MycoData

Cordyceps · 2019 · Comparative Study · MicrobiologyOpen

Metabolic comparison of aerial and submerged mycelia formed in the liquid surface culture of Cordyceps militaris.

An entomopathogenic fungus, Cordyceps sp. has been known to produce cordycepin which is a purine nucleoside antimetabolite and antibiotic with potential anticancer, antioxidant and anti-inflammatory activities..

OncologyEnergy & fatigueGut & microbiome

Lion's Mane · 2019 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

Molecular properties, structure, and antioxidant activities of the oligosaccharide Hep-2 isolated from cultured mycelium of Hericium erinaceus.

The oligosaccharide Hep-2 from cultured mycelium of Hericium erinaceus was obtained with a hollow-fiber ultrafiltration cartridge and purified with a DEAE Sephadex A-50 column followed by a Bio-Gel P-30 column. The properties, structure, and antioxidant activities of Hep-2 were studied..

OncologyImmune supportEnergy & fatigue

Oyster Mushroom · 2019 · Research Support, Non U.S. Gov'T · PloS one

Optimization of extraction of antioxidant polysaccharide from Pleurotus ostreatus (Jacq.) P. Kumm and its cytotoxic activity against murine lymphoid cancer cell line.

The purpose of this study was to optimize the extraction method for polysaccharide from the fruiting bodies of Pleurotus ostreatus (Jacq.) P. Kumm and to assess the antioxidant and cytotoxic potentials of polysaccharide.

OncologyEnergy & fatigueRespiratory

Chaga · 2018 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Chaga ( Inonotus obliquus), a Future Potential Medicinal Fungus in Oncology? A Chemical Study and a Comparison of the Cytotoxicity Against Human Lung Adenocarcinoma Cells (A549) and Human Bronchial Epithelial Cells (BEAS-2B).

BACKGROUND: Inonotus obliquus, also known as Chaga, is a parasitic fungus growing on birches and used in traditional medicine (especially by Khanty people) to treat various health problems..

Cordyceps · 2017 · Research Support, Non U.S. Gov'T · Advances in experimental medicine and biology

Fermented Asterina pectinifera with Cordyceps militaris Mycelia Induced Apoptosis in B16F10 Melanoma Cells.

This prime objective of this study was to explore the anti-cancer activity of fermented Asterina pectinifera with Cordyceps militaris mycelia (FACM) in B16F10 murine melanoma cells. The effect of FACM on cell viability was assessed using MTT assay.

OncologyImmune supportMetabolic healthLiver support

King Oyster · 2016 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Chemical characterization of Pleurotus eryngii polysaccharide and its tumor-inhibitory effects against human hepatoblastoma HepG-2 cells.

This study was designed to investigate the chemical characterization and antitumor effects of Pleurotus eryngii polysaccharides (PEP). The crude PEP was fractionated into two fractions, namely PEP-1 and PEP-2..

Cordyceps · 2016 · Research Support, Non U.S. Gov'T · Food & function

Cordyceps militaris fruit body extract ameliorates membranous glomerulonephritis by attenuating oxidative stress and renal inflammation via the NF-κB pathway.

Membranous glomerulonephritis (MGN) is a common pathogenesis of nephritic syndrome in adult patients. Nuclear factor kappa B (NF-κB) serves as the main transcription factor for the inflammatory response mediated nephropathy..

Cordyceps · 2015 · Journal Article · Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]

[Assessment of Antitumor Effect of Submerged Culture of Ophiocordyceps sinensis and Cordyceps militaris].

Ophiocordyceps sinensis and Cordyceps militaris metabolites showed a high potential in the treatment of tumors as well as some other diseases. Antitumor properties of O.

Cordyceps · 2015 · Research Article · Pharmacognosy magazine

A direct protein kinase B-targeted anti-inflammatory activity of cordycepin from artificially cultured fruit body of Cordyceps militaris.

BACKGROUND: Cordyceps militaris is one of well-known medicinal mushrooms with anti-inflammatory, anti-cancer, anti-diabetic, and anti-obesity activities. OBJECTIVE: The objective of the following study is to isolate chemical components from the ethanol extract (Cm-EE) from Cordyceps militaris and to evaluate their….

