty is whether phenotypic frailty is associated with the cognitive impairment during aging..

Cordyceps · 2019 · Journal Article · Science China. Life sciences

Identification of microRNA-like RNAs in Ophiocordyceps sinensis.

Ophiocordyceps sinensis is well known as a traditional Chinese medicine and has widely been used for over 2,000 years to stimulate immune system, decrease blood pressure and to inhibit tumor growth..

OncologyImmune supportGut & microbiomeSkin & hydration

Turkey Tail · 2019 · Research Article · International journal of medical sciences

In Vitro Anti-proliferative and Anti-invasive Effect of Polysaccharide-rich Extracts from Trametes Versicolor and Grifola Frondosa in Colon Cancer Cells.

Colorectal cancer (CRC) is one of leading causes of mortality in western countries and novel treatment strategies are required. The medicinal application of mushrooms has been used in traditional medicine in many oriental countries..

OncologyImmune supportCognition & nervesEnergy & fatigue

Chaga · 2019 · Journal Article · International journal of biological macromolecules

Inonotus obliquus polysaccharides protect against Alzheimer's disease by regulating Nrf2 signaling and exerting antioxidative and antiapoptotic effects.

Inonotus obliquus polysaccharide (IOPS) was initially separated and purified via precipitation from an aqueous extract with 80% alcohol, a DEAE-52 cellulose anion exchange column, and a Sephadex G-100 gel permeation chromatography system. IOPS was found to have a molecular weight of 111.9 kDa..

Immune supportGut & microbiome

Lion's Mane · 2019 · Journal Article · Food Hydrocolloids

Isolation of crude oligosaccharides from Hericium erinaceus by integrated membrane technology and its proliferative activity

In this study, isolation of crude oligosaccharides from Hericium erinaceus (CHOS), and its physicochemical properties and proliferative effects on lactic acid bacteria were investigated..

Shiitake · 2019 · Research Article · Frontiers in microbiology

Lentinula edodes Mycelium as Effective Agent for Piroxicam Mycoremediation.

Pollution of the environment with inorganic and organic substances is one of the main problems in the world. For this reason, it is necessary to conduct researches for effective methods of biodegradation of xenobiotics, including drugs whose unmetabolized forms are introduced into the environment, especially into….

Mesima · 2019 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Phellinus linteus Grown on Germinated Brown Rice Inhibits IgE-Mediated Allergic Activity through the Suppression of FcεRI-Dependent Signaling Pathway In Vitro and In Vivo.

Phellinus linteus (PL) has been used as a traditional herbal medicine owing to its immune regulatory activity. Previous studies reported that PL grown on germinated brown rice (PBR) exerted immunomodulatory, anticancer, and anti-inflammatory activities..

OncologyImmune support

Lion's Mane · 2019 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Physicochemical, structural and rheological properties of alkali-extracted polysaccharide from fruiting body of Hericium erinaceus

An alkali-extracted polysaccharide (HEAEP-0.5) was prepared from the water insoluble residue of Hericium erinaceus fruiting body. Effects of concentration, temperature, pH and salts on its rheological property were systematically evaluated..

Turkey Tail · 2019 · Journal Article · International journal of biological macromolecules

Polysaccharopeptide from Trametes versicolor blocks inflammatory osteoarthritis pain-morphine tolerance effects via activating cannabinoid type 2 receptor.

Analgesia with opioids such as morphine is an effective clinical strategy for the treatment of cancer pain and chronic inflammatory pain. However, long-term use of morphine can cause morphine tolerance (MT), which limits the clinical application of opioids..

OncologyImmune support

OncologyImmune supportMetabolic healthGut & microbiome

Enoki · 2019 · Journal Article · International journal of biological macromolecules

Preparation and in vitro absorption studies of a novel polysaccharide‑iron (III) complex from Flammulina velutipes.

Iron is essential in fundamental bioactivities, so it makes sense to improve the efficiency of iron on epithelial transport. In this work, a novel polysaccharide‑iron(III) complex (FVP-Fe(III)) was prepared from Flammulina velutipes with a specific structure..

Zhu Ling · 2019 · Journal Article · Carbohydrate polymers

Renoprotective effect and mechanism of polysaccharide from Polyporus umbellatus sclerotia on renal fibrosis

As a fungal polysaccharide, polysaccharide (PPUS) from Polyporus umbellatus sclerotia have showed remarkable anti-inflammatory activities. In view of the closely relationship between inflammation and renal fibrosis, and considering the significant role of other fungal polysaccharides in treatment renal fibrosis, we….

Zhu Ling · 2019 · Journal Article · Carbohydrate polymers

Renoprotective effect and mechanism of polysaccharide from Polyporus umbellatus sclerotia on renal fibrosis.

