MycoData

Lion's Mane · 2026 · Research Article · Poultry science

Alleviation of heat stress-induced jejunal injury in ducks by Hericium erinaceus polysaccharide.

Heat stress (HS) poses a major challenge to the poultry industry, and Hericium erinaceus polysaccharide (HEP), with its antioxidant and anti-inflammatory properties, shows potential to mitigate HS-induced intestinal barrier damage..

OncologyImmune supportLiver support

Reishi · 2026 · Journal Article · BMC complementary medicine and therapies

An integrated strategy for screening Q-markers and elucidating anti-fibrotic mechanisms of Ganoderma lucidum.

BACKGROUND: Ganoderma lucidum (G. lucidum) is a medicinal mushroom known for its hepatoprotective effects against various liver diseases.

Immune supportRespiratory

Reishi · 2026 · Journal Article · Phytochemistry

Anti-influenza virus activities of triterpenes from the antler-shaped fruiting bodies of Ganoderma lucidum.

Ganoderma, a famous fungus, has traditionally been used in China for thousands of years. Fourteen previously undescribed triterpenes were isolated from the antler-shaped fruiting bodies of Ganoderma lucidum..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Almond Mushroom · 2026 · Journal Article · Animal feed science and technology

Astragalus polysaccharide and Agaricus Blazei polysaccharides improve growth performance, meat quality and health status of lambs via rescheduling the rumen microbiota

Since the banning of antibiotics, the use of green feed additives has become crucial for the healthy farming of mutton sheep. Astragalus polysaccharides (APS) and Agaricus Blazei polysaccharides (ABP) exhibit various functions such as antioxidation, immunomodulation, and meat quality improvement..

Immune supportEnergy & fatigueSkin & hydration

Snow Fungus · 2026 · Research Article · NPJ science of food

Beyond conventional drying: improving the quality of dried Tremella fuciformis via a heat-integrated pretreatment.

Hot-air drying (HAD) of Tremella fuciformis often results in poor rehydration capacity, yellowing, and long preparation times, which significantly reduce its industrial and consumer value. This study introduces a heat-integrated pretreatment (HIP) as a simple and viable strategy to improve the quality of dried T..

OncologyImmune supportSkin & hydration

Reishi · 2026 · Research Article · Pharmaceuticals (Basel, Switzerland)

Characterization of a New Biocomposite Based on Bioactive Compounds from Ganoderma lucidum and Jellyfish Collagen Destined for In Vitro Evaluation of Antitumor Effects in the Oral Cavity.

Background/Objectives: Oral squamous cell carcinoma (OSCC) remains a major therapeutic challenge due to treatment-related toxicity and impaired oral tissue regeneration..

Immune supportSkin & hydration

Maitake · 2026 · Journal Article · Journal of dairy science

Characterization of the gel-binding mechanism of Grifola frondosa polysaccharide and polymerized whey protein by simultaneous rheology and Fourier-transform infrared spectroscopy and its application in yogurt.

The study aimed to develop and characterize composite hydrogels composed of polymerized whey protein (PWP, 10% wt/vol) and Grifola frondosa polysaccharide (GFP, 0%-4% wt/vol) as a natural functional additive for yogurt..

Mesima · 2026 · Research Article · Foods (Basel, Switzerland)

Characterization of the Hydrogel-Binding Mechanism of Phellinus linteus Polysaccharides and Polymerized Whey Protein by SR-IR Technology and Its Application in Goat Milk Yogurt.

The development of natural biopolymers to improve the structural and textural defects of whey protein in acidic dairy products is of great interest. This study investigated the interaction between Phellinus linteus polysaccharides (PLPs) and heat-induced polymerized whey protein (PWP), and its application in goat milk….

Almond Mushroom · 2026 · Journal Article · International journal of biological macromolecules

Cold plasma degradation of Agaricus blazei Murill polysaccharides modulates the physicochemical characteristics of nano‑selenium and in vitro gastrointestinal Se release behavior.

Selenium nanoparticles (SeNPs) are a novel supplement with low toxicity but high instability. Polysaccharides are commonly used to stabilize selenium nanoparticles (SeNPs) to enhance their bioactivity..

