MycoData

Spiroinonotsuoxotriols A (1) and B (2), two highly rearranged pentacyclic triterpenoids featuring a novel 7(8 → 9)abeo-21,24-cyclo-lanostane skeleton, together with their proposed precursors 3-5, were isolated from the sclerotia of the white-rot fungus Inonotus obliquus..

High relevance

Shiitake · 2020 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Structure characterization of soluble dietary fiber fractions from mushroom Lentinula edodes (Berk.) Pegler and the effects on fermentation and human gut microbiota in vitro.

Aimed to evaluate the changes of three soluble dietary fibers from Lentinula edodes by-products (LESDF) with different molecular weights in the digestive system and their effects on large intestinal fermentation, fermentation products and the types of gut microbiota were determined..

Energy & fatigueMetabolic healthGut & microbiome

High relevance

Maitake · 2020 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

The hypoglycemic and renal protective effects of Grifola frondosa polysaccharides in early diabetic nephropathy.

Grifola frondosa is a basidiomycete polypore fungus. Polysaccharides from G.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Niu-Chang-Chih · 2020 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

The Leaf Extracts of Toona sinensis and Fermented Culture Broths of Antrodia camphorata Synergistically Cause Apoptotic Cell Death in Promyelocytic Leukemia Cells.

Toona sinensis is a common edible vegetable that is used in certain Chinese dishes and has importance in folk medicine. The leaf extracts of T sinensis possess and exhibit anticancer efficacy against various cancer cell types..

Oncology

High relevance

Turkey Tail · 2020 · Comparative Study · Bioprocess and biosystems engineering

Trametes versicolor laccase production using agricultural wastes: a comparative study in Erlenmeyer flasks, bioreactor and tray.

Laccases are very interesting biocatalysts of recognized importance for several industrial applications. Its production by Trametes versicolor, a white-rot fungus, was induced by a combination of cotton gin wastes (1%), a lignocellulosic waste, and vinasse (15%), an industrial by-product from sugarcane industry..

Energy & fatigue

High relevance

Oyster Mushroom · 2020 · Research Support, Non U.S. Gov'T · FEBS letters

Transcriptional shifts in delignification-defective mutants of the white-rot fungus Pleurotus ostreatus.

White-rot fungi efficiently degrade lignin and, thus, play a pivotal role in the global carbon cycle. However, the mechanisms of lignin degradation are largely unknown.

High relevance

Shiitake · 2020 · Research Support, Non U.S. Gov'T · PloS one

Transcriptome analysis of the edible mushroom Lentinula edodes in response to blue light.

Lentinula edodes is one of the most popular edible mushrooms worldwide and contains important medicinal components such as lentinan, ergosterol, and eritadenine. Mushroom metabolism is regulated by the mycelia and fruit body using light; however, in mushrooms, the underlying molecular mechanisms controlling this….

Energy & fatigue

High relevance

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · BMC microbiology

Uncovering fungal community composition in natural habitat of Ophiocordyceps sinensis using high-throughput sequencing and culture-dependent approaches.

BACKGROUND: The fungal communities inhabiting natural Ophiocordyceps sinensis play critical ecological roles in alpine meadow ecosystem, contribute to infect host insect, influence the occurrence of O. sinensis, and are repertoire of potential novel metabolites discovery..

Gut & microbiome

High relevance

Lion's Mane · 2020 · Research Support, Non U.S. Gov'T · Genomics

Whole genome sequence of an edible and medicinal mushroom, Hericium erinaceus (Basidiomycota, Fungi).

Hericium erinaceus is a well-known culinary and medicinal mushroom in China. The biological and genetic studies on this mushroom is rare, thereby hindering the breeding of elite cultivars.

High relevance

Almond Mushroom · 2019 · Comparative Study · Food research international (Ottawa, Ont.)

A comparative study between conventional and non-conventional extraction techniques for the recovery of ergosterol from Agaricus blazei Murrill.

Response surface methodology was applied to optimize the recovery of ergosterol from an agroindustrial residue of Agaricus blazei Murrill, by comparing conventional (heat-assisted extraction, HAE) and more sustainable non-conventional approaches (ultrasound and microwave-assisted extractions, UAE and MAE,….

Energy & fatigue

High relevance

Maitake · 2019 · Comparative Study · Food & function

A comparative study on the structures of Grifola frondosa polysaccharides obtained by different decolourization methods and their in vitro antioxidant activities.

