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Ganoderma lucidum is a famous traditional Chinese medicinal fungus with health-promoting and pharmacological properties. The present study aimed to provide a liquid medium for G..

Immune support

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Shiitake · 2026 · Research Article · Scientific reports

Oral Lentinula edodes mycelia extract enhances the antitumor effect of radiotherapy via gut-associated activation of dendritic and cytotoxic T cells.

Oral administration of Lentinula edodes mycelia extract (L.E.M.) has been shown to stimulate systemic T cell-mediated antitumor immunity and inhibit tumor growth in mice, suggesting its potential to modulate host immune responses. However, the route of this systemic antitumor effect remains unclear..

OncologyImmune supportCognition & nervesGut & microbiome

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Mesima · 2026 · Research Article · American journal of cancer research

Phellinus linteus polysaccharides inhibit castration-resistant prostate cancer progression possibly via dual modulation of PIK3R1 and PGC-1α: a preclinical evaluation.

Castration-resistant prostate cancer (CRPC) remains a major challenge due to limited treatment options and frequent therapeutic resistance. This study demonstrates that Phellinus linteus polysaccharides (PLP), both in the form of drug-loaded serum and as a purified extract, exhibit potent anti-CRPC activity through a….

OncologyImmune supportEnergy & fatigueLiver support

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Lion's Mane · 2026 · Journal Article · Colloids and surfaces. B, Biointerfaces

Physicochemical properties and immunological effects of macrophage membrane-coated PLGA nanoparticles loaded with Hericium erinaceus polysaccharides.

In this study, we developed biomimetic Hericium erinaceus polysaccharides PLGA nanoparticles (NPs) coated with macrophage membrane (MM-PLGA-HEP) and examined their immune activity in vitro and in vivo..

OncologyImmune supportLiver support

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Oyster Mushroom · 2026 · Research Article · Frontiers in pharmacology

Pleurotus ostreatus ethanolic extract exerts anti-cancer effects via PI3K/Akt/mTOR pathway modulation in DMBA-NMU induced breast cancer in female Sprague Dawley rats.

Hormone receptor-positive Breast Cancer (BC) driven by PI3K/Akt/mTOR signaling remains a major therapeutic challenge, particularly in settings where conventional chemotherapy causes severe systemic and reproductive toxicity..

OncologyImmune support

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Oyster Mushroom · 2026 · Journal Article · Harmful algae

Pleurotus ostreatus polysaccharides improve microcystin-LR-induced intestinal damage in tadpoles by regulating the interaction between microbiota and intestine.

Exposure to microcystins (MCs) can cause severe intestinal damage. This study aimed to assess the efficacy of Pleurotus ostreatus polysaccharide in alleviating intestinal damage induced by microcystin-leucine-arginine (MC-LR) in tadpoles..

OncologyImmune supportGut & microbiome

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Reishi · 2026 · Journal Article · Carbohydrate polymers

Polysaccharide from Ganoderma lucidum-fermented wheat pericarp: Purification, structural features, and lipid-lowering mechanisms

This study purified and characterized a polysaccharide derived from wheat pericarp via solid-state fermentation (SSF) with Ganoderma lucidum, and evaluated its lipid-lowering effects using an oleic acid (OA)-induced HepG2 cell model..

Immune supportMetabolic health

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Reishi · 2026 · Journal Article · Carbohydrate polymers

Polysaccharide from Ganoderma lucidum-fermented wheat pericarp: Purification, structural features, and lipid-lowering mechanisms.

Immune supportMetabolic health

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Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Preparation and In Vitro Bioactivity Evaluation of Ganoderma lucidum Melanin-Stabilized Selenium Nanoparticles.

Selenium nanoparticles (SeNPs), a highly promising candidate as a nutrient fortificant and food additive, face challenges in stability and biosafety. These limitations hinder their application in the food industry.

Immune supportSkin & hydration

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Lion's Mane · 2026 · Journal Article · Journal of the science of food and agriculture

Preparation, characterization and immune enhancement study of Hericium erinaceus polysaccharide-loaded polyethyleneimine-modified poly(lactic-co-glycolic acid) nanoparticles.

BACKGROUND: Hericium erinaceus polysaccharides (HEPs) exhibit remarkable immunomodulatory properties but are hampered by poor oral bioavailability. To overcome these limitations, this study developed and optimized HEP-loaded polyethyleneimine (PEI)-modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles….

OncologyImmune supportLiver support

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Snow Fungus · 2026 · Journal Article · International journal of biological macromolecules

Preparation, characterization, antioxidant activity evaluation and application of high-thickening instant Tremella fuciformis polysaccharide products under the IDDSI framework.

