MycoData

Cordyceps · 2021 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Physicochemical, functional and structural properties of the major protein fractions extracted from Cordyceps militaris fruit body.

The physicochemical and functional as well as structural properties of major protein fractions (albumin, globulin, glutelin) sequentially extracted in water, salt, alkaline solution respectively from Cordyceps militaris Minfu20 fruit body were investigated..

Maitake · 2021 · Brief Report · Journal of fungi (Basel, Switzerland)

Potential Activity of Albino Grifola frondosa Mushroom Extract against Biofilm of Meticillin-Resistant Staphylococcus aureus.

Mushroom extracts are a rich source of natural compounds with antimicrobial properties, which are able to prevent, to some extent, the growth of foodborne pathogens..

Reishi · 2021 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Sporoderm-Removed Ganoderma lucidum Spore Powder May Suppress the Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells Through PI3K/AKT/mTOR and Erk Pathway.

Tumor metastasis is a key factor of therapeutic failure in tumor patients, but the underlying molecular mechanism remains to be explored and novel effective curative strategies are urgently required..

OncologySkin & hydration

Yellow Morel · 2021 · Research Support, Non U.S. Gov'T · Virus research

The unique genome organization of two novel fusariviruses hosted by the true morel mushroom Morchella esculenta.

Two putative mycoviruses belonging to the proposed family "Fusariviridae" were identified in Morchella esculenta by sequencing of double-stranded RNAs extracted from the morel mushroom. These viruses were tentatively named "Morchella esculenta fusarivirus 1″ (MeFV1) and "Morchella esculenta fusarivirus 2″ (MeFV2)..

Respiratory

King Oyster · 2021 · Research Support, Non U.S. Gov'T · Genes

Transcriptomics Analysis of Primordium Formation in Pleurotus eryngii.

Primordium formation is an important stage preceding the growth and development of the Pleurotus eryngii fruiting body. However, the molecular mechanisms underlying primordium formation remain unclear..

Immune supportGut & microbiome

Snow Fungus · 2021 · Research Support, Non U.S. Gov'T · Frontiers in immunology

Tremella fuciformis Polysaccharides Inhibited Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice via Foxp3+ T Cells, Gut Microbiota, and Bacterial Metabolites.

Tremella fuciformis is an edible medicinal mushroom, and its polysaccharide components are found to confer various health benefits. This study identified the protective effects of polysaccharides of Tremella fuciformis (TPs) against dextran sulfate sodium (DSS)-induced colitis in mice..

Immune supportSkin & hydration

Shiitake · 2017 · Systematic Review · International journal of dermatology

Clinical features of shiitake dermatitis: a systematic review.

Shiitake dermatitis is a rare cutaneous reaction to lentinan, a polysaccharide component in the cell walls of shiitake mushrooms (Lentinula edodes). Herein, we systematically review the case report and case series English-language literature on shiitake dermatitis, which refers to a total of 50 patients (38 males, 12….

King Oyster · 2025 · Journal Article · Applied soil ecology: a section of Agriculture, Ecosystems & Environment

Enhanced soil ecosystem multifunctionality and microbial community shifts following spent mushroom substrate application in vineyards

Soil multifunctionality and microbial diversity in agricultural ecosystems are influenced by fertilization. Spent mushroom substrates (SMS) have recently been used as organic fertilizers, but their effects on soil and microbial functions in orchard ecosystems remain understood..

Cordyceps · 2020 · Preprint · journal metadata

Analysis of Reference Genes stability and Histidine Kinase Expression under Cold Stress in Cordyceps militaris

Abstract Background: The development of fungal fruiting bodies from a hyphal thallus represents a transition from simple to complex multicellularity that is inducible under low temperature (cold stress). The molecular mechanism has been subject to surprisingly few studies..

King Oyster · 2020 · Preprint · journal metadata

Bioconversion of Agro-Waste to Product of Bio-protein via Cultivation of Edible Oyster Mushroom Pleurotus eryngii

Abstract This study investigated the potentiality of utilizing some local Agro-wastes (lignocellulose) in Iraq as growing Substrate to product edible oyster mushroom Pleurotus eryngii..

