MycoData

This study aimed to evaluate and compare the effects of oil- and air-heat treatments on the durability of Paulownia tomentosa and Pinus koraiensis woods against Fomitopsis palustris and Trametes versicolor. The wood samples were treated in palm oil and air at 180, 200, and 220 °C for 2 h..

Immune support

Medium relevance

Turkey Tail · 2023 · Research Article · Environmental science and pollution research international

Effective bioremediation of clarithromycin and diclofenac in wastewater by microbes and Arundo donax L.

Bioremediation of pharmaceuticals has gained large research efforts, but there is still a need to improve the performance of bioremediation systems by selecting effective organisms..

Immune supportEnergy & fatigue

Medium relevance

Reishi · 2023 · Journal Article · Fish & shellfish immunology

Effects of dietary co-exposure to fungal and herbal functional feed additives on immune parameters and microbial intestinal diversity in rainbow trout (Oncorhynchus mykiss).

Misuse and overuse of antibiotics in aquaculture has proven to be an unsustainable practice leading to increased bacterial resistance. An alternative strategy involves the inclusion of immunostimulants in fish diets, especially fungal and herbal compounds already authorized for human consumption, hence without….

Immune supportEnergy & fatigueGut & microbiome

Medium relevance

Snow Fungus · 2023 · Journal Article · Food Hydrocolloids

Effects of freeze–thawing treatment on mechanical and structural properties of konjac glucomannan gels containing additives

The mechanical, structural, and water-holding properties of freeze-thawed konjac glucomannan (GM) gels prepared using sodium carbonate as a solidifying agent were examined using various techniques..

Immune support

Medium relevance

Reishi · 2023 · Journal Article · Molecules (Basel, Switzerland)

Evaluating the Application Potential of a Recombinant Ganoderma Protein as Bioactive Ingredients in Cosmetics.

The aim of this study was to evaluate the application potential of a recombinant fungal immunomodulatory protein from Ganoderma lucidum (rFIP-glu). First, a recombinant plasmid pPIC9K::FIP-glu-His was transferred into Pichia pastoris for the production of protein..

OncologyImmune supportSkin & hydration

Medium relevance

Reishi · 2023 · Journal Article · Journal of ethnopharmacology

Immunomodulatory effects and mechanisms of Tiepishihu Xiyangshen granules on cyclophosphamide induced immuno-suppression via TLR4/MAPKs and PI3K/AKT/FOXO3a signal pathways.

ETHNOPHARMACOLOGICAL RELEVANCE: Tiepishihu Xiyangshen granules (TXG) is a traditional Chinese medicine formula composed of Panax quinquefolius L, Dendrobium officinale Kimura & Migo and Ganoderma lucidum (Curtis) P. Karst.

OncologyImmune support

Medium relevance

Reishi · 2023 · Journal Article · Biomedical reports

Immunostimulatory effects of a subcritical water extract of Ganoderma.

Ganoderma, a medicinal mushroom with various physiological activities, has been extensively investigated regarding its effectiveness. The aim of the present study was to examine the effects of a subcritical water extract of Ganoderma (SWEG) on the immune system..

Immune support

Medium relevance

Chaga · 2023 · Journal Article · Drug research

Inotodiol ameliorates the progression of osteoarthritis: An in vitro and in vivo study.

Osteoarthritis is a common chronic degenerative disease, of which the essence is the degenerative changes of bone and joint cartilage, involving damage in multiple structures such as bone, synovium and joints..

Immune support

Medium relevance

Reishi · 2023 · Journal Article · Journal of visualized experiments: JoVE

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma.

One of the biggest challenges in developing effective therapies against glioblastoma is overcoming the strong immune suppression within the tumor microenvironment. Immunotherapy has emerged as an effective strategy to turn the immune system response against tumor cells..

OncologyImmune supportCognition & nerves

Medium relevance

Shiitake · 2023 · Research Article · Parasites & vectors

Lentinan has a beneficial effect on cognitive deficits induced by chronic Toxoplasma gondii infection in mice.

BACKGROUND: Toxoplasma gondii (T. gondii) is increasingly considered a risk factor for neurodegenerative diseases.

Immune supportCognition & nervesEnergy & fatigue

Medium relevance

Mesima · 2023 · Research Article · Biomedicines

Methoxyhispolon Methyl Ether, a Hispolon Analog, Thwarts the SRC/STAT3/BCL-2 Axis to Provoke Human Triple-Negative Breast Cancer Cell Apoptosis In Vitro.

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with few treatment options. A promising TNBC treatment approach is targeting the oncogenic signaling pathways pivotal to TNBC initiation and progression..