OncologyImmune supportLiver supportRespiratory

King Oyster · 2015 · Journal Article · Journal of food biochemistry

Antitumor and Immunomodulatory Activity of Pleurotus eryngii Extract

Pleurotus eryngii (P. eryngii), also known as the king oyster mushroom, contains many bioactive substances, including polysaccharides, lipids, peptides, sterols and triterpenoids.

Chaga · 2015 · Journal Article · Proceedings of the Entomological Society of Washington

First Record of Insect Mycophagy of the Commercially-Important “Chaga” Fungus Inonotus obliquus (Ach. Ex Pers.) Pilát (Hymenochaetales: Hymenochaetaceae) in North America.

Beetles of Family Melandryidae occur under the bark of mature and rotting trees, but have been poorly studied and their life histories have seldom been described. They are thought to feed on rotting wood or fungal hyphae..

OncologyGut & microbiome

Shiitake · 2015 · Research Article · PloS one

Lentinula edodes-derived polysaccharide alters the spatial structure of gut microbiota in mice.

Lentinula edodes-derived polysaccharides possess many therapeutic characteristics, including anti-tumor and immuno-modulation. The gut microbes play a critical role in modulation of immune function.

Maitake · 2015 · Journal Article · Journal of leukocyte biology

Soluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist via dendritic cell-mediated immunity.

The maturation of dendritic cells into more-immunostimulatory dendritic cells by stimulation with different combinations of immunologic agents is expected to provide efficient, adoptive immunotherapy against cancer..

OncologyImmune supportEnergy & fatigueGut & microbiome

Mesima · 2014 · Journal Article · Journal of ethnopharmacology

Anti-inflammatory effect of Phellinus linteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages.

ETHNOPHARMACOLOGICAL RELEVANCE AND AIM OF THE STUDY: Phellinus linteus is a herb used in traditional Asian medicine to treat stomachache, inflammation, and tumors. Recent studies show that the extract of Phellinus linteus has anti-inflammatory and antitumor activities..

OncologyImmune supportLiver supportRespiratory

King Oyster · 2014 · Journal Article · Journal of the science of food and agriculture

Antiproliferative and immunostimulatory activity of a protein from Pleurotus eryngii

BACKGROUND: Currently, the use of mushrooms as functional foods, nutraceuticals or phytopharmaceuticals source has risen. In contrast, the possible cellular cytotoxicity and immunostimulatory activity of Pleurotus eryngii (DC.

Cordyceps · 2014 · Journal Article · Annals of parasitology

Cordyceps fungi as natural killers, new hopes for medicine and biological control factors.

The Cordyceps genus includes many species of fungi, most of which are endoparasitoids on arthropods.The distribution of these fungi is cosmopolitan, but many occur in regions such as Asia with a hot, humid climate. These pathogens of insect pests are promising candidates for use as biological control factors..

Chaga · 2014 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Inhibitory and Acceleratory Effects of Inonotus obliquus on Tyrosinase Activity and Melanin Formation in B16 Melanoma Cells.

The aim of the present study is to preliminarily investigate the antimelanogenesis effect of Inonotus obliquus extracts by cell-free mushroom tyrosinase assay. It was found that petroleum ether and n-butanol extracts might contain unknown potential tyrosinase inhibitors, while its ethyl acetate extract might contain….

OncologySkin & hydration

OncologyImmune supportCognition & nerves

Chaga · 2014 · Journal Article · International journal of medicinal mushrooms

Inhibitory effects of a polysaccharide extract from the Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), on the proliferation of human neurogliocytoma cells.

This study aimed to investigate the inhibitory roles of a polysaccharide extract from Inonotus obliquus on U251 human neurogliocytoma cells cultured in vitro. After administering the polysaccharide extract from I..

OncologyEnergy & fatigueRespiratory

Chaga · 2014 · Journal Article · Journal of photochemistry and photobiology. B, Biology

Mycosynthesis: antibacterial, antioxidant and antiproliferative activities of silver nanoparticles synthesized from Inonotus obliquus (Chaga mushroom) extract.

In the present study, silver nanoparticles (AgNPs) were rapidly synthesized from silver nitrate solution at room temperature using Inonotus obliquus extract. The mycogenic synthesized AgNPs were characterized by UV-Visible absorption spectroscopy, Fourier transform infrared (FTIR), scanning electron microscopy (SEM)….

OncologyImmune supportEnergy & fatigue

Almond Mushroom · 2013 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Anti-Inflammatory Activity of Water-Soluble Polysaccharide of Agaricus blazei Murill on Ovariectomized Osteopenic Rats.