Immune supportMetabolic health

Oyster Mushroom · 2020 · Preprint · journal metadata

Estimation of Protein and Productive Efficiency Profile of Locally Produced Oyster Mushroom (Pleurotus Ostreatus) in Broiler

Background: Pleurotus ostreatus (Oyster) is a worldwide used mushroom, known to have a wide range of nutrients. Effects of the ethanolic and aqueous extracts of Oyster and its isolated proteins on the production profiles and bio health markers in broiler birds were evaluated in the present research..

Oyster Mushroom · 2020 · Preprint · journal metadata

Genome sequence of the oyster mushroom Pleurotus ostreatus strain PC9

The oyster mushroom Pleurotus ostreatus is a basidiomycete commonly found in the rotten wood and it is one of the most cultivated edible mushrooms globally. P.

Immune supportSkin & hydration

Chaga · 2020 · Preprint · journal metadata

Genoprotective effects of Chaga mushroom ( Inonotus obliquus ) polysaccharides in UVB-exposed embryonic zebrafish ( Danio rerio ) through coordinated expression of DNA repair genes

Background Chaga mushroom (Inonotus obliquus) is one of the most promising antioxidants with incredible health-promoting effects. Chaga polysaccharides (IOP) have been reported to enhance immune response and alleviate oxidative stress during development..

Immune supportMetabolic health

Cordyceps · 2020 · Preprint · journal metadata

Homologous Overexpression of Genes in Cordyceps militaris Improves the Production of Polysaccharide

Abstract Background Cordyceps polysaccharides have been used around the globe for its bioactivity for millennia. However, the study and medicinal of Cordyceps militaris polysaccharides has been hampered by the low in natural abundances.

Cordyceps · 2020 · Preprint · journal metadata

Immune modulation of macrophage response by Cordyceps militaris extracts

Backgrounds:: Cordyceps militaris is a well-known medicinal fungus. Cordycepin, a metabolite of this fungus, has strong biological activities against leukemia, oxidative stress, aging, tumors, and inflammation.

OncologyImmune support

Chaga · 2020 · Preprint · journal metadata

Inonotus Obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis

In present study, the effect of Inonotus Obliquus extracts used in traditional medicine was investigated on the expression of matrix metalloproteinases-1 (MMP-1) in the normal human dermal fibroblasts..

Skin & hydration

Reishi · 2020 · Preprint · journal metadata

The ITS region provides a reliable DNA barcode for identifying reishi/lingzhi ( Ganoderma ) from herbal supplements

The dietary supplement industry is a growing enterprise, valued at over $100 billion by 2025 yet, a recent study revealed that up to 60% of herbal supplements may have substituted ingredients not listed on their labels, some with harmful contaminants..

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2020 · Preprint · journal metadata

The Regulation Effect of Crude Polysaccharides from Cordyceps Militaris on Obesity Control and Gut Microbiota Community via High-Fat Diet-Fed Mice Model

Administration of crude polysaccharides extract from natural product is a promising gut microbiota-targeted approach to preventing obesity and associated metabolic disorders. Dietary restrictions can change the type and number of gut bacteria, which is an important factor in delaying the onset and burden of diseases..

Oyster Mushroom · 2019 · Preprint · journal metadata

Evaluation of waste paper for cultivation of oyster mushroom ( Pleurotus ostreatus ) with some added supplementary materials

Mushroom cultivation is an economically feasible bio-technological process for conversion of various lignocellulosic wastes. This study was conducted at Aksum University with the aim of evaluating the suitability of waste paper supplemented with corn stalk and wheat bran for Oyster mushroom cultivation..

Oyster Mushroom · 2019 · Preprint · journal metadata

Yield performance of Oyster mushroom ( Pleurotus ostreatus ) on various crop residues as substrate.

Substrate type is an important factor determining growth and yield of oyster mushroom. Five different substrates namely rice straw, maize husks, banana leaves, fingermillet husk and mixture of rice straw & black gram pod shell (1:1) were evaluated for the yield and related attributes of Pleurotus ostreatus..