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Comparative Analysis of Physicochemical Properties, Antioxidant and Enzyme Inhibitory Activities of Sporoderm-Broken Ganoderma lucidum Spore Powders from Different Regions in China.

Ganoderma lucidum spore powder is widely recognized as a high-grade Ganoderma product and is extensively consumed as a functional food and dietary supplement in China. To compare quality differences, nine batches of sporoderm-broken G..

Immune supportEnergy & fatigue

Enoki · 2026 · Research Article · Mycobiology

Comparative Evaluation of Disinfectants for Controlling Listeria monocytogenes on Flammulina Velutipes.

Flammulina velutipes is the most widely consumed edible mushroom in Korea, with a unique flavor and texture that support its popularity domestically and internationally. Korea produces approximately 26,000 tons of F..

Immune supportEnergy & fatigueGut & microbiome

Enoki · 2026 · Journal Article · Journal of fish biology

Comprehensive analysis of microbiome and transcriptome revealed the mechanisms of Flammulina velutipes stem-base enhance intestinal health in Gymnocypris eckloni.

Although Flammulina velutipes residues are increasingly used in fish feeds, their mode of action in the gut is poorly defined. Here, we show that feeding Gymnocypris eckloni diets supplemented with F..

Snow Fungus · 2026 · Journal Article · Food chemistry

Correlation analysis of monosaccharide composition and in vitro antioxidant and hypoglycemic activities of Tremella fuciformis spore polysaccharides.

Tremella fuciformis polysaccharides have diverse bioactivities and beneficial physicochemical properties, enabling broad use in pharmaceuticals and food. This study analyzed intracellular and extracellular polysaccharides (IPs and EPs) from three T..

OncologyImmune supportMetabolic health

Snow Fungus · 2026 · Journal Article · Journal of the science of food and agriculture

Deep eutectic solvent extraction of Tremella fuciformis polysaccharide and the extract's antioxidant activity

BACKGROUND: No study has, until now, examined the deep eutectic solvent (DES) extraction of Tremella fuciformis polysaccharide (TFP). In this study, a DES composed of choline chloride and citric acid (1:1 molar ratio) was prepared for TFP extraction..

OncologyImmune supportMetabolic health

Snow Fungus · 2026 · Journal Article · Journal of the science of food and agriculture

Deep eutectic solvent extraction of Tremella fuciformis polysaccharide and the extract's antioxidant activity.

Immune supportGut & microbiomeLiver support

Reishi · 2026 · Journal Article · Carbohydrate polymers

Design of functional hydrogel beads based on polysaccharide-encapsulated Ganoderma lucidum spores for stability and targeted gastrointestinal delivery of protein-spore complex.

Oral delivery of protein-based therapeutics and nutraceuticals is often limited by enzymatic degradation and structural instability in gastrointestinal environments, underscoring the need for safe and biocompatible carriers with tailored release profiles..

Immune supportGut & microbiomeLiver support

Reishi · 2026 · Journal Article · Carbohydrate polymers

Design of functional hydrogel beads based on polysaccharide-encapsulated Ganoderma lucidum spores for stability and targeted gastrointestinal delivery of protein–spore complex

Immune supportEnergy & fatigueGut & microbiome

Oyster Mushroom · 2026 · Research Article · Poultry science

Dietary evaluation of Pleurotus ostreatus spent mushroom substrate on productivity, nutrient digestibility, egg quality, antioxidant status, and ovarian cytoprotective responses in laying hens.

This study evaluated the dietary inclusion level effects of Pleurotus ostreatus spent mushroom substrate (SMS) on performance, nutrient digestibility, egg quality and oxidative stability in laying hens..

Snow Fungus · 2026 · Journal Article · Food chemistry

Different modified polysaccharides from Tremella fuciformis and its protective effects on oxidative damage.

Investigating the structure of polysaccharides enables a better understanding of the structure-activity relationship. Different modification methods help to improve the biological activities of polysaccharides..

Reishi · 2026 · Journal Article · Applied soil ecology: a section of Agriculture, Ecosystems & Environment

Disease-induced changes in Ganoderma lucidum microbiome co-occurrence patterns and assembly processes

Host-associated microbial communities significantly influence the growth, development, and health of hosts. Green mold disease (GMD), caused by Trichoderma spp., is one of the predominant diseases encountered during commercial cultivation of Ganoderma lucidum..

