MycoData

OncologyImmune supportCognition & nerves

Reishi · 2022 · Journal Article · Phytochemistry

Lanostane triterpenoids from Ganoderma lucidum and their inhibitory effects against FAAH.

Ganoderma lucidum is a famous edible and medicinal fungus. Through a bioactive phytochemical investigation of the ethanolic extracts of the fruiting bodies of G.

OncologyImmune supportGut & microbiomeRespiratory

Shiitake · 2022 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Lentinula edodes extract increases goblet cell number and Muc2 expression in an intestinal inflammatory model of Trichinella spiralis infection.

AHCC® is a standardized extract of cultured mushroom (Lentinula edodes) mycelia with a wide variety of therapeutic effects including anti-inflammatory, antitumor and antiviral effects. Trichinellosis, a food-borne parasitic zoonosis is caused by the nematode Trichinella spp..

OncologyImmune supportMetabolic healthGut & microbiome

Shiitake · 2022 · Journal Article · Arquivos de gastroenterologia

LENTINULA EDODES POLYSACCHARIDES SUPPRESSED PRO-INFLAMMATORY CYTOKINES EXPRESSION AND COLITIS IN MICE.

BACKGROUND: Polysaccharides from edible mushrooms possess immunomodulatory, anti-inflammatory, and anti-tumor activities. Recent studies indicated that necroptosis plays a role in the pathogenesis of inflammatory diseases and mediates increased expression of inflammatory cytokines..

OncologyImmune supportMetabolic healthGut & microbiome

Yellow Morel · 2022 · Research Article · Frontiers in nutrition

Morchella esculenta mushroom polysaccharide attenuates diabetes and modulates intestinal permeability and gut microbiota in a type 2 diabetic mice model.

Type 2 diabetes mellitus (T2DM) is a health issue that causes serious worldwide economic problems. It has previously been reported that natural polysaccharides have been studied with regard to regulating the gut microbiota, which plays an important role in T2DM..

OncologyImmune supportMetabolic healthLiver support

Yellow Morel · 2022 · Journal Article · Food research international (Ottawa, Ont.)

Mycochemical profile and health-promoting effects of morel mushroom Morchella esculenta (L.) – A review

Mushrooms have been well known for centuries in traditional Chinese medicine for their medicinal properties. Morchella esculenta (L.) Pers.

Lion's Mane · 2022 · Journal Article · Journal of agricultural and food chemistry

Natural Compound 2-Chloro-1,3-dimethoxy-5-methylbenzene, Isolated from Hericium Erinaceus, Inhibits Fungal Growth by Disrupting Membranes and Triggering Apoptosis.

In this study, 2-chloro-1,3-dimethoxy-5-methylbenzene (CDM), a natural product with anti-Candida albicans activity, was discovered from the Hericium erinaceus mycelium. The minimum inhibitory concentration of CDM was 62.5 μg/mL..

OncologyEnergy & fatigue

Reishi · 2022 · Research Article · Frontiers in pharmacology

Nontargeted metabolomics study and pharmacodynamic evaluation of bidirectional fermentation for Ganoderma lucidum with Marsdenia tenacissima.

Lung cancer is one of the malignant tumors with the fastest incidence rate and mortality growth and the greatest threat to human health and life. Marsdenia tenacissima is an antitumor of Chinese medicine..

OncologyRespiratory

OncologyImmune supportEnergy & fatigueMetabolic health

Yellow Morel · 2022 · Research Article · Foods (Basel, Switzerland)

Nutrition Profile and Animal-Tested Safety of Morchella esculenta Mycelia Produced by Fermentation in Bioreactors.

Morchella esculenta (ME), or "true" morel mushrooms, are one of the most expensive mushrooms. M.

OncologyImmune supportSkin & hydration

Zhu Ling · 2022 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Phytochemistry and bioactivities of the main constituents of Polyporus umbellatus (Pers.) Fries.

BACKGROUND: Edible fungi resources have good application prospects in the research and development of food, medicine, and health products. Polyporus umbellatus (Pers.) Fries, as a precious edible and medicinal fungus, has long been used by Chinese medicine to treat urinary systems and related kidney diseases..

OncologyEnergy & fatigueLiver support

Reishi · 2022 · Journal Article · Molecular biology reports

Regulation of Nrf2 and Nrf2-related proteins by ganoderma lucidum ın hepatocellular carcinoma.

