MycoData

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2026 · Journal Article · Cancer letters

Ganoderma lucidum polysaccharide ameliorates cancer cachexia with enhanced efficacy in aged group by reprogramming arginine metabolism to modulate Treg formation.

Cancer cachexia is a syndrome characterized by profound weight loss, muscle wasting, and metabolic disturbance in cancer patients. Cancer-associated cachexia represents significant biological and clinical challenges that profoundly affect human health..

Immune supportEnergy & fatigueLiver supportSkin & hydration

Reishi · 2026 · Journal Article · Molecular pharmaceutics

Ganoderma lucidum-Derived Nanovesicles Attenuate Multiorgan Senescence via Modulation of Oxidative Stress and Inflammation.

Aging is a complex and multifactorial biological process characterized by cellular senescence and is a major risk factor for numerous age-related diseases. Developing safe and effective anti-aging interventions remains a significant challenge..

Oyster Mushroom · 2026 · Journal Article · World journal of microbiology & biotechnology

Heterologous expression and interfacial activity evaluation of Pleurotus ostreatus hydrophobin Vmh2 mutants in Tremella fuciformis.

Hydrophobins are exceptional amphiphilic proteins, yet their industrial adoption is hindered by a dual "production-performance" bottleneck: low natural yields and fixed interfacial properties..

Cognition & nervesEnergy & fatigue

Cordyceps · 2026 · Journal Article · Analytical and bioanalytical chemistry

Identification of geographical origins of Ophiocordyceps sinensis (Berk.) via machine learning-assisted surface-enhanced Raman spectroscopy.

Ophiocordyceps sinensis (Berk.) is a functional food with health. O.

Immune supportEnergy & fatigueSkin & hydration

Snow Fungus · 2026 · Journal Article · Ultrasonics sonochemistry

Impact of ultrasound-assisted enzymatic extraction on the structural and functional properties of Tremella fuciformis polysaccharide and its application in almond-based milk.

Ultrasound, when combined with enzymatic hydrolysis, distinctly influences the macromolecular structure of Tremella fuciformis polysaccharide, yielding a polysaccharide with improved functional properties..

Maitake · 2026 · Research Article · Food chemistry: X

Mechanistic insights into Grifola frondosa-driven fermentation of Rice-wheat bran: Metabolomic profiling, molecular dynamics, and enhanced antioxidant efficacy.

Rice bran (RB) and wheat bran (WB) are rich in bioactives but poorly utilized due to limited bioaccessibility. Here, a fungal fermentation strategy was developed to valorize RB-WB blends.

Oyster Mushroom · 2026 · Research Article · Applied microbiology and biotechnology

Molecular breeding alters mycelium material properties in the white-rot fungus Pleurotus ostreatus.

Mycelium-based materials derived from white-rot fungi have attracted increasing attention as sustainable and eco-friendly alternatives to conventional products. However, their mechanical strength and durability remain relatively inferior..

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2026 · Journal Article · Journal of biotechnology

Morphological and molecular characterization of Mexican Hericium erinaceus strains.

Hericium erinaceus is an edible and medicinal fungus recognized for its antimicrobial, antioxidant, anticancer, neuroprotective, and immunomodulatory properties. Despite its biological and biotechnological relevance, reports of this species in Mexico remain limited, with only one previous molecularly confirmed record….

Energy & fatigueGut & microbiome

Oyster Mushroom · 2026 · Research Article · Plants (Basel, Switzerland)

Morphological Characterization and Metabolomic Analysis of the Inhibitory Effects of Pleurotus ostreatus Mycelium on Triticum aestivum L. Growth and Development.

With the continuous expansion of Pleurotus ostreatus cultivation, substantial quantities of post-harvest spent mushroom substrate (SMS) are generated. Improper disposal of this organic waste poses potential threats to soil health, including contamination and ecological imbalance..

OncologyImmune supportEnergy & fatigueLiver support

Mesima · 2026 · Research Article · American journal of cancer research

Phellinus linteus polysaccharides inhibit castration-resistant prostate cancer progression possibly via dual modulation of PIK3R1 and PGC-1α: a preclinical evaluation.

Castration-resistant prostate cancer (CRPC) remains a major challenge due to limited treatment options and frequent therapeutic resistance. This study demonstrates that Phellinus linteus polysaccharides (PLP), both in the form of drug-loaded serum and as a purified extract, exhibit potent anti-CRPC activity through a….

