MycoData

BACKGROUND: Basic helix-loop-helix (bHLH) transcription factors (TFs) widely exist in eukaryotic organisms and play a key role in plant growth and development in response to environmental stresses..

OncologyLiver support

Medium relevance

Enoki · 2025 · Research Article · Journal of applied glycoscience

Characterization of Chitinase from White-Rot Fungus Irpex lacteus NK-1.

Chitin is a cell wall structural component of many fungi and is important for mycelium growth. Therefore, enzymes like chitinase which break down chitin, are likely important in fungi during morphological changes.

Medium relevance

Shiitake · 2025 · Research Article · Frontiers in nutrition

Combined analysis of proteomics and metabolism reveals critical roles of oxidoreductase activity in mushrooms stimulated by wolfberry and sea buckthorn substrates.

BACKGROUND: Cultivating edible fungi, particularly Lentinula edodes, efficiently transforms agroforestry byproducts into valuable products. However, the mechanism of the promotive effects of those substrates was largely unknown..

Metabolic health

Medium relevance

Reishi · 2025 · Journal Article · Zeitschrift fur Naturforschung. C, Journal of biosciences

Comparison of lignocellulosic enzymes and CAZymes between ascomycetes (Trichoderma) and basidiomycetes (Ganoderma) species: a proteomic approach.

Wood decomposing ascomycetes and basidiomycetes group of fungi are the most valuable microbes on the earth's ecosystem that recycles the source of carbon; therefore, they are essential for the biorefinery industries..

Immune supportMetabolic health

Medium relevance

Oyster Mushroom · 2025 · Research Article · BMC complementary medicine and therapies

Computational development of mushroom-6-glucan/paclitaxel as a synergistic complementary medicine for breast cancer therapy.

BACKGROUND: Breast cancer is chemo-resistant and highly metastatic, often resulting in patient mortality. One of the primary factors contributing to the metastasis and chemotherapy resistance is the presence of cancer stem-like cells..

OncologyImmune supportEnergy & fatigueGut & microbiome

Medium relevance

Turkey Tail · 2025 · Research Article · Biotechnology journal

Conductive Hairy Particles With Homogeneous and Janus Design as Carrier Materials for the Efficient Immobilization of Unspecific Peroxygenases.

Efficient immobilization of unspecific peroxygenases (UPOs) on hairy particles with homogeneous and Janus design possessing conductive core and polymeric shell was demonstrated..

Energy & fatigue

Medium relevance

Reishi · 2025 · Journal Article · Natural product research

Decalin derivatives from an endophytic fungus Trichoderma harzianum GLQ03 and their anti-inflammatory activities.

Eight metabolites (1-8) including a new compound tandyukisin J (1) were isolated from Trichoderma harzianum GLQ03 isolated from Ganoderma lucidum. Their absolute configurations were determined based on spectroscopic analysis and CD comparison..

Immune support

Medium relevance

Reishi · 2025 · Research Article · Cell discovery

Decoding and reprogramming of the biosynthetic networks of mushroom-derived bioactive type II ganoderic acids in yeast.

Mushroom's specialized secondary metabolites possess important pharmacological activities, but their biosynthetic pathway elucidation is extremely challenging, not to mention reprogramming of their biosynthetic networks to target metabolites..

Metabolic health

Medium relevance

Oyster Mushroom · 2025 · Journal Article · International journal of biological macromolecules

Deep-blue emitting fibers: tracking aggregation of a hydrophobin through intrinsic fluorescence.

Amyloid fibrils are highly ordered protein aggregates typically characterized by a cross-β sheet structure. Class I hydrophobin Vmh2, produced by the fungus Pleurotus ostreatus, exhibits a unique ability to self-assemble into giant fibrillar structures and to emit deep-blue fluorescence upon UV excitation, despite….

Medium relevance

Turkey Tail · 2025 · Journal Article · Engineering in life sciences

Design of a Biocatalytic Filter for the Degradation of Diclofenac and Its Ozonation Products.

Posttreatment of the effluents from wastewater treatment plants is becoming increasingly important, as the conventional treatment cannot completely remove organic trace contaminants..

Energy & fatigue

Medium relevance

Yellow Morel · 2025 · Research Article · RSC advances

Design, synthesis, and antimicrobial evaluation of novel 1,2,4-trizaole thioether derivatives with a 1,3,4-thiadiazole skeleton.

