MycoData

Maitake · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

The Nearly Complete Genome of Grifola frondosa and Light-Induced Genes Screened Based on Transcriptomics Promote the Production of Triterpenoid Compounds.

Grifola frondosa, commonly known as turkey tail, is a valuable fungus with medicinal and culinary uses, rich in bioactive compounds like triterpenoid polysaccharides that contribute to health benefits. Here, we constructed a nearly complete genome of G..

Immune supportLiver supportRespiratory

Reishi · 2025 · Research Article · Journal of advanced veterinary and animal research

The protective effects of Ganoderma lucidum polysaccharides on blood physiology, immune function, and organ architecture in growing stressed rabbits.

OBJECTIVE: This experiment explored the plausible effects of Ganoderma lucidum polysaccharides (GLP) to reduce the deterioration effects of heat stress (HS) in growing rabbits by studying blood physiology, growth, immunity, inflammation, and organ structure..

Immune supportMetabolic healthLiver support

Oyster Mushroom · 2025 · Journal Article · International journal of radiation biology

The role of polysaccharide POM extracted from Pleurotus ostreatus in curbing and treating the harmful effects on liver and kidney resulting from radiation exposure.

PURPOSE: This research assesses the radioprotective and antioxidant activity of polysaccharide (POM) derived from Pleurotus ostreatus strain on rats suffering from metabolic problems due to irradiation..

Oyster Mushroom · 2025 · Research Article · Mycology

The transcription factor PoMbp1 promotes the growth and development of Pleurotus ostreatus by regulating polysaccharide utilisation.

The transcription factor Mbp1 was reported to regulate cell growth and proliferation in some fungi; however, its role in Pleurotus ostreatus remains largely unexplored. Here, we cloned the PoMbp1 gene, which encodes a protein contains an APSES domain and is localised in the nucleus..

OncologyImmune supportSkin & hydration

Oyster Mushroom · 2025 · Journal Article · International journal of biological macromolecules

The use of Pleurotus ostreatus by-products for the preparation of a gel-like polysaccharide with bioactive properties.

The mushroom Pleurotus ostreatus is widely produced in Brazil and its stipes are discarded before commercialization. In the present study, this agricultural fungal waste (mushroom stipes), was analyzed by preparing an aqueous extract and obtaining the polysaccharides by ethanol precipitation (POS-extract)..

OncologyImmune supportCognition & nerves

Snow Fungus · 2025 · Journal Article · Molecular neurobiology

Tremella fuciformis Polysaccharides Alleviate Early Brain Injury in Experimental Subarachnoid Hemorrhage by Inhibiting the KDR-Mediated P38 MAPK/NF-κB Pathway.

Subarachnoid hemorrhage (SAH) is associated with high mortality and morbidity rates. In its early stages, a substantial influx of blood into the subarachnoid space triggers excessive activation of microglia, which markedly contributes to early brain injury (EBI), a pivotal determinant of poor prognosis..

Reishi · 2025 · Journal Article · Fitoterapia

Trichodermanols A-C, three new metabolites from the Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02 and their anti-inflammatory activity.

Trichodermanols A-C (1-3), an uncommon nor-steroid (1) and two novel 5/7 ring system sesquiterpenes (2 and 3), along with two known compounds identified as (1S,7R,10S,11R)-3-oxoguai-4-ene-11,12-diol (4) and cyclo-((S)-Pro-(R)-Leu) (5), were isolated and elucidated from a Ganoderma lucidum-derived endophytic fungus….

Immune supportCognition & nerves

Chaga · 2025 · Journal Article · Fitoterapia

Triterpenoids from the edible mushroom Inonotus obliquus attenuates cognitive impairment in vitro and in vivo.

Inonotus obliquus is an edible and medicinal mushroom which is used to multiple products. In this study, 8 secondary metabolites (1-8) were identified from the edible mushroom I.

Enoki · 2025 · Research Article · Food chemistry: X

Ultrasonic assisted three-phase partitioning extraction and bioactivities validation of polysaccharides from Flammulina velutipes residues.

Mushroom residues, especially Flammulina velutipes residues (FVR) rich in bioactive polysaccharides, are under exploited due to inefficient extraction methods conflicting with green chemistry..

