MycoData

Osteoarthritis (OA) is a prevalent degenerative pathology, however, there exists a lack of cost-effective pharmacological interventions that efficaciously inhibit its progression. ganoderic acid A (GAA), a triterpenoid derived from Ganoderma lucidum, possesses antiapoptotic and -inflammatory effects..

OncologyImmune support

Medium relevance

Reishi · 2024 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Ganoderic acid D attenuates gemcitabine resistance of triple-negative breast cancer cells by inhibiting glycolysis via HIF-1α destabilization.

BACKGROUND: Gemcitabine (GEM) resistance is the primary reason why combination chemotherapy is limited in triple-negative breast cancer (TNBC). Ganoderic acid D (GAD), a natural triterpenoid compound obtained from Ganoderma lucidum, has been shown to have antitumor activities..

OncologyImmune supportMetabolic health

Medium relevance

Reishi · 2024 · Journal Article · Atherosclerosis

Ganoderic acids alleviate atherosclerosis by inhibiting macrophage M1 polarization via TLR4/MyD88/NF-κB signaling pathway.

BACKGROUND AND AIMS: Atherosclerosis (AS) is a chronic inflammatory disease characterized by lipid infiltration and plaque formation in blood vessel walls. Ganoderic acids (GA), a class of major bioactive compounds isolated from the Chinese traditional medicine Ganoderma lucidum, have multiple pharmacological….

Immune supportMetabolic healthSkin & hydration

Medium relevance

Reishi · 2024 · Journal Article · Advances in pharmacological and pharmaceutical sciences

Ganoderma tuberculosum Liquid Culture With Vineyard Pruning Extracts for Bioactive Composite Production With Antiproliferative Activity.

Ganoderma species have been studied for their pharmacological approaches, such as anticancer, antitumor, antiproliferative, and antioxidant activity. Elicitors are used to increase Ganoderma bioactive composite production..

OncologyImmune support

Medium relevance

Reishi · 2024 · Journal Article · Food Hydrocolloids

Green and sustainable biomaterials: Edible bioplastic films from mushroom mycelium

Scalable mycelium biomaterials with excellent biodegradable and mechanical properties are attracting widespread attention. However, the inherent brittleness of biomass materials greatly limits their applications in reality, such as packaging and flexibility..

Immune supportSkin & hydration

Medium relevance

Cordyceps · 2024 · Journal Article · International journal of biological macromolecules

Hirsutella sinensis mycelium polysaccharides attenuate the TGF-β1-induced epithelial-mesenchymal transition in human intrahepatic bile duct epithelial cells.

Hirsutella sinensis is the anamorph of Ophiocordyceps sinensis, and its mycelia has been used to effectively treat a variety of hepatobiliary diseases in clinical practice..

Immune supportLiver supportSkin & hydration

Medium relevance

Zhu Ling · 2024 · Research Article · Pharmaceutical biology

Homogeneous Polyporus polysaccharide exerts anti-bladder cancer effects via autophagy induction.

CONTEXT: Polyporus polysaccharide (PPS), the leading bioactive ingredient extracted from Polyporus umbellatus (Pers.) Fr. (Polyporaceae), has been demonstrated to exert anti-bladder cancer and immunomodulatory functions in macrophages..

OncologyImmune support

Medium relevance

Shiitake · 2024 · Journal Article · Food Hydrocolloids

Interactions between sorghum starch and mushroom polysaccharides and their effects on starch gelatinization and digestion

This study aimed at gaining insight into the mechanism of interactions between sorghum starch and mushroom polysaccharides (MPs) obtained from three cultivars Lentinula edodes (LEP), Auricularia auricula (AAP), and Tremella fuciformis polysaccharides (TFP) in relation to gelatinization, retrogradation and….

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Medium relevance

Maitake · 2024 · Journal Article · International journal of biological macromolecules

Investigating immune-modulatory function of α-glucopyranose-rich compound polysaccharides by MC38-N4/OT-I co-culture system.

The potential antitumor function of polysaccharides is well accepted, it is unclear whether polysaccharides have immunoregulatory effect on CD8+ T lymphocyte cells to attack tumor cells. To evaluate the CD8+ T function enhancing role of polysaccharide compounds, the MC38-N4/OT-I co-culture system was established..