The aim of this study was to design and synthesize 17 novel 1,2,4-triazole thioether derivatives containing 1,3,4-thiadiazole thioether. Bioactivity assays indicated that several target compounds exhibited moderate to good antifungal and antibacterial activities..

Medium relevance

Reishi · 2025 · Research Article · Frontiers in nutrition

Development and preliminary mechanistic analysis of compound effervescent hepatoprotective granules.

BACKGROUND: The causes of acute liver injury (ALI) are complex and diverse, including alcohol, drugs, infections, and toxic substances, and it has become a major global health issue..

Immune supportMetabolic healthLiver support

Medium relevance

Oyster Mushroom · 2025 · Journal Article · Biodegradation

Development of a robust enzyme cascade system: co-immobilization of laccase and versatile peroxidase on polyacrylamide hydrogel for enhanced BPA degradation.

Biodegradation using a synergically integrated system of laccase (E.C. 1.10.3.2) and versatile peroxidase (EC 1.11.1.16) co-immobilized on the polyacrylamide (PAM) hydrogel presents a promising solution for removing endocrine disrupting chemicals (EDCs) like bisphenol A (BPA) from wastewater..

Medium relevance

Shiitake · 2025 · Journal Article · Journal of food composition and analysis

Development of an analytical fluorescence method for quantifying β-glucan content from mushroom extracts; utilizing curcumin as a green chemical fluorophore

In this study, a β-glucan quantification method from mushrooms based on the fluorescence enhancement of interaction with curcumin was developed. Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR) was used to confirm the interaction..

Medium relevance

Niu-Chang-Chih · 2025 · Research Article · Molecular medicine reports

Eburicoic acid inhibits endothelial cell pyroptosis and retards the development of atherosclerosis through the Keap1/Nrf2/HO‑1/ROS pathway.

Atherosclerosis (AS)‑related coronary artery disease is the main cause of morbidity and mortality around the globe. Eburicoic acid, a triterpenoid compound from Antrodia camphorata, exerts anti‑inflammatory and anti‑hyperlipidemic effects, although its role in atherogenesis remains unknown..

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Turkey Tail · 2025 · Journal Article · Eur. J. Wood Prod

Eco-friendly laminates for extreme environments: potential for application in high durability structures

The durability of hybrid composites under environmental and biological stresses is a significant challenge for sustainable structural materials. This study assessed vacuum-infused hybrid composites made of Pinus elliottii veneers, unidirectional jute fabrics, fiberglass mats, and an unsaturated isophthalic polyester….

Medium relevance

Zhu Ling · 2025 · Research Article · Pharmaceuticals (Basel, Switzerland)

Effect and Mechanism of Qihua Tongtiao Formula (QHTTF) on Improving Glucose and Lipid Metabolism Disorders in ZDF Rats by Integrating Network Pharmacology, Metabolomics, and Biological Validation.

Background: The dysregulation of both glucose and lipid metabolism is the main clinical features of type 2 diabetes. Qihua Tongtiao Formula (QHTTF) is our team's current clinical empirical formula, and the related patent has been granted..

Immune supportMetabolic healthLiver support

Medium relevance

Lion's Mane · 2025 · Research Article · Food chemistry: X

Effects of adding food ingredients rich in dietary fiber and polyphenols on the microstructure, texture, starch digestibility and functional properties of Chinese steamed bun.

This study incorporated pitaya (dragon fruit), kudzu root, and Hericium erinaceus (DKH) as functional ingredients into Chinese steamed bun (CSB) to investigate their impact on nutritional composition, textural properties, microstructure, starch digestibility, and postprandial glycemic response..

Metabolic healthGut & microbiomeSkin & hydration

Medium relevance

Lion's Mane · 2025 · Journal Article · The Journal of pharmacy and pharmacology

Effects of dietary supplementation with arboreal medicinal mushrooms on stress coping strategies, depressive and anxiety-like behavior of rats.

BACKGROUND: Preclinical studies have demonstrated that the edible arboreal medicinal mushroom Hericium erinaceus (HE) mitigates high corticosterone levels and enhances stress-coping strategies in rodents, with emerging evidence suggesting similar neuroprotective potential for Fomitopsis officinalis (FO) and Pleurotus….

Immune supportCognition & nervesEnergy & fatigue

Medium relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Effects of Ganoderma spent substrate containing with polysaccharides and triterpenoids on the growth performance, antioxidant capacity and immunity level of chickens.

