MycoData

OncologyImmune supportEnergy & fatigueMetabolic health

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · Molecular medicine reports

Composition and antioxidant activity of water-soluble oligosaccharides from Hericium erinaceus.

Oligosaccharide are carbohydrate molecules, comprising repeating units joined together by glycosidic bonds. In recent years, an increasing number of oligosaccharides have been reported to exhibit various biological activities, including antitumor, immune-stimulation and antioxidation effects..

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Natural product communications

Ergosterol of Cordyceps militaris Attenuates LPS Induced Inflammation in BV2 Microglia Cells.

Different solvent extracts of Cordyceps militaris stroma powder were tested for cell viability and inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS) triggered BV2 microglia cells. Chemical investigation of the ethyl acetate fraction resulted in an enriched ergosterol sub-fraction CE3..

OncologyImmune supportGut & microbiome

Chaga · 2015 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer.

AIM OF THE STUDY: In this study, we examined the effect of different fractions and components of Chaga mushroom (Inonotus Obliquus) on viability and apoptosis of colon cancer cells. Among them, one component showed the most effective growth inhibition and was identified as ergosterol peroxide by NMR analysis..

Chaga · 2015 · Research Article · Nutrition research and practice

Ethanol extract of Innotus obliquus (Chaga mushroom) induces G1 cell cycle arrest in HT-29 human colon cancer cells.

BACKGROUND/OBJECTIVES: Inonotus obliquus (I. obliquus, Chaga mushroom) has long been used as a folk medicine to treat cancer.

OncologyGut & microbiome

OncologyImmune supportRespiratory

Shiitake · 2015 · Research Support, Non U.S. Gov'T · Gene

Expression and functional analysis of novel molecule - Latcripin-13 domain from Lentinula edodes C91-3 produced in prokaryotic expression system.

The shiitake mushroom Lentinula edodes has health benefits and is used to treat various diseases due to its immunomodulatory and antineoplastic properties. In the present study, the Latcripin-13 domain, isolated from L.

OncologyMetabolic healthLiver support

Wood Ear · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Hypolipidemic and Hepatic Steatosis Preventing Activities of the Wood Ear Medicinal Mushroom Auricularia auricula-judae (Higher Basidiomycetes) Ethanol Extract In Vivo and In Vitro.

Obesity, a rapidly growing threat to human health worldwide, is responsible for a large proportion of the total burden of disease. Therefore, obesity control could be a vital scheme to prevent many diseases..

OncologyMetabolic healthGut & microbiomeLiver support

King Oyster · 2015 · Research Support, Non U.S. Gov'T · Asian Pacific journal of cancer prevention: APJCP

Inhibition of Azoxymethane-induced Colorectal Aberrant Crypt Foci in Mice Fed a High-fat Diet by Pleurotus eryngii (Eringi) and Hypsizygus marmoreus (Bunashimeji).

Obesity markedly increases the risk of colorectal cancer. Recently, the preventive effects of edible mushrooms on triglyceride elevation and visceral fat accumulation have been reported..

King Oyster · 2015 · Research Support, Non U.S. Gov'T · Plant foods for human nutrition (Dordrecht, Netherlands)

Structure Identification of Triterpene from the Mushroom Pleurotus eryngii with Inhibitory Effects Against Breast Cancer.

Breast cancer is the leading cause of death among women, with approximately 1 million diagnoses annually. Triterpenoids, which have cancer preventive or anti-tumour efficacy towards various tumour cells, may play a role in breast cancer prevention..

Maitake · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Submerged-Culture Mycelia and Broth of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes) Alleviate Type 2 Diabetes-Induced Alterations in Immunocytic Function.

Type 2 Diabetes mellitus (T2DM), a disease with impaired glucose, protein and lipid metabolism, low-grade chronic inflammation, and immune dysfunction, is a global public health crisis. We previously demonstrated that Grifola frondosa has bioactivities in improving glycemic responses in diabetic rats..

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages.

Chronic low-grade inflammation in the adipose tissue accompanying obesity is thought to be an underlying driver of metabolic diseases. In this study, we aimed to investigate the efficacy of Hericium erinaceus on adipose tissue inflammation.

