MycoData

The effects of monokaryotic strains on fruiting body formation of Lentinula edodes were examined through mating and cultivation of the mated dikaryotic mycelia in sawdust medium. To accomplish this, monokaryotic strains of L..

Energy & fatigue

High relevance

Yellow Morel · 2015 · Journal Article · International journal of food properties

Isolation, Purification, and Characterization of Polysaccharides from Wide Morchella esculenta (L.) Pers

A new polysaccharide (MEP-1) was isolated from fruit body of wide Morchella esculenta (L.) Pers with a stepwise procedure of hot water extraction, removal of the protein, dialysis against water, DEAE-Cellulose A52 and Sephadex G-100 columns..

Immune supportEnergy & fatigueMetabolic healthSkin & hydration

High relevance

Zhu Ling · 2015 · Journal Article · Journal of medicinal food

Khz (fusion product of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis in human colon carcinoma HCT116 cells, accompanied by an increase in reactive oxygen species, activation of caspase 3, and increased intracellular Ca²⁺.

Khz (a fusion mycelium of Ganoderma lucidum and Polyporus umbellatus mycelia) is isolated from ganoderic acid and P. umbellatus and it exerts antiproliferative effects against malignant cells.

OncologyEnergy & fatigueGut & microbiome

High relevance

Maitake · 2015 · Clinical Trial, Phase II · Cancer immunology, immunotherapy: CII

Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study.

BACKGROUND: Myelodysplastic syndromes (MDS) are characterized by ineffective erythropoiesis with dysplastic bone marrow leading to peripheral cytopenia, risk of infection, and progression to acute myelogenous leukemia..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Mesima · 2015 · Journal Article · Journal of investigative medicine: the official publication of the American Federation for Clinical Research

The Effects of Phellinus linteus Polysaccharide Extracts on Cholesterol Efflux in Oxidized Low-Density Lipoprotein-Loaded THP-1 Macrophages.

The removal of excess cellular cholesterol is critical for maintaining cellular cholesterol homeostasis. Phellinus linteus polysaccharide extracts (PLPEs) is an immunomudulatory agent with a molecular weight of 153 kd..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Snow Fungus · 2014 · Journal Article · Journal of food processing and preservation

Quality and Sensory Characterization of White Jelly Mushroom (Tremella fuciformis) as a Meat Substitute in Pork Patty Formulation

White jelly mushroom (Tremella fuciformis, WJM) has been used for medicinal purposes due to its diverse physiological activities. This study evaluated the effect of WJM in pork patties on the quality and sensory characteristics of it..

Energy & fatigue

High relevance

Niu-Chang-Chih · 2013 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Ethanol Extract of Antrodia camphorata Grown on Germinated Brown Rice Suppresses Inflammatory Responses in Mice with Acute DSS-Induced Colitis.

The anti-inflammatory activity of Antrodia camphorata (AC) grown on germinated brown rice (CBR) extract was evaluated in vitro and in vivo. CBR suppressed the release of nitric oxide (NO) and prostaglandin (PG) E2 from lipopolysaccharide-(LPS-)stimulated RAW264.7 cells..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Yellow Morel · 2013 · Journal Article · Biotechnology letters

Induction of apoptosis in HepG2 cells by polysaccharide MEP-II from the fermentation broth of Morchella esculenta

A novel polysaccharide, MEP-II, isolated from the fermentation broth of Morchella esculenta inhibited the proliferation of human hepatoma cell line (HepG2) through an apoptotic pathway..

OncologyImmune supportEnergy & fatigueLiver support

High relevance

Mesima · 2013 · Research Article · Chinese medicine

Phellinus linteus polysaccharide extracts increase the mitochondrial membrane potential and cause apoptotic death of THP-1 monocytes.

BACKGROUND: The differentiation resp. death of human monocytic THP-1 cells induced by polysaccharide extracts of the medicinal mushrooms Phellinus linteus, Agaricus bisporus and Agaricus brasiliensis have been studied..