Tremella fuciformis polysaccharides (TP), a natural polysaccharide with dual medicinal and edible values, possesses excellent gelling properties, water-holding capacity, and biological activities, rendering it a promising thickening agent for dysphagia-friendly foods..

Immune support

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Reishi · 2026 · Journal Article · Journal of ethnopharmacology

Protective effects of Ganoderma lucidum polysaccharide peptides against cisplatin-induced toxicity.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum) has been used in traditional Chinese medicine for centuries to enhance vitality and support organ function.

OncologyImmune supportEnergy & fatigueLiver support

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Oyster Mushroom · 2026 · Research Article · Archives of microbiology

Putative transcription factor Skn7 is involved in cell wall formation, oxidative stress response, and hydrophobin gene expression in Pleurotus ostreatus.

The functions of the transcription factor Skn7 in regulating cell wall synthesis and oxidative stress response have been investigated in ascomycetes and a few basidiomycetes. We identified and disrupted the putative skn7 gene in Pleurotus ostreatus, a basidiomycete..

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Oyster Mushroom · 2026 · Journal Article · Fungal biology

Role of the putative transcription factor Rim101 in pH/oxidative stress response and cell wall structure formation in the white-rot fungus Pleurotus ostreatus.

The transcription factor Rim101 regulates various cellular functions in fungi, including maintaining cell homeostasis, regulating redox processes, and transmembrane transport, in response to environmental pH changes and redox stress. White-rot fungi encounter various environmental stresses during wood degradation..

Immune support

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Reishi · 2026 · Research Article · Journal of nanobiotechnology

ROS-responsive Ganoderma lucidum polysaccharide nanocomposite targeting prosenescent oxidative stress niche for structural and functional diabetic tendon regeneration.

Diabetic patients exhibit higher tendon injury incidence, with elevated risks of healing failure and re-rupture than healthy individuals, posing major clinical challenges. Tendon stem/progenitor cells (TSPCs) are crucial for tendon homeostasis maintenance, and their senescence underlies regenerative impairment..

Immune supportEnergy & fatigueMetabolic health

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Lion's Mane · 2026 · Journal Article · Poultry science

Selenium-modified Hericium erinaceus polysaccharides improves intestinal immunity and ND vaccine responses in chickens.

This study aimed to investigate the immunomodulatory effects of selenium-modified Hericium erinaceus polysaccharides on intestinal immunity and Newcastle disease (ND) vaccine responses in chickens..

Immune supportGut & microbiome

High relevance

Reishi · 2026 · Journal Article · Chemistry & biodiversity

Six Undescribed Lanostane-Type Triterpenoids From Ganoderma lucidum.

Six previously undescribed lanostane triterpenoids (1-6), together with 21 known analogues (7-27) were isolated from the fruiting bodies of the medicinal fungus Ganoderma lucidum. Compounds 1-3 are lucidenate-type triterpenoids, whereas compounds 4-6 are ganoderate-type derivatives..

Immune support

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Lion's Mane · 2026 · Journal Article · International journal of biological macromolecules

Strategic ultrasonic degradation enhances immunomodulatory and hypolipidemic activities of Hericium Erinaceus β-glucan.

Bioactive β-glucans from Hericium erinaceus possess health benefits, yet the structure-function relationships of these polysaccharides remain incompletely elucidated. This study employed an ultrasonic degradation strategy to modify a high-molecular-weight β-glucan (H6PC20, 2.39 × 106 g/mol) from its fruiting bodies..

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Lion's Mane · 2026 · Journal Article · Biotechnology and applied biochemistry

Structural Characterization and Anti-Inflammatory Activities of Polysaccharide From Hericium erinaceus Mycelium.

A novel heteropolysaccharide named HEP-S was separated from the mycelium of Hericium erinaceus using hot water extraction. The structure of HEP-S (2.45 × 106 Da) is mainly composed of →4,6)-α-D-Glcp(1→, →2)-α-D-Manp(1→, →4)-α-D-Glcp(1→, →3,6)-β-D-Glcp(1→, T-β-D-Galp(1→, and →4)-β-D-Galp(1→..

Immune support

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Maitake · 2026 · Journal Article · Carbohydrate polymers

Structural characterization and antitumor activity via immune modulation of an α-glucan from Grifola frondosa.

Grifola frondosa is a valued edible and medicinal fungus whose polysaccharides are key bioactive components, yet the identification of specific homogeneous effectors and their detailed immunomodulatory mechanisms remains a critical focus of research. In this study, polysaccharide fractions were isolated from G..