OncologyImmune supportCognition & nerves

Medium relevance

Reishi · 2024 · Journal Article · International journal of biological macromolecules

Investigating the mechanism of Zn cross-linking of chitin in a mycelium-based leather substitute and its performance evaluation.

Mycelium-based leather substitutes with a three-dimensional reticulated structure have attracted attention owing to the negative environmental impacts of natural and synthetic leather..

Immune supportEnergy & fatigue

Medium relevance

Snow Fungus · 2024 · Journal Article · International journal of biological macromolecules

Multiple fingerprint and pattern recognition analysis on polysaccharides of four edible mushrooms.

Quality analysis of edible mushrooms based on polysaccharides is generally difficult due to their complicated structures and hard separation. Here, multiple fingerprint analysis of polysaccharides based on chromatographic and spectrometric techniques were developed, and then applied in comparative analysis of….

Immune supportCognition & nervesGut & microbiome

Medium relevance

Reishi · 2024 · Journal Article · Heliyon

Novel therapeutic role of Ganoderma Polysaccharides in a septic mouse model - The key role of macrophages.

Ganoderma lucidum polysaccharides (G. PS) have been recognized for their immune-modulating properties.

Immune support

Medium relevance

Reishi · 2024 · Journal Article · International journal of biological macromolecules

Physicochemical characterization and anti-angiogenesis activity of polysaccharides from Amauroderma rugosum, a medicinal and edible mushroom.

Amauroderma rugosum (AR) is commonly recognized as a medicinal fungus, often used as an alternative to Ganoderma lucidum. There is a scarcity of comprehensive and in-depth research on its bioactive polysaccharides and their associated biological activities..

Immune support

Medium relevance

Shiitake · 2024 · Research Article · Animals: an open access journal from MDPI

The Canine Gut Health: The Impact of a New Feed Supplement on Microbiota Composition.

This study aimed to determine the impact of a novel formulation of a supplement composed of the natural ingredients, bromelain, quercetin, and Lentinula edodes, on the gut microbiota of healthy adult dogs..

Immune supportGut & microbiome

Medium relevance

Shiitake · 2024 · Journal Article · Food & function

The dose-dependent mechanism behind the protective effect of lentinan against acute alcoholic liver injury via proliferating intestinal probiotics.

Acute alcoholic liver injury (AALI) is a widespread disease that can develop into hepatitis, liver fibrosis, and cirrhosis. In severe cases, it can be life-threatening, while drug treatment presents various side effects..

Immune supportMetabolic healthGut & microbiomeLiver support

Medium relevance

Reishi · 2023 · Review · The American journal of Chinese medicine

A Comprehensive Review on the Chemical Composition, Pharmacology and Clinical Applications of Ganoderma.

Ganoderma is the dried fruiting bodiy of Ganoderma lucidum (Leyss.ex Fr.) Karst. or Ganoderma sinense Zhao, Xu et Zhang, belonging to the family Polyporaceae, which grows mainly in tropical, subtropical, and temperate regions..

OncologyImmune supportMetabolic healthRespiratory

Medium relevance

Reishi · 2023 · Review · Molecules (Basel, Switzerland)

A Review on the Sources, Structures, and Pharmacological Activities of Lucidenic Acids.

Ganoderma lucidum has long been used as a multi-purpose plant and functional food. The pharmacological properties of G.

OncologyImmune supportCognition & nervesMetabolic health

Medium relevance

Reishi · 2023 · Review · Current molecular medicine

Anti-diabetic Effects of Macronutrients via Modulation of Angiogenesis: A Comprehensive Review on Carbohydrates and Proteins.

BACKGROUND: Diabetes is a major global health concern, manifesting the symptoms of chronic hyperglycemia. Either insufficient or excessive angiogenesis is generally involved in the pathogenesis of diabetes and its complications..

Immune supportMetabolic healthSkin & hydration

Medium relevance

Reishi · 2023 · Review · International journal of biological macromolecules

Colorectal cancer inhibitory properties of polysaccharides and their molecular mechanisms: A review.

Colorectal cancer (CRC) is one of the three major malignant tumors in the world. The major treatments currently recommended for it are surgery, radiotherapy, and chemotherapy, all of which are frequently accompanied by a poor prognosis and high recurrence rate..

OncologyImmune supportGut & microbiome

Medium relevance

Chaga · 2023 · Review · Critical reviews in food science and nutrition

Effects and mechanisms of natural products on Alzheimer's disease.

