MycoData

UNLABELLED: In this study, the influence of γ-irradiation with different dose (0, 4, 8, and 16 kGy) on chemical composition, physicochemical features and bioactivities of polysaccharides extracted from Lentinula edodes (LEP) were investigated..

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2023 · Journal Article · International journal of biological macromolecules

The role of post-transcriptional modification on a new tRNAIle(GAU) identified from Ganoderma lucidum in its fragments' cytotoxicity on cancer cells.

Ganoderma lucidum (Ganoderma) is a famous Chinese herbal medicine which has been used clinically for thousands of years in China. Despite numerous studies on triterpenes and polysaccharides, the bioactivity of RNAs abundant in Ganoderma remains unknown..

OncologyImmune support

High relevance

Reishi · 2023 · Research Article · Microbial cell factories

The transcription factor GCN4 contributes to maintaining intracellular amino acid contents under nitrogen-limiting conditions in the mushroom Ganoderma lucidum.

BACKGROUND: Edible mushrooms are delicious in flavour and rich in high-quality protein and amino acids required by humans. A transcription factor, general control nonderepressible 4 (GCN4), can regulate the expression of genes involved in amino acid metabolism in yeast and mammals..

High relevance

Niu-Chang-Chih · 2023 · Research Article · International journal of molecular sciences

The Transcription Factor Nrf2 Mediates the Effects of Antrodia camphorata Extract on Neuropathological Changes in a Mouse Model of Parkinson's Disease.

Parkinson's disease (PD) is a disorder that is characterized by progressive and selective neuronal injury and cell death. Recent studies have provided accumulating evidence for a significant role of the immune system and neuroinflammation in PD pathogenesis..

Immune supportCognition & nerves

High relevance

Reishi · 2023 · Journal Article · Journal of ethnopharmacology

Toxicogenic effects of the mushroom Ganoderma lucidum on human liver and kidney tumor cells and peripheral blood lymphocytes.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Curtis) P. Karst., a bioactive mushroom with medicinal properties, is known to exert immunomodulatory, anti-inflammatory, hypocholesterolemic, hypoglycemic, and hepatoprotective effects.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Turkey Tail · 2023 · Journal Article · Environmental research

Trametes versicolor laccase activity modulated by the interaction with gold nanoparticles.

In this study, the impact of gold nanoparticles (AuNPs) on the structure and activity of laccase from Trametes versicolor (Lc) was described. Fluorescence experiments revealed that AuNPs efficiently quench Lc's tryptophan fluorescence by a static and dynamic process..

Energy & fatigue

High relevance

Oyster Mushroom · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

Transcriptome Analysis Revealed That Hydrogen Peroxide-Regulated Oxidative Phosphorylation Plays an Important Role in the Formation of Pleurotus ostreatus Cap Color.

Pleurotus ostreatus is widely cultivated in China. H2O2, as a signaling molecule, can regulate the formation of cap color, but its regulatory pathway is still unclear, severely inhibiting the breeding of dark-colored strains.

Metabolic healthRespiratory

High relevance

Cordyceps · 2023 · Research Article · Microorganisms

Transcriptome and Metabolome Analyses of Thitarodes xiaojinensis in Response to Ophiocordyceps sinensis Infection.

Ophiocordyceps sinensis exhibits more than 5 months of vegetative growth in Thitarodes xiaojinensis hemocoel. The peculiar development process of O.

Immune supportCognition & nervesEnergy & fatigue

High relevance

Snow Fungus · 2023 · Research Article · Molecules (Basel, Switzerland)

Tremella fuciformis Polysaccharide Induces Apoptosis of B16 Melanoma Cells via Promoting the M1 Polarization of Macrophages.

Anti-tumor activity of Tremella fuciformis polysaccharides (TFPS) has been widely reported, but its mechanism remains poorly understood. In this study, we established an in vitro co-culture system (B16 melanoma cells and RAW 264.7 macrophage-like cells) to explore the potential anti-tumor mechanism of TFPS..

OncologyImmune support

High relevance

Snow Fungus · 2023 · Journal Article · Photochemical & photobiological sciences: Official journal of the European Photochemistry Association and the European Society for Photobiology

Tremella fuciformis polysaccharides alleviates UV-provoked skin cell damage via regulation of thioredoxin interacting protein and thioredoxin reductase 2.