Almond Mushroom · 2015 · Research Support, Non U.S. Gov'T · Journal of medicinal food

The polar high molecular weight fraction of the Agaricus blazei Murill extract, AndoSan™, reduces the activity of the tumor-associated protease, legumain, in RAW 264.7 cells.

AndoSan™ is an extract of Agaricus blazei Murill (AbM; 82.4%), Hericium erinaceum (14.7%), and Grifola frondosa (2.9%). The main ingredient of AndoSan, AbM, is rich in different forms of β-glucans..

OncologyImmune supportEnergy & fatigue

Enoki · 2014 · Research Support, Non U.S. Gov'T · Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

Antioxidant and immunomodulatory activities of a polysaccharide from Flammulina velutipes.

OBJECTIVE: To evaluate the antioxidant and immunomodulatory activities of a unique polysaccharide from the medicinal fungus Flammulina velutipes in vitro. METHODS: Using water extraction and alcohol precipitation, crude polysaccharides were obtained..

OncologyImmune supportLiver supportRespiratory

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Journal of the science of food and agriculture

Antiproliferative and immunostimulatory activity of a protein from Pleurotus eryngii.

BACKGROUND: Currently, the use of mushrooms as functional foods, nutraceuticals or phytopharmaceuticals source has risen. In contrast, the possible cellular cytotoxicity and immunostimulatory activity of Pleurotus eryngii (DC.

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Food & function

Antrodia camphorata induces G(1) cell-cycle arrest in human premyelocytic leukemia (HL-60) cells and suppresses tumor growth in athymic nude mice.

Antrodia camphorata is a well-known medicinal mushroom in Taiwan. The broth from a fermented culture of Antrodia camphorata (AC) has been shown to induce apoptosis in cultured human premyelocytic leukemia (HL-60) cells..

OncologyEnergy & fatigue

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Changes in chemical components and cytotoxicity at different maturity stages of Pleurotus eryngii fruiting body.

The present study investigated the changes of the chemical components and cytotoxicity potency at 5 developmental stages of Pleurotus eryngii fruiting body. The carbohydrate and protein contents increased along the maturity of fruiting body while fat content decreased..

OncologyEnergy & fatigueSkin & hydration

Cordyceps · 2014 · Research Support, Non U.S. Gov'T · Nutrients

Cordyceps militaris extract protects human dermal fibroblasts against oxidative stress-induced apoptosis and premature senescence.

Oxidative stress induced by reactive oxygen species (ROS) is the major cause of degenerative disorders including aging and disease. In this study, we investigated whether Cordyceps militaris extract (CME) has in vitro protective effects on hydrogen peroxide-induced oxidative stress in human dermal fibroblasts (HDFs)..

Shiitake · 2014 · Brief Report · Mycobiology

Determination of Glucan Contents in the Fruiting Bodies and Mycelia of Lentinula edodes Cultivars.

Shiitake mushrooms (Lentinula edodes) containing β-glucans may be beneficial for human health; they have been used in the treatment of cancer, hypertension, and high cholesterol levels..

OncologyMetabolic health

OncologyImmune supportMetabolic healthLiver support

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · TheScientificWorldJournal

Effect of Antrodia camphorata on inflammatory arterial thrombosis-mediated platelet activation: the pivotal role of protein kinase C.

Antrodia camphorata is a rare Taiwanese medicinal mushroom. Antrodia camphorata extract has been reported to exhibit antioxidant, anti-inflammation, antimetastasis, and anticancer activities and plays a role in liver fibrosis, vasorelaxation, and immunomodulation..

OncologyImmune supportEnergy & fatigueMetabolic health

Almond Mushroom · 2014 · Comparative Study · Biological trace element research

Effects of selenium-enriched Agaricus blazei Murill on liver metabolic dysfunction in mice, a comparison with selenium-deficient Agaricus blazei Murill and sodium selenite.

In the present study, we investigated the effects of Se-enriched Agaricus blazei Murill (Se-AbM) on liver injury in mice induced by acute alcohol administration. Mice received ethanol (5 g/kg body weight (BW)) by gavage every 12 h for a total of 3 doses.

Cordyceps · 2014 · Research Support, Non U.S. Gov'T · International journal of oncology

Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells.