OncologyImmune supportEnergy & fatigueLiver support

Reishi · 2026 · Journal Article · Journal of ethnopharmacology

Protective effects of Ganoderma lucidum polysaccharide peptides against cisplatin-induced toxicity.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum) has been used in traditional Chinese medicine for centuries to enhance vitality and support organ function.

Immune supportEnergy & fatigueMetabolic health

Reishi · 2026 · Research Article · Journal of nanobiotechnology

ROS-responsive Ganoderma lucidum polysaccharide nanocomposite targeting prosenescent oxidative stress niche for structural and functional diabetic tendon regeneration.

Diabetic patients exhibit higher tendon injury incidence, with elevated risks of healing failure and re-rupture than healthy individuals, posing major clinical challenges. Tendon stem/progenitor cells (TSPCs) are crucial for tendon homeostasis maintenance, and their senescence underlies regenerative impairment..

Snow Fungus · 2026 · Journal Article · Food Research International

Synergistic emulsions of Tremella fuciformis polysaccharide and sodium caseinate enable melt-resistance and inhibit ice crystals in low-fat ice cream

The potential health risks of excessive fat intake have increased the demand for low-fat ice cream. However, reducing the fat content often compromises the flavor..

Snow Fungus · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Synergistic emulsions of Tremella fuciformis polysaccharide and sodium caseinate enable melt-resistance and inhibit ice crystals in low-fat ice cream.

The potential health risks of excessive fat intake have increased the demand for low-fat ice cream. However, reducing the fat content often compromises the flavor..

Energy & fatigueMetabolic healthLiver support

Shiitake · 2026 · Research Article · Microbiology spectrum

The alterations of the synthetic pathway and metabolic flux of auxin indole-3-acetic acid govern thermotolerance in Lentinula edodes mycelia subjected to heat stress.

Heat stress poses a significant constraint on the annual production of Lentinula edodes (L. edodes), a challenge that has been intensified by global warming.

Chaga · 2026 · Research Article · Frontiers in veterinary science

The effects of polysaccharides from Inonotus obliquus, artemisinin, and dihydroartemisinin on the reproductive system of male mice infected with Neospora caninum.

The present study investigated the protective effects of Inonotus obliquus polysaccharides (IOPs), artemisinin, and dihydroartemisinin (DHA) on Neospora caninum-induced damage of the reproductive system in male BALB/c mice..

Immune supportEnergy & fatigueSkin & hydration

Oyster Mushroom · 2026 · Journal Article · Meat science

The improving effect of Pleurotus ostreatus polysaccharide-EGCG active preservative films on the functional properties of myofibrillar proteins in refrigerated pork.

This study aimed to investigate the effects of chitosan (CS) /collagen (Clg) films loaded with Pleurotus ostreatus polysaccharide-EGCG conjugates (POP-EGCG) and ε-Polylysine (ε-PL, PL) on the functional properties of myofibrillar proteins (MPs) in refrigerated pork..

OncologyImmune supportEnergy & fatigueGut & microbiome

Reishi · 2026 · Journal Article · Molecular and cellular biochemistry

The role of mitochondrial regulation in macrophage polarization by Ganoderma lucidum polysaccharide for the treatment of colitis-associated colorectal cancer.

Colorectal cancer (CRC) is a common malignant tumor of the digestive tract. Ganoderma lucidum polysaccharide (GLP) has shown significant potential in regulating macrophage polarization and treating CRC..

Lion's Mane · 2026 · Research Article · Molecules (Basel, Switzerland)

Ultrasound-Assisted Extraction of Polyphenols from Hericium erinaceus: Optimization, Bioactivities and LC-MS-Based Chemical Profiling.

In this study, the Box-Behnken Design (BBD) was adopted to optimize the ultrasound-assisted extraction (UAE) conditions of polyphenols from Hericium erinaceus (H. erinaceus) on the basis of single-factor experiments, with extraction time, solid-liquid ratio and ethanol concentration as the key investigation factors..

OncologyImmune supportEnergy & fatigueGut & microbiome

Lion's Mane · 2026 · Journal Article · International journal of biological macromolecules

β-Glucan-rich Hericium erinaceus hot-water extract ameliorates acute colitis by suppressing inflammation, preserving the epithelial barrier, and modulating gut microbiota ecosystem.