INTRODUCTION: Skin is exposed to a wide range of environmental risk factors including ultraviolet (UV) and all kinds of pollutants. Excessive UV exposure contributes to many disorders, such as photoaging, skin inflammation, and carcinogenesis..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Reishi · 2023 · Journal Article · Heliyon

Triterpenoids of Ganoderma lucidum inhibited S180 sarcoma and H22 hepatoma in mice by regulating gut microbiota

In order to explore effect of natural plant extracts on anti-tumor and prevent tumor development. The study assessed the antitumor effect of triterpenoids of Ganoderma lucidum (TGL) on S180 and H22 tumor bearing mice..

OncologyGut & microbiomeLiver support

High relevance

Reishi · 2023 · Research Article · Heliyon

Triterpenoids of Ganoderma lucidum inhibited S180 sarcoma and H22 hepatoma in mice by regulating gut microbiota.

OncologyGut & microbiomeLiver support

High relevance

Niu-Chang-Chih · 2023 · Research Article · Frontiers in pharmacology

Turicibacter fermentation enhances the inhibitory effects of Antrodia camphorata supplementation on tumorigenic serotonin and Wnt pathways and promotes ROS-mediated apoptosis of Caco-2 cells.

Introduction: Diet-induced obesity has been shown to decrease the abundance of Turicibacter, a genus known to play a role in the serotonin signaling system, which is associated with colorectal tumorigenesis, making the presence of Turicibacter potentially influential in the protection of intestinal tumorigenesis..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Enoki · 2023 · Journal Article · Journal of Asian natural products research

Two new sesquiterpenoids from plant endophytic fungus Flammulina velutipes.

Two new sesquiterpenoids, flammupin A (1) and flammupin B (2), along with two known compounds, enokipodin C (3) and 5,5'-dibuthoxy-2,2'-bifuran (4) were obtained from Flammulina velutipes, an endophytic fungus isolated from the roots of Caulophyllum robustum Maxim..

Oncology

High relevance

Shiitake · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

Two Strains of Lentinula edodes Differ in Their Transcriptional and Metabolic Patterns and Respond Differently to Thermostress.

Temperature type is one of the key traits determining the cultivation regime of Lentinula edodes. However, the molecular and metabolic basis underling temperature type remain unclear.

Metabolic health

High relevance

Cordyceps · 2023 · Research Article · Medicine

Uncovering anti-influenza mechanism of Ophiocordyceps sinensis using network pharmacology, molecular pharmacology, and metabolomics.

Ophiocordyceps sinensis is a precious Chinese traditional herb with a long medicinal history. This study used UPLC-MS metabolomics to explore and compare the metabolic profiles of the stroma (OSBSz), sclerotium (OSBSh), and mycelium (OSBS) of O sinensis to analyze their differential metabolites and identified….

Metabolic healthRespiratory

High relevance

Cordyceps · 2023 · Journal Article · International journal of medicinal mushrooms

Uncovering Gene Expression Profiles of Three Morphologic Mycelium Forms of the Chinese Caterpillar Mushroom Ophiocordyceps sinensis (Ascomycota) Using High-Throughput Sequencing.

The asexual form of Ophiocordyceps sinensis has been controversial, but various morphologic mycelium appeared when O. sinensis was cultured under experimental conditions..

Energy & fatigue

High relevance

Lion's Mane · 2023 · Research Article · Molecules (Basel, Switzerland)

Unprecedented Neoverrucosane and Cyathane Diterpenoids with Anti-Neuroinflammatory Activity from Cultures of the Culinary-Medicinal Mushroom Hericium erinaceus.

The culinary medicinal mushroom Hericium erinaceus holds significant global esteem and has garnered heightened interest within increasingly ageing societies due to its pronounced neuroprotective and anti-neuroinflammatory properties..

Immune supportCognition & nerves

High relevance

Reishi · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

Unraveling the Polysaccharide Biosynthesis Potential of Ganoderma lucidum: A Chromosome-Level Assembly Using Hi-C Sequencing.

Ganoderma lucidum exhibits the ability to synthesize a diverse range of biologically active molecules with significant pharmaceutical potential, including xylomannan and fucogalactan, which have demonstrated antitumor activity..

OncologyImmune support

High relevance

Yellow Morel · 2023 · Research Article · Open life sciences

Untargeted metabolomics reveals sour jujube kernel benefiting the nutritional value and flavor of Morchella esculenta.

Nucleosides, organic acids, and amino acids separated from Morchella esculenta are well known for their nutritional value and flavor. However, how to increase their content in a better way has been a challenge.

High relevance

Oyster Mushroom · 2023 · Journal Article · Journal of environmental management

Use of oyster mushrooms (Pleurotus ostreatus) for increased circularity and valorization of rapeseed residues.

