MycoData

King Oyster · 2026 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Preparation and characterization of Pleurotus eryngii polysaccharides/hyperbranched poly-L-lysine composite film and its application in cherry preservation

In this study, Pleurotus eryngii polysaccharides (PEP)-hyperbranched poly-L-lysine (HBPL) composite film was prepared, and its physicochemical and functional properties were characterized. Subsequently, cherries were selected as the model system to evaluate the preservation efficacy of the composite film..

Immune support

High relevance

King Oyster · 2026 · Journal Article · Food science and biotechnology

Preparation, characterization and anti-fatigue activity of polysaccharides from Pleurotus eryngii.

The Pleurotus eryngii polysaccharides (PEP1) were isolated and purified. The structure of PEP1 was characterized, and its anti-fatigue activity was studied.

Immune supportEnergy & fatigueGut & microbiomeLiver support

High relevance

Reishi · 2026 · Research Article · Biomedicines

Protective Antioxidant Effects of Ganoderma lucidum Against Prenatal Chlorpyrifos-Induced Developmental Nephrotoxicity in Rats.

Background/Objectives: Chlorpyrifos (CPF), a widely used organophosphate pesticide, has been associated with oxidative stress-mediated renal injury. Prenatal exposure may pose a risk for developmental nephrotoxicity; however, data regarding protective natural agents remain limited..

Immune support

High relevance

Cordyceps · 2026 · Journal Article · Neurotoxicity research

Protective Effect of Cordyceps militaris Extract Against Cigarette Smoke Extract Induced Neurodegeneration in Zebrafish Model.

BACKGROUND AND OBJECTIVES: Neurodegenerative diseases are characterized by degeneration or progressive loss/death of neurons in specific areas of the brain, often worsened by cigarette smoke through oxidative stress and inflammation. Cordyceps militaris (C..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Chaga · 2026 · Journal Article · Planta medica

Quantitative Analysis and Simultaneous Characterization of Triterpenoids and Phenolics in Inonotus obliquus (Chaga) Using LC-PDA-ELSD and LC-DAD-QToF.

Inonotus obliquus is widely recognized as the Chaga mushroom. Chaga contains various bioactive compounds, including polysaccharides, triterpenoids, polyphenols, and melanin..

Immune supportSkin & hydration

High relevance

Snow Fungus · 2026 · Review · International journal of biological macromolecules

Research progress in polysaccharides from the Tremella fuciformis (silver ear): extraction, purification, structural features, health-promoting activities, and potential applications.

Tremella fuciformis polysaccharides (TFPs), as one of the pivotal functional constituents of T. fuciformis, have attracted increasing attention because of their diverse health-promoting activities..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Enoki · 2026 · Research Article · Gels (Basel, Switzerland)

Root-Derived Flammulina velutipes Polysaccharides Improve Myofibrillar Protein Stability and Maintain Catfish Surimi Quality During Freeze-Thaw Cycling.

Frozen surimi, a commonly used raw material in processed aquatic products, is vulnerable to repeated freeze-thaw fluctuations that accelerate protein denaturation and quality loss..

Immune support

High relevance

Oyster Mushroom · 2026 · Research Article · ACS omega

Screening of Natural Inhibitors from Pleurotus ostreatus against PHGDH for Enhancing Antiviral Innate Immunity through Mendelian Randomization, Machine Learning, Molecular Docking, Molecular Dynamics Simulation, and Binding Free Energy Calculation.

The human innate immune response plays a critical role in limiting and controlling viral infections. Consequently, therapeutic strategies that promote or modulate innate antiviral immunity are regarded as promising approaches to combating viral pathogens..

Immune supportCognition & nervesEnergy & fatigueRespiratory

High relevance

Cordyceps · 2026 · Journal Article · Current drug metabolism

Strain Evaluation and Multi-Generational Stability of Cordyceps militaris for Functional Bioactive Compound Production.

BACKGROUND: Cordyceps militaris is a medicinal fungus known for producing bioactive compounds, including cordycepin, adenosine, and polysaccharides, that exhibit antioxidant, immunomodulatory, and anticancer properties..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Shiitake · 2026 · Research Article · Foods (Basel, Switzerland)

Synergistic Mechanistic Insights into Anti-T2DM Benefits of Lentinula edodes: A Peptide- and Polysaccharide-Based Network Pharmacology and Molecular Docking Study.

In recent years, dietary intervention has garnered significant attention for T2DM prevention and adjunctive treatment. Lentinula edodes (commonly known as shiitake mushroom), a common edible fungus, has been demonstrated to improve T2DM, primarily attributed to its main bioactive components like peptides and….