Immune supportMetabolic health

Chaga · 2019 · Research Article · Molecules (Basel, Switzerland)

Simultaneous Use of Stimulatory Agents to Enhance the Production and Hypoglycaemic Activity of Polysaccharides from Inonotus obliquus by Submerged Fermentation.

This study aimed to determine the effect of applying stimulatory agents to liquid cultured Inonotus obliquus on the simultaneous accumulation of exo-polysaccharides (EPS) and their monosaccharide composition..

Immune supportGut & microbiome

Snow Fungus · 2019 · Journal Article · Food Hydrocolloids

Stability, microstructure, and digestibility of whey protein isolate – Tremella fuciformis polysaccharide complexes

Manufacturing of protein-enriched beverages is an interesting field which has attracted a lot of attention from the research community. In this study, polysaccharides extracted from a mushroom (Tremella fuciformis) were used to enhance the stability of 5% whey protein isolate (WPI) solution for enriched beverage….

Immune supportMetabolic healthLiver support

Niu-Chang-Chih · 2019 · Research Article · RSC advances

Structural characterization and anti-inflammatory effect in hepatocytes of a galactoglucan from Antrodia camphorata mycelium.

The galactoglucan ACP2 was isolated from cultured Antrodia camphorata mycelium through anion-exchange column chromatography and Sephadex G-100 chromatography and shown to exhibit hepatoprotective function in L02 cells..

Maitake · 2019 · Research Article · BioMed research international

Structural Elucidation and Immune-Enhancing Effects of Novel Polysaccharide from Grifola frondosa.

Beta-glucan (β-glucan) is a macromolecule structure where glucose unit has bonded through β-glycosidic bond at 1 and 3 positions. It is well known as a natural immunomodulator without exhibiting any side effects via enhancing immunity..

Lion's Mane · 2019 · Journal Article · Carbohydrate polymers

Structural elucidation and immunomodulatory activity of a β-D-glucan prepared by freeze-thawing from Hericium erinaceus

H6PC20, a water-soluble β-D-glucan, with a molecular mass of 2390 kDa (HPSEC-MALLS-RI), was obtained by extracting the fresh fruiting bodies of Hericium erinaceus at mature stage with hot water, freeze-thawing, precipitating and further rinsing with 20% (v/v) of ethanol..

Lion's Mane · 2019 · Journal Article · Carbohydrate polymers

Structural elucidation and immunomodulatory activity of a β-D-glucan prepared by freeze-thawing from Hericium erinaceus.

Enoki · 2019 · Journal Article · International journal of medicinal mushrooms

The Effects of Ethanol Concentration during Isolation and Purity on the In Vitro Antioxidant Properties of Polysaccharides from the Winter Culinary-Medicinal Mushroom, Flammulina velutipes (Agaricomycetes) Stembase.

Natural products with high antioxidant activity have attracted great attention in recent years. A water extraction and alcohol precipitation method were used to extract polysaccharides from the Flammulina velutipes stem-base (FVSP)..

Immune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2019 · Research Article · International journal of molecular sciences

The Neuroprotective Effect of Hericium erinaceus Extracts in Mouse Hippocampus after Pilocarpine-Induced Status Epilepticus.

Hericium erinaceus (HE), a culinary-medicinal mushroom, has shown therapeutic potential in many brain diseases. However, the role of HE in status epilepticus (SE)-mediated neuronal death and its underlying mechanisms remain unclear..

OncologyImmune supportEnergy & fatigueLiver support

Chaga · 2019 · Journal Article · International journal of biological macromolecules

The polysaccharide from Inonotus obliquus protects mice from Toxoplasma gondii-induced liver injury.

The study aimed to explore the protective effects and mechanism of Inonotus obliquus polysaccharide (IOP) on liver injury caused by Toxoplasma gondii (T. gondii) infection in mice..

Immune supportMetabolic healthGut & microbiomeLiver support

Maitake · 2019 · Research Article · International journal of molecular sciences

The Positive Effects of Grifola frondosa Heteropolysaccharide on NAFLD and Regulation of the Gut Microbiota.

: Non-alcoholic fatty liver disease (NAFLD) is a major public health problem in many countries. In this study, the ability of Grifola frondosa heteropolysaccharide (GFP) to ameliorate NAFLD was investigated in rats fed a high-fat diet (HFD)..

Immune supportMetabolic health

Chaga · 2019 · Research Article · Molecules (Basel, Switzerland)

Three-Phase Partitioning for the Extraction and Purification of Polysaccharides from the Immunomodulatory Medicinal Mushroom Inonotus obliquus.

Polysaccharides from the immunomodulatory medicinal mushroom Inonotus obliquus (IOPS) were extracted and purified using three-phase partitioning (TPP), which is an efficient, fast, safe, and green purification technique..