BACKGROUND: HCC is among the most common cancer. Ganoderma lucidum (G.lucidum) has been essential in preventing and treating cancer.

OncologyImmune supportGut & microbiomeLiver support

Reishi · 2022 · Research Article · Frontiers in nutrition

Removing the sporoderm from the sporoderm-broken spores of Ganoderma lucidum improves the anticancer and immune-regulatory activity of the water-soluble polysaccharide.

Plant-derived polysaccharides have demonstrated promising anti-cancer effects via immune-regulatory activity. The aim of the current study was to compare the chemical property and the anticancer effects of polysaccharides extracted from the sporoderm-removed spores of the medicinal mushroom Ganoderma lucidum (RSGLP),….

OncologyCognition & nerves

Niu-Chang-Chih · 2022 · Journal Article · Journal of food biochemistry

Solid‐state‐cultured mycelium of Antrodia camphorata exerts potential neuroprotective activities against 6‐hydroxydopamine‐induced toxicity in PC12 cells

Antrodia camphorata (A. camphorata) is an edible fungus containing various bioactive compounds generally used for health benefits.

OncologyEnergy & fatigueGut & microbiome

Reishi · 2022 · Research Article · Frontiers in pharmacology

Sporoderm-Broken Spores of Ganoderma lucidum Sensitizes Ovarian Cancer to Cisplatin by ROS/ERK Signaling and Attenuates Chemotherapy-Related Toxicity.

Although platinum-based chemotherapeutics such as cisplatin are the cornerstone of treatment for ovarian cancer, their clinical application is profoundly limited due to chemoresistance and severe adverse effects. Sporoderm-broken spores of Ganoderma lucidum (SBSGL) have been reported to possess antitumor effects..

Lion's Mane · 2022 · Research Article · Current research in toxicology

Subchronic toxicity and genotoxicity studies of Hericium erinaceus β-glucan extract preparation.

The medicinal effects of Hericium erinaceus have been long documented in scientific studies of Eastern traditional medicine. It is widely consumed, because of its nutritional qualities and perceived health benefits.

Maitake · 2022 · Journal Article · Journal of food composition and analysis

Supercritical CO2 extraction, structural analysis and bioactivity of polysaccharide from Grifola frondosa

Polysaccharide was extracted from Grifola frondosa with supercritical CO₂ technology. The optimum extraction conditions for the highest yield were determined by Box-Behnken design: the pressure was 34.5Mpa, the extraction temperature was 36.7 ℃, the extraction time was 116.3 min and the ratio of entrainer to raw….

OncologyImmune supportEnergy & fatigueRespiratory

Mesima · 2022 · Journal Article · Molecular biology reports

Systematic evaluation of the anti-tumor effect of Phellinus linteus polysaccharide in thyroid carcinoma in vitro.

BACKGROUND: Thyroid carcinoma (TC) is the most common malignant tumor of the endocrine system. Phellinus linteus polysaccharide (PLP) physiologically acts as a suitable anti-tumor molecule..

OncologyImmune supportGut & microbiomeSkin & hydration

Reishi · 2022 · Journal Article · PloS one

The medicinal mushroom Ganoderma lucidum attenuates UV-induced skin carcinogenesis and immunosuppression.

The medicinal mushroom Ganoderma lucidum is traditionally used for treating multiple diseases, including cancer. This study examined skin cancer preventive activity of a commercial product containing spore and fruiting body in 30:8 ratio (GLSF)..

OncologyImmune supportCognition & nervesMetabolic health

Snow Fungus · 2022 · Research Article · Frontiers in pharmacology

Tremella fuciformis polysaccharides alleviate induced atopic dermatitis in mice by regulating immune response and gut microbiota.

Atopic dermatitis (AD), characterized by severe pruritus, immune imbalance, and skin barrier dysfunction, has a high incidence worldwide. Recent evidence has shown that the modulation of gut microbiota is crucial for alleviating clinical symptoms of AD..

OncologyImmune supportEnergy & fatigueSkin & hydration

Reishi · 2022 · Research Article · Nutrients

Triterpenoids and Polysaccharides from Ganoderma lucidum Improve the Histomorphology and Function of Testes in Middle-Aged Male Mice by Alleviating Oxidative Stress and Cellular Apoptosis.

Aging is an inevitable physiological process accompanied by a decline in body physiology, including male fertility. A preparation from Ganoderma lucidum (GL) containing triterpenes and polysaccharides has been shown to have anti-aging properties..