In Europe, rapeseed is a common oilseed crop, resulting in the production of 20 million tons of rapeseed press cake yearly. This press cake can be further upcycled and a protein fraction can be extracted for food purposes, leaving de-proteinized fiber-rich residues..

Energy & fatigueMetabolic healthGut & microbiome

High relevance

Enoki · 2023 · Research Article · International journal of molecular sciences

Water Extract from Brown Strain of Flammulina velutipes Alleviates Cisplatin-Induced Acute Kidney Injury by Attenuating Oxidative Stress, Inflammation, and Autophagy via PI3K/AKT Pathway Regulation.

One of the most popular edible mushrooms in the world, Flammulina velutipes, has been shown to possess pharmacological properties such as anti-inflammatory and antioxidant properties. However, the potential activity of the brown strain of F..

OncologyImmune support

High relevance

Shiitake · 2023 · Preprint · journal metadata

Wood Decay Measurement of Shiitake Cultivation Logs Based on Spin Relaxation Times Obtained using Magnetic Resonance Imaging

To harvest large shiitake mushrooms ( Lentinula edodes ), it is important to adjust the suitable cultivation environment for shiitake mycelium so that it can extend throughout an entire log, maximizing wood decomposition and nutrient absorption..

High relevance

Turkey Tail · 2023 · Journal Article · Journal of biotechnology

Yellow laccase produced by Trametes versicolor K1 on tomato waste: A comparative study with the blue one produced on semi-synthetic medium.

Laccase production by fungal growth on agrifood waste is still poorly studied. Trametes versicolor K1 isolated from palm bark produced a yellow non glycosylated laccase from tomato waste based medium (TMT) and a blue glycosylated laccase on glucose medium (GLU)..

Metabolic health

High relevance

Maitake · 2022 · Journal Article · International journal of biological macromolecules

A cold-water polysaccharide-protein complex from Grifola frondosa exhibited antiproliferative activity via mitochondrial apoptotic and Fas/FasL pathways in HepG2 cells.

Grifola frondosa (G. frondosa) is widely known for its anti-tumor potential, which has been demonstrated by numerous scientific researches.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Lion's Mane · 2022 · Research Article · Oxidative medicine and cellular longevity

A Mixture of Ginkgo biloba L. Leaf and Hericium erinaceus (Bull.) Pers. Fruit Extract Attenuates Scopolamine-Induced Memory Impairments in Mice.

Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by loss of memory and cognitive impairment via dysfunction of the cholinergic nervous system..

OncologyCognition & nerves

High relevance

Zhu Ling · 2022 · Research Article · Frontiers in plant science

A Mycorrhizal Bacteria Strain Isolated From Polyporus umbellatus Exhibits Broad-Spectrum Antifungal Activity.

The microbes in the rhizosphere (or mycorrhizosphere) could promote plant growth, however, it is unclear whether mycorrhizosphere microbes could fight multiple fungal pathogens..

High relevance

Oyster Mushroom · 2022 · Journal Article · International journal of biological macromolecules

A natural selenium polysaccharide from Pleurotus ostreatus: Structural elucidation, anti-gastric cancer and anti-colon cancer activity in vitro.

The development and application of new natural selenium polysaccharides with relatively clear structure and excellent activity have become hot and difficult issues..

OncologyImmune supportGut & microbiome

High relevance

Niu-Chang-Chih · 2022 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

A network pharmacology-based strategy to explore the pharmacological mechanisms of Antrodia camphorata and antcin K for treating type II diabetes mellitus.

BACKGROUND: Diabetes mellitus is a chronic carbohydrate metabolism disorder, which could develop a series of complications and thus lead to poor quality of life or even mortality. Antrodia camphorata is a rare parasitic fungus and has been proven to be effective for treating type II diabetes..

Immune supportMetabolic health

High relevance

Shiitake · 2022 · Research Article · Archives of microbiology

A novel gene, Le-Dd10, is involved in fruiting body formation of Lentinula edodes.

The cDNA library prepared from Lentinula edodes, Hokken 600 (H600), primordia was screened using cDNA expressed specifically in Dictyostelium discoideum prestalk as a probe. Twenty-one clones, Le-Dd1 ~ 21, were isolated from the L.

High relevance

Maitake · 2022 · Research Article · Frontiers in microbiology

A novel hydrophobin encoded by hgfII from Grifola frondosa exhibiting excellent self-assembly ability.

