MycoData

The Amazon biome hosts a rich fungal biodiversity; however, the biotechnological potential of its macrofungi remains largely underexplored. This study evaluates and compares the mycelial growth and protease production of a wild Amazonian isolate of Pleurotus ostreatus (474) with two commercial strains (542 and 885) to….

High relevance

Chaga · 2025 · Research Support, Non U.S. Gov'T · Bioorganic chemistry

Mechanism studies on α-glucosidase inhibition and glycemic regulation of inotodiol from Inonotus obliquus.

Inonotus obliquus is a medicinal fungus that has been valued for its anti-diabetic properties in China for thousands of years. Inotodiol is a characteristic triterpenoid isolated from Inonotus obliquus..

Metabolic health

High relevance

Cordyceps · 2025 · Data Paper · Data in brief

Metabolomic data on molecular weight fractions of the cultivated fruiting body of Ophiocordyceps sinensis and their pharmacological effects on airway tissues.

Ophiocordyceps sinensis is a medicinal mushroom that has been traditionally used for promoting respiratory health and addressing diverse therapeutic needs. The data in this article provides insights into the metabolic profile of the cultivated fruiting body of Ophiocordyceps sinensis (xOs™) across different molecular….

Energy & fatigueMetabolic healthRespiratory

High relevance

Reishi · 2025 · Research Support, Non U.S. Gov'T · Scientific reports

Selected nutritional properties of Ganoderma lucidum and substrate degradation during multi-cycle reuse with hazelnut branch waste.

In this study, the effects of reusing spent Reishi (Ganoderma lucidum) (Curtis) P. Karst mushroom substrate (SMS) from cultivation-by mixing it with hazelnut branch-based substrate (HB) at different ratios (HB100%, HB75%:SMS25%, HB50%:SMS50%, HB25%:SMS75%, SMS100%)-on the yield, quality, and nutritional composition of….

Energy & fatigue

High relevance

Chaga · 2025 · Methods Article · Frontiers in microbiology

Selection and evaluation of reference genes for qRT-PCR in Inonotus obliquus.

Real-time quantitative reverse transcription PCR (RT-qPCR) is one of the most effective tools for studying gene expression. Inonotus obliquus is a rare and edible medicinal fungus.

High relevance

King Oyster · 2025 · Comparative Study · Journal of the science of food and agriculture

Systematic comparison of the effects of exogenous inorganic selenium and organic selenium on the quality and antioxidant capacity of Pleurotus eryngii.

BACKGROUND: Pleurotus eryngii is an ideal food to improve the nutritional status of selenium (Se) in the human body. Besides Se accumulation and speciation, quality parameters and antioxidant capacity are key factors in determining the nutritional value of P.

Immune support

High relevance

Reishi · 2025 · Research Support, Non U.S. Gov'T · Applied and environmental microbiology

The APSES transcription factor Swi6B upregulates CATALASE 1 transcription to enhance oxidative stress tolerance of Ganoderma lucidum.

As sessile organisms, fungi often encounter various stresses throughout their lifespan, resulting in the overproduction of reactive oxygen species, which impedes the normal growth of fungi. Previously, we revealed that the Swi6B transcription factor is involved in the stress tolerance of Ganoderma lucidum..

Energy & fatigue

High relevance

Oyster Mushroom · 2025 · Research Support, Non U.S. Gov'T · Mycologia

The biosynthesis and impacts of cytokinins on growth of the oyster mushroom, Pleurotus ostreatus.

While a lot is known about cytokinins (CKs) and their actions at the molecular and cellular levels in plants, much less is known about the function of CKs in other kingdoms such as fungi..

Energy & fatigueGut & microbiome

High relevance

Chaga · 2024 · English Abstract · Wei sheng yan jiu = Journal of hygiene research

[Anti-tumor effect of Inonotus obliquus extract on 4T1 tumor-bearing mice].

OBJECTIVE: To explore the antitumor effect of Inonotus obliquus extract on 4T1 tumor-bearing mice in vivo and its possible mechanism. METHODS: 4T1 tumor-bearing mice model was established..

Oncology

High relevance

Reishi · 2024 · Comparative Study · Journal of the science of food and agriculture

Comparing application methods of reishi mushroom (Ganoderma lucidum) extract in deep-fried meatballs: impact on heterocyclic aromatic amine formation.

BACKGROUND: The present research was conducted to investigate the impact of reishi mushroom extract (RME) on the formation of heterocyclic aromatic amines (HAAs) in meatballs..