OncologyImmune supportCognition & nerves

Reishi · 2022 · Journal Article · Fitoterapia

Triterpenoids from the fruiting bodies of Ganoderma lucidum and their inhibitory activity against FAAH.

Seventeen triterpenoids including four new lanostane triterpenoids (1-3 and 5) were isolated from the fruiting bodies of Ganoderma lucidum by various chromatographic techniques. Their chemical structures were determined by extensive spectroscopic data, including 1D-NMR, 2D-NMR, and HRESIMS..

OncologyImmune supportEnergy & fatigue

Cordyceps · 2022 · Preprint · journal metadata

Tumor suppression by Chinese cordyceps extract via anti-angiogenesis

Development of pharmacological agents for anti-angiogenesis to disrupt the vascular supply and starve tumor of nutrients and oxygen is a novel strategy for tumor therapy. Chinese cordyceps ( Ophiocordyceps sinensis ), a traditional Chinese herb, has been widely reported to exhibit antitumor effects..

Shiitake · 2021 · Research Article · Oncology letters

A standardized extract of cultured Lentinula edodes mycelia downregulates cortactin in gemcitabine-resistant pancreatic cancer cells.

AHCC®, a standardized extract of cultured Lentinula edodes mycelia, enhances the therapeutic effects and reduces the adverse effects of chemotherapy. Our previous study reported that treatment with AHCC® downregulated the expression levels of tumor-associated proteins in the gemcitabine-resistant pancreatic cancer….

OncologySkin & hydration

Oyster Mushroom · 2021 · Journal Article · International journal of biological macromolecules

A water-soluble selenium-enriched polysaccharide produced by Pleurotus ostreatus: Purification, characterization, antioxidant and antitumor activities in vitro.

The development and application of new selenium-enriched polysaccharides has become a critical topic in recent years. In this study, a natural selenium-enriched polysaccharide fraction (Se-POP-21) produced by Pleurotus ostreatus was purified, characterized, and investigated the antioxidant and antitumor activities in….

Niu-Chang-Chih · 2021 · Journal Article · Journal of separation science

An efficient high-speed countercurrent chromatography method for preparative isolation of highly potent anti-cancer compound antroquinonol from Antrodia camphorata after experimental design optimized extraction.

To avoid irreversible stationary phase adsorption and tedious and time-consuming separation steps, high-speed countercurrent chromatography was employed for the preparative separation of anti-tumor compound antroquinonol from solid fermentation culture of Antrodia camphorata for the first time..

OncologyEnergy & fatigue

Cordyceps · 2021 · Research Article · Food technology and biotechnology

Antioxidant and Cytotoxic Effects and Identification of Ophiocordyceps sinensis Bioactive Proteins Using Shotgun Proteomic Analysis.

RESEARCH BACKGROUND: Ophiocordyceps sinensis, a highly valued medicinal fungus, is close to extinction due to overexploitation. Successful cultivation of O.

Chaga · 2021 · Journal Article · Natural product research

Aromatic compounds from the sclerotia of Inonotus obliquus.

Three new aromatic compounds (1a/1b, 2) including a pair of enantiomers (1a/1b), were isolated from Inonotus obliquus. The structures of the new compounds were elucidated by extensive spectroscopic analyses, and the absolute configurations of 1a and 1b were determined by electronic circular dichroism (ECD) calculated..

Oncology

Chaga · 2021 · Research Article · Journal of microbiology and biotechnology

Carbon Source Affects Synthesis, Structures, and Activities of Mycelial Polysaccharides from Medicinal Fungus Inonotus obliquus.

The effects of various carbon sources on mycelial growth and polysaccharide synthesis of the medicinal fungus Inonotus obliquus in liquid fermentation were investigated..

OncologyImmune supportEnergy & fatigueMetabolic health

Enoki · 2021 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Characterization of soy protein isolate/Flammulina velutipes polysaccharide hydrogel and its immunostimulatory effects on RAW264.7 cells.

Soy protein isolate (SPI) is a nutritional commercial product, while the poor solubility and gelling restricts its applications for functional foods. To surmount the challenge presented by this poor solubility, the gelling polysaccharide shows potential in ameliorating SPI..

Niu-Chang-Chih · 2021 · Journal Article · Journal of Asian natural products research

Chemical constituents from the dish-cultured Antrodia camphorata and their cytotoxic activities.

