MycoData

Immune supportMetabolic healthGut & microbiomeLiver support

Niu-Chang-Chih · 2021 · Journal Article · Food & function

Antrodin A from Antrodia camphorata modulates the gut microbiome and liver metabolome in mice exposed to acute alcohol intake.

This study aimed to investigate the protective effect of Antrodin A (AdA) from Antrodia camphorata (A. camphorata) mycelium on alcohol-induced gut microbiota and liver metabolomic disorders..

Immune supportEnergy & fatigueMetabolic health

Zhu Ling · 2021 · Research Article · Frontiers in microbiology

Armillaria mellea Symbiosis Drives Metabolomic and Transcriptomic Changes in Polyporus umbellatus Sclerotia.

Sclerotia, the medicinal part of Polyporus umbellatus, play important roles in diuresis and renal protection, with steroids and polysaccharides as the main active ingredients. The sclerotia grow and develop only after symbiosis with Armillaria sp..

Immune supportMetabolic healthGut & microbiomeLiver support

Wood Ear · 2021 · Journal Article · Journal of food science

Auricularia auricula-judae (Bull.) polysaccharides improve type 2 diabetes in HFD/STZ-induced mice by regulating the AKT/AMPK signaling pathways and the gut microbiota.

Auricularia auricula-judae is an edible fungus with high nutritional value due to abundant polysaccharides, and is acknowledged as traditional food and medicine in Asia. Polysaccharides from A.

Metabolic healthRespiratory

Turkey Tail · 2021 · Research Article · International journal of molecular sciences

Biodegradation of Chloroxylenol by Cunninghamella elegans IM 1785/21GP and Trametes versicolor IM 373: Insight into Ecotoxicity and Metabolic Pathways.

Chloroxylenol (PCMX) is applied as a preservative and disinfectant in personal care products, currently recommended for use to inactivate the SARS-CoV-2 virus. Its intensive application leads to the release of PCMX into the environment, which can have a harmful impact on aquatic and soil biotas..

OncologyImmune supportMetabolic health

Chaga · 2021 · Research Article · Journal of microbiology and biotechnology

Carbon Source Affects Synthesis, Structures, and Activities of Mycelial Polysaccharides from Medicinal Fungus Inonotus obliquus.

The effects of various carbon sources on mycelial growth and polysaccharide synthesis of the medicinal fungus Inonotus obliquus in liquid fermentation were investigated..

Lion's Mane · 2021 · Research Article · Frontiers in bioengineering and biotechnology

Characterization and Heterologous Expression of UDP-Glucose 4-Epimerase From a Hericium erinaceus Mutant with High Polysaccharide Production.

Hericium erinaceus is an important medicinal fungus in traditional Chinese medicine because of its polysaccharides and other natural products. Compared terpenoids and polyketides, the analysis of synthetic pathway of polysaccharides is more difficult because of the many genes involved in central metabolism..

Immune supportEnergy & fatigueMetabolic health

Snow Fungus · 2021 · Journal Article · International Journal of Biological Macromolecules

Characterization of chitin-glucan complex from Tremella fuciformis fermentation residue and evaluation of its antibacterial performance

Submerged fermentation of fungi is an efficient way to obtain extracellular polysaccharides, however, in this process, excess discarded biomass is produced. In this study, Tremella fuciformis mycelia were reused as the raw material to isolate a novel fungal chitin-glucan complex (CGC-TFM) using alkaline extraction..

Immune supportEnergy & fatigueMetabolic health

Snow Fungus · 2021 · Journal Article · International journal of biological macromolecules

Characterization of chitin-glucan complex from Tremella fuciformis fermentation residue and evaluation of its antibacterial performance.

OncologyImmune supportEnergy & fatigueMetabolic health

Enoki · 2021 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Characterization of soy protein isolate/Flammulina velutipes polysaccharide hydrogel and its immunostimulatory effects on RAW264.7 cells.

Soy protein isolate (SPI) is a nutritional commercial product, while the poor solubility and gelling restricts its applications for functional foods. To surmount the challenge presented by this poor solubility, the gelling polysaccharide shows potential in ameliorating SPI..