In the present study, we investigated the anti-inflammatory activity of water-soluble polysaccharide of Agaricus blazei Murill (WSP-AbM) on ovariectomized osteopenic rats. The rats were administered orally WSP-AbM (200 mg/kg BW) for 8 weeks..

King Oyster · 2013 · Journal Article · Carbohydrate polymers

Antitumor activity of a polysaccharide from Pleurotus eryngii on mice bearing renal cancer.

One water-soluble polysaccharide (PEPw), with an average molecular weight of 2.5×10(4)Da, was isolated from the fruiting bodies of Pleurotus eryngii and subjected to composition analysis and evaluated for the antitumor and immunomodulatory activity..

OncologyImmune supportLiver supportRespiratory

Almond Mushroom · 2013 · Journal Article · Clinical journal of gastroenterology

Drug-induced liver injury associated with Agaricus blazei Murill which is very similar to autoimmune hepatitis.

Agaricus blazei Murill (ABM) is one of the most popular complementary alternative medicines (CAM). We experienced a case of a 60-year-old woman with severe hepatitis associated with extract of ABM and extract of Ganoderma lucidum, and a case of a 75-year-old man with drug-induced liver injury (DILI) associated with….

Chaga · 2013 · Journal Article · Food research international (Ottawa, Ont.)

Effect of different drying methods on physicochemical properties and antioxidant activities of polysaccharides extracted from mushroom Inonotus obliquus

Inonotus obliquus is a kind of mushroom which has long been used as a folk remedy for curing various diseases such as cancers, heart disease and diabetes in Russian and Eastern Europe. Polysaccharides are one of the main bioactive constituents of Inonotus obliquus with health functions..

OncologyGut & microbiomeRespiratory

Lion's Mane · 2013 · Journal Article · Journal of agricultural and food chemistry

Hericium erinaceus (Lion's Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted mice.

This study investigated the antimetastatic activity of four Hericium erinaceus edible mushroom extracts using CT-26 murine colon carcinoma cells as an indicator of inhibition of cell migration to the lung. Hot water (HWE) and microwaved 50% ethanol (MWE) extracts of H..

King Oyster · 2013 · Journal Article · Archives of microbiology

Medium optimization, molecular characterization, and bioactivity of exopolysaccharides from Pleurotus eryngii.

An optimal medium for exopolysaccharides (EPS) production was obtained through one-factor-at-a-time method and response surface methodology. Under optimal culture medium, the maximum EPS concentration in shake flask was 5.16 g/l..

Maitake · 2013 · Journal Article · International journal of cancer

Oral administration of soluble β-glucans extracted from Grifola frondosa induces systemic antitumor immune response and decreases immunosuppression in tumor-bearing mice.

Maitake D (MD)-Fraction is a highly purified soluble β-glucan derived from Grifola frondosa (an oriental edible mushroom). Intraperitoneal (i.p.) injection of MD-Fraction has been reported to inhibit tumor growth via enhancement of the host immune system..

OncologyMetabolic healthLiver support

Almond Mushroom · 2013 · Research Article · Evidence-based complementary and alternative medicine: eCAM

The Medicinal Values of Culinary-Medicinal Royal Sun Mushroom (Agaricus blazei Murrill).

Agaricus blazei Murrill (ABM), a mushroom native to Brazil, is a basidiomycete brown fungus, which is popularly known as "Cogumelo do Sol" in Brazil or "Himematsutake" in Japan, and there has been a prominent increase in the use of ABM for therapeutic and medicinal purposes..

OncologyImmune supportLiver supportSkin & hydration

Shiitake · 2012 · Journal Article · Biological & pharmaceutical bulletin

Direct Cytotoxicity of Lentinula edodes Mycelia Extract on Human Hepatocellular Carcinoma Cell Line

Lentinula edodes mycelia (L.E.M.) is a dried powder extracted from shiitake mushrooms (Lentinula edodes). We previously demonstrated that it has immunomodulatory effects.

Maitake · 2012 · Journal Article · International journal of medicinal mushrooms

Immunomodulating activities of cultivated maitake medicinal mushroom Grifola frondosa (Dicks.: Fr.) S.F. Gray (higher Basidiomycetes) on peripheral blood mononuclear cells.