OncologyImmune support

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Reishi · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Structural characterization, lipid-lowering activity, and emulsifying properties of polysaccharides derived from wheat pericarp via Ganoderma lucidum solid-state fermentation.

The biotransformation of agricultural by-products through fungal solid-state fermentation (SSF) represents a sustainable and efficient strategy for enhancing the functional properties of plant polysaccharides..

Immune supportMetabolic healthLiver support

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Shiitake · 2026 · Research Article · NPJ science of food

Structural divergence of lentinula edodes polysaccharides is associated with distinct anti-hyperuricemia pathways.

Lentinula edodes (L. edodes) polysaccharides hold therapeutic potential for hyperuricemia (HUA), but their mechanisms remain unclear.

Immune supportGut & microbiome

High relevance

Snow Fungus · 2026 · Journal Article · Food Research International

Synergistic emulsions of Tremella fuciformis polysaccharide and sodium caseinate enable melt-resistance and inhibit ice crystals in low-fat ice cream

The potential health risks of excessive fat intake have increased the demand for low-fat ice cream. However, reducing the fat content often compromises the flavor..

Immune supportEnergy & fatigue

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Snow Fungus · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Synergistic emulsions of Tremella fuciformis polysaccharide and sodium caseinate enable melt-resistance and inhibit ice crystals in low-fat ice cream.

The potential health risks of excessive fat intake have increased the demand for low-fat ice cream. However, reducing the fat content often compromises the flavor..

Immune supportEnergy & fatigue

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Enoki · 2026 · Research Article · International journal of molecular sciences

The Brown Strain of Flammulina velutipes Singer Attenuates 5-Fluorouracil-Induced Intestinal Injury by Suppressing Inflammation, Oxidative Stress, and Barrier Disruption via Modulation of Epithelial-Mesenchymal Transition and Tight Junction Integrity.

5-Fluorouracil (5-FU) remains a cornerstone chemotherapeutic for colorectal cancer, exerting its antitumor effects primarily through disruption of DNA and RNA synthesis and subsequent induction of apoptosis. Nonetheless, its clinical efficacy is often compromised by prominent adverse effects, particularly mucositis..

OncologyImmune supportMetabolic healthGut & microbiome

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Chaga · 2026 · Research Article · Frontiers in veterinary science

The effects of polysaccharides from Inonotus obliquus, artemisinin, and dihydroartemisinin on the reproductive system of male mice infected with Neospora caninum.

The present study investigated the protective effects of Inonotus obliquus polysaccharides (IOPs), artemisinin, and dihydroartemisinin (DHA) on Neospora caninum-induced damage of the reproductive system in male BALB/c mice..

OncologyImmune supportEnergy & fatigue

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Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

The Ganoderma lucidum and Rosa roxburghii Tratt Formulation Prevents Depressive-like Behaviors in Mice by Modulating Tryptophan Metabolism via the Gut-Brain Axis and Upregulating the BDNF/TrkB/PI3K/AKT Pathway.

Depression is a common mental disorder that substantially impairs patients' daily life and work. To identify natural and safe preventive options, we investigated the preventive effect and underlying mechanism of the Ganoderma lucidum and Rosa roxburghii Tratt formula (GLRRTF) on depression..

Immune supportCognition & nervesGut & microbiome

High relevance

Oyster Mushroom · 2026 · Journal Article · Meat science

The improving effect of Pleurotus ostreatus polysaccharide-EGCG active preservative films on the functional properties of myofibrillar proteins in refrigerated pork.

This study aimed to investigate the effects of chitosan (CS) /collagen (Clg) films loaded with Pleurotus ostreatus polysaccharide-EGCG conjugates (POP-EGCG) and ε-Polylysine (ε-PL, PL) on the functional properties of myofibrillar proteins (MPs) in refrigerated pork..

Immune supportEnergy & fatigueSkin & hydration

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Reishi · 2026 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

The paradox of potency: Insights into emergent mechanisms of Ganoderma lucidum's antitumor effects.

BACKGROUND: An arms race between cancer cells and therapeutic pressure fuels drug resistance, immune evasion, and tumor heterogeneity, hindering therapy. Ganoderma lucidum (G.

OncologyImmune supportGut & microbiome

High relevance

Reishi · 2026 · Journal Article · Molecular and cellular biochemistry

The role of mitochondrial regulation in macrophage polarization by Ganoderma lucidum polysaccharide for the treatment of colitis-associated colorectal cancer.

Colorectal cancer (CRC) is a common malignant tumor of the digestive tract. Ganoderma lucidum polysaccharide (GLP) has shown significant potential in regulating macrophage polarization and treating CRC..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Shiitake · 2026 · Journal Article · Fungal biology

Transcriptomic analysis of the dynamic changes in polysaccharide biosynthesis metabolism in Lentinula edodes throughout liquid fermentation.