Alzheimer's disease (AD) is the most common form of dementia in elderly people with a high incidence rate and complicated pathogenesis, and causes progressive cognitive deficit and memory impairment..

OncologyImmune supportCognition & nerves

Medium relevance

Reishi · 2023 · Review · Molecules (Basel, Switzerland)

Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment.

Diabetes mellitus is a complex illness in which the body does not create enough insulin to control blood glucose levels. Worldwide, this disease is life-threatening and requires low-cost, side-effect-free medicine.

OncologyImmune supportMetabolic healthGut & microbiome

Medium relevance

Reishi · 2023 · Review · International journal of medicinal mushrooms

Exploring Mushroom Polysaccharides for the Development of Novel Prebiotics: A Review.

Prebiotics have gained much attention in recent years as functional food ingredients. This has encouraged researchers to look for sustainable alternative sources of prebiotics.

Immune supportGut & microbiome

Medium relevance

Reishi · 2023 · Review · Life (Basel, Switzerland)

Exploring the Bioactive Mycocompounds (Fungal Compounds) of Selected Medicinal Mushrooms and Their Potentials against HPV Infection and Associated Cancer in Humans.

Medicinal mushrooms have been used as a medicinal tool for many centuries and, nowadays, are used in the prevention and therapy of various diseases, including as an adjunct to cancer treatment..

OncologyImmune supportRespiratory

Medium relevance

Reishi · 2023 · Review · Antioxidants (Basel, Switzerland)

Natural Products in Renal-Associated Drug Discovery.

The global increase in the incidence of kidney failure constitutes a major public health problem. Kidney disease is classified into acute and chronic: acute kidney injury (AKI) is associated with an abrupt decline in kidney function and chronic kidney disease (CKD) with chronic renal failure for more than three….

Immune supportCognition & nerves

Medium relevance

Reishi · 2023 · Review · International journal of biological macromolecules

Preclinical pharmacokinetics-related pharmacological effects of orally administered polysaccharides from traditional Chinese medicines: A review.

Polysaccharides (TCMPs) derived from traditional Chinese medicines (TCMs), such as Ganoderma lucidum, Astragalus membranaceus, Lycium barbarum, and Panax ginseng, are considered to be the main active constituents in TCMs..

OncologyImmune supportMetabolic healthGut & microbiome

Medium relevance

Reishi · 2023 · Review · Fitoterapia

Structural diversity, fermentation production, bioactivities and applications of triterpenoids from several common medicinal fungi: Recent advances and future perspectives.

Medicinal fungi are beneficial to human health and it reduces the risk of chronic diseases. Triterpenoids are polycyclic compounds derived from the straight-chain hydrocarbon squalene, which are widely distributed in medicinal fungi..

OncologyImmune support

Medium relevance

Reishi · 2023 · Review · Current HIV research

The Importance of Traditional Chinese Medicine in the Intervention and Treatment of HIV while Considering its Safety and Efficacy.

Natural products have been considered a potential resource for the development of novel therapeutic agents, since time immemorial. It is an opportunity to discover cost-effective and safe drugs at the earliest, with the goal to hit specific targets in the HIV life cycle..

Immune supportRespiratory

Medium relevance

Turkey Tail · 2023 · Review · Foods (Basel, Switzerland)

The Mushroom Glucans: Molecules of High Biological and Medicinal Importance.

Carbohydrates, including polysaccharide macromolecules, are the main constituents of the fungal cell wall. Among these, the homo- or heteropolymeric glucan molecules are decisive, as they not only protect fungal cells but also have broad, positive biological effects on the animal and human bodies..

Immune supportEnergy & fatigueMetabolic health

Medium relevance

Reishi · 2023 · Review · The American journal of Chinese medicine

The Phytochemistry of Ganoderma Species and their Medicinal Potentials.

The Ganoderma genus is known for its diverse use as a functional food and therapeutic agent. This fungus has over 428 species, with Ganoderma lucidum being the most studied..

OncologyImmune support

Medium relevance

Reishi · 2023 · Review · The American journal of Chinese medicine

Traditional Chinese Medicine in Osteoporosis Intervention and the Related Regulatory Mechanism of Gut Microbiome.

The gut microbiome (GM) has become a crucial factor that can affect the progression of osteoporosis. A number of studies have demonstrated the impact of Traditional Chinese Medicine (TCM) on GM and bone metabolism..