Reishi · 2025 · Research Article · Frontiers in nutrition

Unveiling triterpenoid superiority in a newly developed Ganoderma lucidum variety through untargeted metabolomics approach.

The fruiting bodies of Ganoderma lucidum are renowned for their therapeutic properties, primarily due to their triterpenoid content. Variability in G.

Agarikon · 2024 · Journal Article · International journal of biological macromolecules

A fungal polysaccharide from Fomitopsis officinalis as a multi-target molecule to combat cancer.

Some macrofungi have a long history of being used as traditional or folk medicines, making significant contributions to human health. To discover bioactive molecules with potential anticancer properties, a homogeneous heteropolysaccharide (FOBP90-1) was purified from the medicinal macrofungus Fomitopsis officinalis..

Almond Mushroom · 2024 · Journal Article · Carbohydrate polymers

A low-molecular-weight α-glucan from edible fungus Agaricus blazei Murrill activates macrophage TFEB-mediated antibacterial defense to combat implant-associated infection.

Implant-associated infection (IAI) is a prevalent and potentially fatal complication of orthopaedic surgery. Boosting antibacterial immunity, particularly the macrophage-mediated response, presents a promising therapeutic approach for managing persistent infections..

OncologyImmune supportMetabolic healthGut & microbiome

Maitake · 2024 · Journal Article · Molecular nutrition & food research

A Water Polysaccharide-Protein Complex from Grifola frondosa Inhibit the Growth of Subcutaneous but Not Peritoneal Colon Tumor under Fasting Condition.

SCOPE: Grifola frondosa has been shown to induce immune modulatory, modulate autophagy, and apoptosis in cancer cells. However, little is known about its potential for managing tumor progression as an adjunct to nutrient restriction.

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2024 · Journal Article · Plant foods for human nutrition (Dordrecht, Netherlands)

Alcoholic Extracts from the Ganoderma Lucidum Fermentation Product Alleviated Ethanol-Induced Liver Injury, Gut Leakiness, and Gut Dysbiosis in Mice.

The hepatoprotective effect of the alcoholic extracts of Ganoderma lucidum fermentation products (GFE) was investigated. C57BL/6 mice were pretreated with GFE for 7 days and then subjected to the chronic-binge ethanol feeding model..

OncologyImmune supportGut & microbiome

Mesima · 2024 · Journal Article · International journal of biological macromolecules

Ameliorative effect of an acidic polysaccharide from Phellinus linteus on ulcerative colitis in a DSS-induced mouse model.

Phellinus linteus, a rare medicinal fungus, displays strong antitumor and anti-inflammatory activities because of its active metabolites, particularly polysaccharides. We investigated effects of P..

OncologyImmune supportMetabolic health

Agarikon · 2024 · Journal Article · International journal of biological macromolecules

An antitumor fungal polysaccharide from Fomitopsis officinalis by activating immunity and inhibiting angiogenesis.

Macrofungi, a class of unique natural resources, are gaining popularity owing to their potential therapeutic benefits and edibility. From Fomitopsis officinalis, a medicinal macrofungus with anticancer activity, a homogeneous heteropolysaccharide (FOBP50-1) with a molecular weight of 2.21 × 104 g/mol has been….

Immune supportMetabolic healthLiver support

Yellow Morel · 2024 · Journal Article · International journal of medicinal mushrooms

Antioxidation and Hepatoprotection of Selenium Mycelium Polysaccharides Against Alcoholic Liver Diseases from the Cultivated Morel Mushroom Morchella esculenta (Ascomycota).

The liver was regarded as the most important metabolic and detoxification organ in vivo, and Morchella esculenta had been reported as the admittedly rare edible fungus belonging to Ascomycetes contributing to the abundant bioactivities..

Immune supportMetabolic healthGut & microbiomeLiver support

Wood Ear · 2024 · Research Article · Foods (Basel, Switzerland)

Auricularia auricula-judae Attenuates the Progression of Metabolic Syndrome in High-Fat Diet-Induced Obese Rats: Enzymatic Pre-Digestion Technology Is Superior to Superfine Grinding Method.

Auricularia auricula-judae (AAJ) has been cultivated for food in China for centuries, and is also used as a folk medicine for the regulation of glucose and lipid metabolism. However, there are few studies on the effects of different processing technologies on the therapeutic efficacy of AAJ to date..