Immune supportMetabolic health

High relevance

Chaga · 2026 · Research Article · Antioxidants (Basel, Switzerland)

Three Polyphenolic Compounds from Inonotus obliquus: Antioxidant Activity, Xanthine Oxidase Inhibition, and Regulatory Effects on MyD88/TLR4/NF-κB Pathway in MSU-Induced RAW 264.7 Macrophages.

BACKGROUND: Inonotus obliquus (Chaga), a medicinal and edible macrofungus abundant in bioactive polyphenols, is a potential source of natural antioxidants and anti-inflammatory agents for functional foods..

Immune supportEnergy & fatigue

High relevance

Shiitake · 2026 · Research Article · Foods (Basel, Switzerland)

Transcriptome Analysis of Postharvest Lentinula edodes Cell Wall Metabolism During Storage Indicating a Laccase-Mediated Regulatory Network.

Postharvest Lentinula edodes (shiitake mushroom) undergoes rapid textural deterioration, which is primarily driven by complex cell wall remodeling. This study investigates the physiological and transcriptomic changes in L.

Immune supportEnergy & fatigue

High relevance

Reishi · 2025 · Review · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Research progress on chemical constituents and pharmacological effects of Ganoderma lucidum spore oil].

Originating from sporoderm-broken Ganoderma lucidum spores, Ganoderma lucidum spore oil(GLSO) is prepared by supercritical fluid extraction. Chemical composition studies show that GLSO mainly contains nonpolar substances, such as fatty acids, triglycerides, and steroids..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2025 · Research Article · Journal of traditional and complementary medicine

A formulation of combined Poria cocos and Cordyceps militaris rice ameliorates depressive-like effects by downregulating p38 MAPK signaling pathways.

BACKGROUND AND AIM: Poria cocos (PC) is traditional Chinese medicine with sedative, diuretic, and tonic properties. Cordyceps militaris rice (CMR) is a matrix used for the solid-state culture of C.

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · Journal of Ethnopharmacology

A network pharmacology approach and experimental validation to investigate the protection mechanism of Ganoderma lucidum (Leyss. ex Fr.) Karst spore for acute kidney injury through induction of apoptosis via p53/Caspase 3 signaling pathway

According to the Sheng Nong's herbal classic, one of the components Ganoderma lucidum (Leyss. ex Fr.) "benefits waterways and kidney qi".

OncologyImmune supportEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

A network pharmacology approach and experimental validation to investigate the protection mechanism of Ganoderma lucidum (Leyss. ex Fr.) Karst spore for acute kidney injury through induction of apoptosis via p53/Caspase 3 signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: According to the Sheng Nong's herbal classic, one of the components Ganoderma lucidum (Leyss. ex Fr.) "benefits waterways and kidney qi".

OncologyImmune supportEnergy & fatigue

High relevance

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

A polysaccharide from Morchella esculenta mycelia: Structural characterization and protective effect on antioxidant stress on PC12 cells against H2O2-induced oxidative damage.

Morchella esculenta (L.) Pers. is considered a precious edible and medicinal fungus due to its strict growth environment requirements, difficult to cultivate, resulted in expensive in the market.

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Reishi · 2025 · Review · Naunyn-Schmiedeberg's archives of pharmacology

A review of the extraction technologies, structural characterization, chemical modification, and pharmacological effects of Ganoderma lucidum polysaccharides.

Ganoderma lucidum (GL) is a medicinal and edible fungal material with a long history. Ganoderma lucidum polysaccharides (GLPs), as one of the primary bioactive components in GL, exhibit multiple pharmacological effects including anti-tumor, anti-inflammatory, immunomodulatory, antioxidant, and metabolic regulatory….

OncologyImmune supportMetabolic health

High relevance

Lion's Mane · 2025 · Journal Article · Food & function

Absorption and immune-modulating effects of active peptides from Hericium erinaceus proteins in an in vitro gastrointestinal model.

The mechanism by which fungal proteins retain immunomodulatory activity after gastrointestinal digestion remains unknown. To shed light on the mechanism, the proteins and peptides from Hericium erinaceus were explored through in vitro digestion using a Caco-2/RAW264.7 co-culture model..

Immune supportGut & microbiome

High relevance

Lion's Mane · 2025 · Research Article · Nutrients

Alteration of Gastrointestinal Function and the Ameliorative Effects of Hericium erinaceus Polysaccharides in Tail Suspension Rats.

Background/Objectives: Long-term spaceflight in a microgravity environment frequently results in gastrointestinal dysfunction, presenting substantial challenges to astronauts' health..