Decolourization of polysaccharides is one of the crucial procedures that affects their structure, which is closely related to their bioactivity. Here, Grifola frondosa polysaccharide (GFP) was decolourized with H2O2 and AB-8 macroporous resin..

Immune supportMetabolic health

High relevance

Shiitake · 2019 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Analysis of volatile compounds of Lentinula edodes grown in different culture substrate formulations.

Volatile compounds of Lentinula edodes grown in different culture substrate (CS) formulations were analyzed to reveal (i) the relationship between volatile compound production and CS formulations, (ii) the contribution of volatile compounds to L..

High relevance

Niu-Chang-Chih · 2019 · Research Support, Non U.S. Gov'T · Journal of cellular physiology

Antrodia camphorata inhibits epithelial-to-mesenchymal transition by targeting multiple pathways in triple-negative breast cancers.

Antrodia camphorata (AC) exhibits potential for engendering cell-cycle arrest as well as prompting apoptosis and metastasis inhibition in triple-negative breast cancer (TNBC) cells..

OncologyRespiratory

High relevance

Shiitake · 2019 · Comparative Study · BMC genomics

Comparative transcriptome analysis identified candidate genes involved in mycelium browning in Lentinula edodes.

BACKGROUND: Lentinula edodes is one of the most popular edible mushroom species in the world and contains useful medicinal components, such as lentinan. The light-induced formation of brown film on the vegetative mycelial tissues of L..

High relevance

Wood Ear · 2019 · Comparative Study · Scientific reports

Comparative transcriptome analysis reveals relationship of three major domesticated varieties of Auricularia auricula-judae.

Auricularia auricula-judae is an edible mushroom and a traditional medicine in China as well as the fourth largest cultivated mushroom species in the world. Here for the first time, we present comparative transcriptome analyses of the fruiting bodies of three morphologically distinguishable A..

Skin & hydration

High relevance

Shiitake · 2019 · Research Support, Non U.S. Gov'T · Genes

Effects of Medium Composition and Genetic Background on Agrobacterium-Mediated Transformation Efficiency of Lentinula edodes.

The establishment of genetic transformation method is crucial for the functional genomics research in filamentous fungi. Although the transformation method has been developed in several types of fungi, a highly efficient and convenient transformation system is desperately needed in Lentinula edodes..

Cognition & nerves

High relevance

Shiitake · 2019 · Research Support, Non U.S. Gov'T · Genes

Expression Profile of Laccase Gene Family in White-Rot Basidiomycete Lentinula edodes under Different Environmental Stresses.

Laccases belong to ligninolytic enzymes and play important roles in various biological processes of filamentous fungi, including fruiting-body formation and lignin degradation. The process of fruiting-body development in Lentinula edodes is complex and is greatly affected by environmental conditions..

Metabolic healthSkin & hydration

High relevance

Enoki · 2019 · Case Reports · 3 Biotech

First report of the nematicidal activity of Flammulina velutipes, its spent mushroom compost and metabolites.

The aim of the present work was to evaluate the nematicidal potential of Flammulina velutipes and its spent mushroom compost. Additionally, the nematicidal activity of enzymes and metabolites was analyzed.

High relevance

Shiitake · 2019 · Research Support, Non U.S. Gov'T · Scientific reports

Mitogenome types of two Lentinula edodes sensu lato populations in China.

China has two populations of Lentinula edodes sensu lato as follows: L. edodes sensu stricto and an unexcavated morphological species respectively designated as A and B..

Energy & fatigue

High relevance

Cordyceps · 2019 · Research Support, Non U.S. Gov'T · Zoology (Jena, Germany)

Phylogeographic structures of the host insects of Ophiocordyceps sinensis.

A fungus-insect complex, known as DongChong XiaCao, is formed from the infection of the hepialid larvae by the fungus Ophiocordyceps sinensis, which is endemic to the Qinghai-Tibetan Plateau (QTP)..

Energy & fatigue

High relevance

Mesima · 2019 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Potential Impact of Phellinus linteus on Adherence to Adjuvant Treatment After Curative Resection of Pancreatic Ductal Adenocarcinoma: Outcomes of a Propensity Score-Matched Analysis.

BACKGROUND: Surgical resection followed by adjuvant chemotherapy is the only therapeutic option in pancreatic cancer. However, there is limited research evaluating methods of improving adherence to adjuvant treatment after curative resection..