OncologyImmune supportEnergy & fatigue

High relevance

Enoki · 2012 · Journal Article · Animal science journal =

Effects of fermented mushroom (Flammulina velutipes) by‐product diets on growth performance and carcass traits in growing‐fattening Berkshire pigs

This study was conducted to investigate effects of fermented mushroom (Flammulina velutipes) by‐product diets on the growth performance and carcass traits in growing‐fattening Berkshire pigs..

Energy & fatigueMetabolic healthGut & microbiome

High relevance

Niu-Chang-Chih · 2012 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Inhibition of Cell Growth and Induction of Apoptosis by Antrodia camphorata in HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway.

Previously, we demonstrated that a submerged fermentation culture of Antrodia camphorata (AC) promotes cell-cycle arrest and apoptosis in human estrogen receptor-positive/negative breast cancer cells. However, whether AC is effective against HER-2/neu-overexpressing breast cancers has not been thoroughly elucidated..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Zhu Ling · 2012 · Research Article · PloS one

Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species.

Khz is a compound derived from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia that inhibits the growth of cancer cells. The results of the present study show that Khz induced apoptosis preferentially in transformed cells and had only minimal effects on non-transformed cells..

OncologyEnergy & fatigue

High relevance

Niu-Chang-Chih · 2012 · Journal Article · Food chemistry

Protective effect of antrosterol from Antrodia camphorata submerged whole broth against carbon tetrachloride-induced acute liver injury in mice

The hepatoprotective potential of antrosterol (ergostatrien-3Î²-ol, ST1) from Antrodia camphorata (AC) against carbon tetrachloride (CClâ)-induced liver damage was evaluated in preventive models in mice..

OncologyImmune supportEnergy & fatigueLiver support

High relevance

Lion's Mane · 2012 · Journal Article · Carbohydrate polymers

Structure of a water-soluble heteropolysaccharide from fruiting bodies of Hericium erinaceus

A new heteropolysaccharide (HEPF4), with a molecular weight of 2.03×10⁴Da as determined by high-performance liquid chromatography (HPLC), was obtained from the fruiting bodies of Hericium erinaceus. It is composed of 3-O-methylrhamnose, l-fucose, d-galactose and d-glucose in the ratio of 0.12:1.00:3.27:0.28..

Immune supportEnergy & fatigueMetabolic health

High relevance

Niu-Chang-Chih · 2012 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Triterpenoid-Rich Extract from Antrodia camphorata Improves Physical Fatigue and Exercise Performance in Mice.

Antrodia camphorata (AC) is an endemic mushroom that grows in Taiwan. We investigated the fatigue-alleviating effects of AC on endurance capacity in swim-exercised and weight-loading mice..

OncologyEnergy & fatigueMetabolic healthLiver support

High relevance

Lion's Mane · 2011 · Journal Article · Journal of agricultural and food chemistry

Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice.

We investigated antitumor effects of the following four extracts of freeze-dried Hericium erinaceus mushrooms in Balb/c mice intracutaneously transplanted on the backs with CT-26 colon cancer cells: HWE, hot water extraction by boiling in water for 3 h; MWE, microwaving in 50% ethanol/water at 60 W for 3 min; and ACE….

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Turkey Tail · 2011 · Journal Article · Chemosphere

Efficient removal of pollutants from olive washing wastewater in bubble-column bioreactor by Trametes versicolor.

The white-rot fungi Panus tigrinus, Funalia trogii and Trametes versicolor have been tested in shake flasks for the reduction of olive washing wastewater (OWW) pollutants and production of oxidases on OWW-based media. P.