OncologyImmune support

Medium relevance

Reishi · 2023 · Journal Article · Current issues in molecular biology

Mixed Medicinal Mushroom Mycelia Attenuates Alzheimer's Disease Pathologies In Vitro and In Vivo.

Alzheimer's disease (AD) is characterized by memory impairment and existence of amyloid-β (Aβ) plaques and neuroinflammation. Due to the pivotal role of oxidative damage in AD, natural antioxidative agents, such as polyphenol-rich fungi, have garnered scientific scrutiny..

OncologyImmune supportCognition & nervesEnergy & fatigue

Medium relevance

Reishi · 2023 · Journal Article · Nutrients

Mushroom-Based Supplements in Italy: Let's Open Pandora's Box.

Mushrooms and derivates are well known to the scientific community for having different health benefits and exhibit a wide range of pharmacological activities, including lipid-lowering, antihypertensive, antidiabetic, antimicrobic, antiallergic, anti-inflammatory, anticancer, immunomodulating, neuroprotective and….

OncologyImmune supportCognition & nervesMetabolic health

Medium relevance

Lion's Mane · 2023 · Research Article · International journal of molecular sciences

Neuroprotective Effects of Erinacine A on an Experimental Model of Traumatic Optic Neuropathy.

Erinacine A (EA), a natural neuroprotectant, is isolated from a Chinese herbal medicine, Hericium erinaceus. The aim of this study was to investigate the neuroprotective effects of EA in a rat model of traumatic optic neuropathy..

OncologyImmune supportCognition & nervesEnergy & fatigue

Medium relevance

Lion's Mane · 2023 · Journal Article · International journal of biological macromolecules

Semi-solid enzymolysis enhanced the protective effects of fruiting body powders and polysaccharides of Herinaceus erinaceus on gastric mucosal injury.

This study demonstrated the effects of semi-solid enzymolysis on physicochemical properties of fruiting body powders and polysaccharides from Hericium erinaceus and protective effects on gastric mucosal injury..

OncologyImmune supportGut & microbiome

Medium relevance

Snow Fungus · 2023 · Research Article · Food science & nutrition

Synergistic mediating effect of edible fungal polysaccharides (Auricularia and Tremellan) and Crataegus flavonoids in hyperlipidemic rats.

Both edible fungal polysaccharides (Auricularia and Tremellan) and Crataegus flavonoids promote the balance of dyslipidemia, which have a positive biological regulating effect on intestinal flora..

Immune supportMetabolic healthGut & microbiomeLiver support

Medium relevance

Snow Fungus · 2023 · Journal Article · International journal of food science & technology

The effect of different edible fungal polysaccharides on the stability of whey protein isolate solution near isoelectric point

Whey protein isolate (WPI) is unstable near isoelectric point with simultaneous precipitation or phase separation, which negatively affects its application. In the current study, four kinds of edible fungal polysaccharides were selected to improve the WPI stability through non‐covalent interaction..

Immune support

Medium relevance

Reishi · 2023 · Journal Article · Journal of neuroimmunology

The mechanism of LZ-8-mediated immune response in the mouse model of Parkinson's disease.

Parkinson's disease (PD) is associated with microscopic changes in the brain, particularly substantia nigra (SN). Ganoderma lucidum immunoregulatory protein (rLZ-8) is might confer protective effects against PD..

Immune supportCognition & nerves

Medium relevance

Reishi · 2023 · Journal Article · Gene

Transcriptome profiling and bioinformatic analysis of the effect of ganoderic acid T prevents Sendai virus infection.

Ganoderic acid T (GA-T) is an important triterpene of Ganoderma lucidum, which is utilized to treat viral infections. Sendai virus (SeV) is widely studied to determine the molecular biological characteristics of RNA viruses and employed to elucidate the mechanisms governing the innate immune response..

Immune supportRespiratory

Medium relevance

Oyster Mushroom · 2023 · Journal Article · Chemosphere

Various species of Basidiomycota fungi reveal different abilities to degrade pharmaceuticals and also different pathways of degradation.

The presence of pharmaceuticals (PhACs) in the aquatic environment is an emerging problem worldwide. PhACs reach surface water via the effluents of wastewater treatment plants (WWTPs).

Immune supportCognition & nerves

Medium relevance

Turkey Tail · 2023 · Research Article · International journal of analytical chemistry

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds.

Secondary metabolites are hidden gems in mushrooms. Understanding these secondary metabolites' biological and pharmacological effects can be aided by identifying them..