Grifola frondosa is a culinary-medicinal mushroom that contains several physiologically active compounds, of which polysaccharides, specifically β-glucans, are known to possess immunomodulating properties..

King Oyster · 2012 · Journal Article · Natural product communications

Osteoclastogenesis inhibitory effect of ergosterol peroxide isolated from Pleurotus eryngii.

Ergosterol peroxide was isolated from the ethanol extract of Pleurotus eryngii as an inhibitor of osteoclast differentiation. This compound showed an inhibitory effect in a dose-dependent manner and an inhibition rate of up to 62% with low cytotoxicity, even at a concentration as low as 1.0 microg/mL..

OncologyImmune supportLiver support

Almond Mushroom · 2011 · Journal Article · International journal of oncology

Agaricus blazei Murill enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells by NFκB-mediated increase of intracellular doxorubicin accumulation.

It has been demonstrated that the Agaricus blazei Murill (ABM) mushroom, which primarily consists of polysaccharides, possesses anti-tumor activities. However, the mechanisms by which ABM inhibits human hepatocellular carcinoma growth remain unknown..

OncologyImmune supportCognition & nervesGut & microbiome

Chaga · 2011 · Journal Article · International journal of medicinal mushrooms

Anticancer effects of fraction isolated from fruiting bodies of Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae): in vitro studies.

The medicinal mushroom Chaga, Inonotus obliquus (Pers.:Fr.) Pilát (Hymenochaetaceae), has been used in folk medicine in Russia, Poland, and most of the Baltic countries, as a cleansing and disinfecting measure, and as decoctions for stomach diseases, intestinal worms, liver and heart ailments, and cancer treatment..

Yellow Morel · 2011 · Journal Article · Journal of food processing and preservation

Biomass and exopolysaccharide production by morchella esculenta in submerged culture using the extract from waste loquat (eriobotrya japonica l.) kernels

Detoxified loquat kernel extract (DLKE) and neutralized loquat kernel extract (LKE) prepared from waste loquat kernels were used as main carbon sources in the submerged and solid cultures of Morchella esculenta..

Almond Mushroom · 2011 · Journal Article · In vivo (Athens, Greece)

Effect of Agaricus blazei Murrill extract on HT-29 human colon cancer cells in SCID mice in vivo.

Agaricus blazei Murrill (ABM) popularly known as 'Cogumelo do Sol' in Brazil, or 'Himematsutake' in Japan, is a mushroom native to Brazil and widely cultivated in Japan for its medicinal uses and is now considered one of the most important edible and culinary-medicinal biotechnological species..

Maitake · 2011 · Journal Article · Carbohydrate polymers

Effect of the degree of oxidation on the physicochemical and biological properties of Grifola frondosa polysaccharides

Polysaccharide extracted from Grifola frondosa was subjected to 2,2,6,6-tetramethyl-1-piperidine oxoammonium ion (TEMPO)-mediated oxidation of which effects on the structural and biological properties of the polysaccharide were investigated as a function of degree of oxidation..

King Oyster · 2011 · Journal Article · Food Hydrocolloids

Effect of the degree of sulfation on the physicochemical and biological properties of Pleurotus eryngii polysaccharides

Polysaccharides extracted from Pleurotus eryngii were chemically modified by sulfation and the effects on the structural and biological properties of the polysaccharides were investigated as a function of the degree of sulfation. ¹³C NMR spectroscopy demonstrated that polysaccharides from P..

OncologyImmune supportRespiratory

Chaga · 2011 · Journal Article · Chinese journal of integrative medicine

Effects of inotodiol extracts from inonotus obliquus on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line A549.

OBJECTIVE: To observe the proliferation inhibition, apoptosis, and cell proliferation cycle of human lung carcinoma cell line A549 treated with Inotodiol extracts from Inonotus obliquus and explore the possibility of Inotodiol extracts from Inonotus obliquus as a new tumor chemopreventive drug..

OncologyImmune supportGut & microbiomeLiver support

Almond Mushroom · 2011 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Phase I Clinical Study of the Dietary Supplement, Agaricus blazei Murill, in Cancer Patients in Remission.

Although many cancer patients use complementary and alternative medicine, including Agaricus blazei Murill (ABM), safety is not yet well understood. Cancer survivors took 1.8, 3.6, or 5.4 g ABM granulated powder (Kyowa Wellness Co., Ltd., Tokyo, Japan) per day orally for 6 months..

