MycoData

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps militaris is an ingredient of traditional Chinese medicine and have been widely used for inflammatory diseases and cancer. Cordycepin is one of the major bioactive components of Cordyceps militaris, and has been known to have anti-inflammatory and anti-oxidant effects..

OncologyImmune supportCognition & nerves

High relevance

Cordyceps · 2017 · Research Article · Heliyon

Cordyceps militaris improves the survival of Dahl salt-sensitive hypertensive rats possibly via influences of mitochondria and autophagy functions.

The genus Cordyceps and its specific ingredient, cordycepin, have attracted much attention for multiple health benefits and expectations for lifespan extension. We analyzed whether Cordyceps militaris (CM), which contains large amounts of cordycepin, can extend the survival of Dahl salt-sensitive rats, whose survival….

Immune supportCognition & nervesEnergy & fatigueMetabolic health

High relevance

King Oyster · 2017 · Journal Article · International journal of medicinal mushrooms

In Vitro Antioxidant and In Vivo Hypolipidemic Effects of the King Oyster Culinary-Medicinal Mushroom, Pleurotus eryngii var. ferulae DDL01 (Agaricomycetes), in Rats with High-Fat Diet-Induced Fatty Liver and Hyperlipidemia.

We investigated the effect of the culinary-medicinal mushroom Pleurotus eryngii var. ferulae DDL01 on oxidative damage in the liver and brain and a high-fat/high-cholesterol-induced hyperlipidemic model..

Cognition & nervesMetabolic healthLiver support

High relevance

Lion's Mane · 2017 · Journal Article · International journal of medicinal mushrooms

Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), Modulates Purinoceptor-Coupled Calcium Signaling and Murine Nociceptive Behavior.

Hericium erinaceus is well known for the neurotrophic effect it confers by promoting nerve growth factor biosynthesis. We discovered a novel bioactivity of H.

Cognition & nervesLiver support

High relevance

Cordyceps · 2017 · Journal Article · International journal of medicinal mushrooms

Photoperiodic Responses and Characterization of the Cmvvd Gene Encoding a Blue Light Photoreceptor from the Medicinal Caterpillar Fungus Cordyceps militaris (Ascomycetes).

Light is a necessary environmental factor for production of conidia and pigment, formation of stroma, and development of Cordyceps militaris, a well-known edible and medicinal mushroom. In this study, an obvious rhythm loop was observed in certain strains of C..

Cognition & nervesEnergy & fatigue

High relevance

Lion's Mane · 2016 · Research Article · Journal of biomedical science

Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice.

BACKGROUND: The fruiting body of Hericium erinaceus has been demonstrated to possess anti-dementia activity in mouse model of Alzheimer's disease and people with mild cognitive impairment. However, the therapeutic potential of Hericium erinaceus mycelia on Alzheimer's disease remains unclear..

Cognition & nervesMetabolic health

High relevance

Lion's Mane · 2016 · Journal Article · Chinese journal of integrative medicine

Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration.

OBJECTIVE: To study the ability of aqueous extract of Hericium erinaceus mushroom in the treatment of nerve injury following peroneal nerve crush in Sprague-Dawley rats. METHODS: Aqueous extract of Hericium erinaceus was given by daily oral administration following peroneal nerve crush injury in Sprague-Dawley rats..

Immune supportCognition & nerves

High relevance

Lion's Mane · 2016 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Improvement of erinacine A productivity in Hericium erinaceus mycelia and its neuroprotective bioactivity against the glutamate-insulted apoptosis

Hericium erinaceus (Bulliard: Fries) Persoon (HE), synonymously called Monkey Head mushroom or Yamabushitake, contains a huge amount of nutrients, in particular, the erinacines..

OncologyCognition & nervesEnergy & fatigue

High relevance

Snow Fungus · 2016 · Journal Article · Molecular medicine reports

Studies on the purification of polysaccharides separated from Tremella fuciformis and their neuroprotective effect.

The present study aimed to investigate the protective effect of purified polysaccharides from Tremella fuciformis against glutamate-induced cytotoxicity in differentiated PC12 (DPC12) cells..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Lion's Mane · 2015 · Review · Journal of agricultural and food chemistry

Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds.