Angiogenesis is essential for tumor development and metastasis. Among several angiogenic factors, vascular endothelial growth factor receptor (VEGF) is important for tumor-derived angiogenesis and commonly overexpressed in solid tumors..

OncologyImmune supportEnergy & fatigueSkin & hydration

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Immunopotentiation of Pleurotus eryngii (DC. ex Fr.) Quel.

ETHNOPHARMACOLOGICAL RELEVANCE: Pleurotus eryngii (DC. ex Fr.) Quel has been collected from the wild, cultivated and used in traditional medicines to treat various disorders and diseases since antiquity..

Shiitake · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Lentinan degradation in the Lentinula edodes fruiting body during postharvest preservation is reduced by downregulation of the exo-β-1,3-glucanase EXG2.

Lentinan from Lentinula edodes fruiting bodies (shiitake mushrooms) is a valuable β-glucan for medical purposes based on its anticancer activity and immunomodulating activity. However, lentinan content in fruiting bodies decreases after harvesting and storage due to an increase in glucanase activity..

OncologyImmune supportCognition & nerves

Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · International journal of molecular sciences

Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine.

Hericium erinaceus, an edible mushroom, has been demonstrated to potentiate the effects of numerous biological activities. The aim of this study was to investigate whether H..

OncologyImmune supportEnergy & fatigueMetabolic health

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Purification, characterization and antitumor activity of polysaccharides from Pleurotus eryngii residue.

A novel water-soluble polysaccharide from Pleurotus eryngii residue was isolated and further purified by DEAE cellulose-52 chromatography and Sephadex G-100 size-exclusion chromatography to yield PEPE-1, PEPE-2 and PEPE-3. Molecular weights were determined by high-performance size-exclusion chromatography (HPSEC)..

OncologyImmune supportRespiratory

Chaga · 2013 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Aqueous extract from a Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), prevents herpes simplex virus entry through inhibition of viral-induced membrane fusion.

Chaga medicinal mushroom, Inonotus obliquus, a popular prescription in traditional medicine in Europe and Asia, was used to reduce inflammation in the nasopharynx and to facilitate breathing. The aqueous extract from I..

Maitake · 2013 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Characterization of a novel maitake (Grifola frondosa) protein that activates natural killer and dendritic cells and enhances antitumor immunity in mice.

Grifola frondosa, also known as maitake, is a culinary mushroom with immune-enhancing and antitumor effects. Numerous studies have investigated the activity of maitake polysaccharide extracts, but studies of maitake proteins are scarce.

King Oyster · 2013 · Research Support, Non U.S. Gov'T · Protein and peptide letters

Isolation of a phytase with distinctive characteristics from an edible mushroom, Pleurotus eryngii.

From the fresh fruiting bodies of the mushroom Pleurotus eryngii a phytase with a molecular mass of 14 kDa was isolated. The isolation protocol entailed ion exchange chromatography on DEAE-cellulose and CM-cellulose, affinity chromatography on Affi-gel blue gel, and ion exchange chromatography on Q-Sepharose..

OncologyLiver support

OncologyCognition & nervesRespiratory

Lion's Mane · 2013 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.

Neurotrophic factors are important in promoting the growth and differentiation of neurons. Nerve growth factor (NGF) is essential for the maintenance of the basal forebrain cholinergic system.

OncologyImmune supportMetabolic healthLiver support

Mesima · 2013 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Polysaccharide from Phellinus linteus induces S-phase arrest in HepG2 cells by decreasing calreticulin expression and activating the P27kip1-cyclin A/D1/E-CDK2 pathway.

ETHNOPHARMACOLOGY RELEVANCE: Our previous study showed that the proteoglycan P1 from Phellinus linteus (Mesima) exhibits significant anti-tumor activity against human hepatocellular carcinoma cells (HepG2); however, its molecular mechanism remains unknown..

Maitake · 2013 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Purification and characterization of a novel small-molecule polysaccharide from the Maitake medicinal mushroom Grifola frondosa (higher Basidiomycetes).

A novel small-molecule polysaccharide with a molecular mass of 2.6 kDa, was isolated from the culinary-medicinal Maitake mushroom Grifola frondosa. GFPS is composed of fucose, rhamnose, galactose, glucose, and mannose; galactose, glucose, and mannose were the dominant monosaccharides..