Inflammatory bowel disease (IBD) is a chronic disorder marked by mucosal barrier disruption, immune imbalance, and gut dysbiosis. Polysaccharide-enriched extracts of Hericium erinaceus (HE) have shown anti-colitic effects, but the role of its β-glucan-rich water extract (HE-HW) remains unclear..

Maitake · 2025 · Journal Article · International journal of biological macromolecules

A novel water-soluble antibacterial films of gelatin/carboxymethyl cellulose sodium incorporated with Grifola frondosa polysaccharides and pearl powder for fruit preservation.

Grifola frondosa polysaccharides (GFG) is a polysaccharide-protein complex, rich in hydrophilic groups, and has antioxidant and antibacterial biological activities. Nano-pearl powder (PP) with a large amount of calcium carbonate can be used as a chelating agent, antioxidant, and antibacterial agent..

Enoki · 2025 · Research Article · Foods (Basel, Switzerland)

Activity Analysis and Inhibition Mechanism of Four Novel Angiotensin I-Converting Enzyme Inhibitory Peptides Prepared from Flammulina velutipes by Enzymatic Hydrolysis.

In order to innovatively develop high-activity ACE inhibitory peptides from edible fungi, the conditions for a double-enzymatic hydrolysis preparation of ACE inhibitory peptides from Flammulina velutipes were optimized by response surface methodology..

Almond Mushroom · 2025 · Journal Article · Combinatorial chemistry & high throughput screening

Agaricus blazei Murill Extract (FA-2-b-β) Induces Ferroptosis in Diffuse Large B-Cell Lymphoma via the Nrf2/Ho-1 Pathway.

INTRODUCTION: Ferroptosis is a recently identified iron-dependent programmed cell death closely linked to the progression of diffuse large B-cell lymphoma (DLBCL)..

OncologyEnergy & fatigue

Cordyceps · 2025 · Research Article · Journal of pharmacy & bioallied sciences

Analysis and Evaluation of Volatile Chemical Components of Wild Ophiocordyceps sinensis and Its Mycelia in Xizang, China.

BACKGROUND: As a rare traditional Chinese medicinal material, Ophiocordyceps sinensis is subject to counterfeiting in the market due to its limited distribution and insufficient supply and demand. Therefore, conducting research on its volatile components is of great significance for identifying authenticity..

Snow Fungus · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Analysis of Microbial Community Structure and Cultivation Performance Assessment in Tremella fuciformis Liquid Inoculum.

Liquid inoculum is widely adopted in the mushroom industry, yet preparing Tremella fuciformis liquid inoculum remains challenging due to its complex microbial community and dimorphic growth. This study aimed to establish a reliable protocol for T.

Immune supportCognition & nervesEnergy & fatigueGut & microbiome

Lion's Mane · 2025 · Research Article · BMB reports

Anti-inflammatory effects of Hericium erinaceus hot water extract via the JAK1/STAT3 pathway in LPS-stimulated RAW 264.7 macrophages.

Several individual bioactive compounds isolated from Hericium erinaceus exhibit various physiological and biochemical activities, including neuroprotective, neurotrophic, gastrointestinal protective, immunoregulatory, and anti-inflammatory effects. However, the specific anti-inflammatory effects of H..

Reishi · 2025 · Research Article · Foods (Basel, Switzerland)

AOX Affects the Synthesis of Polysaccharides by Regulating the Reactive Oxygen Species in Ganoderma lucidum.

Alternative oxidase (AOX) is a terminal oxidase in the mitochondrial electron transport chain that does not contribute to the generation of ATP. It plays a critical role in maintaining the balance between reactive oxygen species (ROS) production and intracellular redox homeostasis within the mitochondria..

Immune supportEnergy & fatigueGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Association of α-Klotho with anti-aging effects of Ganoderma lucidum in animal models.

ETHNOPHARMACOLOGICAL RELEVANCE: Aging is a complex, universal process characterized by structural and functional decline across multiple organs. Ganoderma lucidum (G.

Oyster Mushroom · 2025 · Research Article · IMA fungus

Asymmetric mitonuclear interactions trigger transgressive inheritance and mitochondria-dependent heterosis in hybrids of the model system Pleurotus ostreatus.