The culinary and medicinal mushroom Hericium erinaceus is widely consumed in Asian countries, but apparently not in the United States, for its nutritional and health benefits..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

High relevance

Lion's Mane · 2014 · Review · Food & function

Hericium erinaceus (Yamabushitake): a unique resource for developing functional foods and medicines.

Hericium erinaceus (HE) is a fungus inhabiting the mountainous areas of the northeast territories in Asia. HE has been used in traditional folk medicine and medicinal cuisine in China, Korea and Japan..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2013 · Review Article · Journal of traditional and complementary medicine

A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in Dong-ChongXiaCao ( Dōng Chóng Xià Cǎo) and Related Bioactive Ingredients.

The caterpillar fungus Ophiocordyceps sinensis (syn.Cordyceps sinensis), which was originally used in traditional Tibetan and Chinese medicine, is called either "yartsa gunbu" or "DongChongXiaCao ( Dōng Chóng Xià Cǎo)" ("winter worm-summer grass"), respectively..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Lion's Mane · 2013 · Review · Journal of complementary & integrative medicine

Hericium erinaceus: an edible mushroom with medicinal values.

Mushrooms are considered as nutritionally functional foods and source of physiologically beneficial medicines. Hericium erinaceus, also known as Lion's Mane Mushroom or Hedgehog Mushroom, is an edible fungus, which has a long history of usage in traditional Chinese medicine..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Lion's Mane · 2012 · Review · International journal of medicinal mushrooms

Neuroregenerative potential of lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review).

We present a model case study of the activity of aqueous extract of Hericium erinaceus fresh fruit bodies in promoting functional recovery following crush injury to the peroneal nerve in adult female Sprague-Dawley rats. The aim was to explore the possible use of this mushroom in nerve repair..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Shiitake · 2026 · Research Support, Non U.S. Gov'T · The breast journal

Lentinula edodes Cultured Extract Intake at Puberty Mitigates Inflammatory Signals at the Mammary Glands by the Involvement of Epigenetic Mechanisms in BALB/c Mice.

Exposure to immune stress or lipopolysaccharide (LPS) during critical developmental stages like puberty may lead to gut microbiome dysbiosis and epigenetic dysregulation in mammary glands, affecting gene expression and potentially elevating breast cancer susceptibility in adulthood..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Lion's Mane · 2025 · Research Support, Non U.S. Gov'T · Bioorganic chemistry

Discovery and biochemical characterization of prenyltransferases in the biosynthetic pathway of hericenones from Hericium erinaceus.

Hericenones, neurotrophic meroterpenoids from the medicinal mushroom Hericium erinaceus, exhibit remarkable nerve growth factor-enhancing properties with therapeutic potential for neurodegenerative disorders..

Cognition & nerves

High relevance

Cordyceps · 2025 · Evaluation Study · Food chemistry

Food traceability analysis and quality marker monitoring in Ophiocordyceps sinensis with multimodal ensemble learning.

Ophiocordyceps sinensis (OS) faces serious risks of food fraud, including quality misrepresentation, adulteration and illegal additives. To preserve the economic interests of consumers and the transparent management of food trade, so this study proposed a rapid and non-destructive detection tool to identify….

Immune supportCognition & nerves

High relevance

Snow Fungus · 2025 · Evaluation Study · Food chemistry

Monitoring Tremella fuciformis submerged fermentation using ATR-MIR combined with chemometrics.

This study employed mid-infrared attenuated total reflection (ATR-MIR) spectroscopy and chemometrics to monitor the submerged fermentation process of Tremella fuciformis (T. fuciformis)..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Lion's Mane · 2025 · Letter · World journal of gastroenterology

Potential of traditional Chinese medicine in gastrointestinal disorders: Hericium erinaceus in chronic atrophic gastritis.

Traditional Chinese medicine (TCM) has been extensively explored with various naturally derived compounds as a potential therapeutic agent for chronic atrophic gastritis (CAG)..

OncologyCognition & nervesGut & microbiome

High relevance

Lion's Mane · 2024 · Research Support, Non U.S. Gov'T · Neuropsychopharmacology reports

Amyloban, extracted from Hericium erinaceus, ameliorates social deficits and suppresses the enhanced dopaminergic system in social defeat stress mice.