Almond Mushroom · 2013 · Research Support, Non U.S. Gov'T · Complementary therapies in medicine

Quality of life improvements among cancer patients in remission following the consumption of Agaricus blazei Murill mushroom extract.

OBJECTIVES: The aim of this preliminary clinical study was to assess if the daily intake of Agaricus blazei Murill (ABM) granulated powder (SSI Co., Ltd., Tokyo, Japan) for 6 months improved the quality of life (QOL) in cancer patients in remission. DESIGN: Open study..

OncologyImmune supportLiver support

Almond Mushroom · 2012 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

An extract of Agaricus blazei Murill administered orally promotes immune responses in murine leukemia BALB/c mice in vivo.

PURPOSE: The edible mushroom (fungus) Agaricus blazei Murill (ABM) is a health food in many countries. Importantly, it has been shown to have antitumor and immune effects.

Mesima · 2012 · Patent · journal metadata

ANTICANCER HEALTH FOOD CONTAINING PHELLINUS LINTEUS AND VEGETABLE WORMS

Disclosed is a health food containing extracts of Phellinus linteus and vegetable worms for preventing and treating cancer. The health food contains ethanol extract of the mixture containing the mycelia of the Phellinus linteus and vegetable worms at a ratio of 1:5 to 5:1..

Wood Ear · 2012 · Comparative Study · International journal of medicinal mushrooms

Comparative antitumor activity of jelly ear culinary-medicinal mushroom, Auricularia auricula-judae (Bull.) J. Schrot. (higher basidiomycetes) extracts against tumor cells in vitro.

The present study compares the antitumor activity of extracts from Auricularia auricula-judae, Phellinus gilvus, Ganoderma lucidum, and 100 Korean wild plants in the P388D1 macrophage cell line. The antitumor activity of A.

OncologyImmune supportLiver supportRespiratory

King Oyster · 2012 · Research Support, Non U.S. Gov'T · International journal of nanomedicine

Delivery of a transforming growth factor β-1 plasmid to mesenchymal stem cells via cationized Pleurotus eryngii polysaccharide nanoparticles.

The objective of this study was to investigate the use of cationized Pleurotus eryngii polysaccharide (CPEPS) as a nonviral gene delivery vehicle to transfer plasmid DNA encoding transforming growth factor beta-1 (pTGF-β1) into mesenchymal stem cells (MSCs) in vitro. Crude P..

King Oyster · 2012 · Research Support, Non U.S. Gov'T · Organic letters

Eryngiolide A, a cytotoxic macrocyclic diterpenoid with an unusual cyclododecane core skeleton produced by the edible mushroom Pleurotus eryngii.

Eryngiolide A (1), the first member of C20 diterpenoids with the skeleton deriving from a cyclododecane core fused with two γ-lactone units, was isolated from the solid culture of the edible mushroom Pleurotus eryngii. The structure of 1 was elucidated by extensive analysis of NMR spectra..

OncologyImmune supportEnergy & fatigueMetabolic health

Shiitake · 2012 · Research Support, Non U.S. Gov'T · Journal of microbiology (Seoul, Korea)

Immunoprophylactic effects of shiitake mushroom (Lentinula edodes) against Bordetella bronchiseptica in mice.

Antimicrobials are used as feed additives to improve growth performance and to prevent subclinical disease challenge in industrial animals. However, these drugs can lead to the development of resistant strains of bacteria.

OncologyImmune supportMetabolic healthLiver support

Reishi · 2012 · Book · journal metadata

Lingzhi, Reishi

Metadata-grounded summary: This book indexes research on Ganoderma lucidum in 2012. MycoData maps the paper to oncology, immune support, metabolic health, liver support based on its title, species context, article metadata, and study classification..

OncologyImmune supportMetabolic healthGut & microbiome

Chaga · 2012 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Orally administered aqueous extract of Inonotus obliquus ameliorates acute inflammation in dextran sulfate sodium (DSS)-induced colitis in mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Chaga mushroom (Inonotus obliquus) has been used in folk medicine to treat several disorders through its various biological functions. I..