One new meroterpenoid, antroquinonol Y (1), a new ergostane-type sterol, antcamphin Y (2), and a new ergostane-type triterpenoid, antcamphin Z (3), together with 10 known ones (4-13), were isolated from the dish-cultured fungus Antrodia camphorata..

Oncology

Niu-Chang-Chih · 2021 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Coenzyme Q0, a novel quinone derivative of Antrodia camphorata, induces ROS-mediated cytotoxic autophagy and apoptosis against human glioblastoma cells in vitro and in vivo.

Coenzyme Q0 (CoQ0, 2,3-dimethoxy-5-methyl-1,4-benzoquinone) derived from Antrodia camphorata exerts anticancer activities against breast, melanoma, and ovarian carcinoma. Glioblastoma multiforme is a common tumor affecting the central nervous system..

OncologyGut & microbiome

OncologyImmune supportMetabolic healthGut & microbiome

Shiitake · 2021 · Journal Article · Journal of food biochemistry

Cytotoxicity, metabolic enzyme inhibitory, and anti-inflammatory effect of Lentinula edodes fermented using probiotic lactobacteria.

We found that the fermented Lentinula edodes (FLE) products exhibited various differences in terms of proximate composition, free sugar, and amino acid. In particular, there were higher levels of ergosterol, and ergothioneine in FLE-Pediococcus pentosaceus (PP) and -Lactobacillus acidophilus (LA) than in the L..

OncologyCognition & nervesEnergy & fatigue

Turkey Tail · 2021 · Research Article · Saudi journal of biological sciences

Deciphering the CNS anti-depressant, antioxidant and cytotoxic profiling of methanol and aqueous extracts of Trametes versicolor and molecular interactions of its phenolic compounds.

The present study sought to evaluate the central nervous system (CNS) depressant, antioxidant, and cytotoxicity activity of methanol and aqueous extract of Trametes versicolor (METV and AETV)..

Oyster Mushroom · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

Differential Induction Pattern Towards Classically Activated Macrophages in Response to an Immunomodulatory Extract from Pleurotus ostreatus Mycelium.

Pleurotus ostreatus mushroom preparations have been investigated because of their ability to modulate the immune function. However, there is still no consensus regarding the activation and polarizing effect on macrophages by Pleurotus-derived bioproducts..

OncologyCognition & nervesMetabolic health

Enoki · 2021 · Journal Article · Nanotechnology

Edible mushroom (Flammulina velutipes) as biosource for silver nanoparticles: from synthesis to diverse biomedical and environmental applications.

The current study reports advanced, ecofriendly and biosynthesized silver NPs for diverse biomedical and environmental applications using Flammulina velutipes as biosource. In the study, a simple aqueous extract of F.

OncologyImmune supportGut & microbiome

Chaga · 2021 · Research Article · PloS one

Effect of Inonotus obliquus polysaccharide on composition of the intestinal flora in mice with acute endometritis.

Inonotus obliquus Polysaccharide (IOP) is a large molecule extracted from Inonotus obliqus, a medicinal fungus, which has a wide range of biological activities and has been shown to be associated with inflammation..

OncologyImmune supportRespiratory

Lion's Mane · 2021 · Journal Article · International journal of biological macromolecules

Effects of Hericium erinaceus polysaccharide on immunity and apoptosis of the main immune organs in Muscovy duck reovirus-infected ducklings.

To investigate the effects of Hericium erinaceus polysaccharide (HEP) on immunity in Muscovy duck reovirus (MDRV)-infected ducklings and explore its mechanism of action, an MDRV contact-infection model was established..

OncologyImmune supportEnergy & fatigueLiver support

Niu-Chang-Chih · 2021 · Research Article · Preventive nutrition and food science

Ergostatrien-3β-ol (EK100) from Antrodia camphorata Attenuates Oxidative Stress, Inflammation, and Liver Injury In Vitro and In Vivo.

Hepatic ischemia/reperfusion (IR) injury is a complication that occurs during liver surgery, whereby hepatic tissue is injured by oxygen deficiency during ischemia, then further damaged by a cascade of inflammatory and oxidative insults when blood is resupplied during reperfusion..

Oyster Mushroom · 2021 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Evaluation of bioactive properties of Pleurotus ostreatus mushroom protein hydrolysate of different degree of hydrolysis

Edible mushrooms are natural sources for numerous bioactive properties which can protect human body from oxidative damages, hypertension, abnormal cell growth etc., The present study disclosed that, bioactive properties of mushroom proteins are significantly enhanced by adopting enzymatic hydrolysis..