Hydrophobins are small proteins from filamentous fungi, which have remarkable self-assembly properties of great potential, e.g., as drug carriers and as anti-bacterial agents, but different hydrophobins, with improved properties, are needed..

High relevance

Chaga · 2022 · Journal Article · International journal of biological macromolecules

A polysaccharide from Inonotus obliquus ameliorates intestinal barrier dysfunction in mice with type 2 diabetes mellitus.

Type 2 diabetes mellitus is a global disease that endangers human health, and the need for the development of nontoxic treatment candidates is urgent. In the present work, one homogeneous polysaccharide from Inonotus obliquus (IN) was isolated, and the protective effect and mechanism of IN on type 2 diabetes mellitus….

Immune supportMetabolic healthGut & microbiome

High relevance

Shiitake · 2022 · Research Article · Frontiers in microbiology

A Standardized Extract of Lentinula edodes Cultured Mycelium Inhibits Pseudomonas aeruginosa Infectivity Mechanisms.

The priority pathogen list of the World Health Organization classified Pseudomonas aeruginosa as the second top critical pathogen. Hence, the development of novel antibacterial strategies to tackle this bacterium is highly necessary..

Immune supportEnergy & fatigue

High relevance

Snow Fungus · 2022 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

A standardized method for the quantification of polysaccharides: An example of polysaccharides from Tremella fuciformis

The most widely used colorimetric method based on the phenol-sulfuric acid system generally has problems of poor reproducibilities and large measurement errors. In this study, bioactive Tremella fuciformis polysaccharides (TFPS) were used as the test materials, a systematic investigation was performed to solve these….

Immune support

High relevance

Snow Fungus · 2022 · Journal Article · Antonie van Leeuwenhoek

Alternative oxidase is involved in oxidative stress resistance and melanin synthesis in Annulohypoxylon stygium, a companion fungus of Tremella fuciformis.

Annulohypoxylon stygium, a companion fungus of Tremella fuciformis, provides nutrition for growth and development of T. fuciformis.

Skin & hydration

High relevance

Snow Fungus · 2022 · Research Article · Polymers

Amelioration of Obesity in Mice Fed a High-Fat Diet with Uronic Acid-Rich Polysaccharides Derived from Tremella fuciformis.

Obesity is rapidly becoming an emerging disease in developing countries due to the Westernization of societies and lifestyle changes. This study evaluated the ameliorative effect of acidic heteropolysaccharides derived from Tremella fuciformis (TFPS) on high-fat diet (HFD; 34.9% fat)-induced obesity in mice..

Immune supportMetabolic healthGut & microbiome

High relevance

Snow Fungus · 2022 · Research Article · International journal of molecular sciences

An Immunological Polysaccharide from Tremella fuciformis: Essential Role of Acetylation in Immunomodulation.

The edible fungus Tremella fuciformis was shown to have a high molecular weight (1.87 × 103 kDa) bioactive polysaccharide, denoted as TFP-F1. Monosaccharide composition and NMR analysis of the polysaccharide and its derivatives indicated it contained fucose (Fucp), xylose (Xylp), mannose (Manp), and glucuronic acid….

Immune support

High relevance

Lion's Mane · 2022 · Research Article · Nutrients

Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts.

Nutrition has relevant consequences for human health and increasing pieces of evidence indicate that medicinal mushrooms have several beneficial effects. One of the main issues in Western countries is represented by the challenges of aging and age-related diseases, such as neurodegenerative disorders..

Cognition & nervesSkin & hydration

High relevance

Chaga · 2022 · Journal Article · Nutricion hospitalaria

Anti-diabetic eﬀects of Inonotus obliquus extract in high fat diet combined streptozotocin-induced type 2 diabetic mice.

Introduction: type 2 diabetes (T2DM) is a complex disease affected by lifestyle and genetic factors. Although the drugs currently used to treat T2DM have certain curative effects, they still have some adverse side effects.

Metabolic healthLiver support

High relevance

Niu-Chang-Chih · 2022 · Research Article · Molecules (Basel, Switzerland)

Anti-Inflammatory Constituents of Antrodia camphorata on RAW 264.7 Cells Induced by Polyinosinic-Polycytidylic Acid.

Antrodia camphorata is an endemic mushroom in Taiwan. This study was designed to screen anti-inflammatory compounds from the methanolic extract of the mycelium of A..

OncologyImmune supportRespiratory

High relevance

Almond Mushroom · 2022 · Journal Article · Bioscience, biotechnology, and biochemistry

Anti-phytopathogenic-bacterial fatty acids from the mycelia of the edible mushroom Agaricus blazei.