Chaga · 2018 · Preprint · journal metadata

Inonotus Obliquus extracts as an inhibitor of α-MSH-induced melanogenesis in B16F10 mouse melanoma cells

Melanogenesis is a biosynthetic pathway for producing of the pigment melanin in human skin. Tyrosinase, a key enzyme, catalyzing is the first step in melanogenesis and the downregulation of the tyrosinase enzyme activity is the most reported method for anti-melanogenesis..

OncologySkin & hydration

Enoki · 2018 · Preprint · journal metadata

Study on physicochemical properties and microbial diversity of flammulina velutipes residue during rapid fermentation

In order to investigate the effects of different mass ratios of corn straw, super absorbent resin (SAR) and cellulose decomposing strains on fermentation of flammulina velutipes residue, the cellulose degradation rate, germination index, bacterial diversity, urease activity, cellulase activity and other indicators….

Immune supportLiver support

Zhu Ling · 1993 · Randomized Controlled Trial · Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

[Therapeutic effect of combined therapy of Salvia miltiorrhizae and Polyporus umbellatus polysaccharide in the treatment of chronic hepatitis B].

90 patients of chronic hepatitis B with positive HBV replication markers and abnormality of ALT were randomly allocated to 3 groups. 30 cases were treated with Salvia miltiorrhizae (SM) and Polyporus Umbellatus polysaccharide (PUP) as group I, 30 cases were treated with SM solely as group II and 30 cases were treated….

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Oyster Mushroom · 2026 · Randomized Controlled Trial · Food & function

A randomised controlled study to investigate the cognitive, mood, metabolic and anti-inflammatory effects of acute oyster mushroom intervention in healthy older adults.

The Pleurotus oyster is a common edible mushroom rich in ergothioneine, a bioactive that has shown benefits to cognition in animals when administered in extract form. The OYSACO study investigated the acute effects of oyster mushroom (OM) on cognition, mood, inflammation and metabolism in healthy older adults..

Oyster Mushroom · 2026 · Research Article · Foods (Basel, Switzerland)

Formulation and Nutritional Evaluation of Instant Vegan Mushroom (Pleurotus ostreatus) Soup Powder Enriched with Moringa (Moringa oleifera), Mung Bean (Vigna radiata), and Pumpkin (Cucurbita maxima).

Although plant-based convenience foods have gained significant market share, many are high in fat, salt, and sugar while low in nutrients. The current study aimed to develop a vegan oyster mushroom soup powder enriched with moringa, mung bean, and pumpkin..

Shiitake · 2026 · Research Article · Food science & nutrition

Immunomodulatory Effects of Zinc and Selenium-Enriched Lentinula edodes Extract: Biochemical Characterization and Bioactivity Relevant to Tuberculosis.

The primary hypothesis of the study was that zinc and selenium supplementation through fortified cookies would enhance the immune response and improve clinical outcomes in tuberculosis patients..

Immune supportCognition & nerves

Lion's Mane · 2026 · Review · Journal of food science

Lion's Mane Mushroom: Nutritional Profile, Bioactive Compounds, Functional Properties, and Applications in Functional Food Systems.

Lion's Mane mushroom (Hericium erinaceus) holds a significant place in traditional Chinese medicine (TCM), valued for centuries for benefiting various internal organs and overall well-being..

Shiitake · 2025 · Research Article · Food chemistry: X

Dynamic analysis of quality characteristics and flavor development in yogurt fermented with Lentinula edodes polysaccharides.

This study investigated the dynamic changes in quality of yogurts containing Lentinula edode polysaccharide (LEP) and enzymatically hydrolyzed Lentinula edode polysaccharide (EH-LEP)..

Immune supportEnergy & fatigue

Shiitake · 2025 · Research Article · Foods (Basel, Switzerland)

Lentinula edodes Stalk Polysaccharide Coating Extends the Shelf-Life of Agaricus bisporus by Modulating Respiration and Energy Metabolism.

This study comprehensively evaluated the effect of a Shiitake Stalk Isolated Polysaccharide (LEP) coating on Agaricus bisporus. The study findings revealed that the application of 1.5% LEP reduced weight loss, maintained firmness and chewiness, as well as the nutritional indices of mushrooms, extended the shelf life….

