MycoData

Lactoferrin (LF) with various biological functions demonstrates great application potential. However, its application was restricted by its poor gelation and instability..

Immune supportGut & microbiome

High relevance

Snow Fungus · 2024 · Journal Article · Food & function

Metagenomic and transcriptomic profiling of the hypoglycemic and hypotriglyceridemic actions of Tremella fuciformis-derived polysaccharides in high-fat-diet- and streptozotocin-treated mice.

Mushroom polysaccharides have great anti-diabetes potential. The fruiting body of Tremella fuciformis is rich in polysaccharides.

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Enoki · 2024 · Journal Article · Food chemistry

Modulation of gut microbiota and metabolites by Flammulina velutipes polysaccharides during in vitro human fecal fermentation: Unveiling Bacteroides as a potential primary degrader.

Flammulina velutipes, a widely cultivated species of edible fungus, exhibits diverse functional activities attributed to its polysaccharides. In this study, we employed an in vitro model to investigate the impact of F..

Immune supportGut & microbiome

High relevance

Shiitake · 2024 · Journal Article · Microbiology and immunology

Modulatory effects of supplementation of Lentinula edodes mycelia extract and l-arginine on the therapeutic efficacy of immunogenic chemotherapy in colon cancer-bearing mice.

Some chemotherapeutic drugs can induce cancer cell death and enhance antitumor T-cell immunity in cancer-bearing hosts. Immunomodulatory reagents could augment such chemotherapy-induced effects..

OncologyImmune supportGut & microbiome

High relevance

Oyster Mushroom · 2024 · Research Article · Brazilian journal of microbiology: [publication of the Brazilian Society for Microbiology]

Multi-metal tolerant Porostereum umbrinoalutaceum isolated from Pleurotus ostreatus fruit body showing root colonization, growth promotion of chilli (Capsicum annuum L.) plant and antagonism against fungal pathogens.

Mushroom associated microbes could be utilized to improve crop productivity providing nutrients, plant growth promoting substances, production of hydrolytic enzymes and protecting plant from biotic and abiotic stress..

Gut & microbiome

High relevance

Mesima · 2024 · Journal Article · Nanoscale

Oral exosome-like nanovesicles from Phellinus linteus suppress metastatic hepatocellular carcinoma by reactive oxygen species generation and microbiota rebalancing.

The biomedical application of nanotechnology in cancer treatment has demonstrated significant potential for improving treatment efficiencies and ameliorating adverse effects..

OncologyEnergy & fatigueGut & microbiomeLiver support

High relevance

Snow Fungus · 2024 · Journal Article · International journal of biological macromolecules

Oral food-derived whey protein isolate-Tremella fuciformis polysaccharides pickering emulsions with adhesive ability to delivery magnolol for targeted treatment of ulcerative colitis.

Magnolol (Mag) is a promising natural compound with therapeutic potential for ulcerative colitis (UC). Here we designed and fabricated an oral food-grade whey protein isolate-Tremella fuciformis polysaccharides (WPI-TFPS) stabilized pickering emulsions to encapsulate Mag (Mag-WPI-TFPS) for targeted treatment of UC..

Immune supportGut & microbiomeLiver support

High relevance

Reishi · 2024 · Journal Article · Journal of Environmental Management

Partitioning Ganoderma lucidum residue biochar differentially boosts anaerobic fermentation performance of cow manure via mediation of anaerobic microbiota assembly

Biochar is a promising strategy to solve the problem of low efficiency and ammonia inhibition during anaerobic digestion (AD). However, the correlation between biochar partitioning and its stimulatory effects on AD remains uncertain..

Energy & fatigueGut & microbiome

High relevance

Reishi · 2024 · Journal Article · Journal of environmental management

Partitioning Ganoderma lucidum residue biochar differentially boosts anaerobic fermentation performance of cow manure via mediation of anaerobic microbiota assembly.

Energy & fatigueGut & microbiome

High relevance

Enoki · 2024 · Research Article · Food chemistry: X

Physicochemical properties and fermentation characteristics of a novel polysaccharide degraded from Flammulina velutipes residues polysaccharide.

Flammulina velutipes (F. velutipes) residues polysaccharide (FVRP) is a high molecular weight polysaccharide with diverse bioactivities extracted from F.

Immune supportGut & microbiome

High relevance

Lion's Mane · 2024 · Journal Article · Food Hydrocolloids

Physicochemical properties of polysaccharides from Hericium erinaceus by steam explosion pretreatment and its effects on human gut microbiota

Crude polysaccharides (HEP) extracted from Hericium erinaceus (H. erinaceus) using hot water soaking were focused in this study.

