MycoData

The parameters to extract polysaccharide-enriched fractions (PEF) from mushrooms using MAE (microwave-assisted extraction) were adjusted following a full factorial 32 experimental design. The highest yield and total carbohydrate values, using Lentinula edodes as model mushroom, were obtained at 180 °C and 30 min..

Immune support

Medium relevance

Shiitake · 2018 · Journal Article · Applied microbiology and biotechnology

Bacteria-produced ferric exopolysaccharide nanoparticles as iron delivery system for truffles (Tuber borchii).

Iron exopolysaccharide nanoparticles were biogenerated during ferric citrate fermentation by Klebsiella oxytoca DSM 29614. Before investigating their effects on Tuber borchii ("bianchetto" truffle) mycelium growth and morphology, they were tested on human K562 cell line and Lentinula edodes pure culture and shown to….

Immune supportEnergy & fatigueLiver support

Medium relevance

Mesima · 2018 · Journal Article · Anticancer research

Combination Effects of Hispidin and Gemcitabine via Inhibition of Stemness in Pancreatic Cancer Stem Cells.

BACKGROUND/AIM: Natural products extracted from plants can be potent for developing pharmaceutical products. Hispidin, a polyphenolic compound mainly derived from the medicinal mushroom Phellinus linteus, has been shown to have a therapeutic potential against cancer cells..

OncologyImmune supportGut & microbiome

Medium relevance

Shiitake · 2018 · Journal Article · Journal of evidence-based integrative medicine

Effects of AHCC® on Immune and Stress Responses in Healthy Individuals.

AHCC® is a functional food from the basidiomycete Lentinula edodes. We evaluated the effects of AHCC® on subjects under different kinds of stress and at rest.

Immune supportCognition & nerves

Medium relevance

Shiitake · 2018 · Journal Article · Frontiers in microbiology

Inhibition of Influenza Virus Infection by Lentinus edodes Mycelia Extract Through Its Direct Action and Immunopotentiating Activity.

Lentinula edodes mycelia (LEM) solid culture extracts contain many bioactive compounds with diverse pharmacological activities such as antitumor, antiviral, and immunopotentiating effects. In this study, we examined the anti-influenza virus activity of LEM in vitro and in vivo..

OncologyImmune supportRespiratory

Medium relevance

Chaga · 2018 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Inotodiol suppresses proliferation of breast cancer in rat model of type 2 diabetes mellitus via downregulation of β-catenin signaling.

Breast cancer is amongst the most common cancers causing death of women worldwide. Breast cancer occurrence is more prominent in people with diabetes.

OncologyImmune supportMetabolic health

Medium relevance

Shiitake · 2018 · Journal Article · Journal of natural medicines

Lignosulfonic acid attenuates NF-κB activation and intestinal epithelial barrier dysfunction induced by TNF-α/IFN-γ in Caco-2 cells.

Lentinula edodes mycelia solid culture extract (MSCE) is used as a medical food ingredient and provides beneficial effects to patients with cancer and chronic type C hepatitis..

OncologyImmune supportGut & microbiomeLiver support

Medium relevance

Mesima · 2017 · Journal Article · International immunopharmacology

3, 4-dihydroxybenzalacetone attenuates lipopolysaccharide-induced inflammation in acute lung injury via down-regulation of MMP-2 and MMP-9 activities through suppressing ROS-mediated MAPK and PI3K/AKT signaling pathways.

3, 4-Dihydroxybenzalacetone (DBL) is a constituent of Phellinus linteus. This study demonstrated the protective effect of DBL on lipopolysaccharide (LPS)-induced acute lung injuries in mice.

OncologyImmune supportEnergy & fatigueRespiratory

Medium relevance

Shiitake · 2017 · Journal Article · BMC gastroenterology

Attenuating the rate of total body fat accumulation and alleviating liver damage by oral administration of vitamin D-enriched edible mushrooms in a diet-induced obesity murine model is mediated by an anti-inflammatory paradigm shift.

BACKGROUND: Hypovitaminosis D is associated with many features of the metabolic syndrome, including non-alcoholic fatty liver disease. Vitamin D-enriched mushrooms extracts exert a synergistic anti-inflammatory effect..

Immune supportMetabolic healthLiver support

Medium relevance

Wood Ear · 2017 · Journal Article · Journal of materials chemistry. B

Dendritic nanotubes self-assembled from stiff polysaccharides as drug and probe carriers.

Dendritic nanotubes (DNTs) with hydrophobic cavities were constructed directly from rigid branched β-1,3-d-glucan (AF1) in aqueous solution, and the AF1 sample was isolated from the fruiting bodies of Auricularia auricula-judae, a household nutritional food..