OncologyEnergy & fatigueLiver supportRespiratory

Cordyceps · 2023 · English Abstract · Nan fang yi ke da xue xue bao = Journal of Southern Medical University

[Cordycepin, a metabolite of Cordyceps militaris, inhibits xenograft tumor growth of tongue squamous cell carcinoma in nude mice].

OBJECTIVE: To evaluate the inhibitory effect of cordycepin on oral cancer xenograft in nude mice and explore the underlying mechanisms. METHODS: Sixteen BALB/c mice bearing subcutaneous human tongue squamous cell carcinoma (TSCC) TCA-8113 cell xenografts were randomized into model group and cordycepin treatment group….

Reishi · 2023 · Preprint · journal metadata

A transcription factor GCN4 contributes to maintaining intracellular amino acid contents under the nitrogen limiting conditions in mushroom Ganoderma lucidum

Background: Edible mushrooms, with their delightful taste and abundant protein and amino acids required by human, can be used as substitutes of meat or plant proteins in a variety of foods and beverages..

Oyster Mushroom · 2023 · Preprint · journal metadata

An Approach For Control Of Phytopathogenic Caenorhabditis elegans N2 Via Regulation of Growth Conditions And Pleurotus ostreatus Po4

Soil phytopathogenic nematodes cause great damage to agricultural plants. Different methods have been used to control them.

OncologyMetabolic healthRespiratory

Maitake · 2023 · Preprint · journal metadata

Anti-α-glucosidase, anti-proliferative and anti-enterovirus 71 activity of secondary metabolites identified from Grifola frondosa

Grifola frondosa, an edible and medicinal resource, is widely used as functional foods worldwide. To explore bioactive compounds against α-glucosidase, human tumor cells and enterovirus 71 (EV71), eight compounds were isolated from G.

Oyster Mushroom · 2023 · Preprint · journal metadata

Antioxidant effect of ethanolic extract of Pleurotus Ostreatus on 4-hydroxy-2-nonenal (HNE) and glutathione (GSH) level in lung rats exposed to cigarette smoke

Background: Cigarette smoke can trigger oxidative stress. An alternative to overcome the harmful effects of cigarette smoke is through antioxidants.

Respiratory

Wood Ear · 2023 · Preprint · journal metadata

Association between Auricularia auricula-judae consumption and sarcopenia: A Cross-Sectional Study

Abstract Background: Several studies have shown that Auricularia auricula-judae (AAJ) can reduce inflammation and oxidative stress. Although these factors are closely involved in the pathogenesis of sarcopenia, limited research has focused on the association between AAJconsumption and sarcopenia in the general….

Cognition & nervesSkin & hydration

Shiitake · 2023 · Preprint · journal metadata

Disentangling the Tissue-Specific Variations of Volatile Flavor Profiles of Lentinula edodes Fruiting Body

For Lentinula edodes, its characteristic flavor is the key determinant for consumer pref-erences. However, the tissue-specific volatile flavor variations of the fruiting body have been overlooked..

Immune supportEnergy & fatigueGut & microbiome

Reishi · 2023 · Preprint · journal metadata

Effect of dietary supplementation of Ganoderma lucidum residue on growth performance, immune organ index and faecal microbial community diversity in broiler chickens

Ganoderma lucidum residue (GLR) contains a variety of medicinal and nutritional components and is a potentially high quality roughage. The purpose of the experiment was to study the effects of GLR on the growth performance, immune function and intestinal flora of broilers..

Reishi · 2023 · Preprint · journal metadata

Effect of dissolved oxygen regulation on the content of ganoderic acid S and R in mycelium of Ganoderma lucidum in a two-stage culture by oscillatory-stationary culture

Currently, liquid fermentation is regarded as a feasible method for cultivating thyme as contrast to subentity culture. Nevertheless, the production of ganoderic acid S and R is still rather limited, thus requiring the need for parameter adjustment in the liquid fermentation process..