Social dysfunctions are common in various psychiatric disorders, including depression, schizophrenia, and autism, and are long-lasting and difficult to treat. The development of treatments for social impairment is critical for the treatment of several psychiatric disorders..

Cognition & nerves

High relevance

Chaga · 2024 · Research Support, Non U.S. Gov'T · Communications biology

Fungal polysaccharides from Inonotus obliquus are agonists for Toll-like receptors and induce macrophage anti-cancer activity.

Fungal polysaccharides can exert immunomodulating activity by triggering pattern recognition receptors (PRRs) on innate immune cells such as macrophages. Here, we evaluate six polysaccharides isolated from the medicinal fungus Inonotus obliquus for their ability to activate mouse and human macrophages..

OncologyImmune supportCognition & nerves

High relevance

Reishi · 2024 · Research Support, Non U.S. Gov'T · Bioscience reports

Screening of active components of Ganoderma lucidum and decipher its molecular mechanism to improve learning and memory disorders.

Learning and memory impairment (LMI), a common degenerative central nervous system disease. Recently, more and more studies have shown that Ganoderma lucidum (GL) can improve the symptoms of LMI..

OncologyImmune supportCognition & nerves

High relevance

Lion's Mane · 2023 · Research Article · Biology

Cognitive Healthy Aging in Mice: Boosting Memory by an Ergothioneine-Rich Hericium erinaceus Primordium Extract.

Brain aging is a crucial risk factor for several neurodegenerative disorders and dementia. The most affected cognitive function is memory, worsening early during aging..

Immune supportCognition & nervesSkin & hydration

High relevance

Shiitake · 2023 · Research Article · Foods (Basel, Switzerland)

Disentangling the Tissue-Specific Variations of Volatile Flavor Profiles of the Lentinula edodes Fruiting Body.

For Lentinula edodes, its characteristic flavor is the key determinant for consumer preferences. However, the tissue-specific volatile flavor variations of the fruiting body have been overlooked..

Cognition & nervesSkin & hydration

High relevance

Lion's Mane · 2023 · Research Article · Biology

Hericium erinaceus Extract Exerts Beneficial Effects on Gut-Neuroinflammaging-Cognitive Axis in Elderly Mice.

Ageing is a biological phenomenon that determines the impairment of cognitive performances, in particular, affecting memory. Inflammation and cellular senescence are known to be involved in the pathogenesis of cognitive decline..

Immune supportCognition & nervesEnergy & fatigueGut & microbiome

High relevance

Lion's Mane · 2023 · Research Article · International journal of molecular sciences

Hericium erinaceus Promotes Anti-Inflammatory Effects and Regulation of Metabolites in an Animal Model of Cerebellar Ataxia.

Cerebellar ataxia is a neurodegenerative disorder with no definitive treatment. Although previous study demonstrated the neuroprotective effects of Hericium erinaceus (H.E.), the mechanisms of H.E.

Immune supportCognition & nervesEnergy & fatigueMetabolic health

High relevance

Turkey Tail · 2023 · Journal Article · Journal of biotechnology

In-situ synchrotron imaging, experimental, and computational investigations on the efficiency of Trametes versicolor laccase on detoxification of P-Cresyl Sulfate (PCS) Protein Bound Uremic Toxin (PBUT).

Protein bound uremic toxins (PBUTs) are small substances binding to larger proteins, mostly human serum albumin (HSA), and are challenging to remove by hemodialysis (HD). Among different classes of PBUTs, p-cresyl sulfate (PCS) is the most widely used marker molecule and major toxin, as 95 % is bound to HSA..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Oyster Mushroom · 2023 · Research Article · Frontiers in nutrition

Lead detoxification of edible fungi Auricularia auricula and Pleurotus ostreatus: the purification of the chelation substances and their effects on rats.

Lead is a global pollutant that causes widespread concern. When a lead enters the body, it is distributed throughout the body and accumulates in the brain, bone, and soft tissues such as the kidney, liver, and spleen..

Immune supportCognition & nervesLiver support

High relevance

Oyster Mushroom · 2023 · Journal Article · Food research international (Ottawa, Ont.)

Lipidomic profiling of Pleurotus ostreatus by LC/MS Q-TOF analysis

In this paper, for the first time a lipidomic analysis on Pleurotus ostreatus species was performed by liquid chromatography quadrupole time-of-flight mass spectrometry (LC/MS Q-TOF). Twenty-seven lipid classes, including polar and non-polar lipid classes, were detected..