Lentinula edodes, a mushroom valued both nutritionally and medicinally, produces polysaccharides as its principal bioactive compounds, known for their significant pharmacological effects. However, low yields have limited their large-scale industrial application..

Immune supportMetabolic health

High relevance

Cordyceps · 2026 · Research Article · BMC microbiology

Transcriptomic and metabolomic insights into the long-term survival strategies of Ophiocordyceps sinensis following host immune perturbation.

BACKGROUND: Ophiocordyceps sinensis is a premier medicinal fungus with a unique slow-killing parasitic strategy, yet the molecular basis of its long-term persistence in host hemocoel remains elusive..

Immune supportCognition & nervesMetabolic health

High relevance

Snow Fungus · 2026 · Research Article · European journal of translational myology

Tremella fuciformis polysaccharide: enhancing ischemic hypoxic adaptation of mesenchymal stem cells.

Human Placenta-Derived Mesenchymal Stem Cells (HP-MSCs) are recognized for their potential in treating various diseases due to their multidirectional differentiation and immunomodulatory abilities. However, the therapeutic efficacy is often compromised in ischemic and hypoxic environments..

OncologyImmune support

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Reishi · 2026 · Journal Article · International journal of biological macromolecules

Unique synergistic and compensatory interaction between β-1,3-glucosyltransferase isoenzyme in Ganoderma lucidum polysaccharide biosynthesis.

Two β-1,3-glucosyltransferase isoenzymes, designated GL20535 and GL24465, are present in Ganoderma lucidum polysaccharide (GLPS) biosynthesis. Previous studies have demonstrated that the expression level of gl20535 significantly influences the yield of GLPS, and silencing gl20535 results in upregulation of gl24465..

Immune supportMetabolic health

High relevance

Shiitake · 2026 · Research Article · RSC advances

Unusual prenylated phenols with antioxidant and immunosuppressive activities from the edible mushroom Lentinula edodes.

Prenylated phenols, the primary class of mushroom-derived meroterpenoids, exhibit significant structural diversity and biological activities. Two new prenylated phenols (1 and 2), along with four aromatic derivatives, were isolated from the wild mushroom Lentinula edodes for the first time..

Immune support

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Enoki · 2026 · Journal Article · Bioresource technology

Valorization of Flammulina velutipes residue into a feed additive via co-fermentation to control Escherichia coli.

Flammulina velutipes residue (FVR) was valorized into a functional feed additive targeting multi-drug resistant (MDR) Escherichia coli B2 (E. coli B2) via multi-strain co-fermentation..

Immune supportGut & microbiome

High relevance

Lion's Mane · 2026 · Research Article · Foods (Basel, Switzerland)

Valorization of Hericium erinaceus By-Products for β-Glucan Recovery via Pulsed Electric Field-Assisted Alkaline Extraction and Prebiotic Potential Analysis.

Hericium erinaceus is a well-known edible fungus rich in β-glucans, widely recognized for its immune-boosting and prebiotic properties. This study used a pulsed electric field (PEF) combined with alkaline extraction to improve β-glucan yield from H.

Immune supportGut & microbiome

High relevance

Reishi · 2026 · Journal Article · Carbohydrate polymers

Virus-inspired Ganoderma lucidum polysaccharide-functionalized adjuvant with pseudo-zwitterionic interface for potentiated nasal immunization.

Intranasal vaccination is promising against respiratory infections but hindered by the mucus barrier. To overcome the adhesion-penetration dilemma, we developed a virus-inspired hybrid nanoparticle (GHNP) by functionalizing a cationic polymer/lipid core (HNP) with Ganoderma lucidum polysaccharide (GLP)..

Immune supportLiver supportRespiratory

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Lion's Mane · 2026 · Journal Article · International journal of biological macromolecules

β-Glucan-rich Hericium erinaceus hot-water extract ameliorates acute colitis by suppressing inflammation, preserving the epithelial barrier, and modulating gut microbiota ecosystem.

Inflammatory bowel disease (IBD) is a chronic disorder marked by mucosal barrier disruption, immune imbalance, and gut dysbiosis. Polysaccharide-enriched extracts of Hericium erinaceus (HE) have shown anti-colitic effects, but the role of its β-glucan-rich water extract (HE-HW) remains unclear..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

A glucan from Ganoderma lucidum: Structural characterization and the anti-inflammatory effect on Parkinson's disease via regulating dysfunctions of intestinal microecology and inhibiting TLR4/MyD88/NF-κB signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Curtis) P. Karst (G.