Immune supportLiver support

Enoki · 2026 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Dual-crosslinked Flammulina velutipes protein-polysaccharide emulsion gels: Structural enhancement for bioactive delivery and 3D food printing

Emulsion gels face challenges in practical application due to insufficient structural robustness, which limits both bioactive protection and 3D printing precision..

Snow Fungus · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Effects of Cultivation Substrate Differences on Quality Formation and Polysaccharide Composition Characteristics of Tremella fuciformis.

Cultivation substrate critically affects the quality of Tremella fuciformis. Five substrates, including cottonseed hulls (MZKs), Machilus pauhoi Kanehira sawdust (BNM), lotus seed hulls (LZKs), Corethrodendron scoparium sawdust (HB), and palm fiber (ZL), were evaluated for their effects on agronomic traits,….

Immune supportEnergy & fatigueGut & microbiomeLiver support

Mesima · 2026 · Research Article · Poultry science

Effects of dietary Phellinus linteus polysaccharides supplementation on productive performance, egg quality, antioxidant status, immune function, cecal microbiota, jejunal morphology, and metabolism in laying hens under lipopolysaccharide challenge.

The effects of Phellinus linteus polysaccharides (PLP) on the immune responses of laying hens remain unclear. This study systematically investigated the impacts of PLP on productive performance, antioxidant status, immune response, cecal microbiota, short-chain fatty acids (SCFAs), jejunal morphology, and metabolism….

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Reishi · 2026 · Research Article · Animals: an open access journal from MDPI

Effects of Enzyme-Microbe Co-Fermented Ganoderma lucidum Spent Substrate on Growth Performance, Apparent Nutrient Digestibility, Organ Indices, and Gut Microbiota in Yellow-Feathered Broilers.

The effects of dietary supplementation of enzyme-microbe co-fermented Ganoderma lucidum spent substrate (EFGLS) on growth performance, apparent nutrient digestibility, organ indices, and cecal microbiota in yellow-feathered broilers are investigated..

Immune supportSkin & hydration

Lion's Mane · 2026 · Research Article · International journal of medical sciences

Efficacy of Combined Hericium erinaceus Mycelium and Undenatured Type II Collagen in Reducing Osteoarthritis Progression in a Preclinical Animal Model.

Osteoarthritis (OA) is a condition linked with aging that impacts joints and leads to functional disability. Hericium erinaceus, a large edible mushroom widely consumed in Asian countries, is recognized as a functional food and has been reported as a beneficial supplement for OA management..

Immune supportEnergy & fatigueMetabolic health

Reishi · 2026 · Research Article · Microorganisms

Enhanced Exopolysaccharide Production in Bidirectional Liquid Fermentation of Ganoderma lucidum Using Clinacanthus nutans (Burm. f.) Lindau.

This study explored the enhancement of exopolysaccharide (EPS) production by Ganoderma lucidum through bidirectional liquid fermentation, employing Clinacanthus nutans (Burm. f.) Lindau leaves as a medicinal substrate.

Immune supportEnergy & fatigueSkin & hydration

Reishi · 2026 · Journal Article · International journal of biological macromolecules

Enhancing wound dressing efficiency: Cellulose nanofiber sponges loaded with Ganoderma lucidum mycelium fractions.

In this study, cellulose nanofiber (CNF)-based sponges incorporating different Ganoderma lucidum biomass fractions were developed and evaluated as bioactive wound dressing materials..

Immune supportCognition & nervesMetabolic healthGut & microbiome

Lion's Mane · 2026 · Journal Article · Journal of food science

Exploring the Prebiotic Effects of Composite Fungal Polysaccharides From Hericium erinaceus and Lyophyllum decastes on Gut Microbiota and Metabolism.

Fungal polysaccharides have attracted considerable scholarly interest due to their potential as prebiotics, with the ability to modulate gut microbiota and enhance host health..

Oyster Mushroom · 2026 · Journal Article · Fungal genetics and biology: FG & B

Functional analysis of the class III chitin synthase genes in the filamentous basidiomycete Pleurotus ostreatus.

Class III chitin synthases (CHSs) are specific to filamentous fungi and are associated with biosynthesis of chitin, a key structural component of fungal cell walls. While extensively studied in ascomycetes, their roles in basidiomycetes remain poorly understood..