High relevance

Cordyceps · 2024 · Research Support, Non U.S. Gov'T · Frontiers in immunology

Cordyceps militaris solid medium extract alleviates lipopolysaccharide-induced acute lung injury via regulating gut microbiota and metabolism.

Acute lung injury (ALI) is a common respiratory disease, Cordycepin has been reported to reduce ALI, which is an effective component in Cordyceps militaris solid medium extract (CMME). Therefore, we aimed to explore the alleviating effect and mechanism of CMME on ALI..

Immune supportMetabolic healthGut & microbiomeRespiratory

High relevance

Oyster Mushroom · 2024 · Data Paper · Data in brief

Data on drying kinetics, moisture sorption isotherm, composition study of Ethiopian oyster mushroom (Pleurotus ostreatus mushroom) drying in tray dryer.

Drying of mushroom up to the optimal moisture content is an important preservation technique. This research contains data of the drying kinetics, moisture sorption isotherm, and evaluation of the important functional groups of fresh and dried oyster mushroom (Pleurotus ostreatus) while drying in tray dryer using hot….

High relevance

Shiitake · 2024 · Research Support, Non U.S. Gov'T · Toxins

Edodin: A New Type of Toxin from Shiitake Mushroom (Lentinula edodes) That Inactivates Mammalian Ribosomes.

Ribosome-inactivating proteins (RIPs) are a group of proteins with rRNA N-glycosylase activity that irreversibly inhibit protein synthesis and consequently cause cell death..

Oncology

High relevance

Turkey Tail · 2024 · Letter · Environmental geochemistry and health

Enhanced biodegradation of benzo[a]pyrene with Trametes versicolor stimulated by citric acid.

Polycyclic aromatic hydrocarbons (PAHs) are a class of persistent organic pollutants with carcinogenic, mutagenic and teratogenic effects. The white-rot fungi in the fungal group have significant degradation ability for high molecular weight organic pollutants..

High relevance

Cordyceps · 2024 · Research Support, Non U.S. Gov'T · Toxins

Functional Characterization and Toxicological Study of Cordyceps militaris in Weaned Pigs.

Cordyceps militaris (CM), a well-known parasitic fungus that grows on the larvae of Lepidoptera, has a variety of pharmacological activities. However, little is known about its safe dosage for animals, including pigs..

Energy & fatigueGut & microbiomeLiver supportRespiratory

High relevance

Oyster Mushroom · 2024 · Research Support, Non U.S. Gov'T · Microbial biotechnology

Genome-wide analysis of bZIP gene family members in Pleurotus ostreatus, and potential roles of PobZIP3 in development and the heat stress response.

The basic leucine zipper (bZIP) transcription factor (TF) is widespread among eukaryotes and serves different roles in fungal processes including nutrient utilization, growth, stress responses and development..

Metabolic health

High relevance

Cordyceps · 2024 · Research Support, Non U.S. Gov'T · Developmental and comparative immunology

Histopathological observations and comparative transcriptome analysis of Ophiocordyceps sinensis infection of Hepialus xiaojinensis in the early stage.

Hepialus xiaojinensis is a Lepidopteran insect and one of the hosts for the artificial cultivation of Cordyceps. Ophiocordyceps sinensis can infect and coexist with H.

Immune supportEnergy & fatigue

High relevance

Wood Ear · 2024 · Brief Report · International journal of molecular sciences

Identification of Laccase Family of Auricularia auricula-judae and Structural Prediction Using Alphafold.

Laccase is an enzyme that plays an important role in fungi, including lignin degradation, stress defense, and formation of fruiting bodies. Auricularia auricula-judae is a white-rot fungus in the Basidiomycota phylum, capable of delignifying wood..

High relevance

Oyster Mushroom · 2024 · Research Support, Non U.S. Gov'T · Fungal genetics and biology: FG & B

Identification of two genes essential for basidiospore formation during the postmeiotic stages in Pleurotus ostreatus.

A sporeless strain is an important breeding target in the mushroom industry. However, basidiospore production in the oyster mushroom Pleurotus ostreatus has been shown to be impaired by single-gene mutations in only two meiosis-related genes, mer3 and msh4..

High relevance

Cordyceps · 2024 · Research Support, Non U.S. Gov'T · Bioorganic chemistry

Isolation and target identification of anti-renal fibrosis compounds from Cordyceps militaris.

Four undescribed compounds including one aromatic glucoside derivative, cordyceglycoside A (1), one new isoleucine derivative inner salt, cordycepisosalt A (2), a rare four-membered lactam, cinerealactam B (3), and one sesquiterpene derivative, cordycepsetp A (4), together with six known compounds were isolated from….