Ganoderma spent substrate (GSS) is the residual material of Ganoderma lucidum (GL) cultivation, which has abundant polysaccharides and triterpenoids. GL is widely recognized for its antioxidant and immune-boosting properties, however, the effects of GSS remain largely unexplored..

OncologyImmune supportEnergy & fatigueSkin & hydration

Medium relevance

Shiitake · 2025 · Research Article · BMC nutrition

Effects of three different dietary β-gulcans supplementation on the microbiota composition and short-chain fatty acid production in mice.

BACKGROUND: Dietary β-glucans from diverse sources exhibit varying prebiotic potentials, yet their comparative impacts on gut microbiota composition and short-chain fatty acid (SCFAs) production remain underexplored..

Cognition & nervesMetabolic healthGut & microbiome

Medium relevance

Turkey Tail · 2025 · Research Article · Frontiers in microbiology

Efficient degradation of neomycin by Bacillus velezensis and Cupriavidus basilensis isolated from mangrove soil and pharmaceutical wastewater.

Neomycin, an aminoglycoside antibiotic, is widely utilized for veterinary medicine in disease prevention. Biodegradation is a key pathway for the removal of neomycin from the environment..

Metabolic health

Medium relevance

Turkey Tail · 2025 · Journal Article · International Journal of Biological Macromolecules

Efficient immobilization of enzyme on covalent organo-framework for remediation of pyrene-contaminated soil and degradation mechanism

Bioremediation of polycyclic aromatic hydrocarbons (PAHs) using immobilized enzymes has garnered significant interest due to its cost-effectiveness, stability, and efficiency. In this regard enzyme laccase have been extensively used for the remediation of organic contaminants in aqueous solutions..

Medium relevance

Turkey Tail · 2025 · Journal Article · International journal of biological macromolecules

Efficient immobilization of enzyme on covalent organo-framework for remediation of pyrene-contaminated soil and degradation mechanism.

Medium relevance

Reishi · 2025 · Journal Article · Biotechnology and applied biochemistry

Elucidating the protective mechanism of ganoderic acid DM on breast cancer based on network pharmacology and in vitro experimental validation.

Ganoderma lucidum, a popular medicinal fungus, has been utilized to treat a variety of diseases. It possesses a unique therapeutic and pharmacological reputation in suppressing cancer/tumor progression, especially breast cancer, due to its embedded rich bioactive chemical constituents, mainly triterpenoids (ganoderic….

OncologySkin & hydration

Medium relevance

Oyster Mushroom · 2025 · Research Article · Current issues in molecular biology

Enzymatic Activity and Nutrient Profile Assessment of Three Pleurotus Species Under Pasteurized Cenchrus fungigraminus Cultivation.

Oyster mushrooms are regarded as one of the most significant edible mushrooms in terms of commercial value because of their rich nutritional profile. Many bioactive extracts from Pleurotus species have been found to exhibit antitumor and antioxidant activities..

OncologyEnergy & fatigue

Medium relevance

Reishi · 2025 · Research Article · Frontiers in pharmacology

Evaluation of in vitro pharmacological activities of medicinal mushrooms in the context of dry eye disease.

INTRODUCTION: Ethnic groups worldwide use mushrooms, particularly polypores (a group of fungi with woody fruiting bodies), to manage inflammatory conditions. In this study, the in vitro anti-inflammatory potential and mycochemical composition of six polypore extracts derived from the fruit bodies of Fomes fomentarius….

OncologyImmune supportEnergy & fatigueSkin & hydration

Medium relevance

Oyster Mushroom · 2025 · Research Article · Foods (Basel, Switzerland)

Evaluation of the Gelation Characteristics and Printability of Edible Filamentous Fungi Flours and Protein Extracts.

There is a pressing need to produce novel food ingredients from sustainable sources to support a growing population. Filamentous fungi can be readily cultivated from low-cost agricultural byproducts to produce functional proteins for food biomanufacturing of structured products..

Energy & fatigue

Medium relevance

Oyster Mushroom · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Evolutionary Dynamics and Functional Bifurcation of the C2H2 Gene Family in Basidiomycota.

This study performed a phylogenomic analysis of the C2H2 gene family across 30 Basidiomycota species, identifying 1032 genes distributed across six evolutionary clades (Groups I-VI)..

Medium relevance

Oyster Mushroom · 2025 · Research Article · Materials (Basel, Switzerland)

Experimental Assessment of Multiple Properties of Mycelium-Based Composites with Sewage Sludge and Bagasse.