OncologyImmune supportLiver support

Medium relevance

Maitake · 2017 · Journal Article · Colloids and surfaces. B, Biointerfaces

Design of antibacterial biointerfaces by surface modification of poly (ε-caprolactone) with fusion protein containing hydrophobin and PA-1.

Class IIa bacteriocin pediocin PA-1 has broad-spectrum activity and is a well-characterized candidate food biopreservative. Here, a simple approach is designed to extend the application of pediocin PA-1 in improving the antibacterial activity of electrospun poly(caprolactone) (PCL) grafts through combining PA-1 with….

Immune support

Medium relevance

Enoki · 2017 · Journal Article · Journal of the science of food and agriculture

Evaluation of different agricultural wastes for the production of fruiting bodies and bioactive compounds by medicinal mushroom Cordyceps militaris.

BACKGROUND: In commercial production of Cordyceps militaris (a famous Chinese medicine), cereal grains are usually utilized as cultivation substrates. This study aimed to evaluate the efficiency of agricultural wastes as substitute materials in the low-cost production of C.

Immune support

Medium relevance

Turkey Tail · 2017 · Research Article · AMB Express

Expression of a new laccase from Moniliophthora roreri at high levels in Pichia pastoris and its potential application in micropollutant degradation.

Laccases have gained significant attention due to their emerging applications including bioremediation, biomass degradation and biofuel cells. One of the prerequisites for the industrial application of laccases is their sufficient availability..

Immune support

Medium relevance

Turkey Tail · 2017 · Journal Article · The Science of the total environment

Formation of 2,4-D bound residues in soils: New insights into microbial metabolism.

The microbial contribution to the formation of bound residues in soils is studied by characterizing the metabolic activity of three microorganisms (Trametes versicolor, Fusarium solani and Ralstonia eutropha) on 14C-2,4-dichlorophenoxyacetic acid (2,4-D) during incubation in synthetic liquid media and soil..

Immune supportMetabolic health

Medium relevance

Chaga · 2017 · Journal Article · International journal of medicinal mushrooms

Growth-Inhibitory and Immunomodulatory Activities of Wild Mushrooms from North-Central British Columbia (Canada).

Wild mushrooms, especially from North America, have not been systematically explored for their medicinal properties. Here we report screening for the growth-inhibitory and immunomodulatory activities of 12 species collected from multiple locations in north-central British Columbia, Canada..

OncologyImmune support

Medium relevance

Mesima · 2017 · Research Article · Oncology letters

Hispolon as an inhibitor of TGF-β-induced epithelial-mesenchymal transition in human epithelial cancer cells by co-regulation of TGF-β-Snail/Twist axis.

Hispolon (HPL), isolated from Phellinus linteus, has been used to treat various types of pathology, including inflammation, gastroenteric disorders, lymphatic diseases and numerous cancer subtypes..

OncologyImmune supportLiver support

Medium relevance

Mesima · 2017 · Journal Article · The American journal of Chinese medicine

Hispolon Suppresses LPS- or LTA-Induced iNOS/NO Production and Apoptosis in BV-2 Microglial Cells.

Hispolon (HIS) is an active polyphenol compound derived from Phellinus linteus (Berkeley & Curtis), and our previous study showed that HIS effectively inhibited inflammatory responses in macrophages [Yang, L.Y., S.C. Shen, K.T.

OncologyImmune supportCognition & nervesEnergy & fatigue

Medium relevance

Turkey Tail · 2017 · Research Article · Oxidative medicine and cellular longevity

Preclinical Antileukemia Activity of Tramesan: A Newly Identified Bioactive Fungal Metabolite.

Despite improvements that occurred in the last decades in the acute myeloid leukemia (AML) treatment, clinical results are still unsatisfactory. More effective therapies are required, and innovative approaches are ongoing, including the discovery of novel antileukemia natural compounds..

OncologyImmune support

Medium relevance

Niu-Chang-Chih · 2017 · Research Article · PloS one

Prevention of TGF-β-induced early liver fibrosis by a maleic acid derivative anti-oxidant through suppression of ROS, inflammation and hepatic stellate cells activation.

Current anti-fibrotic effect of antioxidants in vivo is disappointing due probably to the fact that once liver fibrogenesis is established it is too advanced to be reversed by anti-oxidation mechanism. We consider antioxidant may only act on the early phase of fibrogenesis..

Immune supportEnergy & fatigueLiver supportSkin & hydration

Medium relevance

Turkey Tail · 2017 · Journal Article · Environmental pollution (Barking, Essex: 1987)

Salinity induced effects on the growth rates and mycelia composition of basidiomycete and zygomycete fungi.

