MycoData

Panax ginseng (PG) or Phellinus linteus (PL) have been widely used as traditional medicine owing to their many biological activities, including anti-inflammatory and anti-allergic activities. Previously, our group produced PL that was grown on PG media (PGP) to enhance anti-cancer activities of PGP..

OncologyImmune support

High relevance

Chaga · 2017 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt signal pathway.

Polysaccharides are the main components of mushroom Inonotus obliquus (I. obliquus) with antihyperglycemic activities.

Immune supportMetabolic healthLiver support

High relevance

Chaga · 2017 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Anti-diabetic effects of Inonotus obliquus polysaccharides-chromium (III) complex in type 2 diabetic mice and its sub-acute toxicity evaluation in normal mice.

Polysaccharides are important bioactive ingredients from Inonotus obliquus. This study aimed to synthesize and characterize a novel I.

Immune supportMetabolic health

High relevance

Maitake · 2017 · Journal Article · International journal of medicinal mushrooms

Anti-Inflammation and Lipogenic Inhibition of Taiwanofungus salmonea Mycelium and Grifola frondosa Fruiting Body.

A long-term inflammatory response can cause the development of nonalcoholic steatohepatitis (NASH), which is mainly caused by abnormal metabolism of lipids in the liver..

Immune supportEnergy & fatigueLiver support

High relevance

Maitake · 2017 · Journal Article · International journal of food science & technology

Anti‐inflammatory properties of high pressure‐assisted extracts of Grifola frondosa in lipopolysaccharide‐activated RAW 264.7 macrophages

The aim of this study was to determine the in vitro anti‐inflammatory properties of the shake extract (SE) and the high pressure‐assisted extract (PE) of the mycelia of Grifola frondosa in a lipopolysaccharide‐stimulated RAW 264.7 macrophage model..

Immune support

High relevance

Chaga · 2017 · Research Article · PloS one

Antidiabetic activities of polysaccharides separated from Inonotus obliquus via the modulation of oxidative stress in mice with streptozotocin-induced diabetes.

This study evaluated the effects of Inonotus obliquus polysaccharides (IOs) on diabetes and other underlying mechanisms related to inflammatory factors and oxidative stress in a mouse model of streptozotocin (STZ)-induced diabetes..

Immune supportMetabolic health

High relevance

Enoki · 2017 · Journal Article · Carbohydrate polymers

Antimicrobial and antioxidant activities of Flammulina velutipes polysaccharides and polysaccharide-iron(III) complex [corrected].

FVP is polysacchrides obtained from Flammulina velutipes. A polysacchride named FVP2 was isolated from FVP by DEAE cellulose-52 chromatography and Sephadex G-100 size-exclusion chromatography.

Immune supportLiver support

High relevance

Maitake · 2017 · Journal Article · International journal of biological macromolecules

Antioxidant, antibacterial and anti-aging activities of intracellular zinc polysaccharides from Grifola frondosa SH-05.

In present work, the strain of Grifola frondosa SH-05 was used as a vector of zinc biotransformation to produce the IZPS. The bioactivities including antioxidant and antibacterial activities in vitro and anti-aging properties in vivo of IZPS were investigated comparing with the IPS..

Immune supportSkin & hydration

High relevance

Enoki · 2017 · Journal Article · International journal of medicinal mushrooms

Compositional Differences of the Winter Culinary-Medicinal Mushroom, Flammulina velutipes (Agaricomycetes), under Three Types of Light Conditions.

The focus of this study was to investigate the effect of light on the cultivation and the amounts of bio-active components in Flammulina velutipes. The mushrooms were cultivated under fluorescent tube (T8) grow lights, lightemitting diodes (LEDs), and cold-cathode fluorescent lamps..

Immune support

High relevance

Lion's Mane · 2017 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber-CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice.

Hericium erinaceus (Bull.) Pers. is a medicinal mushroom capable of inducing a large number of modulatory effects on human physiology ranging from the strengthening of the immune system to the improvement of cognitive functions.

Immune supportCognition & nerves

High relevance

Maitake · 2017 · Journal Article · Food chemistry

Effects of different extraction temperatures on the physicochemical properties of bioactive polysaccharides from Grifola frondosa.

This study examined the effects of different extraction temperatures (70°C, 100°C and 121°C) on the physicochemical properties of water soluble polysaccharides (WSP; GF70, GF100 and GF121, respectively) from Grifola frondosa (GF) fruiting bodies, and evaluating their effects on nitric oxide (NO) production in….