Mitonuclear interactions are crucial in governing mitochondrial function, development and responses to stress in eukaryotic organisms. In this study, we explored how varying mitochondrial haplotypes affect the phenotype and oxidative stress response using hybrids of the basidiomycete Pleurotus ostreatus (P..

OncologyImmune supportEnergy & fatigueSkin & hydration

Reishi · 2025 · Research Article · Microbial cell factories

ATP deficiency triggers ganoderic acids accumulation via fatty acid β-oxidation pathway in Ganoderma lucidum.

BACKGROUND: Ganoderic acids (GAs), recognized as significant triterpenoid bioactive components in Ganoderma lucidum, exhibit a broad spectrum of pharmacological activities, including immunomodulation, anti-cancer, and anti-aging properties..

Immune supportEnergy & fatigueGut & microbiomeLiver support

Snow Fungus · 2025 · Journal Article · International journal of biological macromolecules

Biomacromolecular composite microspheres based on sodium alginate and tremella fuciformis polysaccharide for enhanced protection and delivery of camellia oil: A comprehensive study in simulated digestion.

This study presents the development of a novel polysaccharide biomolecule composite microsphere system based on sodium alginate (SA) and tremella fuciformis polysaccharide (TFP) for the encapsulation and controlled release of camellia oil (CO)..

Immune supportEnergy & fatigueLiver support

Turkey Tail · 2025 · Research Article · International journal of molecular sciences

Biopolymers of Polycaprolactone Loaded with Caffeic Acid and Trametes versicolor Extract Induced Proliferation in Human Coronary Artery Endothelial Cells and Inhibited Platelet Activity.

In atherosclerosis, the proliferation and migration of endothelial and smooth muscle cells (SMCs) and platelet activation alter endothelial function. Naturally occurring substances, such as caffeic acid (CA) and Trametes versicolor extract (TvE), have medicinal properties and are traditionally used for their….

Shiitake · 2025 · Journal Article · Food Chemistry

Blue light attenuated the umami loss of postharvest Lentinula edodes during spore discharge: Crucial roles of energy status

Postharvest Lentinula edodes face significant umami quality decline during spore release. Light is a novel strategy for enhancing the flavor of edible mushrooms.

Energy & fatigueMetabolic healthLiver support

Reishi · 2025 · Research Article · International journal of food science

Characterisation and Hypolipidaemic Effects of Tlayudas, Widely Consumed Tortillas, Containing Ganoderma lucidum Extracts on an In Vivo Model of Hypercholesterolaemia.

Tlayudas, a variant of tortillas, are a highly consumed and low-cost traditional Mexican food, typical of the Oaxaca region. We developed new functional food products from tlayudas (T) containing standardised hydroalcoholic extracts (T + Gl-1 and T + Gl-2) of the medicinal mushroom Ganoderma lucidum (Gl) from Mexico..

Immune supportEnergy & fatigueSkin & hydration

Oyster Mushroom · 2025 · Journal Article · International journal of biological macromolecules

Chitosan/collagen films loaded with Pleurotus ostreatus polysaccharide-epigallocatechin gallate conjugates with excellent antioxidant and antibacterial activities for pork preservation.

The purpose of this study was to develop a multifunctional active food packaging composite films to solve the environmental and health problems of traditional petroleum-based plastic packaging and for food preservation..

Reishi · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Combined Transcriptomic and Metabolomic Analyses of the Response of Ganoderma lucidum to Elevated CO2.

Carbon dioxide (CO2) is a key environmental factor that regulates the morphology of fruiting bodies in edible fungi. High CO2 concentrations often lead to the formation of antler-shaped abnormal fruiting bodies in Ganoderma lucidum.

Immune supportEnergy & fatigueMetabolic health

Shiitake · 2025 · Journal Article · Industrial crops and products

Cytology, transcriptomics, and proteomics analyses revealed selenium accumulation mechanisms and nutritional quality changes at sodium selenite in Lentinula edodes

Lentinula edodes is one of the most popular edible mushrooms worldwide, with remarkable potential for selenium (Se) biofortification. However, little is known about the mechanisms underlying Se stress in L.