High relevance

King Oyster · 2024 · Research Support, Non U.S. Gov'T · Journal of proteomics

Label-free comparative proteomic analysis of Pleurotus eryngii grown on sawdust, bagasse, and peanut shell substrates.

The white rot fungi Pleurotus eryngii are environmental microorganisms that can effectively break down lignocellulosic biomass. However, understanding of the mechanisms by which P.

Metabolic health

High relevance

Shiitake · 2024 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Marker recycling in Lentinula edodes via 5-fluoroorotic acid counter-selection.

Shiitake (Lentinula edodes) contains various beneficial compounds and possesses several notable properties. However, there are few reports on its molecular breeding due to delay in development of its gene-modifying technology..

Gut & microbiome

High relevance

Cordyceps · 2024 · Research Support, Non U.S. Gov'T · Applied and environmental microbiology

Neurotransmitter acetylcholine mediates the mummification of Ophiocordyceps sinensis-infected Thitarodes xiaojinensis larvae.

Parasites can manipulate host behavior to facilitate parasite transmission. One such host-pathogen interaction occurs between the fungus Ophiocordyceps sinensis and the ghost moth Thitarodes xiaojinensis.

Cognition & nervesMetabolic health

High relevance

Maitake · 2024 · Research Support, Non U.S. Gov'T · International journal of biological sciences

Polysaccharide isolated from Grifola frondosa eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T cells responses.

Myeloid derived suppressor cells (MDSCs) are known to accumulate in cancer patients and tumor-bearing mice, playing a significant role in promoting tumor growth. Depleting MDSCs has emerged as a potential therapeutic strategy for cancer..

OncologyImmune support

High relevance

Shiitake · 2024 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Simulated human digestion and fermentation of a high-molecular weight polysaccharide from Lentinula edodes mushroom and protective effects on intestinal barrier.

Lentinula edodes (Shiitake) is an important edible mushroom and polysaccharides are its major constituents with proven health benefits. The study was to investigate the gut bacterial fermentation and subsequent effects on gut barrier function of a glucan-rich polysaccharide, LePS40 precipitated from the mushroom water….

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2024 · Research Support, Non U.S. Gov'T · Scientific reports

The impact of continuous cultivation of Ganoderma lucidum on soil nutrients, enzyme activity, and fruiting body metabolites.

To explore the impacts of continuous Ganoderma lucidum cultivation on soil physicochemical factors, soil enzyme activity, and the metabolome of Ganoderma lucidum fruiting bodies, this study conducted two consecutive years of cultivation on the same plot of land..

Metabolic health

High relevance

Cordyceps · 2024 · Comparative Study · Current microbiology

Topical Infection of Cordyceps militaris in Silkworm Larvae Through the Cuticle has Lower Infectivity Compared to Beauveria bassiana and Metarhizium anisopliae.

Topical infection of entomopathogenic fungi in insects occurs when the fungal conidia attach to the insect's surface (cuticle), germinate, and then form appressoria that penetrate the cuticle and enter their bodies..

High relevance

Reishi · 2023 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

A 26-week repeated dose toxicity evaluation of sporoderm-removed Ganoderma lucidum spores in rats.

Ganoderma lucidum spore powder is a traditional Chinese medicine with a variety of health benefits. Sporoderm-removed Ganoderma lucidum spores (RGLS) can be more effectively absorbed and utilized by the body..

Immune supportMetabolic health

High relevance

Oyster Mushroom · 2023 · Research Article · Frontiers in microbiology

A lectin gene is involved in the defense of Pleurotus ostreatus against the mite predator Tyrophagus putrescentiae.

The storage mite, Tyrophagus putrescentiae, found worldwide in many habitats, is an important pest of edible mushrooms. Excessive chemical spraying for pest control has been linked to environmental pollution, health risks, insecticide resistance development, and food safety..

Energy & fatigue

High relevance

Reishi · 2023 · Journal Article · Journal of ethnopharmacology

A proteoglycan isolated from Ganoderma lucidum attenuates diabetic kidney disease by inhibiting oxidative stress-induced renal fibrosis both in vitro and in vivo.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum) was regarded as "miraculous herb" by the Chinese and recorded detailly in the "Shen Nong Ben Cao Jing" as a tonic to improve health and prolong life..

Energy & fatigueMetabolic healthSkin & hydration

High relevance

Oyster Mushroom · 2023 · Research Article · Heliyon

Acaricidal assessment of the fungal extract of Pleurotus ostreatus against Rhipicephalus microplus: Role of in vitro and in silico analysis.