Soil salinization, as the combination of primary and secondary events, can adversely affect organisms inhabiting this compartment. In the present study, the effects of increased salinity were assessed in four species of terrestrial fungi: Lentinus sajor caju, Phanerochaete chrysosporium, Rhizopus oryzae and Trametes….

Immune support

Medium relevance

Shiitake · 2017 · Journal Article · Food chemistry

Screening of beta-glucan contents in commercially cultivated and wild growing mushrooms.

Mushrooms have unique sensory properties and nutritional values as well as health benefits due to their bioactive compounds, especially beta-glucans. Well-known edible and medicinal mushroom species as well as uncommon or unknown species representing interesting sources of bioactive beta-glucans have been widely….

Immune support

Medium relevance

Shiitake · 2016 · Journal Article · International immunopharmacology

Active hexose correlated compound modulates LPS-induced hypotension and gut injury in rats.

We hypothesized that AHCC; (Amino UP Chemical Co., Ltd., Sapporo, Japan), a mushroom mycelium extract obtained from liquid culture of Lentinula edodes, restores immune function in LPS-induced inflammation in the gut, especially when the nitric oxide signaling pathway is impaired..

Immune supportMetabolic healthGut & microbiome

Medium relevance

Wood Ear · 2016 · Journal Article · Journal of materials chemistry. B

Anti-hepatoma activity of the stiff branched β-d-glucan and effects of molecular weight.

The water soluble β-(1 → 3)-d-glucan with short branches (AF1) isolated from Auricularia auricula-judae was successfully fractionated by ultrasonication into three fractions with different weight-average molecular weights (Mws)..

OncologyImmune supportLiver support

Medium relevance

Wood Ear · 2016 · Journal Article · Genetics and molecular research: GMR

Antioxidant activity, anti-proliferative activity, and amino acid profiles of ethanolic extracts of edible mushrooms.

Biological activities of various mushrooms have recently been discovered, particularly, immunomodulatory and antitumor activities. Herein, three edible mushrooms, Auricularia auricula-judae (AA), Pleurotus abalonus (PA) and Pleurotus sajor-caju (PS) extracted using Soxhlet ethanol extraction were evaluated for their….

OncologyImmune supportEnergy & fatigue

Medium relevance

Maitake · 2016 · Journal Article · International journal of medicinal mushrooms

Antitumor Activity of Extracts from Medicinal Basidiomycetes Mushrooms.

Aqueous extracts from the vegetative submerged mycelia of cultivated Basidiomycetes Ganoderma lucidum, Lentinus edodes, and Grifola frondosa, as well as from the fruiting bodies of G. lucidum, were found to have antitumor activity..

OncologyImmune supportSkin & hydrationRespiratory

Medium relevance

Maitake · 2016 · Journal Article · Applied microbiology and biotechnology

Comparative characterization of physicochemical properties and bioactivities of polysaccharides from selected medicinal mushrooms.

Mushroom polysaccharides have been known to possess various pharmacological activities. However, information on their chemical and biological differences between mushrooms remains limited..

Immune supportMetabolic health

Medium relevance

Shiitake · 2016 · Journal Article · Molecules (Basel, Switzerland)

Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties.

The cosmetic industry is in a constant search for natural compounds or extracts with relevant bioactive properties, which became valuable ingredients to design cosmeceutical formulations. Mushrooms have been markedly studied in terms of nutritional value and medicinal properties..

Immune supportSkin & hydration

Medium relevance

Lion's Mane · 2015 · Review · Critical reviews in biotechnology

Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism.

Mushrooms have long been used not only as food but also for the treatment of various ailments. Although at its infancy, accumulated evidence suggested that culinary-medicinal mushrooms may play an important role in the prevention of many age-associated neurological dysfunctions, including Alzheimer's and Parkinson's….

Immune supportCognition & nerves

Medium relevance

Maitake · 2014 · Review · Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]

[Antiviral properties of basidiomycetes metabolites].

The data on the antiviral action of the Ganoderma lucidum, Lentinus edodes, Grifola frondosa, Agaricus brasiliensis and other basidiomycetes metabolites are summurized..

Immune supportLiver supportRespiratory

Medium relevance

Turkey Tail · 2014 · Review · Integrative medicine (Encinitas, Calif.)

Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology.

This review discusses the immunological roles of 5 major mushrooms in oncology: Agaricus blazei, Cordyceps sinensis, Grifola frondosa, Ganoderma lucidum, and Trametes versicolor. These mushrooms were selected based on the body of research performed on mushroom immunology in an oncology model..