OncologyImmune supportMetabolic healthGut & microbiome

Shiitake · 2021 · Journal Article · Journal of food biochemistry

Cytotoxicity, metabolic enzyme inhibitory, and anti-inflammatory effect of Lentinula edodes fermented using probiotic lactobacteria.

We found that the fermented Lentinula edodes (FLE) products exhibited various differences in terms of proximate composition, free sugar, and amino acid. In particular, there were higher levels of ergosterol, and ergothioneine in FLE-Pediococcus pentosaceus (PP) and -Lactobacillus acidophilus (LA) than in the L..

Shiitake · 2021 · Research Article · Frontiers in microbiology

De novo Sequencing and Comparative Transcriptome Analyses Provide First Insights Into Polysaccharide Biosynthesis During Fruiting Body Development of Lentinula edodes.

Polysaccharides separated from Lentinula edodes are well known for their medicinal properties. However, the precise molecular mechanisms of polysaccharide biosynthesis in L.

OncologyCognition & nervesMetabolic health

Enoki · 2021 · Journal Article · Nanotechnology

Edible mushroom (Flammulina velutipes) as biosource for silver nanoparticles: from synthesis to diverse biomedical and environmental applications.

The current study reports advanced, ecofriendly and biosynthesized silver NPs for diverse biomedical and environmental applications using Flammulina velutipes as biosource. In the study, a simple aqueous extract of F.

Oyster Mushroom · 2021 · Journal Article · Journal of food biochemistry

Effect of aqueous extracts of Pleurotus ostreatus and Lentinus subnudus on activity of adenosine deaminase, arginase, cholinergic enzyme, and angiotensin-1-converting enzyme.

Pleurotus ostreatus (P. ostreatus) and Lentinus subnudus (L.

Oyster Mushroom · 2021 · Journal Article · Journal of food biochemistry

Effect of aqueous extracts of Pleurotus ostreatus and Lentinus subnudus on activity of adenosine deaminase, arginase, cholinergic enzyme, and angiotensin‐1‐converting enzyme

Pleurotus ostreatus (P. ostreatus) and Lentinus subnudus (L.

Oyster Mushroom · 2021 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Evaluation of bioactive properties of Pleurotus ostreatus mushroom protein hydrolysate of different degree of hydrolysis

Edible mushrooms are natural sources for numerous bioactive properties which can protect human body from oxidative damages, hypertension, abnormal cell growth etc., The present study disclosed that, bioactive properties of mushroom proteins are significantly enhanced by adopting enzymatic hydrolysis..

OncologyMetabolic health

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Enoki · 2021 · Journal Article · International journal of biological macromolecules

Flammulina velutipes polysaccharide improves C57BL/6 mice gut health through regulation of intestine microbial metabolic activity.

Flammulina velutipes polysaccharides (FVP) can improve gut health through gut microbiota and metabolism regulation. In this study, the 28-days fed experiment was used to investigate gut microbime and metabolic profiling induced by FVP..

Lion's Mane · 2021 · Journal Article · Food and Bioproducts Processing

Formulation of bio-hydrogels from Hericium erinaceus in Paulownia elongata x fortunei autohydrolysis aqueous extracts

Elaboration of bio-hydrogels was proposed using autohydrolysis extracts of Hericium erinaceus and Paulownia elongata x fortunei (leaves, bark and petioles). Paulownia extracts have been used as a solvent of H.

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2021 · Research Article · Journal of Zhejiang University. Science. B

Heme oxygenase-1/carbon monoxide signaling participates in the accumulation of triterpenoids of Ganoderma lucidum.

Ganoderic triterpenoids (GTs) are the primary bioactive constituents of the Basidiomycotina fungus, Ganoderma lucidum. These compounds exhibit antitumor, anti-hyperlipidemic, and immune-modulatory pharmacological activities.

Chaga · 2021 · Research Article · BMC chemistry

Inonotus obliquus polysaccharide ameliorates serum profiling in STZ-induced diabetic mice model.

BACKGROUND: Diabetes mellitus is a systemic disease mainly caused by the disorder of metabolism, which has become huge threat to human health. Polysaccharides are the main active substance from Inonotus obliquus (I.