OncologyMetabolic health

Shiitake · 2021 · Journal Article · Archives of microbiology

Expression and in vitro anticancer activity of Lp16-PSP, a member of the YjgF/YER057c/UK114 protein family from the mushroom Lentinula edodes C91-3.

Latcripin-16 (Lp16-PSP) is a gene that was extracted as a result of de novo characterization of the Lentinula edodes strain C91-3 transcriptome. The aim of the present study was to clone, express, and investigate the selective in vitro anticancer potential of Lp16-PSP in human cell lines..

Oncology

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2021 · Research Article · Journal of Zhejiang University. Science. B

Heme oxygenase-1/carbon monoxide signaling participates in the accumulation of triterpenoids of Ganoderma lucidum.

Ganoderic triterpenoids (GTs) are the primary bioactive constituents of the Basidiomycotina fungus, Ganoderma lucidum. These compounds exhibit antitumor, anti-hyperlipidemic, and immune-modulatory pharmacological activities.

Reishi · 2021 · Journal Article · Internal medicine (Tokyo, Japan)

Hypereosinophilia with Hepatic Nodule Formation Caused by Ganoderma lucidum

A 61-year-old man who underwent surgery for rectal adenocarcinoma developed multiple hepatic nodules. The nodules were 1-3 cm without a capsular structure or contrast enhancement on computed tomography/magnetic resonance imaging, findings that were atypical for adenocarcinoma metastases..

OncologyLiver support

Mesima · 2021 · Research Article · BMC complementary medicine and therapies

Immunomodulatory and anti-inflammatory effects of Phellinus linteus mycelium.

BACKGROUND: The present study extensively aimed to evaluate the underlying mechanism of the immunomodulatory and anti-inflammatory effects of Phellinus linteus mycelium (PLM)..

OncologyImmune supportGut & microbiome

Lion's Mane · 2021 · Research Article · Nutrients

Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study.

Hericium erinaceus (H. erinaceus) is widely studied as a medicinal and edible fungus.

Chaga · 2021 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Inhibitory Effects of Inonotus obliquus Polysaccharide on Inflammatory Response in Toxoplasma gondii-Infected RAW264.7 Macrophages.

Our previous reports have shown that Inonotus obliquus polysaccharide (IOP) has protective effects against Toxoplasma gondii (T. gondii) infection in vivo.

Enoki · 2021 · Journal Article · International journal of biological macromolecules

Isolation, characterization and HepG-2 inhibition of a novel proteoglycan from Flammulina velutipes.

Flammulina velutipes has anti-inflammatory, immunomodulatory, antioxidant and many bioactive properties with high contents of carbohydrate, proteins and fibers. In this study, a novel proteoglycan with polysaccharide complexes and protein chain, named PGD1-1, was isolated from F.

OncologyImmune supportCognition & nerves

Yellow Morel · 2021 · Research Article · Molecules (Basel, Switzerland)

Isolation, Characterization, and Medicinal Potential of Polysaccharides of Morchella esculenta.

Mushroom polysaccharides are active medicinal compounds that possess immune-modulatory and anticancer properties. Currently, the mushroom polysaccharides krestin, lentinan, and polysaccharopeptides are used as anticancer drugs..

Lion's Mane · 2021 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Isolation, purification and identification of immunologically active peptides from Hericium erinaceus.

Biologically active peptides released by proteins are important in regulating immunity. The purpose of this study was to isolate and purify an immunologically active peptide from Hericium erinaceus (H.

OncologyGut & microbiomeSkin & hydration

Shiitake · 2021 · Journal Article · European journal of pharmacology

Latcripin-7A from Lentinula edodes C91-3 induces apoptosis, autophagy, and cell cycle arrest at G1 phase in human gastric cancer cells via inhibiting PI3K/Akt/mTOR signaling.

Gastric cancer (G.C) is one of the most lethal cancer types worldwide. Current treatment requires surgery along with chemotherapy, which causes obstacles for speedy recovery.

Reishi · 2021 · Research Article · Frontiers in chemistry

Meroterpenoids From Ganoderma lucidum Mushrooms and Their Biological Roles in Insulin Resistance and Triple-Negative Breast Cancer.

Ganoderma fungi as popular raw materials of numerous functional foods have been extensively investigated. In this study, five pairs of meroterpenoid enantiomers beyond well-known triterpenoids and polysaccharides, dayaolingzhiols I-M (1-5), were characterized from Ganoderma lucidum..