MycoData

OncologyImmune supportEnergy & fatigueLiver support

Yellow Morel · 2013 · Research Support, Non U.S. Gov'T · Biotechnology letters

Induction of apoptosis in HepG2 cells by polysaccharide MEP-II from the fermentation broth of Morchella esculenta.

A novel polysaccharide, MEP-II, isolated from the fermentation broth of Morchella esculenta inhibited the proliferation of human hepatoma cell line (HepG2) through an apoptotic pathway..

Turkey Tail · 2013 · Comparative Study · Bioprocess and biosystems engineering

Laccase production by free and immobilized mycelia of Peniophora cinerea and Trametes versicolor: a comparative study.

The production of laccase by immobilized mycelia of Peniophora cinerea and Trametes versicolor was studied. In an initial stage, experimental assays were performed in Erlenmeyer flasks using free and immobilized mycelium, and the performance of the fungal strains to produce the enzyme was compared..

OncologyCognition & nervesEnergy & fatigueLiver support

Mesima · 2013 · Research Support, Non U.S. Gov'T · Phytomedicine: international journal of phytotherapy and phytopharmacology

Phellinus linteus mushroom protects against tacrine-induced mitochondrial impairment and oxidative stress in HepG2 cells.

Tacrine (THA) was the first drug licensed for the treatment of Alzheimer's disease. Unfortunately, reversible hepatotoxicity is evident in about 30% of patients and limits its clinical use.

Mesima · 2013 · Research Support, Non U.S. Gov'T · Prikladnaia biokhimiia i mikrobiologiia

Purification and characterization of laccase secreted by Phellinus linteus MTCC-1175 and its role in the selective oxidation of aromatic methyl group.

A laccase from the culture filtrate of Phellinus linteus MTCC-1175 has been purified to homogeneity. The method involved concentration of the culture filtrate by ammonium sulphate precipitation and an anion exchange chro- matography on DEAE-cellulose..

Turkey Tail · 2013 · Comparative Study · Water science and technology: a journal of the International Association on Water Pollution Research

Removal of trace organic contaminants by nitrifying activated sludge and whole-cell and crude enzyme extract of Trametes versicolor.

The resistance of certain anthropogenic trace organic contaminants (TrOCs) to conventional wastewater treatment and their potential adverse effects on human and ecological health raise significant concerns and have prompted research on their bioremediation by white-rot fungi..

Immune supportEnergy & fatigue

Zhu Ling · 2013 · Research Support, Non U.S. Gov'T · PloS one

Sclerotial formation of Polyporus umbellatus by low temperature treatment under artificial conditions.

BACKGROUND: Polyporus umbellatus sclerotia have been used as a diuretic agent in China for over two thousand years. A shortage of the natural P.

OncologyImmune supportEnergy & fatigueGut & microbiome

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

The anti-cancer activity of Antrodia camphorata against human ovarian carcinoma (SKOV-3) cells via modulation of HER-2/neu signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Antrodia camphorata (AC) is well known in Taiwan as a traditional Chinese medicinal fungus. However, the anticancer activity of AC against human HER-2/neu-overexpressing ovarian cancers is poorly understood..

OncologyImmune supportEnergy & fatigue

Mesima · 2012 · Research Support, Non U.S. Gov'T · PloS one

Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo.

Inotilone was isolated from Phellinus linteus. The anti-inflammatory effects of inotilone were studied by using lipopolysaccharide (LPS)-stimulated mouse macrophage RAW264.7 cells and λ-carrageenan (Carr)-induced hind mouse paw edema model..

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · Anticancer research

Anticancer effects of eleven triterpenoids derived from Antrodia camphorata.

Eleven derivatives from Antrodia camphorata were isolated in order to evaluate their selective cytotoxicity toward 14 types of human cancer cell and two non-transformed cell types..

OncologyEnergy & fatigueMetabolic health

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · Phytomedicine: international journal of phytotherapy and phytopharmacology

Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models.

Antrodia camphorata (AC) is a native Taiwanese mushroom which is used in Asian folk medicine as a chemopreventive agent. The triterpenoid-rich fraction (FEA) was obtained from the ethanolic extract of AC and characterized by high performance liquid chromatography (HPLC)..

Turkey Tail · 2012 · Research Support, Non U.S. Gov'T · Environmental technology

Biodegradation of organics in landfill leachate by immobilized white rot fungi, Trametes versicolor BCC 8725.

Immobilized Trametes versicolor BCC 8725 was evaluated for the biodegradation of the organic components of four different types of landfill leachate collected at different time periods and locations from the Nonthaburi landfill site of Thailand in batch treatment..