OncologyImmune supportMetabolic health

Enoki · 2021 · Journal Article · International journal of biological macromolecules

Isolation, characterization and HepG-2 inhibition of a novel proteoglycan from Flammulina velutipes.

Flammulina velutipes has anti-inflammatory, immunomodulatory, antioxidant and many bioactive properties with high contents of carbohydrate, proteins and fibers. In this study, a novel proteoglycan with polysaccharide complexes and protein chain, named PGD1-1, was isolated from F.

Lion's Mane · 2021 · Research Article · BMC genomics

Key metabolism pathways and regulatory mechanisms of high polysaccharide yielding in Hericium erinaceus.

BACKGROUND: Hericium erinaceus, a rare edible and medicine fungus, is widely used in the food and medical field. Polysaccharides from H.

Energy & fatigueMetabolic health

Oyster Mushroom · 2021 · Research Article · PeerJ

Ligninolytic activity of the Penicillium chrysogenum and Pleurotus ostreatus fungi involved in the biotransformation of synthetic multi-walled carbon nanotubes modify its toxicity.

Multi-walled carbon nanotubes (MWCNTs) are of multidisciplinary scientific interest due to their exceptional physicochemical properties and a broad range of applications. However, they are considered potentially toxic nanoparticles when they accumulate in the environment..

Immune supportMetabolic healthLiver support

Chaga · 2021 · Research Article · Foods (Basel, Switzerland)

Lipid-Lowering Effects of Inonotus obliquus Polysaccharide In Vivo and In Vitro.

Excessive lipid intake will cause hyperlipidemia, fatty liver metabolism disease, and endanger people's health. Edible fungus polysaccharide is a natural active substance for lipid lowering.

OncologyImmune supportMetabolic health

Reishi · 2021 · Research Article · Frontiers in chemistry

Meroterpenoids From Ganoderma lucidum Mushrooms and Their Biological Roles in Insulin Resistance and Triple-Negative Breast Cancer.

Ganoderma fungi as popular raw materials of numerous functional foods have been extensively investigated. In this study, five pairs of meroterpenoid enantiomers beyond well-known triterpenoids and polysaccharides, dayaolingzhiols I-M (1-5), were characterized from Ganoderma lucidum..

Oyster Mushroom · 2021 · Journal Article · Scientific reports

Nano urea effects on Pleurotus ostreatus nutritional value depending on the dose and timing of application.

The work investigated the effect of Lithovit-Urea50 on the composition of Pleurotus ostreatus (Jacq. Ex Fr.) P.

Energy & fatigueMetabolic healthSkin & hydration

Chaga · 2021 · Journal Article · Journal of natural medicines

Phelligridin D from Inonotus obliquus attenuates oxidative stress and accumulation of ECM in mesangial cells under high glucose via activating Nrf2.

Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus and becomes the financial burden and health problem. Pathogenesis of DN has revealed that high glucose has resulted in the oxidative stress and accumulation of extracellular matrix (ECM)..

Zhu Ling · 2021 · Research Article · Frontiers in pharmacology

Polyporus Umbellatus Protects Against Renal Fibrosis by Regulating Intrarenal Fatty Acyl Metabolites.

Background: Chronic renal failure (CRF) results in significant dyslipidemia and profound changes in lipid metabolism. Polyporus umbellatus (PPU) has been shown to prevent kidney injury and subsequent kidney fibrosis..

Immune supportMetabolic healthGut & microbiomeLiver support

Enoki · 2021 · Journal Article · Food & function

Polysaccharide from Flammulina velutipes attenuates markers of metabolic syndrome by modulating the gut microbiota and lipid metabolism in high fat diet-fed mice.

Natural biological macromolecules with putative functions of gut microbiota regulation possess the advantage of improving metabolic syndrome (MS). In this research, we aimed to determine the effects of Flammulina velutipes polysaccharide (FVP) (Expt.

Energy & fatigueMetabolic health

Turkey Tail · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

Proteomics Reveals Octyl Gallate as an Environmentally Friendly Wood Preservative Leading to Reactive Oxygen Species-Driven Metabolic Inflexibility and Growth Inhibition in White-Rot Fungi (Lenzites betulina and Trametes versicolor).