Immune supportMetabolic health

High relevance

Niu-Chang-Chih · 2017 · Journal Article · Molecular medicine reports

Ethanol extract of Antrodia camphorata inhibits proliferation of HCT-8 human colorectal cancer cells by arresting cell cycle progression and inducing apoptosis.

Antrodia camphorata (AC) is well known in Taiwan as a traditional Chinese medicine, with a long history of use in treating cancer and inflammation. Previous studies have revealed that AC exhibits anticancer effects in various cancer cell lines..

OncologyImmune supportGut & microbiome

High relevance

Snow Fungus · 2017 · Journal Article · International journal of medicinal mushrooms

Extraction Optimization, Composition Analysis, and Antioxidation Evaluation of Polysaccharides from White Jelly Mushroom, Tremella fuciformis (Tremellomycetes).

We investigated the sonication-assisted extraction (SAE) conditions of Tremella fuciformis polysaccharides. Single-factor experiments showed that the optimal sonication intensity was 6 W/cm2; the other SAE conditions were further optimized using response surface experimental design..

Immune support

High relevance

Lion's Mane · 2017 · Research Article · Oncotarget

Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota.

Hericium erinaceus (HE), a traditional edible mushroom, is known as a medicine food homology to ameliorate gastrointestinal diseases. To investigate whether HE is clinically effective in alleviating inflammatory bowel disease (IBD), HE extracts (polysaccharide, alcoholic extracts and whole extracts were prepared using….

OncologyImmune supportGut & microbiome

High relevance

Niu-Chang-Chih · 2017 · Journal Article · Journal of ethnopharmacology

Hepatoprotective activities of Antrodia camphorata and its triterpenoid compounds against CCl4-induced liver injury in mice.

ETHNOPHARMACOLOGY RELEVANCE: Antrodia camphorata (AC) is a rare and precious fungus indigenous to Taiwan used as a traditional medicine for the treatment of liver injury. Triterpenoids are the major bioactive constituents of A.

Immune supportLiver support

High relevance

Chaga · 2017 · Research Article · International journal of biological macromolecules

Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses.

Inonotus obliquus polysaccharides (IOPs) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, AIDs, pancreatitis and other diseases. In this study, we found that IOP can act as a broad-spectrum antiviral drug against feline viruses in the in vitro experiment..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Lion's Mane · 2017 · Research Article · Frontiers in immunology

Immunomodulatory Activities of a Fungal Protein Extracted from Hericium erinaceus through Regulating the Gut Microbiota.

A single-band protein (HEP3) was isolated from Hericium erinaceus using a chemical separation combined with pharmacodynamic evaluation methods. This protein exhibited immunomodulatory activity in lipopolysaccharide-activated RAW 264.7 macrophages by decreasing the overproduction of tumor necrosis factor-α, interleukin….

OncologyImmune supportGut & microbiome

High relevance

Lion's Mane · 2017 · Journal Article · Food & function

Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology.

This study was aimed at investigating the immunomodulating activity of Hericium erinaceus polysaccharide (HEP) in mice, by assessing splenic lymphocyte proliferation (cell-mediated immunity), serum hemolysin levels (humoral immunity), phagocytic capacity of peritoneal cavity phagocytes (macrophage phagocytosis), and….

Immune supportGut & microbiome

High relevance

Lion's Mane · 2017 · Journal Article · International journal of biological macromolecules

Immunomodulatory effects of hydroxyethylated Hericium erinaceus polysaccharide on macrophages RAW264.7.

Hericium erinaceus polysaccharide (HEP) has been shown to possess a variety of biological activities. In present study, HEP was successfully modified to obtain its hydroxyethylated derivative hHEP.

Immune support

High relevance

Chaga · 2017 · Research Article · AMB Express

Inonotus obliquus polysaccharide regulates gut microbiota of chronic pancreatitis in mice.

Polysaccharide is efficient in attenuation of metabolic ailments and modulation of gut microbiota as prebiotics. The therapeutic effect of Inonotus obliquus polysaccharide (IOP) on chronic pancreatitis (CP) in mice has been validated in our previous study..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Shiitake · 2017 · Research Article · Molecular and clinical oncology

Lentinula edodes mycelia extract plus adjuvant chemotherapy for breast cancer patients: Results of a randomized study on host quality of life and immune function improvement.

Anthracycline-based chemotherapies for breast cancer are known to adversely affect patients' quality of life (QOL) and immune function. For that reason, adjuvants that improve those impairments are required..

OncologyImmune support

High relevance

Snow Fungus · 2017 · Journal Article · Journal of separation science

Molecular characterization of branched polysaccharides from Tremella fuciformis by asymmetrical flow field-flow fractionation and size exclusion chromatography.

