MycoData

OncologyImmune supportEnergy & fatigueLiver support

Niu-Chang-Chih · 2015 · Research Support, Non U.S. Gov'T · PloS one

Apoptosis of Hepatocellular Carcinoma Cells Induced by Nanoencapsulated Polysaccharides Extracted from Antrodia Camphorata.

Antrodia camphorata is a well-known medicinal mushroom in Taiwan and has been studied for decades, especially with focus on anti-cancer activity. Polysaccharides are the major bioactive compounds reported with anti-cancer activity, but the debates on how they target cells still remain..

Shiitake · 2015 · Brief Report · Toxicology reports

Deficiency of macro- and micronutrients induced by Lentinula edodes.

Mushroom Lentinula edodes has been widely studied therapeutically. However, there is no data regarding its daily intake level safety.

Energy & fatigueMetabolic healthLiver support

Niu-Chang-Chih · 2015 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Ergostatrien-3β-ol from Antrodia camphorata inhibits diabetes and hyperlipidemia in high-fat-diet treated mice via regulation of hepatic related genes, glucose transporter 4, and AMP-activated protein kinase phosphorylation.

This study was designed to explore the effects and mechanism of ergostatrien-3β-ol (EK100) from the submerged whole broth of Antrodia camphorata on diabetes and dyslipidemia in high fat diet (HFD)-fed mice for 12 weeks..

Snow Fungus · 2015 · Research Support, Non U.S. Gov'T · Biotechnology letters

Oral vaccination of mice with Tremella fuciformis yeast-like conidium cells expressing HBsAg.

Tremella fuciformis yeast-like conidium (YLC) cells were transformed by co-cultivation with Agrobacterium cells harboring the hepatitis B surface antigen (HBsAg) gene construct under the control of the CaMV35S promoter. Integration of HBsAg DNA into the YLC genome was confirmed by PCR and dot-blot hybridization..

OncologyImmune supportMetabolic healthLiver support

Niu-Chang-Chih · 2015 · Research Support, Non U.S. Gov'T · BioMed research international

The Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Induces Cell Cycle Arrest and Enhances Cytotoxicity of Cisplatin and Doxorubicin on Human Hepatocellular Carcinoma Cells.

Taiwanofungus camphoratus (synonym Antrodia camphorata) is a widely used medicinal fungus in the folk medicine of Taiwan with several pharmacological features such as anti-inflammatory, liver protection, antihypertensive, and antioxidative activities. The ethanolic extract of T..

Chaga · 2014 · Research Support, Non U.S. Gov'T · Journal of natural products

Chemical constituents from Inonotus obliquus and their biological activities.

Seven new triterpenes, inonotusol A-G (1-7), one new diterpene, inonotusic acid (8), and 22 known compounds were isolated from Inonotus obliquus. Their structures were elucidated on the basis of spectroscopic analysis, including homonuclear and heteronuclear correlation NMR ((1)H-(1)H COSY, ROESY, HSQC, and HMBC)….

Immune supportEnergy & fatigueMetabolic healthLiver support

Mesima · 2014 · Comparative Study · International journal of food sciences and nutrition

Effects of polysaccharide from fruiting bodies of Agaricus bisporus, Agaricus brasiliensis, and Phellinus linteus on alcoholic liver injury.

In the present study, the curative effects of crude polysaccharides (PSs) from mushrooms on the symptoms of alcoholic liver injury were investigated. PSs from Agaricus bisporus, Agaricus brasiliensis, and Phellinus linteus fruiting bodies were administered by gavage at levels of 100 mg per kg body weight per day for 7….

Cognition & nervesLiver support

Almond Mushroom · 2014 · Research Support, Non U.S. Gov'T · Molecules (Basel, Switzerland)

Effects of the continuous administration of an Agaricus blazei extract to rats on oxidative parameters of the brain and liver during aging.

An investigation of the effects of an aqueous extract of Agaricus blazei, a medicinal mushroom, on the oxidative state of the brain and liver of rats during aging (7 to 23 months) was conducted. The treatment consisted in the daily intragastric administration of 50 mg/kg of the extract.

OncologyCognition & nervesLiver supportRespiratory

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · TheScientificWorldJournal

Extract of Antrodia camphorata exerts neuroprotection against embolic stroke in rats without causing the risk of hemorrhagic incidence.