Cognition & nervesEnergy & fatigue

High relevance

Lion's Mane · 2023 · Journal Article · Natural product research

New benzaldehyde derivatives from the fruiting bodies of Hericium erinaceus with cytotoxic activity.

Four new natural compounds named hericenone O (1), hericenone P (2), hericenone Q (3), and hericenone R (4), two of them were reported synthetically (3-4), together with eleven known compounds were isolated from the fruiting bodies of Hericium erinaceus..

OncologyCognition & nerves

High relevance

Reishi · 2023 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Non-destructive detection of polysaccharides and moisture in Ganoderma lucidum using near-infrared spectroscopy and machine learning algorithm

Ganoderma lucidum, the fruiting body of the Poraceae fungi G. lucidum or Ganoderma sinense, has a long history of use in promoting health and longevity in Asian countries.

Immune supportCognition & nerves

High relevance

Enoki · 2023 · Journal Article · International journal of biological macromolecules

Polysaccharide from Flammulina velutipes residues protects mice from Pb poisoning by activating Akt/GSK3β/Nrf-2/HO-1 signaling pathway and modulating gut microbiota.

Lead (Pb) can cause damages to the brain, liver, kidney, endocrine and other systems. Flammulina velutipes residues polysaccharide (FVRP) has been reported to exhibit anti-heavy metal toxicity on yeast, but its regulating mechanism is unclear..

OncologyImmune supportCognition & nervesGut & microbiome

High relevance

Niu-Chang-Chih · 2023 · Research Article · International journal of molecular sciences

The Transcription Factor Nrf2 Mediates the Effects of Antrodia camphorata Extract on Neuropathological Changes in a Mouse Model of Parkinson's Disease.

Parkinson's disease (PD) is a disorder that is characterized by progressive and selective neuronal injury and cell death. Recent studies have provided accumulating evidence for a significant role of the immune system and neuroinflammation in PD pathogenesis..

Immune supportCognition & nerves

High relevance

Cordyceps · 2023 · Research Article · Microorganisms

Transcriptome and Metabolome Analyses of Thitarodes xiaojinensis in Response to Ophiocordyceps sinensis Infection.

Ophiocordyceps sinensis exhibits more than 5 months of vegetative growth in Thitarodes xiaojinensis hemocoel. The peculiar development process of O.

Immune supportCognition & nervesEnergy & fatigue

High relevance

Lion's Mane · 2023 · Research Article · Molecules (Basel, Switzerland)

Unprecedented Neoverrucosane and Cyathane Diterpenoids with Anti-Neuroinflammatory Activity from Cultures of the Culinary-Medicinal Mushroom Hericium erinaceus.

The culinary medicinal mushroom Hericium erinaceus holds significant global esteem and has garnered heightened interest within increasingly ageing societies due to its pronounced neuroprotective and anti-neuroinflammatory properties..

Immune supportCognition & nerves

High relevance

Lion's Mane · 2022 · Research Article · Oxidative medicine and cellular longevity

A Mixture of Ginkgo biloba L. Leaf and Hericium erinaceus (Bull.) Pers. Fruit Extract Attenuates Scopolamine-Induced Memory Impairments in Mice.

Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by loss of memory and cognitive impairment via dysfunction of the cholinergic nervous system..

OncologyCognition & nerves

High relevance

Lion's Mane · 2022 · Research Article · Nutrients

Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts.

Nutrition has relevant consequences for human health and increasing pieces of evidence indicate that medicinal mushrooms have several beneficial effects. One of the main issues in Western countries is represented by the challenges of aging and age-related diseases, such as neurodegenerative disorders..

Cognition & nervesSkin & hydration

High relevance

Lion's Mane · 2022 · Journal Article · International journal of medicinal mushrooms

Aqueous Extracts of Pleurotus ostreatus and Hericium erinaceus Protect against Ultraviolet A-Induced Damage in Human Dermal Fibroblasts.

Pleurotus ostreatus (PO) and Hericium erinaceus (HE) have been traditionally used to treat various diseases, owing to their antioxidant, antimicrobial, neuroprotective, and antitumor effects. However, few studies have been reported on their antiaging effects..