The Pleurotus ostreatus mushroom, commonly referred to as the oyster mushroom, is a widely consumed edible mushroom that grows in clusters on dead or dying trees. In addition to its culinary uses, research has found that the mushroom may also have potential medicinal properties..

High relevance

Oyster Mushroom · 2023 · Journal Article · Food research international (Ottawa, Ont.)

Activation of mycelial defense mechanisms in the oyster mushroom Pleurotus ostreatus induced by Tyrophagus putrescentiae

Fungal chemicals are vital in processes recognizing damage- and microbe-associated molecules (DAMPs/MAMPs) that trigger defense responses in fungi. Pleurotus ostreatus is a widely cultivated edible fungus that is prone to attack from fungivorous insects and mites.

Energy & fatigueMetabolic healthSkin & hydration

High relevance

Cordyceps · 2023 · Research Article · Antioxidants (Basel, Switzerland)

Adenosine Deaminase Inhibitory Activity of Medicinal Plants: Boost the Production of Cordycepin in Cordyceps militaris.

Cordycepin, also known as 3'-deoxyadenosine, is a major active ingredient of Cordyceps militaris with diverse pharmacological effects. Due to its limited supply, many attempts have been conducted to enhance the cordycepin content..

Immune support

High relevance

Almond Mushroom · 2023 · Research Article · Nutrients

Agaricus blazei Polysaccharide Alleviates DSS-Induced Colitis in Mice by Modulating Intestinal Barrier and Remodeling Metabolism.

Ulcerative colitis (UC) is a chronic noninfectious intestinal disease that severely affects patients' quality of life. Agaricus blazei Murrill polysaccharide (ABP) is an effective active ingredient extracted from Agaricus blazei Murrill (ABM)..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Lion's Mane · 2023 · Journal Article · Food & function

Ameliorating effects of Hericium erinaceus polysaccharides on intestinal barrier injury in immunocompromised mice induced by cyclophosphamide.

Hericium erinaceus is a kind of large fungus with rich nutrition and its polysaccharides exhibit various biological activities. In recent years, widespread interest has been focused on maintaining or improving intestinal health through the consumption of edible fungi..

Immune supportGut & microbiomeLiver support

High relevance

Chaga · 2023 · Research Article · Frontiers in pharmacology

Anti-cancer activity of Chaga mushroom (Inonotus obliquus) against dog bladder cancer organoids.

Despite its disadvantages, chemotherapy is still commonly used for the treatment of bladder cancer (BC). Developing natural supplements that can target cancer stem cells (CSCs) which cause drug resistance and distant metastasis is necessary..

OncologyEnergy & fatigue

High relevance

Cordyceps · 2023 · Research Article · PloS one

Antimicrobial, antioxidant, anti-inflammatory, and cytotoxic activities of Cordyceps militaris spent substrate.

Cordyceps militaris is a medicinal mushroom and has been extensively used as a traditional medicine in East Asia. After the chrysalis seeds are matured and harvested, the spent substrate of C.

OncologyImmune supportSkin & hydrationRespiratory

High relevance

King Oyster · 2023 · Research Article · Molecules (Basel, Switzerland)

Antioxidant Activity of Polysaccharides from the Edible Mushroom Pleurotus eryngii.

In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii was evaluated.

Immune supportCognition & nervesEnergy & fatigue

High relevance

Lion's Mane · 2023 · Research Article · Molecules (Basel, Switzerland)

Antioxidative Activities of Micronized Solid-State Cultivated Hericium erinaceus Rich in Erinacine A against MPTP-Induced Damages.

The Lion's mane mushroom (Hericium erinaceus, HE) is a traditional medical mushroom with high nutritional and economic value. HE possesses anticancer, antimicrobial, antioxidant, immunomodulating, neurotrophic, and neuroprotective activities..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Niu-Chang-Chih · 2023 · Journal Article · Environmental toxicology

Antrodia camphorata and coenzyme Q0, a novel quinone derivative of Antrodia camphorata, impede HIF-1α and epithelial-mesenchymal transition/metastasis in human glioblastoma cells.

Antrodia camphorata (AC) and Coenzyme Q0 (CoQ0 ), a novel quinone derivative of AC, exhibits antitumor activities. The present study evaluated EMT/metastasis inhibition and autophagy induction aspects of AC and CoQ0 in human glioblastoma (GBM8401) cells..