OncologyImmune supportEnergy & fatigue

Almond Mushroom · 2012 · Research Support, Non U.S. Gov'T · PloS one

The anti-tumorigenic mushroom Agaricus blazei Murill enhances IL-1β production and activates the NLRP3 inflammasome in human macrophages.

Agaricus blazei Murill (AbM) has been reported to possess immune activity against tumors and infections through stimulation of mononuclear phagocytes. Recently, AbM extract was shown to induce the production of the pro-inflammatory cytokine, interleukin-1β (IL-1β), in human monocytes..

Niu-Chang-Chih · 2012 · Retracted Publication · Evidence-based complementary and alternative medicine: eCAM

The Antitumor Activity of Antrodia camphorata in Melanoma Cells: Modulation of Wnt/β-Catenin Signaling Pathways.

Antrodia camphorata (AC) is well known in Taiwan as a traditional Chinese medicine. The aim of this study was to investigate whether a fermented culture broth of AC could inhibit melanoma proliferation and progression via suppression of the Wnt/β-catenin signaling pathway..

OncologyImmune supportLiver support

Almond Mushroom · 2011 · Research Support, Non U.S. Gov'T · In vivo (Athens, Greece)

Agaricus blazei Murill extract abrogates CCl4-induced liver injury in rats.

Agaricus blazei Murill (ABM) is enriched with polysaccharides, lipids, vitamins, fibers and minerals. Many studies have shown that ABM possesses immune-enhancing and anti-tumor effects.

Chaga · 2011 · Research Support, Non U.S. Gov'T · Phytochemical analysis: PCA

Analysis of antioxidant metabolites by solvent extraction from sclerotia of Inonotus obliquus (Chaga).

INTRODUCTION: The sclerotia of Inonotus obliquus (Chaga) are effective therapeutic agents to treat several human malignant tumours and other diseases without unacceptable toxic side-effects. OBJECTIVE: To investigate solvent effects on metabolic profiles and antioxidant activities of extracts of Chaga..

Niu-Chang-Chih · 2011 · Patent · journal metadata

ANTI-CANCER ACTIVE SUBSTANCE FROM ANTRODIA CAMPHORATA, METHOD FOR PREPARING THE SAME AND USE THEREOF

An anti-cancer active substance from Antrodia Camphorata, produced from mycelium of Antrodia Camphorata by following steps: (1) culturing mycelium of Antrodia Camphorata by liquid fermentation (2) extracting the thus-obtained mycelium with ethanol and concentrating the extracted solution to obtain an ethanol extract….

OncologyImmune supportCognition & nerves

Maitake · 2011 · Research Support, Non U.S. Gov'T · Pharmaceutical biology

Enhancement of in vitro and in vivo anticancer activities of polysaccharide peptide from Grifola frondosa by chemical modifications.

CONTEXT: Grifola frondosa (Polyporaceae), maitake, is a widely consumed edible mushroom in some Asian countries. The fruit bodies and mycelia of maitake have shown different bioactive compounds with anticancer and other therapeutic properties..

Chaga · 2011 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

In vitro antitumor activity and structure characterization of ethanol extracts from wild and cultivated Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae).

Inonotus obliquus (Pers.:Fr.) Pilát has been traditionally used as a folk remedy for treatment of cancers, cardiovascular disease and diabetes in Russia, Poland, and most of the Baltic countries, but natural reserves of this fungus have nearly been exhausted..

OncologyMetabolic health

OncologyImmune supportGut & microbiome

Chaga · 2011 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Inonotus obliquus extracts suppress antigen-specific IgE production through the modulation of Th1/Th2 cytokines in ovalbumin-sensitized mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Chaga mushroom (Inonotus obliquus, IO) has been used as a folk remedy for cancer, digestive system diseases, and other illnesses in Russia and Eastern Europe. AIM OF THE STUDY: In the present study, we investigated the immunomodulating effects of IO through in vivo and ex vivo studies..

Lion's Mane · 2011 · Research Support, Non U.S. Gov'T · Food & function

Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells.

Phytochemicals in some foods are a potential source of bioactive safe compounds for cancer chemoprevention and suppression of tumor initiation, promotion, and metastasis..

OncologyEnergy & fatigue