Immune supportGut & microbiome

High relevance

Oyster Mushroom · 2024 · Journal Article · Environmental pollution (Barking, Essex: 1987)

Pleurotus ostreatus polysaccharide-mediated modulation of skin damage caused by microcystin-LR in tadpoles.

In this study, we aimed to evaluate the effect of dietary supplementation with edible mushroom (Pleurotus ostreatus)-derived polysaccharides on microcystin leucine-arginine (MC-LR)-induced skin damage in Pelophylax nigromaculatus tadpoles..

OncologyImmune supportGut & microbiomeSkin & hydration

High relevance

Lion's Mane · 2024 · Journal Article · International journal of biological macromolecules

Polysaccharides from an edible mushroom, Hericium erinaceus, alleviate ulcerative colitis in mice by inhibiting the NLRP3 inflammasomes and reestablish intestinal homeostasis.

This study aimed to assess the effects of polysaccharides extracted from Hericium erinaceus fruiting bodies (HEFPs) on the inflammatory response to oxidative stress in a mouse model of ulcerative colitis (UC) induced by ingestion of dextran sodium sulfate..

Immune supportGut & microbiome

High relevance

Mesima · 2024 · Journal Article · International journal of biological macromolecules

Polysaccharides from Phellinus linteus attenuate type 2 diabetes mellitus in rats via modulation of gut microbiota and bile acid metabolism.

Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder. Polysaccharides from Phellinus linteus (PLP) have been found to have anti-diabetes effects, but the mechanism has not been elucidated..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Turkey Tail · 2024 · Research Article · Microorganisms

Polysaccharides from Trametes versicolor as a Potential Prebiotic to Improve the Gut Microbiota in High-Fat Diet Mice.

Polysaccharides derived from Trametes versicolor have been found to exhibit hypolipidemic activity in hyperlipidemic mice, but the mechanism by which they modulate intestinal flora is still unclear..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Oyster Mushroom · 2024 · Journal Article · International journal of biological macromolecules

Regulating role of Pleurotus ostreatus insoluble dietary fiber in high fat diet induced obesity in rats based on proteomics and metabolomics analyses.

This study aims to reveal the effects of Pleurotus ostreatus insoluble dietary fiber (POIDF) on liver protein and cecal metabolites in obese rats and its potential mechanism by intestinal microbes..

Metabolic healthGut & microbiomeLiver support

High relevance

Lion's Mane · 2024 · Journal Article · Carbohydrate polymers

Resveratrol-loaded sulfated Hericium erinaceus β-glucan-chitosan nanoparticles: Preparation, characterization and synergistic anti-inflammatory effects

Resveratrol (RES) is a natural polyphenol with excellent biological activity. But the poor stability and bioavailability of RES severely limit its application.

Immune supportGut & microbiome

High relevance

Lion's Mane · 2024 · Journal Article · Carbohydrate polymers

Resveratrol-loaded sulfated Hericium erinaceus β-glucan-chitosan nanoparticles: Preparation, characterization and synergistic anti-inflammatory effects.

Resveratrol (RES) is a natural polyphenol with excellent biological activity. But the poor stability and bioavailability of RES severely limit its application.

Immune supportGut & microbiome

High relevance

Maitake · 2024 · Journal Article · International journal of biological macromolecules

Selective impact of three homogenous polysaccharides with different structural characteristics from Grifola frondosa on human gut microbial composition and the structure-activity relationship.

Natural polysaccharides interact with gut microbes to enhance human well-being. Grifola frondosa is a polysaccharides-rich edible and medicinal mushroom.

Immune supportGut & microbiome

High relevance

Chaga · 2024 · Journal Article · International journal of biological macromolecules

Structural analysis of polysaccharide from Inonotus obliquus and investigate combined impact on the sex hormones, intestinal microbiota and metabolism in SPF male mice.

The dysregulation of sex hormone levels is associated with metabolic disorders such as obesity. Inonotus obliquus polysaccharide (IOP) exhibits a promising therapeutic effect on conditions like obesity and diabetes, potentially linked to its influence on intestinal microbiota and metabolism..

Immune supportMetabolic healthGut & microbiome

High relevance

Snow Fungus · 2024 · Journal Article · Journal of the science of food and agriculture

Structural characterization of a novel polysaccharide from Tremella fuciformis and its interaction with gut microbiota

BACKGROUND: Because of their diverse biological activities, polysaccharides derived from Tremella fuciformis have received growing attention. This study aimed to investigate the structural characterization of a purified polysaccharide (designated as PTP‐3a) derived from T..