Oncology

High relevance

Oyster Mushroom · 2023 · Research Article · Frontiers in nutrition

Assessing the nutritional quality of Pleurotus ostreatus (oyster mushroom).

There is a huge gap between food production and the exploding population demands in various parts of the world, especially developing countries. This increases the chances of malnutrition, leading to increased disease incidence and the need for functional foods to reduce mortality..

Metabolic health

High relevance

Shiitake · 2023 · Research Article · Brazilian journal of microbiology: [publication of the Brazilian Society for Microbiology]

Bioconversion of rice straw by Lentinula edodes under different spawn formulations.

To attend to the growing world demand for mushrooms, it is interesting to increase the system's productivity, improve quality and reduce production costs. This study aimed to optimize the production and quality of fruiting bodies of the edible and medicinal mushroom Lentinula edodes (shiitake), in agroresidues….

High relevance

Enoki · 2023 · Research Article · IET nanobiotechnology

Biosynthesis of gold nanoparticles in the fruiting body of enoki mushrooms (Flammulina velutipes) under Pb2+ induction.

Fungi can produce many compounds, such as proteins, enzymes, amino acids, and polysaccharides, which are internalised and enriched for metals, and are widely used as reducing and stabilising agents for the biosynthesis of gold nanoparticles (Au NPs)..

Immune supportEnergy & fatigue

High relevance

Cordyceps · 2023 · Research Article · Pharmaceutics

CD44-Targeted Lipid Polymer Hybrid Nanoparticles Enhance Anti-Breast Cancer Effect of Cordyceps militaris Extracts.

This study aimed to improve the anticancer effect of Cordyceps militaris herbal extract (CME) on breast cancer cells with hyaluronic acid (HYA) surface-decorated lipid polymer hybrid nanoparticles (LPNPs) and evaluate the applicability of a synthesized poly(glycerol adipate) (PGA) polymer for LPNP preparation..

OncologyMetabolic healthLiver supportSkin & hydration

High relevance

Reishi · 2023 · Research Article · Evidence-based complementary and alternative medicine: eCAM

CD8+ T Cell-Mediated Therapeutic Antitumor Effect of an Herbal Mixture Containing Ganoderma lucidum.

Although Kampo-a traditional Japanese herbal medicine-contributes in the control of tumor growth in vivo in experimental animals, most of the antitumor effects are prophylactic and not therapeutic..

OncologyImmune support

High relevance

Chaga · 2023 · Journal Article · International journal of medicinal mushrooms

Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), Polysaccharides Alleviate Photoaging by Regulating Nrf2 Pathway and Autophagy.

Inonotus obliquus is a medicinal mushroom that contains the valuable I. obliquus polysaccharides (IOP), which is known for its bioactive properties.

OncologyImmune supportSkin & hydration

High relevance

Reishi · 2023 · Journal Article · Industrial crops and products

Changes in polyphenols composition and antioxidative properties of hemp (Cannabis sativa L.) inflorescences pretreated by Ganoderma lucidum

The purpose of present study was to improve the antioxidative activity and explore the potential biotransformation mechanism in hemp (Cannabis sativa L.) inflorescences pretreated with Ganoderma lucidum..

High relevance

Shiitake · 2023 · Research Article · Foods (Basel, Switzerland)

Changes in the Physical Properties and Volatile Odor Characteristics of Shiitake Mushrooms (Lentinula edodes) in Far Infrared Radiation Drying.

The effects of far infrared radiation drying (FID) on physical properties (drying kinetics, color, shrinkage ratio, rehydration ratio, and microstructural characterization) and volatile odor characteristics (volatile odor profile distinction and volatile compounds) of shiitake mushrooms were evaluated in this study..

Skin & hydration

High relevance

Cordyceps · 2023 · Research Article · Life (Basel, Switzerland)

Chitinase Is Involved in the Fruiting Body Development of Medicinal Fungus Cordyceps militaris.

Cordyceps militaris is a famous traditional edible and medicinal fungus in Asia, and its fruiting body has rich medicinal value. The molecular mechanism of fruiting body development is still not well understood in C.

High relevance

Cordyceps · 2023 · Journal Article · International journal of biological macromolecules

CM3-SII polysaccharide obtained from Cordyceps militaris ameliorates hyperlipidemia in heterozygous LDLR-deficient hamsters by modulating gut microbiota and NPC1L1 and PPARα levels.

Accumulating evidence has demonstrated that polysaccharides derived from edible fungi have lipid-lowering effects in mice. However, the lipid metabolism mechanisms in mice and humans are different..

Immune supportMetabolic healthGut & microbiomeLiver support