Immune supportGut & microbiome

Medium relevance

Reishi · 2022 · Review · Food chemistry advances

A concise review of mushrooms antiviral and immunomodulatory properties that may combat against COVID-19.

The World Health Organization (WHO) declared COVID-19 as a pandemic on March 11, 2020, because of its widespread transmission and infection rates. The unique severe disease was found in Wuhan, China, since December 2019, and swiftly spread throughout the world..

Immune supportRespiratory

Medium relevance

Reishi · 2022 · Review · International journal of biological macromolecules

A review on plant polysaccharide based on drug delivery system for construction and application, with emphasis on traditional Chinese medicine polysaccharide.

Carbohydrate polymers with unique chemical composition, molecular weight and functional chemical groups show multiple potentials in drug delivery. Most carbohydrate polymers such as plant polysaccharides exhibit advantages of biodegradability, ease of modification, low immunogenicity and low toxicity..

OncologyImmune supportLiver supportSkin & hydration

Medium relevance

Almond Mushroom · 2022 · Preprint · journal metadata

Agent-based vs. equation-based multi-scale modeling for macrophage polarization

Macrophages show high plasticity and result in heterogenic subpopulations or polarized states identified by specific cellular markers. These immune cells are typically characterized as pro-inflammatory, or classically activated M1, and anti-inflammatory, or alternatively activated M2..

Immune support

Medium relevance

Reishi · 2022 · Review · Nutrients

Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms.

Edible and medicinal fungi, a group of eukaryotic organisms with numerous varieties, including Coriolus versicolor, Ganoderma lucidum, Cordyceps sinensis, Pleurotus ostreatus, and Grifola frondosa, have been demonstrated to possess a board range of pharmaceutical properties, including anti-virus, anti-inflammation,….

OncologyImmune supportCognition & nervesRespiratory

Medium relevance

Almond Mushroom · 2022 · Review · Frontiers in pharmacology

Fungal Mushrooms: A Natural Compound With Therapeutic Applications.

Fungi are extremely diverse in terms of morphology, ecology, metabolism, and phylogeny. Approximately, 130 medicinal activities like antitumor, immunomodulation, antioxidant, radical scavenging, cardioprotective and antiviral actions are assumed to be produced by the various varieties of medicinal mushrooms..

OncologyImmune supportCognition & nervesMetabolic health

Medium relevance

Reishi · 2022 · Review · Applied microbiology and biotechnology

Ganoderma immunomodulatory proteins: mushrooming functional FIPs.

Fungal immunomodulatory protein (FIP) is a novel functional protein family with specific immunomodulatory activity identified from several macro-fungi. A variety of biological activities of FIPs have been reported, such as anti-allergy, anti-tumor, mitogenic activity, and immunomodulation..

OncologyImmune support

Medium relevance

Snow Fungus · 2022 · Review · Carbohydrate polymers

Insight on updates in polysaccharides for ocular drug delivery.

Ocular drug delivery is a significantly challenging task due to the presence of various anatomical and physiological barriers in the eye. Naturally available polysaccharides, when used as drug vehicles provide increased retention time, bioavailability, and penetration due to their unique mucoadhesive and….

Immune supportLiver supportSkin & hydration

Medium relevance

Reishi · 2022 · Review · Molecules (Basel, Switzerland)

Medicinal Fungi with Antiviral Effect.

Pandemics from various viruses make natural organisms face challenges over and over again. Therefore, new antiviral drugs urgently need to be found to solve this problem.

Immune supportRespiratory

Medium relevance

Almond Mushroom · 2022 · Preprint · journal metadata

Quantification of spatial and phenotypic heterogeneity in an agent-based model of tumour-macrophage interactions

We introduce a new spatial statistic, the weighted pair correlation function (wPCF). The wPCF extends the existing pair correlation function (PCF) to describe spatial relationships between points marked with combinations of discrete and continuous labels..

OncologyImmune supportEnergy & fatigue

Medium relevance

Wood Ear · 2022 · Review · Frontiers in microbiology

Research progress of Auricularia heimuer on cultivation physiology and molecular biology.

Auricularia heimuer (A. heimuer F.

OncologyImmune supportSkin & hydration

Medium relevance

Oyster Mushroom · 2021 · Review · Journal of autoimmunity

Mushrooms and immunity.

In the wide field of nutraceuticals, the effects of mushrooms on immunity, cancer and including autoimmunity have been proposed for centuries but in recent years a growing interest has led scientists to elucidate which specific compounds have bioactive properties and through which mechanisms..