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2026 · Journal Article · Cancer letters

Ganoderma lucidum polysaccharide ameliorates cancer cachexia with enhanced efficacy in aged group by reprogramming arginine metabolism to modulate Treg formation.

Cancer cachexia is a syndrome characterized by profound weight loss, muscle wasting, and metabolic disturbance in cancer patients. Cancer-associated cachexia represents significant biological and clinical challenges that profoundly affect human health..

OncologyImmune supportLiver support

Reishi · 2026 · Research Article · Pharmaceutics

Ganoderma lucidum Polysaccharide Potentiates mRNA-LNP Efficacy: Synergizing Oxidative Stress Mitigation with Innate Immune Modulation.

Background/Objectives: As a primary mRNA delivery platform, lipid nanoparticles (LNPs) often induce oxidative stress that compromises mRNA translation efficiency. Natural polysaccharides are known for their antioxidant properties..

OncologyImmune supportLiver supportRespiratory

Reishi · 2026 · Research Article · Materials today. Bio

Ganoderma lucidum polysaccharide-decorated extracellular vesicle enables synergistical antitumor immunotherapy.

Ganoderma lucidum polysaccharide (GLP) holds considerable promise for tumor therapy, but its clinical application is limited by its poor tumor-targeting capability..

Immune supportMetabolic healthGut & microbiome

Reishi · 2026 · Journal Article · Journal of agricultural and food chemistry

Ganoderma lucidum Polysaccharides Alleviate High-Fat Diet-Induced Obesity by Promoting Lipolysis and Inhibiting Inflammation through Lactobacillus johnsonii-Butyrate Axis.

Ganoderma lucidum polysaccharides (GLPs) exert antiobesity effects that are linked to gut-microbiota modulation, yet the underlying mechanisms remain elusive. Here, we show that GLPs raise the fecal butyrate level, which in turn inhibits high-fat diet (HFD)-induced weight gain, fat accumulation, adipocyte hypertrophy,….

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2026 · Journal Article · Journal of ethnopharmacology

Ganoderma lucidum polysaccharides alleviate non-alcoholic fatty liver disease by modulating gut microbiota against TLR4/NF-κB/MAPK pathway and activating AMPK pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Leyss. ex Fr.) Karst has been a revered traditional Chinese medicinal herb, widely used in folk medicine to treat various metabolic diseases due to its remarkable bioactivities.

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2026 · Research Article · International journal of molecular medicine

Ganoderma lucidum polysaccharides improve liver metabolic disorders by modulating gut microbiota of ovariectomized mice.

The morbidity of cardiovascular disease in postmenopausal patients increases due to the lack of estrogen protection. One of the most common conditions is hyperlipidemia characterized by abnormally elevated low‑density lipoprotein cholesterol (LDL‑C) and total cholesterol (TC)..

Immune supportEnergy & fatigueLiver supportSkin & hydration

Reishi · 2026 · Journal Article · Molecular pharmaceutics

Ganoderma lucidum-Derived Nanovesicles Attenuate Multiorgan Senescence via Modulation of Oxidative Stress and Inflammation.

Aging is a complex and multifactorial biological process characterized by cellular senescence and is a major risk factor for numerous age-related diseases. Developing safe and effective anti-aging interventions remains a significant challenge..

Reishi · 2026 · Journal Article · Biotechnology letters

Gene expression profiling to elucidate the promotive effects of the volatile organic compound 3-octanone on the mycelial growth of Ganoderma lucidum

To investigate the effects of fungal volatile organic compounds (FVOCs) on the mycelial growth of Ganoderma lucidum, and to elucidate the molecular mechanisms underlying the growth-promoting effect of 3-octanone. G..

Reishi · 2026 · Research Article · Biotechnology letters

Gene expression profiling to elucidate the promotive effects of the volatile organic compound 3-octanone on the mycelial growth of Ganoderma lucidum.

Zhu Ling · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Genetic-Geographic-Chemical Framework of Polyporus umbellatus Reveals Lineage-Specific Chemotypes for Elite Medicinal Line Breeding.

Polyporus umbellatus is a valuable fungus with both dietary and medicinal applications. However, heterogeneous germplasm and chemical variability constrain its sustainable use.