Mycelium-based composites (MBCs) have a lot of potential as an alternative lightweight material due to their small environmental footprint and their biodegradability. The unique properties of cellulose-rich sewage sludge (SS) allow it to be used as a substrate for manufacturing MBCs..

Medium relevance

Zhu Ling · 2025 · Journal Article · Biotechnology and applied biochemistry

Exploration of Basidiomycetes for Anthraquinone Dyes Decolorization in Textile Wastewater.

Anthraquinone (AQ) dyes are utilized extensively in the textile industry due to their ability to fasten fabrics. The intricate and rigid structures of AQ dyes, however, prevent them from biodegradation..

Medium relevance

Oyster Mushroom · 2025 · Journal Article · Innovative Food Science and Emerging Technologies

Exploring an eco-friendlier strategy for chitosan production and valuable compounds recovery from mushroom by-products with modified subcritical water

Chitosan is the deacetylated derivative of chitin, the second most abundant polysaccharide in nature. It is a promising eco-friendly polymer with immense potential owing to its unique properties and high versatility, offering notable contributions to various industries..

Immune support

Medium relevance

Oyster Mushroom · 2025 · Research Article · Frontiers in microbiology

Exploring the multifunctionality of myco-synthesized selenium nanoparticles: biological, docking study and plant growth-promoting perspectives.

Selenium is a vital trace mineral that regulates essential physiological functions, and the development of sustainable methods for synthesizing selenium nanoparticles (SeNPs) is an active area of research..

Respiratory

Medium relevance

Lion's Mane · 2025 · Research Article · Foods (Basel, Switzerland)

Exploring the Nutraceutical Potential of a Food-Medicine Compound for Metabolic-Associated Fatty Liver Disease via Lipidomics and Network Pharmacology.

Metabolic-associated fatty liver disease (MAFLD) is a prevalent global health issue closely tied to dietary habits, impacting a significant portion of the adult population..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Reishi · 2025 · Journal Article · International journal of medicinal mushrooms

Fatty Acid Determination and Activity Evaluation of Wild Higher Fungi from Southern Sichuan, China.

To study the species composition and resource value of wild higher fungi, 29 mushrooms were collected in southern Sichuan, China. The antioxidant activity was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), and total reducing power..

Oncology

Medium relevance

Reishi · 2025 · Research Article · Polymers

Functionalized Micellar Membranes from Medicinal Mushrooms as Promising Self-Growing Bioscaffolds.

Micellar or mycelial membranes from medicinal mushrooms are self-growing fibrous polymeric biocomposites that are biocompatible, biodegradable, cost-effective, and environmentally friendly..

Metabolic healthSkin & hydration

Medium relevance

Turkey Tail · 2025 · Journal Article · International Journal of Biological Macromolecules

Fungal competition in thermally modified Scots pine wood as related to changes in lignocellulosic composition and laccase activity

Lignocellulosic composition undergoes significant changes after thermal modification (TM), thus affecting the competitive environment for decaying fungi and ultimately the decay resistance of the thermally modified wood (TMW)..

Medium relevance

Turkey Tail · 2025 · Journal Article · International journal of biological macromolecules

Fungal competition in thermally modified Scots pine wood as related to changes in lignocellulosic composition and laccase activity.

Medium relevance

Turkey Tail · 2025 · Journal Article · Eur. J. Wood Prod

Fungal decay resistance, formaldehyde emission and weathering resistance of plywood modified with phenol-formaldehyde resin with partial substitution of phenol by pyrolysis cleavage products of softwood kraft lignin

Wood modification by impregnation with phenol-formaldehyde (PF) resins is a promising method to improve the woods’ fungal decay resistance, weathering resistance, and dimensional stability..

Medium relevance

Enoki · 2025 · Research Article · Scientific reports

Fungal immunomodulatory protein FIP-fve mitigates airway inflammation and metabolic dysfunction in an obese allergic asthma model.

Obesity is a growing global health concern that exacerbates the risk and severity of allergic asthma, yet effective therapies and mechanistic understanding remain limited..

Immune supportMetabolic healthLiver supportRespiratory

Medium relevance

Oyster Mushroom · 2025 · Journal Article · Industrial crops and products

Fungal mycelium enhanced magnetic biochar from rice straw for efficient tetracycline adsorption: A sustainable strategy for agricultural waste valorization

This study presents a sustainable fungal-biochar refinery approach to convert rice straw into a high-performance magnetic adsorbent. The material was synthesized via solid-state fermentation using Pleurotus ostreatus followed by carbonization and KHCO₃ activation at 900 °C..