In this study, the neuroprotective effect of an extract of Antrodia camphorata (A. camphorata), a fungus commonly used in Chinese folk medicine for treatment of viral hepatitis and cancer, alone or in combination with aspirin was investigated in a rat embolic stroke model..

OncologyImmune supportEnergy & fatigueLiver support

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Methanol extract of Antrodia camphorata protects against lipopolysaccharide-induced acute lung injury by suppressing NF-κB and MAPK pathways in mice.

Antrodia camphorata (AC) has been used as a herbal medicine for drug intoxication for the treatment of inflammation syndromes and liver-related diseases in Taiwan. This study demonstrates the protective effect of the methanol extract of AC (MAC) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice..

OncologyImmune supportMetabolic healthLiver support

Mesima · 2013 · Research Support, Non U.S. Gov'T · Chemico-biological interactions

Activation of P27kip1-cyclin D1/E-CDK2 pathway by polysaccharide from Phellinus linteus leads to S-phase arrest in HT-29 cells.

Our previous study showed that polysaccharide (P1) from Phellinus linteus exhibits a significant inhibitive activity on human colorectal carcinoma cells (HT-29). However its novel molecular mechanism remains unknown..

Immune supportEnergy & fatigueLiver supportSkin & hydration

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Applied microbiology and biotechnology

Antrodia camphorata-fermented product cultured in deep ocean water has more liver protection against thioacetamide-induced fibrosis.

Antrodia camphorata is a unique fungus in Taiwan; the submerged fermentation product is used as the functional food for liver protection. Deep ocean water (DOW) containing rich metals and trace elements is proven to stimulate the production of functional metabolites and health function of functional fungus product in….

Enoki · 2013 · Research Support, Non U.S. Gov'T · International journal of pharmaceutics

Cytotoxic effect of novel Flammulina velutipes sterols and its oral bioavailability via mixed micellar nanoformulation.

The aim of this study was to investigate the anti-tumor effect of sterols initially separated from Flammulina velutipes and the pharmacokinetics and tissue distribution after oral administration of F. velutipes sterol nanomicelles (FVSNs).

Immune supportCognition & nervesMetabolic healthLiver support

Almond Mushroom · 2013 · Research Support, Non U.S. Gov'T · BioMed research international

Effects of an Agaricus blazei aqueous extract pretreatment on paracetamol-induced brain and liver injury in rats.

The action of an Agaricus blazei aqueous extract pretreatment on paracetamol injury in rats was examined not only in terms of the classical indicators (e.g., levels of hepatic enzymes in the plasma) but also in terms of functional and metabolic parameters (e.g., gluconeogenesis)..

OncologyLiver supportRespiratory

Enoki · 2013 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Enhanced oral bioavailability and tissue distribution of a new potential anticancer agent, Flammulina velutipes sterols, through liposomal encapsulation.

This study innovatively investigated the anticancer effect of Flammulina velutipes sterols (FVSs), the in vivo pharmacokinetics, and the tissue distribution of FVS-loaded liposomes..

OncologyImmune supportEnergy & fatigueLiver support

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Food chemistry

Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury.

The hepatoprotective effects of eburicoic acid (TR1) and dehydroeburicoic acid (TR2) from Antrodia camphorata (AC) against carbon tetrachloride (CCl4)-induced liver damage were investigated in mice. TR1 and TR2 was administered intraperitoneally (i.p.) for 7 days prior to the administration of CCl4..

OncologyImmune supportMetabolic healthLiver support

Mesima · 2013 · Research Support, Non U.S. Gov'T · The American journal of Chinese medicine

Hispolon from Phellinus linteus induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukaemia cells.

Hispolon (a phenolic compound isolated from Phellinus linteus) has been shown to possess strong antioxidant, anti-inflammatory, anticancer, and antidiabetic properties..

OncologyImmune supportEnergy & fatigueLiver support

Yellow Morel · 2013 · Research Support, Non U.S. Gov'T · Biotechnology letters

Induction of apoptosis in HepG2 cells by polysaccharide MEP-II from the fermentation broth of Morchella esculenta.