Energy & fatigue

High relevance

Maitake · 2011 · Journal Article · World journal of microbiology & biotechnology

On the role of carbohydrate-protein highly selective interactions in the biological activity of glycoconjugates: Grifola frondosa (Fr.) S.F. Gray lectin binding to specific and non-specific antibodies

Both quantitative and qualitative estimations of the basidiomycete Grifola frondosa lectin binding to the specific and non-specific polyclonal rabbit antibodies were attempted..

Cognition & nervesEnergy & fatigue

High relevance

Enoki · 2010 · Journal Article · Journal of agricultural and food chemistry

Effects of ergothioneine from mushrooms (Flammulina velutipes) on melanosis and lipid oxidation of kuruma shrimp (Marsupenaeus japonicus).

The antimelanosic and antioxidative properties of a hot water extract prepared from the fruiting body of the edible mushroom (Flammulina velutipes) were evaluated by dietary supplementation in Kuruma shrimp (Marsupenaeus japonicus) for possible aquaculture application..

Immune supportEnergy & fatigue

High relevance

Yellow Morel · 2010 · Journal Article · Pharmaceutical biology

Evaluation of free radical scavenging activity of morel mushroom, Morchella esculenta mycelia: a potential source of therapeutically useful antioxidants.

Cellular damage caused by reactive oxygen species (ROS) has been implicated in several diseases and antioxidants are known to protect the body from this damage. Antioxidants thus, have gained significant importance in human health..

Energy & fatigue

High relevance

Mesima · 2010 · Journal Article · Archives of pharmacal research

Hispidin produced from Phellinus linteus protects pancreatic beta-cells from damage by hydrogen peroxide.

Phellinus linteus, which is a traditional medicinal mushroom used in Asian countries for the treatment of various diseases, has attracted a lot of attention due to its antioxidant, anti-inflammatory, anti-mutagenicity, and cell-mediated immunity properties in addition to its ability to inhibit tumor growth and….

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Turkey Tail · 2010 · Journal Article · Acta chimica Slovenica

Oxidation of Coniferyl Alcohol Catalyzed by Laccases from Trametes versicolor.

Oxidation of coniferyl alcohol catalyzed by commercial laccase and crude laccase produced during the submerged cultivation of Trametes versicolor MZKI G-99 in a medium containing the waste from paper industry was investigated..

Energy & fatigue

High relevance

Niu-Chang-Chih · 2010 · Research Article · Chinese medicine

Quality evaluation of mycelial Antrodia camphorata using high-performance liquid chromatography (HPLC) coupled with diode array detector and mass spectrometry (DAD-MS).

BACKGROUND: Antrodia camphorata (AC) is an important fungus native to Taiwanese forested regions. Scientific studies have demonstrated that extracts of AC possess a variety of pharmacological functions..

Energy & fatigue

High relevance

Enoki · 2009 · Journal Article · Aquaculture

Preventing discoloration and lipid oxidation in dark muscle of yellowtail by feeding an extract prepared from mushroom (Flammulina velutipes) cultured medium

A hydrophilic extract prepared from waste medium from mushroom (Flammulina velutipes) cultivation contained ergothioneine (ESH) at a concentration of 340mg/L (=48mg/kg of solid medium). The content of ESH in the extract at which 50% of the DPPH radical was scavenged was 0.3μg..

Energy & fatigue

High relevance

Snow Fungus · 2008 · Journal Article · Journal of basic microbiology

Identification and antioxidant activity of melanin isolated from Hypoxylon archeri, a companion fungus of Tremella fuciformis.

Melanin produced by Hypoxylon archeri, a companion fungus of Tremella fuciformis, was purified from the submerged culture medium and designated as HM. Ultraviolet-visible and FTIR spectra of the purified HM showed significant similarities with those of the synthesized melanin derived from tyrosine..

Energy & fatigueSkin & hydration

High relevance

Maitake · 2007 · Journal Article · Se pu = Chinese journal of chromatography

[Behaviors of beta-glucan from Grifola frondosa in high performance gel permeation chromatography].