Immune supportMetabolic healthGut & microbiome

High relevance

Snow Fungus · 2024 · Journal Article · Journal of the science of food and agriculture

Structural characterization of a novel polysaccharide from Tremella fuciformis and its interaction with gut microbiota.

Immune supportMetabolic healthGut & microbiome

High relevance

Enoki · 2024 · Research Article · Ultrasonics sonochemistry

Structural characterization, antioxidant activity, and fermentation characteristics of Flammulina velutipes residue polysaccharide degraded by ultrasonic assisted H2O2-Vc technique.

Adhere to the concept of low-carbon environmental protection and turning waste into treasure, polysaccharides from Flammulina velutipes residue polysaccharide (FVRP) has been developed and possesses diverse bioactivities, comprising antioxidant, hypoglycemic, and relieving heavy metal damage, which still has the….

Immune supportMetabolic healthGut & microbiome

High relevance

Oyster Mushroom · 2024 · Research Article · Scientific reports

Tea and Pleurotus ostreatus intercropping modulates structure of soil and root microbial communities.

Intercropping with Pleurotus ostreatus has been demonstrated to increase the tea yield and alleviate soil acidification in tea gardens. However, the underlying mechanisms remain elusive..

Immune supportGut & microbiome

High relevance

Reishi · 2024 · Research Article · Animals: an open access journal from MDPI

The Addition of Hot Water Extract of Juncao-Substrate Ganoderma lucidum Residue to Diets Enhances Growth Performance, Immune Function, and Intestinal Health in Broilers.

The purpose of this experiment was to investigate the effects of Hot Water Extract of Juncao-substrate Ganoderma lucidum Residue (HWE-JGLR) on the immune function and intestinal health of yellow-feather broilers..

Immune supportEnergy & fatigueGut & microbiome

High relevance

Reishi · 2024 · Journal Article · Food Research International

The effect of Mesona blume straw fermented by Ganoderma lucidum to improve physicochemical, in vitro digestion and gut bacteria of noodles

Mesona blume straw (MBS) is a class of high-fiber, low-value Mesona blume’s colloid by-products. We investigated the changes in dietary fiber (DF), triterpenoid, and polysaccharide contents of fermented Mesona blume straw (FMBS) by Ganoderma lucidum (GL), we also examined the effect of adding FMBS at different levels….

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2024 · Journal Article · Food research international (Ottawa, Ont.)

The effect of Mesona blume straw fermented by Ganoderma lucidum to improve physicochemical, in vitro digestion and gut bacteria of noodles.

Mesona blume straw (MBS) is a class of high-fiber, low-value Mesona blume's colloid by-products. We investigated the changes in dietary fiber (DF), triterpenoid, and polysaccharide contents of fermented Mesona blume straw (FMBS) by Ganoderma lucidum (GL), we also examined the effect of adding FMBS at different levels….

Immune supportMetabolic healthGut & microbiome

High relevance

Snow Fungus · 2024 · Research Article · Foods (Basel, Switzerland)

The Effects of Tremella fuciformis Polysaccharide on the Physicochemical, Multiscale Structure and Digestive Properties of Cyperus esculentus Starch.

In this study, we have investigated the effects of Tremella fuciformis polysaccharide (TP) on the pasting, rheological, structural and in vitro digestive properties of Cyperus esculentus starch (CS)..

Immune supportGut & microbiomeSkin & hydration

High relevance

Maitake · 2024 · Research Article · Life (Basel, Switzerland)

The Role of Grifola frondosa Polysaccharide in Preventing Skeletal Muscle Atrophy in Type 2 Diabetes Mellitus.

Type 2 diabetes mellitus (T2DM) is a burgeoning public health challenge worldwide. Individuals with T2DM are at increased risk for skeletal muscle atrophy, a serious complication that significantly compromises quality of life and for which effective prevention measures are currently inadequate..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Snow Fungus · 2024 · Research Article · Nutrients

Tremella fuciformis Berk Alleviated Atherosclerosis Symptoms via Nuclear Factor-Kappa B-Mediated Inflammatory Response in ApoE-/- Mice.

BACKGROUND: Atherosclerosis, a persistent inflammatory disease marked by the presence of atherosclerotic plaques or fibrous plaques, is a significant contributor to the onset of the development of cardiovascular disease..