OncologyImmune supportCognition & nervesSkin & hydration

High relevance

Enoki · 2022 · Research Article · Frontiers in bioengineering and biotechnology

Biocompatible and antibacterial Flammulina velutipes-based natural hybrid cryogel to treat noncompressible hemorrhages and skin defects.

Hemorrhage, infection, and frequent replacement of dressings bring great clinical challenges to wound healing. In this work, Flammulina velutipes extract (FV) and hydroxyethyl cellulose (HEC) were chemically cross-linked and freeze-dried to obtain novel HFV cryogels (named HFVn, with n = 10, 40, or 70 corresponding to….

Immune supportCognition & nervesLiver supportSkin & hydration

High relevance

Reishi · 2022 · Journal Article · Translational andrology and urology

Ganoderma lucidum polysaccharide ameliorated diabetes mellitus-induced erectile dysfunction in rats by regulating fibrosis and the NOS/ERK/JNK pathway.

BACKGROUND: Diabetes mellitus-induced erectile dysfunction (DMED) is a frequent complication of diabetes mellitus (DM), with limited therapy at present. This study aimed to explore the role and mechanism of Ganoderma lucidum polysaccharide (GLP) on DMED..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Reishi · 2022 · Journal Article · Nutrients

Ganoderma Lucidum Triterpenoids Improve Maternal Separation-Induced Anxiety- and Depression-like Behaviors in Mice by Mitigating Inflammation in the Periphery and Brain.

Although early life stress (ELS) can increase susceptibility to adulthood psychiatric disorders and produce a greater inflammatory response in a stressful event, targeted preventive and therapeutic drugs still remain scarce..

Immune supportCognition & nervesLiver support

High relevance

Reishi · 2022 · Journal Article · Applied and environmental microbiology

GCN4 Enhances the Transcriptional Regulation of AreA by Interacting with SKO1 To Mediate Nitrogen Utilization in Ganoderma lucidum.

Fungi utilize a wide range of nitrogen to adapt their metabolism. The transcription factor GCN4 has a pivotal role in nitrogen metabolism.

Cognition & nerves

High relevance

Lion's Mane · 2022 · Research Article · Journal of animal science and technology

Gut microbiota profiling in aged dogs after feeding pet food contained Hericium erinaceus.

Health concern of dogs is the most important issue for pet owners. People who have companied the dogs long-term provide the utmost cares for their well-being and healthy life.

Immune supportCognition & nervesMetabolic healthGut & microbiome

High relevance

Reishi · 2022 · Journal Article · Phytochemistry

Lanostane triterpenoids from Ganoderma lucidum and their inhibitory effects against FAAH.

Ganoderma lucidum is a famous edible and medicinal fungus. Through a bioactive phytochemical investigation of the ethanolic extracts of the fruiting bodies of G.

OncologyImmune supportCognition & nerves

High relevance

Oyster Mushroom · 2022 · Journal Article · Food research international (Ottawa, Ont.)

Lipidomic profiling of Pleurotus ostreatus by LC/MS Q-TOF analysis.

Cognition & nervesEnergy & fatigue

High relevance

Chaga · 2022 · Journal Article · Natural product research

Phenolic compounds from the sclerotia of Inonotus obliquus.

Three phenolic compounds (±1 and 2) including a pair of new enantiomers were isolated from the sclerotia of Inonotus obliquus. Their structures were assigned by extensive spectroscopic analyses..

Cognition & nerves

High relevance

Reishi · 2022 · Journal Article · Food & function

Polysaccharide from Ganoderma lucidum alleviates cognitive impairment in a mouse model of chronic cerebral hypoperfusion by regulating CD4+CD25+Foxp3+ regulatory T cells.

Ganoderma lucidum (G. lucidum) is a kind of edible and medicinal mushroom.

Immune supportCognition & nervesEnergy & fatigue

High relevance

Lion's Mane · 2022 · Research Article · Nutrients

Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The "Longevity Vitamin" Improves Locomotor Performances during Aging.

Phenotypic frailty is characterized by a progressive decline in physical functioning. During ageing, morphological and functional alterations involve the brain, and chief theories involve oxidative stress, free radical accumulation, and reduced antioxidant defenses as the most implicated mechanisms..

Immune supportCognition & nervesEnergy & fatigueSkin & hydration