Immune supportMetabolic healthGut & microbiome

High relevance

Wood Ear · 2025 · Research Article · Frontiers in nutrition

Ameliorating potential of Auricularia auricula-judae polysaccharides in mitigating hypercaloric diet-induced behavioral disorders through gut microbiota regulation.

As a major nutraceutical component of a traditional edible fungus Auricularia auricula-judae, Auricularia auricula-judae polysaccharide (AAP) has been well-documented due to its outstanding hypolipidemic and hypoglycemic bioactivities..

Immune supportCognition & nervesMetabolic healthGut & microbiome

High relevance

Cordyceps · 2025 · Journal Article · International journal of medicinal mushrooms

Anti-Allergic Effects of Dietary Caterpillar Mushroom Cordyceps militaris (Ascomycota) Derived from Eri Silkworm.

Allergic disorders affect a substantial proportion of the global population, and current treatments often focus on symptom management rather than addressing the underlying immunological imbalances. Cordyceps militaris (L.) Fr.

Immune supportGut & microbiome

High relevance

Snow Fungus · 2025 · Research Article · Nutrients

Anti-Stress Effects of Tremella fuciformis Berk. Enzymatic Extracts: A Preclinical Study.

Background/Objectives: Chronic stress disrupts neurochemical balance, triggers inflammation, and compromises neuronal integrity, contributing to the development of stress-related disorders..

OncologyImmune supportCognition & nerves

High relevance

Turkey Tail · 2025 · Journal Article · Food chemistry

Antioxidant, anti-inflammatory, and antiproliferative properties of extracted Turkey tail (Trametes versicolor Lloyd) mushroom components microencapsulated with inulin.

The stability, interactions, and bioaccessibility of bioactive components modify the potential functionality of newly developed inulin-based microcapsules containing polysaccharide (PF) and ethanol-extractable fractions (EEF) of turkey tail..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Maitake · 2025 · Preprint · journal metadata

Attenuative effect of Grifola frondosa (maitake mushroom) on severe DSS-induced colitis in vitamin D-deficient mice

Scope Vitamin D deficiency, which has been a global health issue for decades, is involved in gut health and diseases. We examined the health benefits of Grifola frondosa (maitake mushroom), a potent dietary source of fungal vitamin D (D 2 ), on DSS-induced colitis in vitamin D-deficient mice..

Immune supportGut & microbiome

High relevance

Lion's Mane · 2025 · Systematic Review · Frontiers in nutrition

Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review.

INTRODUCTION: Hericium erinaceus (HE), commonly known as the Lion's Mane mushroom, is an edible, medicinal fungus containing bioactive polysaccharides. It shows promising properties, including neuroprotective, anti-tumor, antioxidant, anti-proliferative, and anti-inflammatory effects..

OncologyImmune supportCognition & nervesGut & microbiome

High relevance

Lion's Mane · 2025 · Review · Molecules (Basel, Switzerland)

Bioactive Polysaccharides from Hericium erinaceus: Extraction, Structure, Bioactivities, and Applications.

Hericium erinaceus, an edible fungus belonging to the family Odontaceae, is predominantly found in Western Europe, North America, and East Asia. In China, it primarily thrives in the mountainous and forested regions in the northeast, north, and southwest..

OncologyImmune supportMetabolic healthRespiratory

High relevance

Shiitake · 2025 · Research Article · Bioengineered

Biorefining spent substrates of shiitake (Lentinula edodes) and oyster mushroom (Pleurotus ostreatus): enzymatic saccharification of cellulose and xylan, with lignin recovery from residues.

Spent mushroom substrate (SMS), the main by-product of mushroom cultivation, is a source of sugars that can be released by saccharification. This work aimed at investigating the enzymatic saccharification of the polysaccharides of the SMS of shiitake (Lentinula edodes) and oyster mushroom (Pleurotus ostreatus) and….

Immune supportGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies.

BACKGROUND: The human gut microbiota plays a crucial role in various aspects of health, extending beyond digestion and nutrient absorption. Ganoderma lucidum (Reishi) and Hericium erinaceus (Lion's Mane), traditional medicinal mushrooms, have garnered interest due to their potential to exert positive health effects..

Immune supportCognition & nervesMetabolic healthGut & microbiome

High relevance

King Oyster · 2025 · Journal Article · Carbohydrate polymers

Carboxymethyl chitosan-induced modification of the structure and regulation of the thermal aggregation of Pleurotus eryngii protein fractions to improve gel properties

In recent years, interactions between polysaccharides and proteins have been widely considered for use to improve protein gel performances. We previously found carboxymethyl chitosan (CMCS) can increase Pleurotus eryngii protein (PEP) gel properties, but the contributions of different key PEP fractions to overall gel….