The high performance gel permeation chromatographic (HPGPC) behaviors of four beta-1, 3/1, 6-glucans (GF1, GF2, GF3, GF4) with different protein contents and one alpha-1, 4/1, 6-glucan (P100) from Grifola frondosa were examined with different concentrations of NaCl solution and pH values..

Immune supportEnergy & fatigue

High relevance

Niu-Chang-Chih · 2007 · Journal Article · Acta pharmacologica Sinica

Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorata.

AIM: To investigate the effect of water soluble-ethanol precipitation fraction (AC-1) and alkaline extraction-isoelectric precipitation fraction (AC-2) from Antrodia camphorata (Polyporaceae, Aphyllophorales) on lipopolysaccharide (LPS)-induced gene activation in mouse macrophages..

Immune supportEnergy & fatigue

High relevance

Snow Fungus · 2006 · Journal Article · Applied microbiology and biotechnology

Chromosomal integration of the Vitreoscilla hemoglobin gene and its physiological actions in Tremella fuciformis.

The Vitreoscilla hemoglobin (VHb) gene was expressed in yeast-like conidia (YLCs) of Tremella fuciformis (T. fuciformis) to increase cell density in submerged fermentation by enhancing oxygen uptake..

Energy & fatigue

High relevance

Maitake · 2006 · Journal Article · Journal of lipid research

Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK.

We found that Grifola frondosa extracts induced the activation of mitogen-activated protein kinase (MAPK) in cultured PC12 cells, a line of rat pheochromocytoma cells..

OncologyCognition & nervesEnergy & fatigueSkin & hydration

High relevance

Yellow Morel · 2006 · Journal Article · Journal of food engineering

Morchella esculenta (morel) rehydration process modelling

Rehydration of air-dried Morchella esculenta mushrooms was examined at different temperatures (15, 20, 25, 30, 45, 55 and 70 degrees C). Two kinds of models were considered to describe the kinetics: a diffusion model for a slab and two empirical equations, Peleg and Weibull..

Energy & fatigueSkin & hydration

High relevance

Niu-Chang-Chih · 2005 · Patent · journal metadata

A new extraction method and application of antrodia camphorata in promoting the energy and the ability of exercise and anti-fatigue

We found a new application of Antrodia camphorata in promoting the Energy and the ability of exercise. We used the gene expression analysis and absorbance value of creatinine-picric acid complex to prove the new application..

Energy & fatigueLiver support

High relevance

Chaga · 2005 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus.

The mushroom Inonotus obliquus (Fr.) Pilát (Hymenochaetaceae), has been traditionally used for the treatment of gastrointestinal cancer, cardiovascular disease and diabetes in Russia, Poland and most of Baltic countries..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Mesima · 2005 · Patent · journal metadata

METHOD FOR PRODUCING EXTRACT OF PHELLINUS LINTEUS TENG HAVING HIGH ANTIOXIDATIVE ACTIVITY

PURPOSE: Provided is a method for producing the extract of Phellinus Linteus Teng which has high antioxidative activity to reducing extraction time, energy, labor cost and the like..

Energy & fatigue

High relevance

Mesima · 2004 · Comparative Study · Journal of ethnopharmacology

Acidic polysaccharide isolated from Phellinus linteus enhances through the up-regulation of nitric oxide and tumor necrosis factor-alpha from peritoneal macrophages.

Medicinal mushrooms are increasingly used to treat a wide variety of disease processes. Aqueous extract from the fruiting body or mycelia of Phellinus linteus has been reported to produce antitumor and immunomodulatory activities in vivo and in vitro..

OncologyImmune supportEnergy & fatigue

High relevance

Niu-Chang-Chih · 2003 · Comparative Study · Life sciences

The vasorelaxation of Antrodia camphorata mycelia: involvement of endothelial Ca(2+)-NO-cGMP pathway.