A novel polysaccharide, MEP-II, isolated from the fermentation broth of Morchella esculenta inhibited the proliferation of human hepatoma cell line (HepG2) through an apoptotic pathway..

OncologyCognition & nervesEnergy & fatigueLiver support

Mesima · 2013 · Research Support, Non U.S. Gov'T · Phytomedicine: international journal of phytotherapy and phytopharmacology

Phellinus linteus mushroom protects against tacrine-induced mitochondrial impairment and oxidative stress in HepG2 cells.

Tacrine (THA) was the first drug licensed for the treatment of Alzheimer's disease. Unfortunately, reversible hepatotoxicity is evident in about 30% of patients and limits its clinical use.

Chaga · 2012 · English Abstract · Yao xue xue bao = Acta pharmaceutica Sinica

[Triterpenoids from Inonotus obliquus protect mice against oxidative damage induced by CCl4].

To investigate the effects of lanosterol (1), inotodiol (2) and trametenolic acid (3) from Inonotus obliquus against oxidative damage induced by CCl4 in mice, 1, 2 and 3 (20, 10 and 5 mg x kg(-1)) were respectively administered to mice, once a day for 3 days..

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · Anticancer research

Anticancer effects of eleven triterpenoids derived from Antrodia camphorata.

Eleven derivatives from Antrodia camphorata were isolated in order to evaluate their selective cytotoxicity toward 14 types of human cancer cell and two non-transformed cell types..

Lion's Mane · 2012 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Antioxidant and hepatoprotective potential of endo-polysaccharides from Hericium erinaceus grown on tofu whey.

Three fractions of the endo-polysaccharides from the mycelium of Hericium erinaceus (HEP) grown on tofu whey were obtained by the fractional precipitation with gradient concentrations of ethanol (HEP40, HEP60 and HEP80)..

Immune supportGut & microbiomeLiver support

Lion's Mane · 2012 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Hericium erinaceus mushroom extracts protect infected mice against Salmonella Typhimurium-Induced liver damage and mortality by stimulation of innate immune cells.

The present study investigated the antibacterial effect of four extracts from the fruitbody of the edible medicinal mushroom Hericium erinaceus (hot water extract, HWE; microwave/50% ethanol extract, MWE; acid extract, ACE; and alkaline extract, AKE) against murine salmonellosis..

Maitake · 2012 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Isolation, purification and antioxidant activities of polysaccharides from Grifola frondosa.

The crude polysaccharides (GFP) were isolated from the fruiting bodies of Grifola frondosa and purified by DEAE cellulose-52 chromatography and Sephadex G-100 size-exclusion chromatography in that order. Three main fractions, GFP-1, GFP-2 and GFP-3, were obtained through the isolation and purification steps..

OncologyImmune supportLiver support

Niu-Chang-Chih · 2011 · Other · Evidence-based complementary and alternative medicine: eCAM

An Extract of Antrodia camphorata Mycelia Attenuates the Progression of Nephritis in Systemic Lupus Erythematosus-Prone NZB/W F1 Mice.

Antrodia camphorata is used in folk medicine for the treatment of inflammation syndromes and liver-related diseases in Taiwan. The goal of this study was to evaluate the efficacy of the mycelial extract of A.

Niu-Chang-Chih · 2011 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway.

The triterpenoids methylantcinate B (MAB) and antcin B (AB), isolated from the medicinal mushroom Antrodia camphorata, have been identified as strong cytotoxic agents against various type of cancer cells; however, the mechanisms of MAB- and AB-induced cytotoxicity have not been adequately explored..

Niu-Chang-Chih · 2011 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Effects of Antrodia camphorata on alcohol clearance and antifibrosis in livers of rats continuously fed alcohol.

Alcoholic fatty liver disease (AFLD) is the result of an excessive or chronic consumption of alcohol. Nine male Wistar rats per group were randomly assigned to one of the following drinking treatments: a 20% (w/w) alcohol solution (ALC); a 20% (w/w) alcohol solution cotreated with 0.25 g silymarin/kg BW/day; or a 20%….

Niu-Chang-Chih · 2011 · Research Support, Non U.S. Gov'T · Natural product research

Further studies on the hepatoprotective effect of Antrodia camphorata in submerged culture on ethanol-induced acute liver injury in rats.