Immune supportEnergy & fatigueSkin & hydration

High relevance

King Oyster · 2025 · Journal Article · Carbohydrate polymers

Carboxymethyl chitosan-induced modification of the structure and regulation of the thermal aggregation of Pleurotus eryngii protein fractions to improve gel properties.

Immune supportEnergy & fatigueSkin & hydration

High relevance

Reishi · 2025 · Journal Article · Journal of pharmaceutical and biomedical analysis

Characterization of metabolites of ganoderic acids extract from Ganoderma lucidum in rats using UHPLC-MS/MS.

Ganoderic acids, the primary active compound cluster in Ganoderma lucidum (Chinese name: Lingzhi), one of the most reputed herbal medicines, play a crucial role in its immunomodulatory, anti-inflammatory, and anticancer properties..

OncologyImmune supportMetabolic health

High relevance

Reishi · 2025 · Journal Article · South African journal of botany

Cold atmospheric plasma is a potent tool to improve cosmetic bioactive compounds in Ganoderma lucidum suspension cultures

In the current decade, biological researchers have explored the use of cold plasma elicitors to increase the production of secondary metabolites in laboratory settings because of limitations in the natural harvesting of medicinal plants and fungi..

Immune supportSkin & hydration

High relevance

King Oyster · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Comparative analysis of electrohydrodynamic, hot air, and natural air drying techniques on quality attributes and umami enhancement in king oyster mushroom (Pleurotus eryngii)

This study systematically examined the impacts of three distinct drying techniques (Electrohydrodynamics, Hot air and Natural air) on the physicochemical characteristics of king oyster mushroom..

Immune supportEnergy & fatigueSkin & hydration

High relevance

Enoki · 2025 · Preprint · journal metadata

Comparative Analysis of Methanol and Ethanol Extract of Flammulina velutipes on Primary Hippocampal Culture: From Neurodevelopment to Neuroprotection

Flammulina velutipes is a well-known edible mushroom which is consumed for its nutri-tional value. F.

Immune supportCognition & nerves

High relevance

Cordyceps · 2025 · Journal Article · Journal of ethnopharmacology

Cordyceps militaris alleviates COPD by regulating amino acid metabolism, gut microbiota and short chain fatty acids.

ETHNOPHARMACOLOGICAL RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a global health challenge with the high morbidity and mortality. Cordyceps militaris (CM) is a medicinal fungus that has been widely used in Asia for centuries..

Immune supportGut & microbiomeRespiratory

High relevance

Cordyceps · 2025 · Research Article · Journal of traditional and complementary medicine

Cordyceps militaris and Armillaria mellea formula alleviates depressive behaviors via microglia regulation in an unpredictable chronic mild stress animal model.

BACKGROUND AND AIM: Cordyceps militaris (CM) and Armillaria mellea (AM) are medicinal mushrooms with potential applications in the treatment of mood disorders, including depression and anxiety..

Immune supportCognition & nerves

High relevance

Cordyceps · 2025 · Research Article · Frontiers in immunology

Cordyceps militaris extract and cordycepin ameliorate LPS-challenged colonic damage in piglets by modulating the microbiota and metabolite profiles.

INTRODUCTION: Cordyceps militaris extract (CME) and cordycepin (CPN) are biomolecules with a wide range of biological activities, including anti-inflammatory, antioxidant and anti-tumour effects..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2025 · Review · Gels (Basel, Switzerland)

Cordyceps militaris-Derived Bioactive Gels: Therapeutic and Anti-Aging Applications in Dermatology.

Cordyceps militaris is a medicinal mushroom widely utilized in traditional East Asian medicine, recognized for its diverse therapeutic properties. This review explores the potential of C..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Cordyceps · 2025 · Journal Article · Journal of natural products

Cordycepsterols A-C, Anti-Inflammatory C30 Ergosterols with a 6/6/6/5/6-Fused Ring System from Cordyceps militaris.

Cordyceps militaris is a valuable edible and medicinal fungus. Its chemical composition and biological activity have become the focus of attention.

OncologyImmune support

High relevance

Cordyceps · 2025 · Journal Article · Journal of functional foods

Cultivated Cordyceps militaris exerts anti-allergic effects in a cockroach-induced allergic dermatitis mouse model by suppressing inflammation and enhancing epidermal homeostasis

The study evaluated the anti-allergic effects of ethanol extract derived from laboratory-cultivated Cordyceps militaris (ECM) using the HaCaT cells and cockroach allergen Per a 2-induced allergic dermatitis mouse model..