Five compounds including a new compound (1) were isolated from mycelia of a mushroom-forming fungus Agaricus blazei. Compound 2 was isolated from nature for the first time.

High relevance

Reishi · 2022 · Research Article · International journal of molecular sciences

Anticancer and Antioxidant Activities in Ganoderma lucidum Wild Mushrooms in Poland, as Well as Their Phenolic and Triterpenoid Compounds.

The goal of this study was to the assess anti-cancer and antioxidant properties of the Ganoderma lucidum fruiting body, and to identify bioactive compounds found in their extracts. Significant antiproliferative activity was observed against MCF-7, MCF-7/DX, LOVO, LOVO/DX, MDA-MB 231, SW 620, and NHDF cell lines..

Oncology

High relevance

Oyster Mushroom · 2022 · Journal Article · International journal of medicinal mushrooms

Anticancer Properties of Selenium-Enriched Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), in Colon Cancer In Vitro.

Mushrooms have become an important way to safely supply the body with the daily needs of organic selenium and they also possess remarkable medicinal properties. In this study, we examined the ability of the Pleurotus ostreatus mushroom to grow in selenium (Se) and its ability to accumulate and convert Se from….

OncologyImmune supportGut & microbiome

High relevance

Reishi · 2022 · Journal Article · Carbohydrate polymers

Antimelanoma effect of a fucoxylomannan isolated from Ganoderma lucidum fruiting bodies.

A fucoxylomannan (FXM) was isolated from the mushroom Ganoderma lucidum through alkaline extraction followed by dialysis, freeze-thawing, and fractionation by Fehling's solution..

OncologyImmune supportGut & microbiome

High relevance

Niu-Chang-Chih · 2022 · Research Article · Frontiers in molecular biosciences

Antrodia camphorata-Derived Antrodin C Inhibits Liver Fibrosis by Blocking TGF-Beta and PDGF Signaling Pathways.

Hepatic stellate cells (HSCs) play an essential role in the development of liver fibrosis. Antrodia camphorata (A.

Energy & fatigueLiver supportSkin & hydration

High relevance

Lion's Mane · 2022 · Journal Article · International journal of medicinal mushrooms

Aqueous Extracts of Pleurotus ostreatus and Hericium erinaceus Protect against Ultraviolet A-Induced Damage in Human Dermal Fibroblasts.

Pleurotus ostreatus (PO) and Hericium erinaceus (HE) have been traditionally used to treat various diseases, owing to their antioxidant, antimicrobial, neuroprotective, and antitumor effects. However, few studies have been reported on their antiaging effects..

OncologyImmune supportCognition & nervesSkin & hydration

High relevance

Reishi · 2022 · Research Article · Molecules (Basel, Switzerland)

Autotoxicity of Endogenous Organic Acid Stress in Two Ganoderma lucidum Cultivars.

Ganoderma lucidum has been used as a rare medical mushroom for centuries in China, due to its health-promoting properties. Successive cropping obstacles are common in the cultivation of G.

Energy & fatigueMetabolic health

High relevance

Oyster Mushroom · 2022 · Journal Article · International journal of food microbiology

Bacterial microbiota profiling of oyster mushrooms (Pleurotus ostreatus) based on cultivation methods and distribution channels using high-throughput sequencing.

The annual consumption and production of oyster mushrooms (Pleurotus ostreatus) have continued to rise due to its nutritive and health-promoting benefits. Cultivated mushrooms are mostly grown in small to medium-scaled scale production plants that present hygienic challenges which could, in turn, increase associated….

Gut & microbiome

High relevance

Oyster Mushroom · 2022 · Journal Article · Acta parasitologica

Bio-directed Chemical Study of Pleurotus ostreatus Spent Substrate and Its Nematicidal Activity.

PURPOSE: In the present study, the nematicidal activity of the chemical fractionation of the spent substrate of the edible mushroom Pleurotus ostreatus against eggs and L3 larvae of Haemonchus contortus was evaluated..

High relevance

Yellow Morel · 2022 · Journal Article · International journal of medicinal mushrooms

Bioactive Extract of Morel Mushroom, Morchella esculenta (Ascomycota) Attenuates Doxorubicin-Induced Oxidative Stress Leading to Myocardial Injury.

Doxorubicin (DOX) is an extensively used anticancer drug for chemotherapy. Cardiotoxicity induced by DOX is an impediment in its clinical use.

OncologyEnergy & fatigue