Reishi · 2023 · Preprint · journal metadata

Hydrogen sulfide maintains redox homeostasis and suppresses ganoderic acids biosynthesis under heat stress via S-sulfhydrating thioredoxin 1 in Ganoderma lucidum

Abstract Hydrogen sulfide (H 2 S) is considered to be a novel gaseous signalling molecule with multiple physiological functions. Recently, the identification of sulfhydrated proteins has become a new hotspot in the analysis of the underlying mechanism of H 2 S..

Skin & hydration

OncologyImmune supportMetabolic health

Reishi · 2023 · Preprint · journal metadata

Optimization of chemical conditions for metabolites production by Ganoderma lucidum using response surface methodology and investigation of antimicrobial as well as anticancer activities

Ganoderma lucidum ( G. lucidum ) is a medical mushroom known for its tendency to produce physiologically active compounds with far-reaching effects on human health..

Shiitake · 2023 · Preprint · journal metadata

Optimization of Se- and Zn-Enriched Mycelium of Lentinula edodes (Berk.) Pegler as a Dietary Supplement with Immunostimulatory Activity

Mycelial cultures of Lentinula edodes, an edible and medicinal mushroom, have been used in our previous research to obtain selenium-containing immunomodulatory preparations..

Immune supportEnergy & fatigueMetabolic healthSkin & hydration

Chaga · 2023 · Preprint · journal metadata

Protective effect of Inonotus obliquus polysaccharide on fibroblasts after MGO-induced nonenzymatic glycation

Abstract Background Nonenzymatic glycation of fibroblasts causes functional downregulation and behavioral disorders in skin. Methods To investigate the effect of Inonotus obliquus on the nonenzymatic glycation of skin, we examined advanced glycation end product (AGE) inhibition by four extract fractions: n-butanol,….

Enoki · 2023 · Preprint · journal metadata

The genome sequence of the Velvet Shank, Flammulina velutipes (Curtis) Singer, 1951

We present a genome assembly from a specimen of Flammulina velutipes (the Velvet Shank; Basidiomycota; Agaricomycetes; Agaricales; Physalacriaceae). The genome sequence is 37.4 megabases in span.

Shiitake · 2022 · Preprint · journal metadata

A Novel Gene, Le-Dd 10, Is Involved in Fruiting Body Formation of Lentinula Edodes

Abstract The cDNA library prepared from Lentinula edodes, Hokken 600 (H600), primordia was screened by using cDNA expressed specifically in Dictyostelium discoideum prestalk as a probe. Twenty-one clones, Le-Dd 1~21, were isolated from the L.

Oyster Mushroom · 2022 · Preprint · journal metadata

Biotransformation of Kraft lignin by Pleurotus ostreatus Florida in conditions optimized for laccase production

Abstract White-rot fungi are efficient degraders of the lignin moiety due to the production of extracellular enzymes that includes the laccases which are able to depolymerize lignin oxidative processes to low-molecular weight phenolic and aromatic compounds..

Immune supportRespiratory

Lion's Mane · 2022 · Preprint · journal metadata

In vitro assessment of multipotential therapeutic importance of Hericium erinaceus mushroom extracts using different solvents

Abstract Infectious disease is one of the major threats to humans and it is the second leading cause of death worldwide, especially at present in which the Covid-19 and its modified variants. Edible mushrooms have many nutritional and medicinal values to human health..

Chaga · 2022 · Preprint · journal metadata

Inonotus obliquus (Fr.) Pilat (IOPE) ameliorates immune response via LKB1- Bax-Casepase-3-PARP pathways in B16-F10 cells induced low immunity BALB/c mice model

Objective: Inonotus obliquus (Fr.) Pilat extract (IOPE) is a major active carbohydrate, an important herb used in traditional medicine, the aim of this study was to investigate the immunomodulatory effects and possible underlying mechanisms of IOPE in B16-F10 cells induced low immunity mice..

Oyster Mushroom · 2022 · Preprint · journal metadata

Nutritional and antioxidant changes in lentil and quinoa induced by fungal solid-state fermentation with Pleurotus ostreatus

Abstract Solid-state fermentation (SSF) could be considered a suitable bioprocess to produce protein-vegetal ingredients with increased nutritional and functional value..

Metabolic health