Energy & fatigue

Medium relevance

Shiitake · 2025 · Research Article · Microorganisms

Fungal β-Glucans Enhance Lactic Acid Bacteria Growth by Shortening Their Lag Phase and Increasing Growth Rate.

The gut microbiome has a significant role in general health and well-being. Novel types of prebiotics, such as fungal polysaccharides, show potential for the formulation of new synbiotic formulations.

Immune supportGut & microbiome

Medium relevance

Lion's Mane · 2025 · Research Article · Materials (Basel, Switzerland)

Fungal-Derived Chitosan from In Vitro Mushroom Cultures as an Antimicrobial Matrix for Silver Nanoparticles in Advanced Bioactive Materials.

This study investigates chitosan extracted from in vitro cultures of Hericium erinaceus and Pleurotus ostreatus mushrooms as a novel antimicrobial matrix. The physicochemical properties including specific surface area, pore volume, and molecular structure were characterized by BET, SEM, and FTIR-ATR analyses..

Medium relevance

Lion's Mane · 2025 · Journal Article · Histology and histopathology

Galangin alleviates gastric mucosal injury in rats with chronic atrophic gastritis by reducing ferroptosis.

OBJECTIVE: Chronic atrophic gastritis (CAG) is a precancerous lesion and is the first stage in a multistep precancerous cascade that can lead to gastric adenocarcinoma. This study aimed to reveal the role and mechanism of galangin in CAG..

OncologyImmune supportEnergy & fatigue

Medium relevance

Reishi · 2025 · Journal Article · J Nat Med

Ganoderic acid A ameliorated LPS-induced depression-like behaviors via suppression of acute neuroinflammation

Research context reveals that major depressive disorder (MDD), as a prevalent chronic relapsing psychiatric condition affecting up to one-third of patients with treatment resistance, necessitates urgent development of novel therapeutic agents..

Immune supportCognition & nervesEnergy & fatigue

Medium relevance

Reishi · 2025 · Journal Article · Journal of natural medicines

Ganoderic acid A ameliorated LPS-induced depression-like behaviors via suppression of acute neuroinflammation.

Immune supportCognition & nervesEnergy & fatigue

Medium relevance

Reishi · 2025 · Journal Article · World journal of surgical oncology

Ganoderic acid a potentiates cisplatin's cytotoxicity on gallbladder cancer cells by promoting DNA damage and inhibiting cell stemness.

BACKGROUND: Ganoderma acid A (GAA), a triterpenoid compound from Ganoderma lucidum, has gained attention for its anti-tumor properties. Herein, we hypothesized that GAA may enhance cisplatin's (DDP) anticancer effect in gallbladder cancer (GBC) cells by promoting DNA damage response, particularly through upregulation….

OncologyImmune supportGut & microbiome

Medium relevance

Reishi · 2025 · Journal Article · International immunopharmacology

Ganoderic acid A regulates CSF1R to reprogram tumor-associated macrophages for immune therapy of hepatocellular carcinoma.

BACKGROUND: The tumor microenvironment (TME) plays a crucial role in cancer progression, with tumor-associated macrophages (TAMs) constituting the core cell population of the tumor immune microenvironment. TAMs can differentiate into M1 or M2 types based on the TME, either inhibiting or promoting tumor development..

OncologyImmune supportLiver support

Medium relevance

Reishi · 2025 · Research Article · International journal of molecular sciences

Ganoderic Acid Ameliorates Ulcerative Colitis by Improving Intestinal Barrier Function via Gut Microbiota Modulation.

Ulcerative colitis (UC) is a chronic and recurrent gastrointestinal disease that affects millions of humans worldwide and imposes a huge social and economic burden. It is necessary to find safe and efficient drugs for preventing and treating UC..

Immune supportMetabolic healthGut & microbiome

Medium relevance

Shiitake · 2025 · Journal Article · Genomics

Gap-free genome assembly and comparative analysis reveal the evolution and lignin degradation mechanisms of Cylindrobasidium torrendii.

The Physalacriaceae family comprises numerous saprophytic edible and medicinal fungi with significant ecological and economic importance. However, the lack of high-quality genomic data has hindered systematic studies of this family..