Oncology

High relevance

Lion's Mane · 2019 · Comparative Study · Neurological research

Regenerative activity of Hericium erinaceus on axonal injury model using in vitro laser microdissection technique.

OBJECTIVE: Peripheral nerve injury (PNI) is an important global health problem. Nerve Growth Factor (NGF) plays crucial role in the survival, growth, and maintenance of various neurons in the mammalian nervous system, human included..

Cognition & nerves

High relevance

Shiitake · 2019 · Research Support, Non U.S. Gov'T · Genes

Selection and Validation of Reference Genes for qRT-PCR in Lentinula edodes under Different Experimental Conditions.

Lentinula edodes is the most consumed mushroom in Asia due to its nutritional and medicinal values, and the optimal reference gene is crucial for normalization of its gene expression analysis. Here, the expression stability of 18 candidate reference genes (CRGs) in L..

High relevance

Turkey Tail · 2019 · Research Support, Non U.S. Gov'T · Protein science: a publication of the Protein Society

The structure of Trametes versicolor glutathione transferase Omega 3S bound to its conjugation product glutathionyl-phenethylthiocarbamate reveals plasticity of its active site.

Trametes versicolor glutathione transferase Omega 3S (TvGSTO3S) catalyzes the conjugation of isothiocyanates (ITC) with glutathione (GSH). Previously, this isoform was investigated in depth both biochemically and structurally..

High relevance

Shiitake · 2019 · Research Support, Non U.S. Gov'T · Genes

Variable Number Tandem Repeats in the Mitochondrial DNA of Lentinula edodes.

Variable number tandem repeats (VNTRs) in mitochondrial DNA (mtDNA) of Lentinula edodes are of interest for their role in mtDNA variation and their application as genetic marker. Sequence analysis of three L.

Energy & fatigue

High relevance

Enoki · 2018 · Comparative Study · Journal of agricultural and food chemistry

A Comparative Proteome Approach Reveals Metabolic Changes Associated with Flammulina velutipes Mycelia in Response to Cold and Light Stress.

In some industrial processes, cold and light stresses are recognized as two important environmental triggers for the transformation of mycelia into fruit-bodies via intermediate primordia in Flammulina velutipes cultivation. To gain insights into the mechanism of regulation of F..

Energy & fatigueMetabolic health

High relevance

Almond Mushroom · 2018 · Evaluation Study · Food & function

A natural food ingredient based on ergosterol: optimization of the extraction from Agaricus blazei, evaluation of bioactive properties and incorporation in yogurts.

In recent years, mycosterols have emerged as potential functional ingredients for the development of sterol-enriched food products and dietary supplements. Agaricus blazei is a mushroom rich in bioactive compounds.

Liver support

High relevance

Niu-Chang-Chih · 2018 · Research Support, Non U.S. Gov'T · Cytokine

Analogous corticosteroids, 9A and EK100, derived from solid-state-cultured mycelium of Antrodia camphorata inhibit proinflammatory cytokine expression in macrophages.

Antrodia camphorata mycelium is used in traditional Chinese medicine in Taiwan. The wild-type mycelium is rare and expensive, so a solid-state-cultured mycelium of A.

Immune supportRespiratory

High relevance

Shiitake · 2018 · Research Support, Non U.S. Gov'T · Fungal biology

Cell wall structure of secreted laccase-silenced strain in Lentinula edodes.

Laccase1 (Lcc1) is abundantly secreted from vegetative mycelia into culture medium by Lentinula edodes. Down-regulation of lcc1 in L.

Immune support

High relevance

Almond Mushroom · 2018 · Research Support, Non U.S. Gov'T · Journal of food and drug analysis

Characteristics of fucose-containing polysaccharides from submerged fermentation of Agaricus blazei Murill.

Fucose is one of important residues of recognition pattern for many immune cells. In this study, we characterized bioactive fucose-containing acidic polysaccharides from submerged fermentation of Agaricus blazei Murill..

Immune supportCognition & nervesMetabolic health

High relevance

Lion's Mane · 2018 · Comparative Study · Nutrients

Chondroprotective Effects of a Standardized Extract (KBH-JP-040) from Kalopanax pictus, Hericium erinaceus, and Astragalus membranaceus in Experimentally Induced In Vitro and In Vivo Osteoarthritis Models.