To accurately characterize branched polysaccharides with high molecular weights from medicinal and edible mushrooms and identify the limitations of size exclusion chromatography, molecular characteristics of polysaccharides from Tremella fuciformis were determined and compared by asymmetrical flow field-flow….

Immune support

High relevance

Enoki · 2017 · Journal Article · Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

Oral fungal immunomodulatory protein-Flammulina velutipes has influence on pulmonary inflammatory process and potential treatment for allergic airway disease: A mouse model.

BACKGROUND/PURPOSE: House dust mite (HDM) is well known as one of the major indoor allergens that trigger allergic inflammation, especially asthma, and accounts for 85% of all cases. So far, asthma has been thought of as a condition of imbalance between T helper (Th)1 and Th2..

Immune supportRespiratory

High relevance

Enoki · 2017 · Journal Article · Food and agricultural immunology

Preparation, characterization, and anti-inflammatory effect of the chelate of Flammulina velutipes polysaccharide with Zn

The optimal conditions for preparing Zn- Flammulina velutipes polysaccharide (Zn-FVP) chelate were studied by using L ₉ (3 ⁴) orthogonal test. The results showed that the optimized conditions for the chelating reaction were as follows: initial concentration of Zn (II), 6 mg/mL; ratio of purified polysaccharide (FVPp)….

OncologyImmune support

High relevance

Yellow Morel · 2017 · Journal Article · International journal of biological macromolecules

Purification, antitumor and immunomodulatory activity of polysaccharides from soybean residue fermented with Morchella esculenta.

Crude polysaccharides (MPS) from soybean residue fermented with Morchella esculenta were extracted and purified by DEAE Sephadex A-50 chromatography and Sephadex G-100 size-exclusion chromatography in sequence. Three main fractions MP-1, MP-3 and MP-4 were obtained during the purification steps..

OncologyImmune supportLiver supportSkin & hydration

High relevance

Turkey Tail · 2017 · Journal Article · International journal of biological macromolecules

Quorum sensing molecule-farnesol increased the production and biological activities of extracellular polysaccharide from Trametes versicolor.

A novel strategy of exposing 2-day-old mycelia cultures to 0.8mM farnesol was developed to stimulate extracellular polysaccharide (EPS) production in Trametes versicolor submerged cultures..

OncologyImmune supportMetabolic health

High relevance

Maitake · 2017 · Journal Article · Food chemistry

Rice bran polysaccharides and oligosaccharides modified by Grifola frondosa fermentation: Antioxidant activities and effects on the production of NO.

Rice bran polysaccharides (RBPSs) are valuable compounds with many biological activities. In this work, a fungus called Grifola frondosa, was selected to ferment defatted rice bran water extracts and modify the RBPSs, which were then isolated by ethanol precipitation and deproteinization..

Immune supportMetabolic health

High relevance

Lion's Mane · 2017 · Journal Article · International journal of biological macromolecules

Selenizing Hericium erinaceus polysaccharides induces dendritic cells maturation through MAPK and NF-κB signaling pathways.

In this study, polysaccharides extracted from Hericium erinaceus were modified to obtain its nine selenium derivatives, sHEP1-sHEP9. Their structures were identified, yields and selenium contents were determined, the phenotypic and functional maturation of murine bone marrow-derived dendritic cells (DCs) and relevant….

Immune support

High relevance

Enoki · 2017 · Journal Article · International journal of medicinal mushrooms

Structural Characteristics of the Novel Polysaccharide FVPA1 from Winter Culinary-Medicinal Mushroom, Flammulina velutipes (Agaricomycetes), Capable of Enhancing Natural Killer Cell Activity against K562 Tumor Cells.

FVPA1, a novel polysaccharide, has been isolated from fruiting bodies of the culinary-medicinal mushroom Flammulina velutipes, a historically popular, widely cultivated and consumed functional food with an attractive taste, beneficial nutraceutical properties such as antitumor and immunomodulatory effects, and a….

OncologyImmune supportEnergy & fatigue

High relevance

Maitake · 2017 · Journal Article · Apoptosis: an international journal on programmed cell death

The induction of apoptosis and autophagy in human hepatoma SMMC-7721 cells by combined treatment with vitamin C and polysaccharides extracted from Grifola frondosa.

Polysaccharides extracted from the mushroom Grifola frondosa (GFP) are a potential anticancer agent. The objective of this study was to investigate the effect of GFP and vitamin C (VC) alone and in combination on the viability of human hepatocarcinoma SMMC-7721 and HepG2 cells..