Oyster Mushroom · 2024 · Research Article · PeerJ

Beeswax waste improves the mycelial growth, fruiting body yield, and quality of oyster mushrooms (Pleurotus ostreatus).

Heilongjiang Province has the third largest bee population in China, producing over 2,000 tons of beeswax waste (BW) each year. Most of this BW is discarded or burned.

OncologyImmune supportEnergy & fatigue

Yellow Morel · 2024 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Bioactive extract of Morchella esculenta ameliorates cyclophosphamide-induced mitochondrial dysfunction and cardiotoxicity by modulating KEAP1/NRF2 and pro-inflammatory genes expression.

Prevention of anticancer drugs-induced cardiotoxicity remains an imperative area of oncology research as it continues to be a major challenge in cancer chemotherapy..

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2024 · Journal Article · Heliyon

Bioactivities and industrial standardization status of Ganoderma lucidum: A comprehensive review

Ganoderma lucidum (GL) is a potent source of bioactive compounds with diverse nutritional and pharmacological benefits. Its popularity as a dietary supplement, herbal remedy, and wellness product is steadily on the rise..

Maitake · 2024 · Journal Article · International journal of biological macromolecules

Bone protective effects of the polysaccharides from Grifola frondosa on ovariectomy-induced osteoporosis in mice via inhibiting PINK1/Parkin signaling, oxidative stress and inflammation.

BACKGROUND: Polysaccharides from Grifola frondosa(GFP) have gained worldwide attention owing to their promising biological activities and potential health benefits..

OncologyImmune supportMetabolic health

Reishi · 2024 · Journal Article · International journal of biological macromolecules

Carbon starvation drives biosynthesis of high mannose-composition polysaccharides in Ganoderma lucidum.

Polysaccharides with high mannose composition exhibit favorable antitumor activity, but there is currently a lack of well-defined and practical approaches to efficiently manufacture this type of polysaccharide..

Immune supportMetabolic health

Reishi · 2024 · Research Article · Molecules (Basel, Switzerland)

Changes of Active Substances in Ganoderma lucidum during Different Growth Periods and Analysis of Their Molecular Mechanism.

Ganoderma lucidum, renowned as an essential edible and medicinal mushroom in China, remains shrouded in limited understanding concerning the intrinsic mechanisms governing the accumulation of active components and potential protein expression across its diverse developmental stages..

Oyster Mushroom · 2024 · Journal Article · International journal of biological macromolecules

Characterization of free radical-mediated Pleurotus ostreatus polysaccharide-EGCG conjugates for chilled minced pork preservation.

To improve the functions of Pleurotus ostreatus polysaccharide (POP), POP-EGCG conjugates were prepared using free radical graft polymerization reactions and were characterized using UV-vis, FT-IR, SEM, XRD, DSC, TG, particle size and potential, three-phase contact angle, and rheological tests; The antioxidant and….

Immune supportGut & microbiome

Enoki · 2024 · Journal Article · International journal of biological macromolecules

Chitosan from the base of Flammulina velutipes stipe alleviates oral Candida albicans infection via modulating Th-17 cell differentiation and Streptococcus mutans.

The base of Flammulina velutipes (F. velutipes) stipe are agricultural wastes generated during the cultivation of edible fungus F.

Reishi · 2024 · Journal Article · Biomedical chromatography: BMC

Comparative pharmacokinetic analysis of sporoderm-broken and sporoderm-removed Ganoderma lucidum spore in rat by using a sensitive plasma UPLC-QqQ-MS method.

Previous studies have found that removing the sporoderm significantly enhanced antitumor and immunoregulatory activities of Ganoderma lucidum spore (GLS) compared with breaking the sporoderm. However, the pharmacokinetics of sporoderm-removed GLS (RGLS) and sporoderm-broken GLS (BGLS) remain elusive..

Chaga · 2024 · Research Article · Foods (Basel, Switzerland)

Comparison of the Controlled Atmosphere Treatment for Submerged and Solid-State Fermentation of Inonotus obliquus.

In this study, a controlled atmosphere (CA) treatment was used in the submerged (SM) and solid-state (SS) fermentation of Inonotus obliquus to determine the optimal conditions. The goal was to accelerate the artificial fermentation to obtain I.