OncologyImmune supportMetabolic health

Maitake · 2026 · Journal Article · Journal of the science of food and agriculture

Grifola frondosa polysaccharide ameliorates adenine-induced CKD by inhibiting TGF-β1/Smad signaling pathway in mice.

BACKGROUND: Chronic kidney disease (CKD) is pathologically characterized by oxidative stress, inflammation, and renal fibrosis, yet effective therapeutic interventions for this condition remains limited. Grifola frondosa polysaccharide (GFP), an active component derived from the edible and medicinal mushroom G..

Immune supportEnergy & fatigueSkin & hydration

Snow Fungus · 2026 · Journal Article · Ultrasonics sonochemistry

Impact of ultrasound-assisted enzymatic extraction on the structural and functional properties of Tremella fuciformis polysaccharide and its application in almond-based milk.

Ultrasound, when combined with enzymatic hydrolysis, distinctly influences the macromolecular structure of Tremella fuciformis polysaccharide, yielding a polysaccharide with improved functional properties..

OncologyImmune supportMetabolic healthSkin & hydration

Reishi · 2026 · Research Article · Molecules (Basel, Switzerland)

In Vitro and In Vivo Evaluation of the Skincare Bioactivity of β-1,3;1,6-Glucans-Rich Ganoderma lucidum Polysaccharides.

Extracted from Ganoderma lucidum mycelium, the developed β-1,3;1,6-glucan rich polysaccharides have the potential to be used during the industrial production of health food products due to their inhibition of metabolic syndrome, immunomodulatory and antitumor activities and other health benefits..

Immune supportMetabolic healthGut & microbiomeLiver support

Chaga · 2026 · Research Article · Foods (Basel, Switzerland)

Inonotus obliquus Polysaccharides Prevent High-Fat Diet-Induced Obesity in Mice Related to Reshaping Gut Microbiota.

Obesity development is linked to disturbances in the gut microbiota. Inonotus obliquus polysaccharides (IOPs) have potential therapeutic efficacy in alleviating metabolic disorders.

Snow Fungus · 2026 · Journal Article · Food chemistry

Mechanism of pH-driven gelation in Tremella fuciformis polysaccharide-soy protein isolate composite systems.

The gelling properties of soy protein isolate (SPI) are limited, but can be enhanced by adding polysaccharides, with their interactions strongly influenced by pH. This paper explored the effects of pH (5-9) on gel mechanisms of Tremella fuciformis polysaccharide (TFP)-SPI complexes..

OncologyImmune supportEnergy & fatigue

Maitake · 2026 · Research Article · Food chemistry: X

Mechanistic insights into Grifola frondosa-driven fermentation of Rice-wheat bran: Metabolomic profiling, molecular dynamics, and enhanced antioxidant efficacy.

Rice bran (RB) and wheat bran (WB) are rich in bioactives but poorly utilized due to limited bioaccessibility. Here, a fungal fermentation strategy was developed to valorize RB-WB blends.

Lion's Mane · 2026 · Journal Article · International journal of biological macromolecules

Metabolomics study on Hericium erinaceus polysaccharides in intervening ethanol induced gastric ulcer in mice.

Based on previous evidence indicating the gastroprotective potential of Hericium erinaceus polysaccharides (HEP), this study aimed to evaluate their protective effects against ethanol-induced gastric ulcers in mice and characterize the associated serum metabolic changes using an untargeted metabolomics approach..

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2026 · Journal Article · Journal of biotechnology

Morphological and molecular characterization of Mexican Hericium erinaceus strains.

Hericium erinaceus is an edible and medicinal fungus recognized for its antimicrobial, antioxidant, anticancer, neuroprotective, and immunomodulatory properties. Despite its biological and biotechnological relevance, reports of this species in Mexico remain limited, with only one previous molecularly confirmed record….

Reishi · 2026 · Research Article · Scientific reports

Multi-dimensional immunoprotection of Ganoderma lucidum spore oil in immunosuppressed mice via microbiome-proteome-metabolome network analysis.

Ganoderma lucidum has a long-standing history of use as a medicinal mushroom, with its spore oil (GLSO) extracted from broken cell walls using CO2 supercritical extraction..