Immune supportGut & microbiome

High relevance

Oyster Mushroom · 2024 · Journal Article · International journal of food microbiology

Using pre-fermented sugar beet pulp as a growth medium to produce Pleurotus ostreatus mycelium for meat alternatives.

This study aimed to determine the compatibility of pre-fermented sugar beet pulp to support the growth of Pleurotus ostreatus mycelium in submerged fermentation. The goal was to create a meat alternative based on mycelial-fermented pulp..

Gut & microbiome

High relevance

Reishi · 2023 · Review · Chinese medicine

A review of anti-tumour effects of Ganoderma lucidum in gastrointestinal cancer.

Gastrointestinal (GI) cancer is the most common cancer in the world and one of the main causes of cancer-related death. Clinically, surgical excision and chemotherapy are the main treatment methods for GI cancer, which is unfortunately accompanied with serious adverse reactions and drug toxicity, bringing irreversible….

OncologyImmune supportGut & microbiome

High relevance

Niu-Chang-Chih · 2023 · Review · Journal of ethnopharmacology

A review on the protective effect of active components in Antrodia camphorata against alcoholic liver injury.

ETHNOPHARMACOLOGICAL RELEVANCE: Antrodia camphorata is a genus of wood-rot basidiomycete in the family Fomitopsidaceae. It is a valuable medicinal fungus in China that contains more than 78 kinds of active compounds.

Immune supportGut & microbiomeLiver support

High relevance

Lion's Mane · 2023 · Review · World journal of gastroenterology

Hericium erinaceus, a medicinal fungus with a centuries-old history: Evidence in gastrointestinal diseases.

Hericium erinaceus is an edible and medicinal mushroom commonly used in traditional Chinese medicine for centuries. Several studies have highlighted its therapeutic potential for gastrointestinal disorders such as gastritis and inflammatory bowel diseases..

OncologyImmune supportGut & microbiome

High relevance

Oyster Mushroom · 2023 · Review · Foods (Basel, Switzerland)

Modulation of the Gut Microbiota with Prebiotics and Antimicrobial Agents from Pleurotus ostreatus Mushroom.

Pleurotus ostreatus (Jacq. ex Fr.) P.

Immune supportGut & microbiomeRespiratory

High relevance

Chaga · 2021 · Review · Journal of ethnopharmacology

Deciphering the antitumoral potential of the bioactive metabolites from medicinal mushroom Inonotus obliquus.

ETHNOPHARMACOLOGICAL RELEVANCE: The crude extracts of the medicinal mushroom Inonotus obliquus have been used as an effective traditional medicine to treat malicious tumors, gastritis, gastric ulcers, and other inflammatory conditions in Russia and most Baltic countries..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Turkey Tail · 2014 · Randomized Controlled Trial · Gut microbes

Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial.

BACKGROUND: Interactions between the microbial flora of the intestine and the human host play a critical role inmaintaining intestinal health and in the pathophysiology of a wide variety of disorders such as antibiotic associated diarrhea, Clostridium difficile infection, and inflammatory bowel disease..

Immune supportGut & microbiome

High relevance

Reishi · 2023 · Retracted Publication · Scientific reports

The effect of Ganoderma lucidum polysaccharide extract on sensitizing prostate cancer cells to flutamide and docetaxel: an in vitro study.

Ganoderma lucidum polysaccharide is the most widely used complementary therapy in cancer. The present study aims to investigate the possible interaction between Ganoderma lucidum polysaccharide and Docetaxel (a chemotherapy drug) and the first-line medication for prostate cancer treatment (Flutamide) and sensitizing….

OncologyImmune supportGut & microbiome

High relevance

Chaga · 2022 · Evaluation Study · Journal of the science of food and agriculture

Improving crude protein and methionine production, selective lignin degradation and digestibility of wheat straw by Inonotus obliquus using response surface methodology.

BACKGROUND: To date, fungus-assisted pretreatment of agricultural residue has not become the preferred method to produce protein-enriched and ruminally digestible animal feed because of low time efficiency of fungal delignification and protein production, i.e..

Gut & microbiome

High relevance

Cordyceps · 2022 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Polysaccharides from Cordyceps militaris prevent obesity in association with modulating gut microbiota and metabolites in high-fat diet-fed mice.

Improved gut microbes and nutritious metabolites have been considered as the mediators of health benefits from indigestible polysaccharides, but their role in the anti-obesity effect of polysaccharides from Cordyceps militaris (CMP) remains elusive..