Maitake · 2010 · Research Article · Cancer immunology, immunotherapy: CII

A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer.

We previously isolated the novel heteropolysaccharide maitake Z-fraction (MZF) from the maitake mushroom (Grifola frondosa), and demonstrated that MZF significantly inhibited tumor growth by inducing cell-mediated immunity..

Chaga · 2010 · Research Article · Nutrition research and practice

Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells.

The Chaga mushroom (Inonotus obliquus) has been used in folk medicine to treat cancers. However, limited information exists on the underlying anticancer effects of the major component of I.

OncologyRespiratory

Maitake · 2010 · Journal Article · Journal of medicinal food

Potential antitumor activity of a low-molecular-weight protein fraction from Grifola frondosa through enhancement of cytokine production.

Edible mushrooms contain an abundance of immune-enhancing nutritients. Some of these compounds, referred to as biological response modifiers (BRMs), have been used in biological therapies for cancer treatment..

OncologyImmune supportEnergy & fatigueMetabolic health

Enoki · 2010 · Journal Article · The American journal of Chinese medicine

Purification, characterization and immuno-modulating properties of polysaccharides isolated from Flammulina velutipes mycelium.

To investigate the immuno-modulating activity of Flammulina velutipes mycelium, three different Flammulina velutipes polysaccharides (FVPs) were isolated by fractionation using gel filtration and were identified as the immunomodulators of murine peritoneal macrophages..

OncologyImmune supportRespiratory

Mesima · 2009 · Research Article · Mycobiology

Anti-cancer Activities of Ginseng Extract Fermented with Phellinus linteus.

In the present study, the anti-cancer effects of ginseng fermented with Phellinus linteus (GFPL) extract were examined through in vitro and in vivo assays. GFPL was produced by co-cultivating ginseng and Phellinus linteus together..

Maitake · 2009 · Journal Article · Oncology reports

Antitumor effects of a water-soluble extract from Maitake (Grifola frondosa) on human gastric cancer cell lines.

We investigated the effects of a water-soluble extract of Maitake (Grifola frondosa), a Japanese edible mushroom, on the proliferation and cell death of four human gastric cancer cell lines (TMK-1, MKN28, MKN45 and MKN74)..

Chaga · 2009 · Journal Article · Journal of medicinal food

Cancer cell cytotoxicity of extracts and small phenolic compounds from Chaga [Inonotus obliquus (persoon) Pilat].

Previously, we studied the antioxidant potential of Chaga mushroom [Inonotus obliquus (persoon) Pilat] extracts and isolated several small (poly)phenolic compounds as the major antioxidant components in the 80% methanol (MeOH) extract..

Chaga · 2009 · Journal Article · Free radical biology & medicine

Prevention of hydrogen peroxide-induced oxidative stress in PC12 cells by 3,4-dihydroxybenzalacetone isolated from Chaga (Inonotus obliquus (persoon) Pilat).

Chaga (Inonotus obliquus (persoon) Pilat) is a mushroom traditionally used as a folk medicine for tumors and stomach ulcers in Russia. Previously, we reported the antioxidant potential of Chaga extracts and seven isolated phenolic ingredients..

OncologyEnergy & fatigue

Niu-Chang-Chih · 2008 · Journal Article · Journal of ethnopharmacology

Immunomodulatory effect of Antrodia camphorata mycelia and culture filtrate.

AIM OF THE STUDY: Antrodia camphorata, a precious folkloric medicinal mushroom, has been used to treat tumorigenic diseases in Taiwan. This study was to investigate the innate immunity augmentation effects of different fractions prepared from hot water extracts of submerged cultured Antrodia camphorata (AC)..

Mesima · 2008 · Research Article · Mycobiology

Submerged Culture of Phellinus linteus for Mass Production of Polysaccharides.

In order to increase the mycelial production of Phellinus linteus, which exhibits potent anticancer activity, some ingredients of the medium used to culture P. linteus were investigated..

King Oyster · 2006 · Journal Article · Applied microbiology and biotechnology

A hemolysin from the mushroom Pleurotus eryngii.

A monomeric 17-kDa hemolysin designated as eryngeolysin was isolated from fresh fruiting bodies of the mushroom Pleurotus eryngii, using a protocol that involved gel filtration on Superdex 75, ion exchange chromatography on Mono Q and gel filtration on Superdex 75..