OncologyImmune supportLiver support

High relevance

Mesima · 2017 · Journal Article · International journal of medicinal mushrooms

Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) and IL-23 Induced by Polysaccharide of the Black Hoof Medicinal Mushroom, Phellinus linteus (Agaricomycetes).

Matrix metalloproteinase-9 (MMP-9) has diverse roles associated with cell growth, migration, invasion, and angiogenesis. Tissue inhibitor of metalloproteinase-1 (TIMP-1) is known to inhibit MMP-9 by complexing with it at a 1:1 ratio..

OncologyImmune supportLiver supportRespiratory

High relevance

Shiitake · 2016 · Journal Article · International immunopharmacology

Activation of the NRF2-ARE signalling pathway by the Lentinula edodes polysaccharose LNT alleviates ROS-mediated cisplatin nephrotoxicity.

The nephrotoxicity of cisplatin (cis-DDP) limits its general clinical applications. Lentinan (LNT), a dextran extracted from the mushroom Lentinula edodes, has been shown to have multiple pharmacological activities..

OncologyImmune supportEnergy & fatigue

High relevance

Shiitake · 2016 · Journal Article · Cancer immunology, immunotherapy: CII

Age-associated impairment of antitumor immunity in carcinoma-bearing mice and restoration by oral administration of Lentinula edodes mycelia extract.

Because cancer is associated with aging, immunological features in the aged should be considered in anticancer immunotherapy. In this study, we investigated antitumor immunity in aged mice using a CT26 colon carcinoma model..

OncologyImmune supportGut & microbiome

High relevance

Niu-Chang-Chih · 2016 · Journal Article · Antiviral therapy

Anti-herpes simplex virus activities of bioactive extracts from Antrodia camphorata mycelia.

BACKGROUND: Antrodia camphorata, a traditional Chinese medicine, is widely used in the treatment of liver diseases and cancers. Anti-inflammatory properties have also been described.

OncologyImmune supportLiver supportRespiratory

High relevance

Niu-Chang-Chih · 2016 · Research Article · Molecules (Basel, Switzerland)

Antiinflammatory and Antiphotodamaging Effects of Ergostatrien-3β-ol, Isolated from Antrodia camphorata, on Hairless Mouse Skin.

Ergostatrien-3β-ol (EK100), isolated from the submerged whole broth of Antrodia camphorata, has antidiabetic, hyperlipidemic, and hepatoprotective activities. However, the antiphotodamage activity of EK100 has still not been revealed..

Immune supportMetabolic healthLiver supportSkin & hydration

High relevance

Chaga · 2016 · Journal Article · International journal of biological macromolecules

Antioxidant activity of Inonotus obliquus polysaccharide and its amelioration for chronic pancreatitis in mice.

Inonotus obliquus polysaccharide (IOP) was extracted by water with a yield of 9.83% and purified by an anion-exchange DEAE cellulose column and Sephadex G-200 gel with a polysaccharide content of 98.6%..

Immune supportMetabolic health

High relevance

Maitake · 2016 · Journal Article · International journal of food science & technology

Antioxidant and antitumour activities of exopolysaccharide from liquid‐cultured Grifola frondosa by chemical modification

Grifola frondosa is a popular edible mushroom for its tasty flavour and can be used as a dietary supplement for its functional substances. In this study, an exopolysaccharide (EPS), purified from the submerged culture of G..

OncologyImmune supportEnergy & fatigue

High relevance

Enoki · 2016 · Journal Article · Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]

Antitumor and Antioxidant Properties of Water-Soluble Polysaccharides from Submerged Mycelium of Flammulina velutipes.

The aim of the study was to evaluate antitumor and antioxidant properties of water-soluble polysaccharides from submerged myceliumn of Flammulina velutipes grown under optimized conditions..

OncologyImmune supportMetabolic health

High relevance

Niu-Chang-Chih · 2016 · Research Article · Frontiers in pharmacology

Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells.

Antrodia camphorata is a Taiwanese-specific fungus which has been used clinically to treat hypertension, immune- and liver-related diseases and cancer; however, it has never been studied in type 2 diabetes mellitus (T2DM). Hyperglycemia in T2DM causes endoplasmic reticulum (ER) stress, leading to β-cell dysfunction..

OncologyImmune supportMetabolic healthLiver support

High relevance

Shiitake · 2016 · Research Article · Molecules (Basel, Switzerland)

Chemical Composition and Inhibitory Effect of Lentinula edodes Ethanolic Extract on Experimentally Induced Atopic Dermatitis in Vitro and in Vivo.