OncologyImmune supportMetabolic health

Medium relevance

Maitake · 2022 · Research Article · Optoelectronics letters

A label-free lateral offset spliced coreless fiber MZI biosensor based on hydrophobin HGFI for TNF-α detection.

A real-time label-free lateral offset spliced coreless fiber (CF) Mach-Zehnder interferometer (MZI) biosensor functionalized with hydrophobin Grifola frondosa I (HGFI) was proposed for the detection of cytokine tumour necrosis factor alpha (TNF-α)..

OncologyImmune supportCognition & nerves

Medium relevance

Shiitake · 2022 · Journal Article · Frontiers in oncology

AHCC® Supplementation to Support Immune Function to Clear Persistent Human Papillomavirus Infections.

OBJECTIVE: To determine the efficacy, safety, and durability of the use of AHCC supplementation for 6 months to support the host immune system to clear high-risk human papillomavirus (HPV) infections..

OncologyImmune supportRespiratory

Medium relevance

Maitake · 2022 · Research Article · Oxidative medicine and cellular longevity

Ameliorating Effect on Glycolipid Metabolism of Spirulina Functional Formulation Combination from Traditional Chinese Medicine.

Insulin resistance is the major factor involved in the pathogenesis of type 2 diabetes. Although the oral drug metformin (MH) is widely used to reduce hyperglycemia, it is associated with adverse effects..

Immune supportMetabolic healthGut & microbiomeLiver support

Medium relevance

Oyster Mushroom · 2022 · Journal Article · Antioxidants (Basel, Switzerland)

Antioxidant and Anti-Inflammatory Activity of Five Medicinal Mushrooms of the Genus Pleurotus.

Within the group of higher fungi, edible medicinal mushrooms have a long history of being used as food and in folk medicine. These species contain biologically active substances with many potential beneficial effects on human health..

Immune support

Medium relevance

Turkey Tail · 2022 · Journal Article · Natural product research

Antiviral effect of a commercially phytotherapeutic compound against feline immunodeficiency virus.

The feline immunodeficiency virus (FIV) is a widespread lentivirus of felids. Due to its worldwide diffusion and the lack of an effective preventive and therapeutic protocol, it has a high impact on the cats' health..

Immune supportRespiratory

Medium relevance

Reishi · 2022 · Journal Article · Journal of the science of food and agriculture

Association of gut microbiota characteristics and metabolites reveals the regulation mechanisms under cadmium consumption circumstance.

BACKGROUND: Cadmium is a non-biodegradable heavy metal with a long biological half-life. Although its negative impact on human health has been previously reported, the association of cadmium consumption overdose with changes in the gut microbiota and its corresponding metabolites has not been fully elucidated so far..

OncologyImmune supportMetabolic healthGut & microbiome

Medium relevance

Niu-Chang-Chih · 2022 · Research Article · Plants (Basel, Switzerland)

Botanical Antcin K Alleviates High-Fat Damage in Palm Acid Oil-Treated Vascular Endothelial Cells and Macrophages.

Lipid metabolism disorder is the most critical risk factor for atherosclerosis, and the process involves lipid deposition in the arterial intima. In Taiwan, antcin K, an active triterpenoid from the fruiting bodies of Antrodia camphorata, has been considered a potential lipid-lowering agent..

Immune supportMetabolic health

Medium relevance

Turkey Tail · 2022 · Research Article · Journal of fungi (Basel, Switzerland)

Changes in Chemical Structure of Thermally Modified Spruce Wood Due to Decaying Fungi.

Fungi play a critical role in the decomposition of wood and wood-based products in use. The ability of decaying fungi to cause degradation of polysaccharides and lignin in the thermally modified Norway spruce (Picea abies L..

Immune supportMetabolic health

Medium relevance

Reishi · 2022 · Journal Article · Frontiers in microbiology

Christensenella regulated by Huang-Qi-Ling-Hua-San is a key factor by which to improve type 2 diabetes.

There is a lot of evidence that oral hypoglycemic drugs work by affecting gut microbes, but the key strains responsible for this effect are not well known. Huang-Qi-Ling-Hua-San (HQLHS), composed of Astragalus Membranaceus, Ganoderma lucidum, Inonotus obliquus, and Momordica charantia L., is a specially designed….

Immune supportMetabolic healthGut & microbiomeLiver support

Medium relevance

Reishi · 2022 · Journal Article · Analytica chimica acta

CoN4-supported Co2N metal clusters for developing sensitive chemiluminescent immunochromatographic assays.

In view of the optimal catalytic efficiency (∼100%), single-atom site catalysts are being widely exploited in a range of areas including organic synthesis, energy conversion, environmental remediation, biotherapy, etc..