Antrodia camphorata, a medicinal fungus, has been used to treat cardiovascular diseases such as hypertension for many years. The purpose of this study was to examine the effects of mycelia extracts, from five Antrodia camphorata strains, on vascular tension and underlying mechanisms were explored..

Energy & fatigueMetabolic health

High relevance

King Oyster · 2001 · Research Support, Non U.S. Gov'T · Biochimica et biophysica acta

Expression of Pleurotus eryngii aryl-alcohol oxidase in Aspergillus nidulans: purification and characterization of the recombinant enzyme.

Aryl-alcohol oxidase (AAO) is an extracellular flavoenzyme involved in lignin biodegradation by some white-rot fungi. The enzyme catalyzes the extracellular oxidation of aromatic alcohols to the corresponding aldehydes.

Energy & fatigue

High relevance

King Oyster · 2000 · Research Support, Non U.S. Gov'T · Applied and environmental microbiology

Oxygen activation during oxidation of methoxyhydroquinones by laccase from Pleurotus eryngii.

Oxygen activation during oxidation of the lignin-derived hydroquinones 2-methoxy-1,4-benzohydroquinone (MBQH(2)) and 2, 6-dimethoxy-1,4-benzohydroquinone (DBQH(2)) by laccase from Pleurotus eryngii was examined..

Energy & fatigue

High relevance

King Oyster · 1999 · Research Support, Non U.S. Gov'T · Applied and environmental microbiology

Regulation of peroxidase transcript levels in liquid cultures of the ligninolytic fungus Pleurotus eryngii.

A versatile peroxidase able to oxidize Mn(2+) as well as phenolic and nonphenolic aromatic compounds is produced in peptone-containing liquid cultures of Pleurotus eryngii encoded by the gene mnpl. The regulation of its transcript levels was investigated by Northern blotting of total RNA..

Energy & fatigueMetabolic health

High relevance

King Oyster · 1997 · Comparative Study · Applied and environmental microbiology

Laccase isoenzymes of Pleurotus eryngii: characterization, catalytic properties, and participation in activation of molecular oxygen and Mn2+ oxidation.

Two laccase isoenzymes produced by Pleurotus eryngii were purified to electrophoretic homogeneity (42- and 43-fold) with an overall yield of 56.3%. Laccases I and II from this fungus are monomeric glycoproteins with 7 and 1% carbohydrate content, molecular masses (by sodium dodecyl sulfate-polyacrylamide gel….

Energy & fatigue

High relevance

King Oyster · 1997 · Research Support, Non U.S. Gov'T · Archives of biochemistry and biophysics

Quinone redox cycling in the ligninolytic fungus Pleurotus eryngii leading to extracellular production of superoxide anion radical.

Quinone redox cycling is generally known as an intracellular process that implies the reduction of quinones (Q) into semiquinones (Q-.) or hydroquinones (QH2), which autoxidize reducing oxygen to superoxide anion radical (O-.2)..

Energy & fatigue

Medium relevance

Reishi · 2026 · Clinical Trial Protocol · JMIR research protocols

Effectiveness and Safety of a Supplement Containing a Pharmacologically Active Basidiomycete Mushroom for Chronic Fatigue and Post-COVID-19 Fatigue Syndrome: Protocol for a Randomized Controlled Trial.

BACKGROUND: Chronic fatigue syndrome, or myalgic encephalomyelitis, is characterized by persistent, unexplained exhaustion unalleviated by rest, with a pathophysiology distinct from underlying medical conditions..

Immune supportCognition & nervesEnergy & fatigueRespiratory

Medium relevance

Cordyceps · 2026 · Video Audio Media · Journal of visualized experiments: JoVE

Effects of Cordyceps Polysaccharides on D-Galactose-induced Renal Senescence.

Chronic kidney disease (CKD) poses a significant global health concern. Aging of renal tubular epithelial cells (RTECs) impairs kidney regeneration and repair and promotes CKD progression through the release of the senescence-associated secretory phenotype (SASP)..