To further understand the hepatoprotective activity of Antrodia camphorata in living systems and the possible mechanisms of this protection, the effects of fractions from A. camphorata in submerged culture on the liver and its antioxidative system in acute ethanol intoxicated rats were investigated..

Immune supportMetabolic healthLiver supportRespiratory

Maitake · 2011 · Comparative Study · Journal of agricultural and food chemistry

Profiling of hepatic gene expression of mice fed with edible japanese mushrooms by DNA microarray analysis: comparison among Pleurotus ostreatus, Grifola frondosa, and Hypsizigus marmoreus.

To compare and estimate the effects of dietary intake of three kinds of mushrooms (Pleurotus ostreatus, Grifola frondosa, and Hypsizigus marmoreus), mice were fed a diet containing 10-14% of each mushroom for 4 weeks. Triacylglycerol in the liver and plasma decreased and plasma cholesterol increased in the P..

OncologyImmune supportLiver support

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3beta-ol from Antrodia camphorata submerged whole broth in mice.

Ergostatrien-3beta-ol (ST1), an active and major ingredient from Antrodia camphorata (AC) submerged whole broth was evaluated for the analgesic and anti-inflammatory effects..

Metabolic healthLiver support

Chaga · 2010 · Research Support, Non U.S. Gov'T · Natural product research

Beneficial effects of the ethanol extract from the dry matter of a culture broth of Inonotus obliquus in submerged culture on the antioxidant defence system and regeneration of pancreatic beta-cells in experimental diabetes in mice.

The antihyperglycaemic and antilipidperoxidative effects of the ethanol extract from the dry matter of a culture broth (DMCB) of Inonotus obliquus were investigated in alloxan-induced diabetic mice and the possible mechanism of action was also discussed..

Yellow Morel · 2010 · Research Support, Non U.S. Gov'T · Bioresource technology

Extraction optimization and in vivo antioxidant activities of exopolysaccharide by Morchella esculenta SO-01.

Response surface methodology was used to optimize extraction parameters for Morchella esculenta SO-01 exopolysaccharide (EPS) produced during submerged culture. The optimum conditions for EPS extraction were predicted to be, concentration at 84.07 degrees C, precipitation for 22.19 h and pH 8.44, and EPS production….

Metabolic healthLiver support

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage.

An alcoholic fatty liver disease was induced by drinking water containing 20% (w/w) alcohol. Therapeutic groups were orally administrated dosages of 0.25 g silymarin/kg body weight (BW) and a low dosage of Niuchangchih (Antrodia camphorata) (0.025 g/kg BW) and a high dosage of Niuchangchih (0.1 g/kg BW) per day..

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Chemical research in toxicology

Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway.

We investigated the effects of antcin A, antcin C, and methyl antcinate A (MAA) isolated from Antrodia camphorata on the proliferation of human liver cancer cell lines Huh7, HepG2, and Hep3B and the normal cell rat hepatocytes..

OncologyMetabolic healthLiver support

Chaga · 2010 · Research Support, Non U.S. Gov'T · Journal of the science of food and agriculture

Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus.

BACKGROUND: Inonotus obliquus is a medicinal mushroom that has been used as an effective agent to treat various diseases such as diabetes, tuberculosis and cancer. In order to elucidate the active fraction and its constituents, the effects of ethyl acetate fraction from I..

Energy & fatigueLiver support

Mesima · 2009 · Research Support, Non U.S. Gov'T · BMB reports

Anti-oxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage.

Anti-oxidative effect of Phellinus linteus (P. linteus) and red ginseng extracts on DNA damage induced by reactive oxygen species (ROS) were investigated in this study.

OncologyLiver supportRespiratory

Niu-Chang-Chih · 2009 · Patent · journal metadata

Novel compounds from antrodia camphorata

Antroquinonol B (X=OH) and Antroquinonol C (X=OMe) are described. They can be isolated from Antrodia camphorata extracts and may inhibit the growth of cancer cells (e.g.

Niu-Chang-Chih · 2009 · Research Support, Non U.S. Gov'T · ChemMedChem

Rapid evaluation of Antrodia camphorata natural products and derivatives in tumourigenic liver progenitor cells with a novel cell proliferation assay.