The aim of this study was to investigate the chondroprotective effect of a standardized extract (KBH-JP-040) of the Korean traditional herbs Kalopanax pictus Castor-Aralia, Hericium erinaceus (Bull.) Persoon, and Astragalus membranaceus Schischkin on in vivo and in vitro osteoarthritis (OA) models..

Immune supportMetabolic healthSkin & hydration

High relevance

Enoki · 2018 · Evaluation Study · Journal of food and drug analysis

Combination of on-line desalting and HPLC-UV-ESI-MS for simultaneous detection and identification of FIP-fve and flammutoxin in Flammulina velutipes.

A rapid analytical approach, on-line desalting HPLC-UV-ESI-MS method, for the analysis of FIP-fve and flammutoxin (FTX), two important bioactive proteins in the fruiting bodies of Flammulina velutipes, was developed..

Gut & microbiome

High relevance

Shiitake · 2018 · Comparative Study · Scientific reports

Comparative transcriptome analysis of dikaryotic mycelia and mature fruiting bodies in the edible mushroom Lentinula edodes.

Lentinula edodes is a popular cultivated edible mushroom with high nutritional and medicinal value. To understand the regulation of gene expression in the dikaryotic mycelium and mature fruiting body in the commercially important Korean L..

Energy & fatigue

High relevance

Enoki · 2018 · Comparative Study · Journal of basic microbiology

De novo transcriptome sequencing of Flammulina velutipes uncover candidate genes associated with cold-induced fruiting.

To understand molecular mechanism of cold-induced fruiting in Flammulina velutipes, which is one of most popular edible fungi in east Asia, de novo assembly of the F. velutipes transcriptome was carried out.

High relevance

Chaga · 2018 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Effects of simulated gastrointestinal digestion in vitro on the chemical properties, antioxidant activity, α-amylase and α-glucosidase inhibitory activity of polysaccharides from Inonotus obliquus.

This study was aimed to investigate the impacts of gastrointestinal digestion in vitro on the physicochemical properties and the biological activities of polysaccharides from Inonotus obliquus (UIOPS-1)..

Immune supportMetabolic healthGut & microbiome

High relevance

Shiitake · 2018 · Research Support, Non U.S. Gov'T · Virus research

Genetic variation and phylogenetic analyses reveal transmission clues of Lentinula edodes partitivirus 1 (LePV1) from the Chinese L. edodes core collection.

Lentinula edodes partitivirus 1 (LePV1), a new mycovirus possibly responsible for serious morphological deformities during L. edodes cultivation, is widespread in the Chinese L.

Respiratory

High relevance

Almond Mushroom · 2018 · Research Support, Non U.S. Gov'T · Biotechnology progress

High-performance of Agaricus blazei fungus for the biological pretreatment of elephant grass.

Biological pre-treatment seems to be promising being an eco-friendly process, with no inhibitor generated during the process. The potential for elephant grass pre-treatment with white degradation fungi Pleurotus ostreatus, Agaricus blazei, Lentinula edodes, Pleurotus citrinopileatus, and Pleurotus djamor, in isolated….

Energy & fatigue

High relevance

Chaga · 2018 · Research Support, Non U.S. Gov'T · Molecular and cellular probes

Immunopotentiating effect of Inonotus obliquus fermentation products administered at vaccination in chickens.

Vaccination is an important approach for the control of avian viral diseases. The aim of this study was to evaluate the immune-potentiating effect of oral administration of Inonotus obliquus fermentation products (IOFP) at vaccination in chickens..

Immune supportRespiratory

High relevance

Turkey Tail · 2018 · Research Support, Non U.S. Gov'T · Scientific reports

Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor.

Wood decay fungi have complex detoxification systems that enable them to cope with secondary metabolites produced by plants. Although the number of genes encoding for glutathione transferases is especially expanded in lignolytic fungi, little is known about their target molecules..

Cognition & nerves

High relevance

Cordyceps · 2018 · Research Support, Non U.S. Gov'T · Scientific reports

Multiuse of Bar-HRM for Ophiocordyceps sinensis identification and authentication.

Bar-HRM is a hybrid method which combines DNA barcoding and High Resolution Melting analysis. It has proven to be a fast, cost-effective and reliable molecular approach for species identification and authentication.