Immune supportEnergy & fatigue

Medium relevance

Shiitake · 2026 · Evaluation Study · Food chemistry

High-energy fluidic microfluidization: Enhancing non-volatile and volatile flavor of shiitake mushrooms slurry.

Shiitake mushrooms slurry (SMS) was innovatively prepared using a high-energy fluidic microfluidizer (HEFM) under different pressure (0-120 MPa). The equivalent umami concentrations value increased by 171.40 % in SMS treated with HEFM at 120 MPa than the untreated sample, and the contents of total 5'-nucleotides,….

Energy & fatigue

Medium relevance

Lion's Mane · 2026 · Review · International journal of molecular sciences

Phytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.

This narrative review proposes the 'Brain Health Triad' as a novel integrative framework for neurorehabilitation and cognitive enhancement, built upon three interdependent biological pillars: neurostimulation, neurotrophy, and neuroprotection..

Cognition & nervesEnergy & fatigue

Medium relevance

Shiitake · 2026 · Evaluation Study · Food chemistry

Study on the mechanism of flavor development in ultrasound-assisted microwave vacuum drying of shiitake mushrooms: Dosage effect of ultrasonic amplitude.

In this study, the regulatory pathways of aroma formation in dried shiitake mushrooms under different ultrasound amplitudes (50 %, 70 %, and 90 %) were elucidated using GC-MS and non-targeted metabolomics combined with dynamic analysis of γ-GT and CS lyase activities..

Energy & fatigueMetabolic health

Medium relevance

Shiitake · 2025 · Comparative Study · Food chemistry

4D-label free based comparative proteomics revealed the responsive mechanisms of quality deterioration driven by spore release in shiitake mushrooms.

Label-free quantitative proteomics profiles combined with biochemical analysis were applied in three spore release stages to investigate the proteome responses related to spore release inducing the quality loss of mushrooms..

Energy & fatigue

Medium relevance

Shiitake · 2025 · Evaluation Study · Food chemistry

Exploring the possible mechanisms of X-rays treatment for retention aroma volatiles in shiitake mushrooms during low temperature storage.

X-rays irradiation has been demonstrated to effectively preserve the freshness of edible fungi and delay the loss of aroma during storage. In this study, shiitake mushrooms were irradiated with X-rays dose of 0.5 kGy and stored at 2 °C for 35 days.

Energy & fatigue

Medium relevance

Shiitake · 2025 · Evaluation Study · Food chemistry

Ultrasound-assisted microwave vacuum drying enhances flavor release during stewing of dried shiitake mushrooms.

The introduction of ultrasonic energy into microwave vacuum drying (MVD) enhances drying efficiency and product quality. To investigate the effect of ultrasonically coupled microwave vacuum (USMVD) drying on the flavor release of shiitake mushrooms, differences in the pore structure of dried mushrooms were analyzed in….

Energy & fatigue

Medium relevance

Cordyceps · 2023 · Research Article · Molecules (Basel, Switzerland)

A New Galactoglucomannan from the Mycelium of the Medicinal Parasitic Fungus Cordyceps cicadae and Its Immunomodulatory Activity In Vitro and In Vivo.

A new galactoglucomannan (C-0-1) was purified from the medicinal parasitic fungus of Cordyceps cicadae using an anion-exchange column and gel permeation column. The results of high-performance liquid chromatography and high-performance gel permeation chromatography indicated that C-0-1 consists of galactose, glucose,….

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Medium relevance

Shiitake · 2023 · Journal Article · Food chemistry

Development of bio-based PLA/cellulose antibacterial packaging and its application for the storage of shiitake mushroom.

This study presents the extraction of cellulose from water bamboo byproducts to prepare polylactic acid (PLA)/cellulose antibacterial packaging material. The cellulose was modified using a silane coupling agent, which improved the interfacial compatibility between cellulose and PLA..

Energy & fatigue