Immune supportCognition & nervesGut & microbiome

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Reishi · 2025 · Journal Article · International journal of biological macromolecules

A glucomannan from defatted Ganoderma lucidum spores: structural characterization and immunomodulatory activity via activating TLR4/MyD88/NF-κB signaling pathway.

Ganoderma lucidum spores are tiny mature germ cells ejected from the abaxial side of the pileus and were responsible for multiple pharmacological properties. The defatted G.

OncologyImmune supportMetabolic health

High relevance

Reishi · 2025 · Research Article · Frontiers in chemistry

A new lanostane-type triterpene with lipid-lowering activity from Ganoderma lucidum and an additional analogue.

Non-alcoholic fatty liver disease (NAFLD) represents a chronic liver disorder with widespread global prevalence, primarily attributed to hepatic lipid accumulation, oxidative stress, and inflammatory responses..

Immune supportMetabolic healthLiver support

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Lion's Mane · 2025 · Research Article · International journal of medical sciences

A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation.

Hericium erinaceus, renowned for its pharmaceutical potential, is particularly notable for its isolated diterpenoid derivative, erinacine S. Colorectal cancer (CRC) is one of the most prevalent cancers, characterized by CSC that contribute to chemoresistance and sustained tumor growth..

OncologyImmune supportCognition & nerves

High relevance

Reishi · 2025 · Journal Article · Carbohydrate polymers

A novel galactoglucan from Ganoderma lucidum ameliorates ethanol-induced gastric ulcers by modulating FAK-MAPK signaling pathway

Gastric ulcer (GU) is a prevalent gastrointestinal disorder that significantly impacts patients' quality of life. Current treatments, including proton pump inhibitors and H₂ receptor antagonists, often present limitations such as adverse side effects and incomplete healing, highlighting the urgent need for new….

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Carbohydrate polymers

A novel galactoglucan from Ganoderma lucidum ameliorates ethanol-induced gastric ulcers by modulating FAK-MAPK signaling pathway.

Gastric ulcer (GU) is a prevalent gastrointestinal disorder that significantly impacts patients' quality of life. Current treatments, including proton pump inhibitors and H2 receptor antagonists, often present limitations such as adverse side effects and incomplete healing, highlighting the urgent need for new….

Immune supportMetabolic healthGut & microbiome

High relevance

Maitake · 2025 · Journal Article · International journal of biological macromolecules

A novel water-soluble antibacterial films of gelatin/carboxymethyl cellulose sodium incorporated with Grifola frondosa polysaccharides and pearl powder for fruit preservation.

Grifola frondosa polysaccharides (GFG) is a polysaccharide-protein complex, rich in hydrophilic groups, and has antioxidant and antibacterial biological activities. Nano-pearl powder (PP) with a large amount of calcium carbonate can be used as a chelating agent, antioxidant, and antibacterial agent..

Immune supportEnergy & fatigue

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Reishi · 2025 · Journal Article · Plant Foods Hum Nutr

Alcoholic Extracts from the Ganoderma Lucidum Fermentation Product Alleviated Ethanol-Induced Liver Injury, Gut Leakiness, and Gut Dysbiosis in Mice

The hepatoprotective effect of the alcoholic extracts of Ganoderma lucidum fermentation products (GFE) was investigated. C57BL/6 mice were pretreated with GFE for 7 days and then subjected to the chronic-binge ethanol feeding model..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Enoki · 2025 · Journal Article · International journal of biological macromolecules

Alkaline-heat treatment Flammulina velutipes polysaccharides/sodium carboxymethyl cellulose biodegradable composite film for fresh-cut cantaloupe preservation.

As concerns about the safety and sustainability of plastic wrap grow, the development of biodegradable film for use in fresh-cut fruits and vegetables has become an inevitable trend..

Immune support

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Wood Ear · 2025 · Journal Article · International journal of biological macromolecules

An environment-friendly strategy for direct characterization of polysaccharides in Auricularia auricula-judae by ATR-FTIR spectra and chemometrics.

The traditional polysaccharide component analysis often depends on utilization of chemical reagents, which pose potential threats to human health and environmental safety..

Immune support

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Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Analysis of Amino Acid and Derivative Diversity and Antioxidant Capacity in Ophiocordyceps sinensis and Its Substitutes.

In this study, we used liquid chromatography-tandem mass spectrometry (LC-MS/MS) combined with multivariate statistical analysis to conduct comprehensive qualitative and quantitative profiling of amino acids and their derivatives in wild Ophiocordyceps sinensis (O..

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