Immune supportMetabolic healthGut & microbiome

High relevance

King Oyster · 2022 · Research Support, Non U.S. Gov'T · Frontiers in immunology

β-1,6-Glucan From Pleurotus eryngii Modulates the Immunity and Gut Microbiota.

Polysaccharides from Pleurotus eryngii exhibit a variety of biological activities. Here, we obtained a homogeneous branched β-1,6-glucan (APEP-A-b) from the fruiting bodies of P.

Immune supportGut & microbiome

High relevance

Snow Fungus · 2021 · Research Support, Non U.S. Gov'T · Frontiers in immunology

Tremella fuciformis Polysaccharides Inhibited Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice via Foxp3+ T Cells, Gut Microbiota, and Bacterial Metabolites.

Tremella fuciformis is an edible medicinal mushroom, and its polysaccharide components are found to confer various health benefits. This study identified the protective effects of polysaccharides of Tremella fuciformis (TPs) against dextran sulfate sodium (DSS)-induced colitis in mice..

Immune supportGut & microbiome

High relevance

Cordyceps · 2020 · Preprint · journal metadata

The Regulation Effect of Crude Polysaccharides from Cordyceps Militaris on Obesity Control and Gut Microbiota Community via High-Fat Diet-Fed Mice Model

Administration of crude polysaccharides extract from natural product is a promising gut microbiota-targeted approach to preventing obesity and associated metabolic disorders. Dietary restrictions can change the type and number of gut bacteria, which is an important factor in delaying the onset and burden of diseases..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2023 · Preprint · journal metadata

Effect of dietary supplementation of Ganoderma lucidum residue on growth performance, immune organ index and faecal microbial community diversity in broiler chickens

Ganoderma lucidum residue (GLR) contains a variety of medicinal and nutritional components and is a potentially high quality roughage. The purpose of the experiment was to study the effects of GLR on the growth performance, immune function and intestinal flora of broilers..

Immune supportEnergy & fatigueGut & microbiome

High relevance

Reishi · 2022 · Preprint · journal metadata

Overexpression of purine nucleoside phosphorylase increases the adenosine content in Ganoderma lucidum

Adenosine has been getting increasing attention due to its positive role in immunomodulation, anti-inflammation, and anti-cancer, etc.. The low production of Ganoderma adenosine is a bottleneck for clinical trials and commercial applications..

OncologyImmune supportGut & microbiome

High relevance

Reishi · 2022 · Preprint · journal metadata

Overexpression of purine nucleoside phosphorylase increases the adenosine content in Ganoderma lucidum

Background: Adenosine has been getting increasing attention due to its positive role in immunomodulation, anti-inflammation, and anti-cancer, etc.. The low production of Ganoderma adenosine is a bottleneck for clinical trials and commercial applications..

OncologyImmune supportGut & microbiome

High relevance

Chaga · 2021 · Preprint · journal metadata

Potential Target Screening and Molecular Docking of Newly Isolated Compound From Inonotus Obliquus

Compound (1-(4-hydroxyphenyl)-3-methoxypropan-1-one) is a newly isolated compound from Inonotus obliquus. In this paper, four target protein prediction methods were used to search the potential targets of compounds.

OncologyImmune supportGut & microbiome

High relevance

Oyster Mushroom · 2021 · Preprint · journal metadata

Treatment of Rice Stubble with Pleurotus Ostreatus and Urea Improves the Growth Performance in Slow-Growing Goats

The objective of this study was to evaluate the efficacy of fungal treatment (Pleurotus ostreatus) of urea-treated rice stubble on growth performance in slow-growing goats..

Energy & fatigueMetabolic healthGut & microbiome

High relevance

King Oyster · 2020 · Journal Article · Ying yong sheng tai xue bao = The journal of applied ecology

[Effects of sawdust dosage on the diversity and community structure of bacteria associated with the hyphae of Pleurotus eryngii].

Some fungi engage symbiosis with bacteria, which can effectively promote the metabolism and growth of fungi. The diversity and community structure of bacteria can reflect the growth and substrate utilization of fungi..

Gut & microbiome

High relevance

Cordyceps · 2020 · Journal Article · Natural product research

1H NMR-based metabonomics of the hypoglycemic effect of polysaccharides from Cordyceps militaris on streptozotocin-induced diabetes in mice.

The crude polysaccharide was extracted from Cordyceps militaris. Material ratio of powder and water was 1:10.

Immune supportEnergy & fatigueMetabolic healthGut & microbiome