Immune supportSkin & hydration

High relevance

Cordyceps · 2025 · Journal Article · International journal of medicinal mushrooms

Dectin-1-Dependent Activation of Flt3 Ligand-Induced Dendritic Cells by the Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes) Fruiting Body.

Cordyceps militaris, an entomopathogenic fungus traditionally used in East Asian medicine, contains 1,3-β-glucans with well-known immunomodulatory properties. Our previous research has demonstrated that both fruit body powder and hot water extract of C..

OncologyImmune support

High relevance

Reishi · 2025 · Research Article · Frontiers in cell and developmental biology

Developmental and reproductive toxicity assessment of sporoderm-removed Ganoderma lucidum spores.

INTRODUCTION: Ganoderma lucidum is a fungus used in traditional Chinese medicine with high medicinal value and is also widely used in modern healthcare. Its spores are reported to contain antitumor and anti-inflammatory properties, among other biological benefits; however, the thick spore wall limits its….

OncologyImmune supportCognition & nerves

High relevance

King Oyster · 2025 · Journal Article · Journal of agricultural and food chemistry

Effects and Mechanisms of Pleurotus eryngii Polysaccharide on Intestinal Barrier Damage: Based on the Perspective of Its Interaction with Intestinal Mucus during Gut Digestion.

In this study, pathways and mechanisms of action of a new type of Pleurotus eryngii polysaccharide (PEP) with known structural characteristics and probiotic properties in the intestine were investigated..

Immune supportGut & microbiome

High relevance

Cordyceps · 2025 · Research Article · Animal bioscience

Effects of Cordyceps militaris solid medium on the growth performance, immunity parameters and intestinal health of broilers.

OBJECTIVE: This study aimed to investigate the impact of Cordyceps militaris solid medium (CMM) on the growth performance, immunity parameters, intestinal health and gut microbiota of broilers..

Immune supportEnergy & fatigueGut & microbiome

High relevance

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Effects of ethanol extracts of Lycium chinense berry fruit on the production, structure and bioactivity of exopolysaccharides in Cordyceps militaris.

The addition of ethanol extracts from traditional Chinese medicine effectively promotes the production of exopolysaccharides (EPSs) through liquid fermentation of fungi. The impact of these extracts on the structure and activity of EPSs warrants further investigation..

Immune support

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Effects of Ganoderma lucidum fermentation on the structure of Tartary buckwheat polysaccharide and its impact on gut microbiota composition.

Fermentation modifies plant polysaccharides and enhances their bioactivity. In this study, polysaccharides were extracted from Ganoderma lucidum-fermented (FBP) and non-fermented (NBP) Tartary buckwheat.

Immune supportMetabolic healthGut & microbiome

High relevance

King Oyster · 2025 · Research Article · Biomedicines

Effects of In Vitro Fermented Pleurotus eryngii on Intestinal Barrier Integrity and Immunomodulation in a Lipopolysaccharide-Induced Colonic Model.

Background: This study investigates the impact of fermentation supernatants (FSs) from Pleurotus eryngii whole mushrooms (PEWS), as well as its subcomponents, digested (PEWSD) and extracted (PEWSE) forms, on intestinal barrier function and immune modulation in lipopolysaccharide (LPS) -stimulated Caco-2 cells..

Immune supportMetabolic healthGut & microbiome

High relevance

Turkey Tail · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Effects of Trametes versicolor fermented Rosa roxburghii Tratt and Coix seed complex on the physicochemical properties, microstructure, and shelf-life prediction of yogurt

Edible fungi fermentation enhances flavor and physicochemical properties of raw materials, yet its application in yogurt is underexplored. This study investigated changes in flavor, physicochemical properties, rheological, and structural characteristics of yogurt made with a Rosa roxburghii Tratt and Coix seed complex….

Immune support

High relevance

Chaga · 2025 · Research Article · International journal of molecular sciences

Elucidating the Anti-Diabetic Mechanisms of Mushroom Chaga (Inonotus obliquus) by Integrating LC-MS, Network Pharmacology, Molecular Docking, and Bioinformatics.

Diabetes mellitus is characterized by insulin resistance, impaired glucose homeostasis, and dysregulated glucose metabolism, leading to complications. Inonotus obliquus (Chaga) has shown potential anti-diabetic effects, but the bioactive compounds and molecular targets remain unclear..

Immune supportMetabolic health