Reishi · 2025 · Journal Article · Journal of food composition and analysis

Data fusion strategy for rapid prediction of glyceryl trioleate and polysaccharide content in Ganoderma lucidum spore powder based on near-infrared spectroscopy and hyperspectral imaging

Glyceryl trioleate and polysaccharide are key components in Ganoderma lucidum spore powder (GLSP), which is highly valued for its nutritional value. Traditional methods for assessing these contents are often destructive and time-consuming, while non-destructive techniques like near-infrared spectroscopy (NIRS) and….

Snow Fungus · 2025 · Journal Article · International journal of biological macromolecules

Effect of water-soluble antimicrobial films of carboxymethyl chitosan containing pearl powder and Tremella fuciformis polysaccharides on strawberry fresh-keeping.

Tremella fuciformis polysaccharides (TFPS) extracted from an edible fungus, with abundant hydrophilic groups, possess biological activities such as antioxidant, moisturizing, and immune-enhancing effects..

Oyster Mushroom · 2025 · Journal Article · International journal of biological macromolecules

Effective decolorization and detoxification of single and mixed dyes of different structural types by a laccase LAC-Yang1 purified from Pleurotus ostreatus strain Yang1.

This study systematically investigated the decolorization and detoxification abilities of a laccase LAC-Yang1, purifeid from white-rot fungus Pleurotus ostreatus, for single and mixed dyes, to obtain deeper insights into and utilize the potential of laccases in degrading and detoxifying various dye types..

Immune supportEnergy & fatigueGut & microbiome

Enoki · 2025 · Research Article · BMC veterinary research

Effects of flammulina velutipes stipe wastes on egg performance, cecum microbiota, intestinal barrier and serum immune response of laying hens.

BACKGROUND: Improving production performance and health is the key goal of laying hens farming. This experiment was conducted to examine the effects of Flammulina velutipes stipe wastes (FVW) on the performance of laying hens by regulating cecum microbiota, intestinal barrier and immune response..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Reishi · 2025 · Research Article · Animals: an open access journal from MDPI

Effects of Ganoderma lucidum Polysaccharides on Dexameth-Asone-Induced Immune Injury in Goslings.

This study aimed to investigate the role of ganoderma lucidum polysaccharides (GLP) in mitigating dexamethasone (DEX)-induced immune injury in goslings. Dexamethasone (DEX) is commonly used to establish an animal model of immune suppression, which mimics the immune injury caused by stress or certain pathological….

Oyster Mushroom · 2025 · Journal Article · Frontiers in bioscience (Elite edition)

Effects of Natural Metabolites from Fungi, Bacteria, and Plants on the Degradation of Polycyclic Aromatic Hydrocarbons by Pleurotus ostreatus var. Florida.

BACKGROUND: Ligninolytic fungi are promising organisms in developing bioremediation technologies due to their ability to degrade various pollutants. Fungi and their extracellular enzymes in soil inevitably collide with metabolites produced by other organisms..

Snow Fungus · 2025 · Research Article · International journal of molecular sciences

Effects of ε-Poly-L-Lysine/Chitosan Composite Coating on the Storage Quality, Reactive Oxygen Species Metabolism, and Membrane Lipid Metabolism of Tremella fuciformis.

This study aimed to investigate the efficacy of a composite coating composed of 150 mg/L ε-Poly-L-lysine (ε-PL) and 5 g/L chitosan (CTS) in extending the shelf life and maintaining the postharvest quality of fresh Tremella fuciformis. Freshly harvested T..

Mesima · 2025 · Journal Article · Biotechnology letters

Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells

Phellinus linteus (PL) is a medicinal fungus known for producing hispolon, a bioactive compound with antioxidant, anti-inflammatory, and anticancer properties. However, the natural scarcity of PL and the unsuccessful cultivation of its fruiting bodies have led to the exploration of alternative methods for enhancing….

Mesima · 2025 · Journal Article · Biotechnology letters

Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells

Mesima · 2025 · Journal Article · Biotechnology letters

Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells.

Immune supportCognition & nervesEnergy & fatigue

Shiitake · 2025 · Journal Article · Neuroscience

Ergothioneine-rich Lentinula edodes mushroom extract restores mitochondrial functions in senescent HT22 cells.

A decline in mitochondrial functions associated with ageing is the key factor of free radical generation which contributes to age-related pathologies. Protecting healthy functional mitochondrial networks with antioxidants is critical in promoting healthy ageing..