OncologyImmune support

Medium relevance

Niu-Chang-Chih · 2013 · Review · Current topics in medicinal chemistry

Mycotherapy of cancer: an update on cytotoxic and antitumor activities of mushrooms, bioactive principles and molecular mechanisms of their action.

Mycotherapy is defined as the study of the use of extracts and compounds obtained from mushrooms as medicines or health-promoting agents. The present review updates the recent findings on anticancer/antitumor agents derived from mushroom extracts and their metabolites..

OncologyImmune support

Medium relevance

Maitake · 2011 · Review Article · Journal of advanced pharmaceutical technology & research

Preparation, characterization, and biological properties of β-glucans.

β-Glucans are soluble fibers with physiological functions, such as, interference with absorption of sugars and reduction of serum lipid levels. β-glucans are found in different species, such as, Rhynchelytrum repens, Lentinus edodes, Grifola frondosa, Tremella mesenterica, Tremella aurantia, Zea may, Agaricus blazei,….

Immune supportEnergy & fatigueMetabolic health

Medium relevance

Maitake · 2006 · Review · Alternative medicine review: a journal of clinical therapeutic

Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators.

UNLABELLED: Modulation of cytokine secretion may offer novel approaches in the treatment of a variety of diseases. One strategy in the modulation of cytokine expression may be through the use of herbal medicines..

Immune support

Medium relevance

Maitake · 2003 · Journal Article · Cancer letters

Relationship between dendritic cells and the D-fraction-induced Th-1 dominant response in BALB/c tumor-bearing mice.

Dendritic cells (DCs) are known to not only induce the activation of T cells, but are also associated with the differentiation of T cells. The D-fraction, a beta-glucan extracted from maitake (Grifola frondosa) which expresses anti-tumor effects by establishing a helper (Th)-1 dominance in BALB/c mice, enhanced….

OncologyImmune support

Medium relevance

King Oyster · 1996 · Research Article · Applied and environmental microbiology

Analysis of Lignin-Polysaccharide Complexes Formed during Grass Lignin Degradation by Cultures of Pleurotus Species.

A brown material, precipitable with ethanol, was formed during wheat straw and lignin degradation by liquid cultures of different species of Pleurotus. Fourier transform infrared spectroscopy and cross-polarization and magic-angle-spinning (sup13)C nuclear magnetic resonance spectroscopy showed that most of the….

Immune support

Low relevance

Agarikon · 2011 · Journal Article · International journal of medicinal mushrooms

New dietary supplements from medicinal mushrooms: Dr Myko San--a registration report.

In December 2010 the Ministry of Health and Social Welfare of the Republic of Croatia registered tablet preparations AGARIKON. 1 and MYKOPROTECT.

OncologyImmune supportLiver supportRespiratory

Low relevance

Wood Ear · 2005 · Patent · journal metadata

Black fungus oats soup and its preparation method

A health-care Auricularia auricula-judae-oats gruel in the form of instant particles contanis oats, Auricularia auricula-judae, sesame. Its health-care functions includes decreasing blood sugar and blood fat, lowering blood pressure, preventing thrombocyte coagulation and thrombus, improving immunity, delaying….

Immune supportMetabolic health

Low relevance

Chaga · 2004 · Patent · journal metadata

COMPOSITION OF COMPONENTS FOR PREPARING CURATIVE-PROPHYLACTIC BALSAM "GEYA-VENERA KOS PLA"

FIELD: nonalcoholic industry, medicine, food industry, cosmetology. SUBSTANCE: balsam represents semi-oily an aqueous extract of herbs containing propolis, shilagit, Inonotus obliquus, sea algae (food bladder wrack, laminarian), Dead Sea salts and 48 species of above-ground herbs: club- moss, wild ginger, fly agaric,….

Immune supportSkin & hydration

Low relevance

Niu-Chang-Chih · 2004 · Patent · journal metadata

New phenyl maleic anhydride and maleimide derivatives used for lowering blood pressure, increasing high-density lipoprotein or as central cholinergic agonists, hepatoprotective, antiinflammatory agents and antitumor agents

Phenyl maleic anhydride and maleimide derivatives (I) are new. Phenyl maleic anhydride and maleimide derivatives of formula (I), are new.

OncologyImmune supportMetabolic healthLiver support

Low relevance

Mesima · 2004 · Patent · journal metadata

PRODUCTION OF GINSENG PRODUCT HAVING INCREASED CONTENT OF GINSENOSIDE AND BETA-GLUCAN BY SOAKING GINSENG IN YEAST EXTRACT, INOCULATING WITH MUSHROOM STRAINS AND CULTURING IT

PURPOSE: A method of making a ginseng product by soaking cut pieces of ginseng in the yeast extract, inoculating them with mushroom strains such as Paecilomyces tenuipes, Cordyceps militaris, Cordyceps sinensis and Phellinus Linteus and then culturing them is provided..