The most commonly applied wood preservatives are based on creosote, pentachlorophenol, and waterborne chromate copper arsenate, which negatively affect the environment. Thus, environmentally friendly wood preservatives are required..

Immune supportMetabolic healthSkin & hydration

Wood Ear · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

Skin Wound-Healing Potential of Polysaccharides from Medicinal Mushroom Auricularia auricula-judae (Bull.).

Auricularia auricula-judae, a nutrient-rich mushroom used in traditional medicine, is a macrofungi that exhibits various biological properties. In this study, we have reported on the mechanisms that promote the wound-healing effects of a water-soluble polysaccharide-rich extract obtained from A.

Metabolic healthGut & microbiome

Lion's Mane · 2021 · Journal Article · Carbohydrate polymers

Structural elucidation of a branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system

A water-soluble β-glucan from fruiting body of Hericium erinaceus was obtained after water extraction, purification and fractionation. Analyses of monosaccharide composition, molecular weight and linkage mode demonstrated that it is a β-glucan with 1→3 and 1→6 linkage modes and a molecular weight of 13.3 kDa..

Metabolic healthGut & microbiome

Lion's Mane · 2021 · Journal Article · Carbohydrate polymers

Structural elucidation of a branch-on-branch β-glucan from Hericium erinaceus with A HPAEC-PAD-MS system.

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Enoki · 2021 · Journal Article · International journal of biological macromolecules

The biological regulatory activities of Flammulina velutipes polysaccharide in mice intestinal microbiota, immune repertoire and heart transcriptome.

The effects of a novel Flammulina velutipes polysaccharide (FVP) on intestinal microbiota, immune repertoire and heart transcriptome were investigated in this study. The results showed that FVP treatment could effectively regulate the abundance of colonic microbiota..

Energy & fatigueMetabolic healthGut & microbiome

Oyster Mushroom · 2021 · Research Article · Animals: an open access journal from MDPI

Treatment of Rice Stubble with Pleurotus ostreatus and Urea Improves the Growth Performance in Slow-Growing Goats.

The objective of this study was to evaluate the efficacy of the fungal treatment (Pleurotus ostreatus) of urea-treated rice stubble on growth performance in slow-growing goats..

Energy & fatigueMetabolic health

Oyster Mushroom · 2021 · Research Article · Microbial cell factories

Trehalose alleviates high-temperature stress in Pleurotus ostreatus by affecting central carbon metabolism.

BACKGROUND: Trehalose, an intracellular protective agent reported to mediate defense against many stresses, can alleviate high-temperature-induced damage in Pleurotus ostreatus..

Immune supportMetabolic healthGut & microbiome

Snow Fungus · 2021 · Journal Article · International journal of biological macromolecules

Tremella fuciformis polysaccharides ameliorated ulcerative colitis via inhibiting inflammation and enhancing intestinal epithelial barrier function.

The purpose of this paper was to explore the therapeutic effect and underlying mechanism of Tremella fuciformis polysaccharides (TFP) on ulcerative colitis (UC) based on dextran sodium sulfate (DSS)-induced mice UC model and lipopolysaccharide (LPS)-stimulated Caco-2 cells model..

OncologyImmune supportMetabolic healthRespiratory

Reishi · 2021 · Research Article · Polymers

WSG, a Glucose-Rich Polysaccharide from Ganoderma lucidum, Combined with Cisplatin Potentiates Inhibition of Lung Cancer In Vitro and In Vivo.

Lung cancer has the highest global mortality rate of any cancer. Although targeted therapeutic drugs are commercially available, the common drug resistance and insensitivity to cisplatin-based chemotherapy, a common clinical treatment for lung cancer, have prompted active research on alternative lung cancer therapies….

Maitake · 2007 · Clinical Trial · Journal of veterinary internal medicine

Mushroom-derived maitake PETfraction as single agent for the treatment of lymphoma in dogs.

BACKGROUND: Maitake PETfraction is a standardized essence extracted from the mushroom Maitake (Grifola frondosa) that has antitumor activity in tumor-bearing mice..