OncologyImmune supportMetabolic healthRespiratory

Medium relevance

Maitake · 2021 · Review · Molecules (Basel, Switzerland)

Mycomedicine: A Unique Class of Natural Products with Potent Anti-tumour Bioactivities.

Mycomedicine is a unique class of natural medicine that has been widely used in Asian countries for thousands of years. Modern mycomedicine consists of fruiting bodies, spores, or other tissues of medicinal fungi, as well as bioactive components extracted from them, including polysaccharides and, triterpenoids, etc..

OncologyImmune support

Medium relevance

Maitake · 2021 · Review · Molecules (Basel, Switzerland)

Proteomic Research on the Antitumor Properties of Medicinal Mushrooms.

Medicinal mushrooms are increasingly being recognized as an important therapeutic modality in complementary oncology. Until now, more than 800 mushroom species have been known to possess significant pharmacological properties, of which antitumor and immunomodulatory properties have been the most researched..

OncologyImmune support

Medium relevance

Lion's Mane · 2021 · Review · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases.

Neurodegenerative diseases (NDs) represent a common neurological pathology that determines a progressive deterioration of the brain or the nervous system. For treating NDs, comprehensive and alternative medicines have attracted scientific researchers' attention recently..

OncologyImmune supportCognition & nerves

Medium relevance

Mesima · 2020 · Journal Article · Journal of medicinal food

Dietary Mixed Cereal Grains Ameliorate the Azoxymethane and Dextran Sodium Sulfate-Induced Colonic Carcinogenesis in C57BL/6J Mice.

The chemopreventive effects of various mixed cereal grain (MCG) samples on azoxymethane (AOM, 10 mg/kg) and dextran sulfate sodium (DSS, 0.02 g/mL)-induced colorectal cancer (CRC) in C57BL/6J mice were studied..

OncologyImmune supportGut & microbiome

Medium relevance

Maitake · 2018 · Journal Article · Journal of agricultural and food chemistry

Anti-inflammatory and Proapoptotic Properties of the Natural Compound o-Orsellinaldehyde.

Metabolic syndrome is a cluster of medical conditions that increases the risk of developing cardiovascular disease and type 2 diabetes. Numerous studies have shown that inflammation is directly involved in the onset of metabolic syndrome and related pathologies..

Immune supportMetabolic health

Medium relevance

Nameko · 2015 · Research Support, Non U.S. Gov'T · Journal of the science of food and agriculture

Antioxidant and anti-ageing activities of mycelia zinc polysaccharide from Pholiota nameko SW-03.

BACKGROUND: Edible fungi polysaccharides usually exhibit antioxidant activity, and zinc has been shown to have antioxidant properties. In the present work, Pholiota nameko SW-03 was used as a vector of zinc biotransformation in order to obtain mycelia zinc polysaccharide (MZPS), and the structural characterization and….

Immune supportMetabolic health

Medium relevance

Nameko · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

In Vitro and In Vivo Antioxidant Effects of Polysaccharides from Nameko Medicinal Mushroom, Pholiota nameko SW-01 (Higher Basidiomycetes).

Extra- (EPS) and intracellular polysaccharides (IPS) from Pholiota nameko SW-01 were extracted, and in vitro and in vivo antioxidant effects were processed. Briefly, the in vitro antioxidant results indicated that the inhibition effects of IPS at a dose of 500 mg/L on superoxide anions, hydroxyl radicals, and….

Immune supportLiver support

Medium relevance

Shiitake · 2015 · Case Reports · Anais brasileiros de dermatologia

Shiitake dermatitis.

Shiitake Dermatitis is a skin eruption that resembles whiplash marks and occurs after consumption of raw shiitake mushrooms. It is caused by a toxic reaction to lentinan, a thermolabil polysaccharide which decomposes upon heating.

Immune supportCognition & nervesSkin & hydration

Medium relevance

Maitake · 2013 · Research Support, Non U.S. Gov'T · Journal of medicinal food

Genes related to suppression of malignant phenotype induced by Maitake D-Fraction in breast cancer cells.

It is already known that the Maitake (D-Fraction) mushroom is involved in stimulating the immune system and activating certain cells that attack cancer, including macrophages, T-cells, and natural killer cells. According to the U.S..

OncologyImmune support