Immune supportEnergy & fatigue

Medium relevance

Oyster Mushroom · 2022 · Journal Article · Foods (Basel, Switzerland)

Effect of Fortification with Mushroom Polysaccharide β-Glucan on the Quality of Ovine Soft Spreadable Cheese.

In the present work, a fresh spreadable cheese from ovine milk with or without (control) fortification with β-glucan was manufactured. β-Glucan was extracted from the mushroom Pleurotus ostreatus and its concentration in the cheese was 0.4% (w/w)..

Immune support

Medium relevance

Lion's Mane · 2022 · Journal Article · Life sciences

Erinacine A attenuates glutamate transporter 1 downregulation and protects against ischemic brain injury.

Maintaining glutamate homeostasis through astrocyte-enriched glutamate transporter 1 (GLT-1) is critical for neuronal survival, but it is often disrupted after brain injury..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Medium relevance

Shiitake · 2022 · Research Article · Journal of personalized medicine

Experience with Photodynamic Therapy Using Indocyanine Green Liposomes for Refractory Cancer.

We reported the development of an effective cancer treatment using a multidisciplinary treatment, including photodynamic therapy (PDT) with indocyanine green (ICG) liposomes and a combination of Lentinula edodes mycelia (LEM) and hydrogen gas inhalation therapy..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Enoki · 2022 · Research Article · Frontiers in nutrition

FIP-fve Stimulates Cell Proliferation and Enhances IL-2 Release by Activating MAP2K3/p38α (MAPK14) Signaling Pathway in Jurkat E6-1 Cells.

FIP-fve, a fungal fruiting body protein from Flammulina velutipes, has potential immunomodulatory properties. Here, we investigated the immunomodulation mechanism of FIP-fve in Jurkat E6-1 cells by conducting a cell viability assay and IL-2 release assay..

Immune support

Medium relevance

Enoki · 2022 · Research Article · Frontiers in microbiology

Flammulina velutipes Polysaccharides Modulate Gut Microbiota and Alleviate Carbon Tetrachloride-Induced Hepatic Oxidative Injury in Mice.

A carbon tetrachloride-induced acute liver injury mouse model is used to study the regulation of gut microbiota and hepatoprotective effect of polysaccharides from Flammulina velutipes (FVPs)..

Immune supportMetabolic healthGut & microbiomeLiver support

Medium relevance

Oyster Mushroom · 2022 · Journal Article · iScience

Fungal glycoside hydrolase family 44 xyloglucanases are restricted to the phylum Basidiomycota and show a distinct xyloglucan cleavage pattern.

Xyloglucan is a prominent matrix heteropolysaccharide binding to cellulose microfibrils in primary plant cell walls. Hence, the hydrolysis of xyloglucan facilitates the overall lignocellulosic biomass degradation.

Immune support

Medium relevance

Mesima · 2022 · Research Article · International journal of molecular sciences

Hispolon Cyclodextrin Complexes and Their Inclusion in Liposomes for Enhanced Delivery in Melanoma Cell Lines.

Hispolon, a phenolic pigment isolated from the mushroom species Phellinus linteus, has been investigated for anti-inflammatory, antioxidant, and anticancer properties; however, low solubility and poor bioavailability have limited its potential clinical translation..

OncologyImmune supportLiver support

Medium relevance

Mesima · 2022 · Research Article · International journal of molecular sciences

Hispolon Methyl Ether, a Hispolon Analog, Suppresses the SRC/STAT3/Survivin Signaling Axis to Induce Cytotoxicity in Human Urinary Bladder Transitional Carcinoma Cell Lines.

Bladder cancer is a leading human malignancy worldwide. Signal transducer and activator of transcription (STAT) 3 is an oncogenic transcription factor commonly hyperactivated in most human cancers, including bladder cancer..

OncologyImmune support

Medium relevance

Oyster Mushroom · 2022 · Journal Article · Scientific reports

Immunomodulatory activity of extracts from five edible basidiomycetes mushrooms in Wistar albino rats.

Mushrooms are nutritious foods that are widely cultivated all over the world. They are rich in a range of compounds linked to improving functions of the immune system including carotenoids, alkaloids, lectins, enzymes, folates, fats, organic acids, minerals, polysaccharides, phenolics, proteins, tocopherols,….

OncologyImmune support

Medium relevance

Mesima · 2022 · Research Article · Pharmaceutics

Immunomodulatory Effect of Hispolon on LPS-Induced RAW264.7 Cells and Mitogen/Alloantigen-Stimulated Spleen Lymphocytes of Mice.