OncologyMetabolic health

Oyster Mushroom · 2024 · Randomized Controlled Trial · The Journal of nutrition

Consuming Mushrooms When Adopting a Healthy Mediterranean-Style Dietary Pattern Does Not Influence Short-Term Changes of Most Cardiometabolic Disease Risk Factors in Healthy Middle-Aged and Older Adults.

BACKGROUND: Mushrooms are a nutritious food, though knowledge of the effects of mushroom consumption on cardiometabolic risk factors is limited and inconsistent. OBJECTIVE: We assessed the effects of consuming mushrooms as part of a healthy United States Mediterranean-style dietary pattern (MED) on traditional and….

Metabolic healthLiver support

Cordyceps · 2023 · Research Article · Molecules (Basel, Switzerland)

Characterization of Metabolite Landscape Distinguishes Medicinal Fungus Cordyceps sinensis and other Cordyceps by UHPLC-Q Exactive HF-X Untargeted Metabolomics.

Cordyceps represent a valuable class of medicinal fungi with potential utilization. The overexploitation and resource scarcity of Cordyceps sinensis (CS) have led to the emergence of Cordyceps such as Cordyceps militaris (CM) and Cordyceps cicadae (CC) as substitutes..

Cordyceps · 2022 · Research Article · Frontiers in pharmacology

Comparative metabolic profiling of wild Cordyceps species and their substituents by liquid chromatography-tandem mass spectrometry.

Cordyceps is a genus of ascomycete fungi and used widely in fungal drugs. However, in-depth studies of the metabolites of wild Cordyceps species and their substituents are lacking..

Metabolic healthSkin & hydration

Shiitake · 2022 · Journal Article · International journal of food science & technology

Utilisation of dried shiitake, black ear and silver ear mushrooms into sorghum biscuits manipulates the predictive glycaemic response in relation to variations in biscuit physical characteristics

The nutritional quality of gluten‐free products is important to the health of individuals with coeliac disease. Mushrooms are good sources of vitamins, dietary fibres and proteins, and are a low‐calorie option that can be used in gluten‐free diets to improve their nutritional value..

Shiitake · 2021 · Journal Article · Journal of the science of food and agriculture

Screening candidate genes related to volatile synthesis in shiitake mushrooms and construction of regulatory networks to effectively improve mushroom aroma

BACKGROUND: Metabolite formation is a physiological stress response during the growth and development of shiitake mushrooms (Lentinula edodes). The characteristic flavor metabolites are important quality components in shiitake mushrooms..

Shiitake · 2021 · Journal Article · Journal of the science of food and agriculture

Screening candidate genes related to volatile synthesis in shiitake mushrooms and construction of regulatory networks to effectively improve mushroom aroma.

Energy & fatigueMetabolic healthLiver supportRespiratory

Cordyceps · 2021 · Journal Article · Journal of ethnopharmacology

Toxicological safety evaluation of the cultivated Chinese cordyceps.

ETHNOPHARMACOLOGICAL RELEVANCE: The Chinese cordyceps, a parasitic Thitarodes insect-Ophiocordyceps sinensis fungus complex in the Qinghai-Tibet Plateau, is one of the most valuable traditional Chinese medicines and health food for ameliorating conditions associated with aging and for treating fatigue, night sweats,….

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2020 · Research Article · Animals: an open access journal from MDPI

Effect of Spent Mushroom (Cordyceps militaris) on Growth Performance, Immunity, and Intestinal Microflora in Weaning Pigs.

There are limited published reports regarding the optimal dosage of spent mushroom. This study investigated the effect of various levels of spent mushroom derived from C..

Cordyceps · 2020 · Journal Article · International journal of biological macromolecules

Structural characterization and immune-enhancing activity of a novel high-molecular-weight polysaccharide from Cordyceps militaris.

A novel homogeneous polysaccharide (CMP-III) was extracted and purified from C. militaris.

Cordyceps · 2019 · Research Article · RSC advances

Tussah silkmoth pupae improve anti-tumor properties of Cordyceps militaris (L.) Link by increasing the levels of major metabolite cordycepin.

Silkworms have been reported to promote the growth and production of the stromata of C. militaris (L.) Link as a parasite insect medium and may improve its metabolites.

OncologyMetabolic health