The ethanolic extract of Lentinula edodes was partially analyzed and then characterized for its efficacy in treating atopic dermatitis. Polyphenols were determined to be the major antioxidant component in the extract (6.12 mg/g), followed by flavonoids (1.76 mg/g), β-carotene (28.75 μg/g), and lycopene (5.25 μg/g)..

Immune supportSkin & hydration

High relevance

Maitake · 2016 · Journal Article · Applied biochemistry and biotechnology

Control of Grifola frondosa Morphology by Agitation and Aeration for Improving Mycelia and Exo-Polymer Production.

The present study describes the improved mycelia and exo-polymer production under control of Grifola frondosa morphology by changing the aeration rate and agitation intensity in a 25-L stirred fermentor..

Immune supportMetabolic health

High relevance

Enoki · 2016 · Journal Article · Carbohydrate polymers

Development, physiochemical characterization and forming mechanism of Flammulina velutipes polysaccharide-based edible films.

Edible films of Flammulina velutipes polysaccharide were prepared and characterized in terms of rheological, optical, morphologic, mechanical and barrier properties to evaluate their potential application in food packaging..

Immune supportEnergy & fatigue

High relevance

Almond Mushroom · 2016 · Research Article · PloS one

Effect of the Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSanTM, on Symptoms, Fatigue and Quality of Life in Patients with Crohn's Disease in a Randomized Single-Blinded Placebo Controlled Study.

BACKGROUND: Ingestion of AndoSanTM, based on the mushroom Agaricus blazei Murill, has previously shown an anti-inflammatory effect through reduction of pro-inflammatory cytokines in healthy individuals and patients with Crohn's disease (CD)..

Immune supportEnergy & fatigue

High relevance

Mesima · 2016 · Journal Article · International journal of medicinal mushrooms

Effects of Black Hoof Medicinal Mushroom, Phellinus linteus (Agaricomycetes), Polysaccharide Extract in Streptozotocin-Induced Diabetic Rats.

In this article we report the healing effects of a Phellinus linteus fruiting body hot water extract (PLE) in streptozotocin (STZ)-induced diabetic rats. PLE was given before and after STZ..

Immune supportMetabolic health

High relevance

Chaga · 2016 · Journal Article · Molecular medicine reports

Effects of polysaccharides isolated from Inonotus obliquus against hydrogen peroxide-induced oxidative damage in RINm5F pancreatic β-cells.

The purpose of the present study was to elucidate the cytoprotective effects of polysaccharides isolated from Inonotus obliquus. The polysaccharides were extracted from the fruiting body of I.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Turkey Tail · 2016 · Research Article · Molecules (Basel, Switzerland)

Enhancing the Antioxidant Ability of Trametes versicolor Polysaccharopeptides by an Enzymatic Hydrolysis Process.

Polysaccharopeptides (PSPs) are among the main bioactive constituents of Trametes versicolor (T. versicolor).

Immune supportEnergy & fatigue

High relevance

Enoki · 2016 · Research Article · Pharmacognosy research

Extracts from Flammulina velutipes Inhibit the Adhesion of Pathogenic Fungi to Epithelial Cells.

BACKGROUND: Recently, extracts from natural sources have been tested for their antifungal properties. In this aspect, Flammulina velutipes extracts possess a significant amount of branch-chained carbohydrates with mannose moieties that, hypothetically, can reduce the adhesion..

Immune supportMetabolic health

High relevance

Lion's Mane · 2016 · Research Article · BMC complementary and alternative medicine

High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity.

BACKGROUND: Hericium erinaceus (HE) is a well-known mushroom in traditional Chinese food and medicine. HE extracts from the fruiting body and mycelia not only exhibit immunomodulatory, antimutagenic and antitumor activity but also have neuroprotective properties..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Turkey Tail · 2016 · Research Article · Molecules (Basel, Switzerland)

In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden).

Two ergostanes, 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (1) and 5α-ergost-7,22-dien-3β-ol (2), and a lanostane, 3β-hydroxylanostan-8,24-diene-21-oic acid (trametenolic acid) (3), were isolated from an n-hexane extract prepared from the fruiting body of Trametes versicolor (Bres. Rivarden)..

OncologyImmune support

High relevance

Snow Fungus · 2016 · Journal Article · International journal of medicinal mushrooms

Morphological and Molecular Analysis Identifies the Associated Fungus ("Xianghui") of the Medicinal White Jelly Mushroom, Tremella fuciformis, as Annulohypoxylon stygium.

White jelly mushroom, Tremella fuciformis, is a popular edible mushroom with interesting medicinal properties (e.g., immunostimulating, antidiabetic). The formation of T.

Immune supportMetabolic health