OncologyImmune supportEnergy & fatigueSkin & hydration

Low relevance

Zhu Ling · 1992 · English Abstract · Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

[A study on the role of immunosuppression in the pathogenesis of brucellosis].

An immunosuppressive effect was seen in murine brucellosis as detected by using plaque forming cell (PFC) and 3H-labelled lymphocyte blastogenesis transformation (LBT) assays. The immunosuppression PFC could last until 11 months after infection, while that of LBT was only seen at 3 months after infection..

Immune support

Low relevance

Cordyceps · 2023 · Case Reports · World journal of clinical cases

Severe inflammatory disorder in trisomy 8 without myelodysplastic syndrome and response to methylprednisolone: A case report.

BACKGROUND: Patients with trisomy 8 consistently present with myeloid neoplasms and/or auto-inflammatory syndrome. A possible link between myelodysplastic syndromes (MDS) with trisomy 8 (+8-MDS) and inflammatory disorders is well recognized, several cases having been reported..

OncologyImmune supportEnergy & fatigueRespiratory

Low relevance

Maitake · 2022 · Retracted Publication · Journal of healthcare engineering

A Study on the Evaluation of Polyenoic Vegetable Oils and Their Female Health Benefits Based on Time Series Analysis Model: The Case of Peony Seed Oil.

Polyenoic vegetable oils mainly contain polyenoic acids such as linoleic acid and linolenic acid, as well as active ingredients such as VE, phytosterols, mineral elements, and squalene..

Immune supportMetabolic healthSkin & hydration

Low relevance

King Oyster · 2015 · Comparative Study · International journal of medicinal mushrooms

Comparison of antioxidant and antiproliferation activities of polysaccharides from eight species of medicinal mushrooms.

Polysaccharides from mushrooms including Pleurotus eryngii, P. ostreatus, P.

OncologyImmune supportEnergy & fatigue

Low relevance

Mesima · 2015 · Research Support, Non U.S. Gov'T · Biochemical and biophysical research communications

Hispolon inhibits the growth of estrogen receptor positive human breast cancer cells through modulation of estrogen receptor alpha.

Human estrogen receptor α (ERα) is a nuclear transcription factor that is a major therapeutic target in breast cancer. The transcriptional activity of ERα is regulated by certain estrogen-receptor modulators..

OncologyImmune supportLiver support

Low relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Applied biochemistry and biotechnology

Concurrent biosurfactant and ligninolytic enzyme production by Pleurotus spp. in solid-state fermentation.

Pleurotus spp. is known as one of the significant producers of ligninolytic enzymes which efficiently degrade lignocellulosic materials.

Immune support

Low relevance

King Oyster · 2013 · Research Support, Non U.S. Gov'T · Journal of food science

The applications of polysaccharides from various mushroom wastes as prebiotics in different systems.

The bases or stipes of mushrooms are normally discarded as low-economic value animal feed and compost. There are no known reports on deriving polysaccharides from these mushroom wastes for use as prebiotics..

Immune supportGut & microbiome

Low relevance

King Oyster · 2013 · Evaluation Study · Enzyme and microbial technology

Versatile peroxidase as a valuable tool for generating new biomolecules by homogeneous and heterogeneous cross-linking.

The modification and generation of new biomolecules intended to give higher molecular-mass species for biotechnological purposes, can be achieved by enzymatic cross-linking. The versatile peroxidase (VP) from Pleurotus eryngii is a high redox-potential enzyme with oxidative activity on a wide variety of substrates..

Immune support

Low relevance

Maitake · 2012 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Hypoglycemic and hypolipidemic activities of MT-α-glucan and its effect on immune function of diabetic mice.

The hypoglycemic and hypolipidemic effect of an α-glucan (designed here as MT-α-glucan) from fruit body of maitake (Grifola frondosa) on diabetic mouse model induced by streptozotocin and high-fat-diet were evaluated, and its effect on immune function of diabetic mice was investigated..

Immune supportMetabolic health

Low relevance

Maitake · 2010 · Patent · journal metadata

Beta-Glucan Enhances Hematopoietic Progenitor Cells Engraftment and Promotes Recovery from Chemotoxicity

Methods to use beta glucans in the culture of cell populations containing CD34+ cells in order to expand the numbers of CD34+ subsets of progenitor and stem cells are provided..

OncologyImmune support