Immune supportEnergy & fatigue

Reishi · 2024 · Journal Article · Computational biology and chemistry

Computational exploration of Ganoderma lucidum metabolites as potential anti-atherosclerotic agents: Insights from molecular docking and dynamics simulations.

Ganoderma lucidum is a unique form of fungus utilized in Chinese medicine for various therapies as it exhibits a wide range of pharmacological activity. In this study, the purpose is to evaluate the possible drug-like qualities of the metabolites of G..

Snow Fungus · 2024 · Journal Article · International journal of biological macromolecules

Cu-Tremella fuciformis polysaccharide-based tumor microenvironment-responsive injectable gels for cuproptosis-based synergistic osteosarcoma therapy.

Cuproptosis affects osteosarcoma locally, and the exploitation of cuproptosis-related biomaterials for osteosarcoma treatment is still in its infancy. We designed and synthesized a novel injectable gel of Cu ion-coordinated Tremella fuciformis polysaccharide (TFP-Cu) for antiosteosarcoma therapy..

Immune supportMetabolic healthSkin & hydration

Snow Fungus · 2024 · Journal Article · International journal of biological macromolecules

Cuttlefish ink-derived melanin nanoparticle-embedded tremella fuciformis polysaccharide hydrogels for the treatment of MRSA-infected diabetic wounds.

Diabetic wounds arise great attention as they are difficult to heal and easily suffer from serious bacterial infection. However, the overuse of antibiotics increases the resistance of bacteria and makes common drugs ineffective..

Immune supportCognition & nerves

Lion's Mane · 2024 · Research Article · Molecules (Basel, Switzerland)

Discovery of a New Compound, Erinacerin W, from the Mycelia of Hericium erinaceus, with Immunomodulatory and Neuroprotective Effects.

One new compound with an isoindolinone skeleton, along with erinacines A, C, and S, was isolated from the mycelia of Hericium erinaceus, an edible fungus with a long history of use in traditional Chinese medicine..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Enoki · 2024 · Journal Article · International journal of food science & technology

Effect of extraction and purification on the structure and activity of Flammulina velutipes polysaccharides: a review

Flammulina velutipes (F. velutipes) is one of the most widely consumed edible mushrooms worldwide.

OncologyImmune supportGut & microbiomeRespiratory

Yellow Morel · 2024 · Research Article · Frontiers in veterinary science

Effect of Morchella esculenta polysaccharides on the rectal microbiota of mice challenged with lipopolysaccharides.

INTRODUCTION: Intestinal dysfunction poses a severe problem by preventing the digestion and absorption of nutrients. The gut, being the most vital organ for these processes, plays a crucial role in ensuring our body receives the nutrients it needs..

Snow Fungus · 2024 · Journal Article · International journal of biological macromolecules

Effect of polysaccharide concentration on heat-induced Tremella fuciformis polysaccharide-soy protein isolation gels: Gel properties and interactions.

The formation of a single soybean protein isolate (SPI) gel is limited by the processing conditions, and has the disadvantages of poor gel property, and it is usually necessary to add other biomacromolecules to improve its property..

Immune supportMetabolic healthSkin & hydration

Chaga · 2024 · Journal Article · Chemistry & biodiversity

Effects of Chemical Modification on the Structure and Biological Activities of Polysaccharides Extracted from Inonotus Obliquus by Microwave.

A novel polysaccharide, Inonotus obliquus polysaccharide (IOP), was extracted using a microwave extraction method and subsequently subjected to modifications through sulfation, carboxymethylation, phosphorylation, and acetylation..

Oyster Mushroom · 2024 · Journal Article · Applied biochemistry and biotechnology

Effects of Cold Plasma Pretreatment on the Synthesis of Polysaccharide from Pleurotus ostreatus.

Fungal polysaccharides have attracted wide attention because of their medical pharmaceutical and health care value. So far, many efforts have been made in strain improvement to produce polysaccharides on a large scale at low cost..

Immune supportMetabolic health

Lion's Mane · 2024 · Journal Article · Fish physiology and biochemistry

Effects of dietary Hericium erinaceus extract on growth, nutrient utilization, hematology, expression of genes related immunity response, and disease resistance of Nile tilapia (Oreochromis niloticus).