High relevance

Lion's Mane · 2018 · Research Support, Non U.S. Gov'T · The Journal of nutritional biochemistry

Polysaccharide of Hericium erinaceus attenuates colitis in C57BL/6 mice via regulation of oxidative stress, inflammation-related signaling pathways and modulating the composition of the gut microbiota.

Inflammatory bowel disease (IBD) is a disease caused by a dysregulated immune with unknown etiology. Hericium erinaceus (H.

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Turkey Tail · 2018 · Research Support, Non U.S. Gov'T · PloS one

Potential activities and mechanisms of extracellular polysaccharopeptides from fermented Trametes versicolor on regulating glucose homeostasis in insulin-resistant HepG2 cells.

Polysaccharides derived from mushrooms have potential to control blood sugar, reduce insulin resistance and prevent diabetic complications. The intracellular polysaccharopeptides of Trametes versicolor (TV) have been used as immunologic and oncologic adjuvants..

OncologyImmune supportMetabolic healthLiver support

High relevance

Cordyceps · 2018 · Research Support, Non U.S. Gov'T · Fungal biology

Profile of Ophiocordyceps sinensis transcriptome and differentially expressed genes in three different mycelia, sclerotium and fruiting body developmental stages.

Ophiocordyceps sinensis, a Chinese complementary and alternative medicine (CAM), is an entomopathogenic, fungus, parasitizing larvae of the moth genus Thitarodes..

High relevance

Enoki · 2018 · Research Support, Non U.S. Gov'T · Scientific reports

Structural elucidation of a polysaccharide from Flammulina velutipes and its immunomodulation activities on mouse B lymphocytes.

A novel polysaccharide FVPB2 was purified from fruiting bodies of Flammulina velutipes. Its structure was elucidated by monosaccharide composition and methylation analyses, UV-Visible and FTIR spectroscopy as well as NMR..

Immune supportMetabolic health

High relevance

Shiitake · 2018 · Research Support, Non U.S. Gov'T · Fungal genetics and biology: FG & B

The heat shock protein 40 LeDnaJ regulates stress resistance and indole-3-acetic acid biosynthesis in Lentinula edodes.

DnaJ proteins, termed heat shock proteins based on their molecular weight, function as molecular chaperones that play critical roles in regulating organism growth and development as well as adaptation to the environment. However, little has been reported on their gene function in higher basidiomycetes..

High relevance

Turkey Tail · 2018 · Research Support, Non U.S. Gov'T · FEBS letters

Trametes versicolor glutathione transferase Xi 3, a dual Cys-GST with catalytic specificities of both Xi and Omega classes.

Glutathione transferases (GSTs) from the Xi and Omega classes have a catalytic cysteine residue, which gives them reductase activities. Until now, they have been assigned distinct substrates..

High relevance

Enoki · 2018 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Variation of volatile terpenes in the edible fungi mycelia Flammulina velutipes and communications in fungus-mite interactions.

Many mites rely on fungi for nutrients, and fungi benefit from them with regard to spore dispersal, or nutrient resources. The interactions among mites and fungi are still not clear in most cases..

High relevance

Snow Fungus · 2017 · Brief Report · Mycobiology

An Improved Total RNA Extraction Method for White Jelly Mushroom Tremella fuciformis Rich in Polysaccharides.

An improved method for extracting high quality and quantity RNA from a jelly mushroom and a dimorphic fungus-Tremella fuciformis which is especially rich in polysaccharides, is described. RNA was extracted from T.

Immune support

High relevance

Lion's Mane · 2017 · Research Support, Non U.S. Gov'T · Scientific reports

Antihyperglycaemic and organic protective effects on pancreas, liver and kidney by polysaccharides from Hericium erinaceus SG-02 in streptozotocin-induced diabetic mice.

The present work was designed to investigate the antihyperglycaemic and protective effects of two Hericium erinaceus intracellular polysaccharide (HIPS) purified fractions (HIPS1 and HIPS2) from mycelia of H. erinaceus SG-02 on pancreas, liver and kidney in streptozotocin (STZ)-induced diabetic mice..

Immune supportMetabolic healthLiver support

High relevance

Enoki · 2017 · Comparative Study · Journal of agricultural and food chemistry

Comparative Proteome Reveals Metabolic Changes during the Fruiting Process in Flammulina velutipes.

Understanding the molecular mechanisms regulating the fruiting process in macro-fungi, especially industrially cultivated mushrooms, has long been a goal in mycological research..

Metabolic health