Hispolon is a potent anticancer, anti-inflammatory, antioxidant, and antidiabetic agent isolated from Phellinus linteus, an oriental medicinal mushroom. However, the immunomodulatory mechanisms by which hispolon affects macrophages and lymphocytes remain poorly characterized..

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Reishi · 2022 · Journal Article · Frontiers in oncology

Integrated Whole-Transcriptome Profiling and Bioinformatics Analysis of the Polypharmacological Effects of Ganoderic Acid Me in Colorectal Cancer Treatment.

Ganoderic acid Me (GA-Me) is a natural bioactive compound derived from Ganoderma lucidum. Our present results suggested that GA-Me inhibited proliferation, induced DNA fragmentation and significantly activated caspase-9 and caspase-3 in HCT116 cells..

OncologyImmune support

Medium relevance

Niu-Chang-Chih · 2022 · Research Article · Frontiers in cell and developmental biology

Large-scale transcriptomic analysis of coding and non-coding pathological biomarkers, associated with the tumor immune microenvironment of thyroid cancer and potential target therapy exploration.

Papillary thyroid carcinoma (PTC) is the most prevalent endocrine malignancy with a steadily increasing global incidence in recent decades. The pathogenesis of PTC is poorly understood, and the present diagnostic protocols are deficient..

OncologyImmune support

Medium relevance

Shiitake · 2022 · Journal Article · Molecular and cellular biochemistry

Lentinan triggers oxidative stress-mediated anti-inflammatory responses in lung cancer cells.

Inflammatory responses change several aspects of malignancies such as proliferation, survival, angiogenesis, and metastasis and lead to tumor progression. Lung cancer is the leading type of cancer worldwide and cancer-related inflammatory mediators challenge the successful treatments..

OncologyImmune supportEnergy & fatigueGut & microbiome

Medium relevance

Reishi · 2022 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Lucidenic acid A inhibits the binding of hACE2 receptor with spike protein to prevent SARS-CoV-2 invasion.

High infection caused by mutations of SARS-CoV-2 calls for new prevention strategy. Ganoderma lucidum known as a superior immunoenhancer exhibits various antiviral effects, whether it can resist SARS-CoV-2 remains unclear..

Immune supportRespiratory

Medium relevance

Cordyceps · 2022 · Journal Article · Frontiers in pharmacology

Medicinal Plants and Fungi Traditionally Used by Dulong People in Northwest Yunnan, China.

The Dulong, an ethnic group living in the isolated Northwest Yunnan of Southwest China, have directly used a wide of plants to serve their needs and have accumulated rich traditional knowledge about medicinal plants over years..

Immune support

Medium relevance

Reishi · 2022 · Journal Article · Molecules (Basel, Switzerland)

Mushroom-Derived Novel Selenium Nanocomposites' Effects on Potato Plant Growth and Tuber Germination.

Multicomponent materials, where nanosized selenium (Se) is dispersed in polymer matrices, present as polymer nanocomposites (NCs), namely, selenium polymer nanocomposites (SeNCs). Selenium as an inorganic nanofiller in NCs has been extensively studied for its biological activity..

Immune supportEnergy & fatigue

Medium relevance

Reishi · 2022 · Journal Article · Frontiers in pharmacology

Polysaccharides, Next Potential Agent for the Treatment of Epilepsy?

Epilepsy is a chronic neurological disorder. Current pharmacological therapies for epilepsy have limited efficacy that result in refractory epilepsy (RE).

Immune supportCognition & nervesGut & microbiome

Medium relevance

Reishi · 2022 · Journal Article · Journal of microbiological methods

Quantitative detection of Ganodermati lucidum immunomodulatory protein-8 by a peptide-antigen-antibody sandwich ELISA.

In order to rapidly determine the concentration of recombinant Ganoderma lucidum immunomodulatory protein-8 (rLZ-8) at a lower cost, a peptide-antigen-antibody sandwich ELISA method was developed based on a dodecapeptide LTPHKHHKHLHA with higher affinity for rLZ-8, which was identified from phage display after four….

Immune support

Medium relevance

Chaga · 2022 · Journal Article · Waste management (New York, N.Y.)

Reclamation of ginseng residues using two-stage fermentation and evaluation of their beneficial effects as dietary feed supplements for piglets.

Environmental pollution caused by herbal residues, such as ginseng residue (GR), and the huge waste of medicinal ingredients in such residues hinder the development of the pharmaceutical industry. Few studies focused on the biotransformation of GRs and the practical utilization of their bioproducts..

Immune supportEnergy & fatigueGut & microbiome