In recent years, there has been a growing focus on using herbal extracts as immune enhancers for aquatic species, replacing antibiotics. In the present study, the effects of dietary supplementation of Hericium erinaceus extract (HE) on growth, feed utilization, hematology, expression of immunity-related genes, and….

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Almond Mushroom · 2024 · Research Article · Animal bioscience

Effects of dietary supplementation of polysaccharide from Agaricus blazei Murr on productive performance, egg quality, blood metabolites, intestinal morphology and microbiota of Korean quail.

OBJECTIVE: This study aimed to investigate the effects of dietary supplementation with Agaricus blazei polysaccharide (ABP) at varying concentrations on the performance, egg quality, blood biochemistry, intestinal morphology, and microflora of quail..

Immune supportGut & microbiome

Reishi · 2024 · Journal Article · Journal of the science of food and agriculture

Effects of different wall-breaking methods on the nutrient release of Ganoderma lucidum spore powder during in vitro digestion.

BACKGROUND: The hard double-walled structure of Ganoderma lucidum spore powder (GLSP) is difficult for the human body to digest, so it is very important to break the wall of GLSP..

Immune supportGut & microbiome

Reishi · 2024 · Journal Article · Journal of the science of food and agriculture

Effects of different wall‐breaking methods on the nutrient release of Ganoderma lucidum spore powder during in vitro digestion

BACKGROUND: The hard double‐walled structure of Ganoderma lucidum spore powder (GLSP) is difficult for the human body to digest, so it is very important to break the wall of GLSP..

Immune supportEnergy & fatigueGut & microbiome

Enoki · 2024 · Research Article · Frontiers in microbiology

Effects of Flammulina velutipes mushroom residues on growth performance, apparent digestibility, serum biochemical indicators, rumen fermentation and microbial of Guizhou black goat.

INTRODUCTION: The primary objective of the current study was to evaluate the effects of Flammulina velutipes mushroom residue (FVMR) in a fermented total mixed ration (FTMR) diet on the fattening effect and rumen microorganisms in Guizhou black male goats..

Enoki · 2024 · Journal Article · Meat science

Effects of Flammulina velutipes polysaccharide with ice recrystallization inhibition activity on the quality of beef patties during freeze-thaw cycles: An emphasis on water status and distribution

The antifreeze activity of Flammulina velutipes polysaccharide (FVP) autoclave-extracted with dilute alkaline and effects of FVP on moisture status, size of ice crystals, physical and chemical characteristics of beef patties during repeated freeze-thaw (F-T) cycles were investigated..

Enoki · 2024 · Journal Article · Meat science

Effects of Flammulina velutipes polysaccharide with ice recrystallization inhibition activity on the quality of beef patties during freeze-thaw cycles: An emphasis on water status and distribution.

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2024 · Journal Article · Journal of applied poultry research

Effects of Ganoderma Lucidum supplementation on the growth performance, biochemical blood parameters, antioxidant and immunity status, and meat quality in slow-growing broilers

Ganoderma Lucidum (G. lucidum) is an edible mushroom and it has been used as a medicinal fungus for centuries.

OncologyImmune supportEnergy & fatigueGut & microbiome

Lion's Mane · 2024 · Journal Article · Comparative biochemistry and physiology. Toxicology & pharmacology: CBP

Effects of Hericium erinaceus polysaccharide in porcine IPEC-J2 intestinal epithelial cells against apoptosis induced by oxidative stress.

This study was intended to investigate whether Hericium erinaceus polysaccharides (HEP) prevent oxidative stress and apoptosis of intestinal porcine epithelial cells from jejunum (IPEC-J2 cells) induced by hydrogen peroxide (H2O2). Crude HEP were extracted and purified by chromatography..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Chaga · 2024 · Research Article · Frontiers in pharmacology

Effects of Inonotus obliquus on ameliorating podocyte injury in ORG mice through TNF pathway and prediction of active compounds.

BACKGROUND: Podocyte injury is a common pathologic mechanism in diabetic kidney disease (DKD) and obesity-related glomerulopathy (ORG). Our previous study confirmed that Inonotus obliquus (IO) improved podocyte injury on DKD rats..