We report the syntheses of five natural product maleimide and maleic anhydrides from the mushroom Antrodia camphorata. The ability of these compounds to affect proliferation in non-tumourigenic and tumourigenic liver progenitor cell lines was monitored by the Cellscreen system, a novel and nondestructive….

Niu-Chang-Chih · 2009 · Research Support, Non U.S. Gov'T · The American journal of Chinese medicine

The augmented anti-tumor effects of Antrodia camphorata co-fermented with Chinese medicinal herb in human hepatoma cells.

Antrodia camphorata, unique fungal specie, has been used as a folk medicine in Taiwan for many years. The purpose of this study was to compare the extracts from the solid-state culture of A..

Niu-Chang-Chih · 2008 · Patent · journal metadata

4-hydroxy-2,3-disubstituted-cyclohex-2-en-1-on-5-yl isoprenoids, extractable from Antrodia camphorata, as anti-tumour & cardiovascular agents, & antioxidant

Compounds of formula (1): '''wherein: X and Y are O or S R' are independently H or C1-13 linear alkyl and n is 1-12 can be isolated and purified from an extract of Antrodia camphorata, and used to inhibit the growth of cancer cells (such as breast cancer, hepatic cancer and prostate cancer), to prevent heart disease….

Niu-Chang-Chih · 2008 · Patent · journal metadata

Cyclohexenone compounds from Antrodia Camphorata for use in the treatment of liver disease

A compound of formula (I) as defined therein can be obtained from Antrodia camphorata and finds use in liver protection, in particular 4-hydroxy-2,3-dimethoxy-6-methyl- 5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone..

OncologyImmune supportEnergy & fatigueLiver support

Chaga · 2008 · Research Support, Non U.S. Gov'T · Current microbiology

Identification of Inonotus obliquus and analysis of antioxidation and antitumor activities of polysaccharides.

Inonotus obliquus, a wild wood-decay fungus which grows on Betula trees in cool climates, has a variety of biological activities that the scientific community is paying more and more attention to. However, the research work is moving at a snail's pace..

Niu-Chang-Chih · 2008 · Patent · journal metadata

LIVER PROTECTION COMPOUNDS OF THE CYCLOHEXENONE TYPE FROM ANTRODIA CAMPHORATA

The present invention relates to a compound of Antrodia camphorata used for liver protection, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated from Antrodia camphorate..

Niu-Chang-Chih · 2008 · Patent · journal metadata

NOVEL CYCLOHEXENONE COMPOUNDS FROM ANTRODIA CAMPHORATA AND APPLICATION THEREOF

A cyclohexenone compound is provided to suppress the growth of cancer cells such as breast cancer, liver cancer, and prostatic cancer, and to ensure antioxidant activities..

OncologyImmune supportLiver supportRespiratory

Niu-Chang-Chih · 2008 · Research Support, Non U.S. Gov'T · International immunopharmacology

Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni.

Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities..

Niu-Chang-Chih · 2007 · Research Support, Non U.S. Gov'T · Planta medica

A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata.

Antroquinonol ( 1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data..

OncologyImmune supportEnergy & fatigueLiver support

Maitake · 2007 · Research Support, Non U.S. Gov'T · Toxicology in vitro: an international journal published in association with BIBRA

Induction of apoptosis in SGC-7901 cells by polysaccharide-peptide GFPS1b from the cultured mycelia of Grifola frondosa GF9801.

The biological function of GFPPS1b, a novel polysaccharide-peptide isolated from cultured mycelia of Grifola frondosa GF9801, was well investigated. GFPS1b has anti-tumor activity and can significantly inhibit the proliferation of SGC-7901 cells, whereas slightly influences the growth of human normal liver cell line….

Mesima · 2007 · Research Support, Non U.S. Gov'T · Phytotherapy research: PTR

Protective effects of Phellinus linteus extract against iron overload-mediated oxidative stress in cultured rat hepatocytes.

Phellinus linteus (PL) mushroom has been reported to possess antioxidant activity. The present study was designed to investigate whether an ethanol extract obtained from PL might ameliorate oxidative stress and enhance antioxidant enzyme activities in primary rat hepatocytes, which were overloaded with iron using….