Energy & fatigueMetabolic health

Turkey Tail · 2012 · Evaluation Study · Journal of environmental science & engineering

Biological decolourisation of pulp mill effluent using white rot fungus Trametes versicolor.

The conventional biological treatment methods employed in the pulp and paper industries are not effective in reducing the colour and chemical oxygen demand (COD). The white-rot fungi are reported to have the ability to biodegrade the lignin and its derivatives..

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · Journal of pharmaceutical and biomedical analysis

Chemical profiling of the cytotoxic triterpenoid-concentrating fraction and characterization of ergostane stereo-isomer ingredients from Antrodia camphorata.

Antrodia camphorata (AC), also known as Antrodia cinnamomea, an endemic species in Taiwan, is one of the treasured medicinal mushrooms. AC is traditionally used for its chemopreventive biofunctions..

OncologyEnergy & fatigue

Turkey Tail · 2012 · Research Support, Non U.S. Gov'T · Journal of hazardous materials

Continuous degradation of a mixture of sulfonamides by Trametes versicolor and identification of metabolites from sulfapyridine and sulfathiazole.

In this study, we assessed the degradation of the sulfonamides sulfapyridine (SPY) and sulfathiazole (STZ) by the white-rot fungus Trametes versicolor. Complete degradation was accomplished in fungal cultures at initial pollutant concentrations of approximately 10 mg L(-1), although a longer period of time was needed….

Turkey Tail · 2012 · Research Support, Non U.S. Gov'T · Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

Dechlorination of chlorinated compounds by Trametes versicolor ATCC 200801 crude laccase and quantitative structure-activity relationship of toxicity.

Chlorinated compounds constitute an important class of xenobiotics. Crude laccase was produced using Trametes versicolor ATCC (200801) in potato dextrose broth, with wheat bran as an inducing medium, and its ability to dechlorinate eight compounds was determined..

Energy & fatigueMetabolic healthGut & microbiome

Enoki · 2012 · Research Support, Non U.S. Gov'T · Animal science journal = Nihon chikusan Gakkaiho

Effects of fermented mushroom (Flammulina velutipes) by-product diets on growth performance and carcass traits in growing-fattening Berkshire pigs.

This study was conducted to investigate effects of fermented mushroom (Flammulina velutipes) by-product diets on the growth performance and carcass traits in growing-fattening Berkshire pigs..

Turkey Tail · 2012 · Research Support, Non U.S. Gov'T · Bioresource technology

Functionalized magnetic mesoporous silica nanoparticles: fabrication, laccase adsorption performance and direct laccase capture from Trametes versicolor fermentation broth.

A simple and highly efficient protocol using magnetic mesoporous silica nanoparticles (MMSNPs) with metal affinity ligands was developed to directly capture laccase from Trametes versicolor fermentation broth..

Immune supportEnergy & fatigue

Lion's Mane · 2012 · Research Support, Non U.S. Gov'T · Immunopharmacology and immunotoxicology

Hericium erinaceus suppresses LPS-induced pro-inflammation gene activation in RAW264.7 macrophages.

The aim of this study was to investigate the anti-inflammatory properties of each fraction of Hericium erinaceus (HE). The ethanol extract from HE was partitioned with different solvents in the order of increasing polarity..

Mesima · 2012 · Brief Report · Mycobiology

Neuraminidase Inhibitors from the Culture Broth of Phellinus linteus.

During the search for neuraminidase inhibitors from medicinal fungi, we found that the culture broth of Phellinus linteus exhibited potent inhibitory activity. Solvent partition, Sephadex LH-20 column chromatography, and high-performance liquid chromatography (HPLC) were performed for purification of two active….

OncologyImmune supportEnergy & fatigue

Maitake · 2012 · Research Support, Non U.S. Gov'T · Inflammation

Pharmacological and pharmacokinetic studies with agaricoglycerides, extracted from Grifola frondosa, in animal models of pain and inflammation.

The objective of the present study was to demonstrate the anti-inflammatory and antinociceptive properties of agaricoglycerides of the fermented mushroom of Grifola frondosa (AGF)..

Niu-Chang-Chih · 2011 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway.

The triterpenoids methylantcinate B (MAB) and antcin B (AB), isolated from the medicinal mushroom Antrodia camphorata, have been identified as strong cytotoxic agents against various type of cancer cells; however, the mechanisms of MAB- and AB-induced cytotoxicity have not been adequately explored..

OncologyEnergy & fatigueGut & microbiome

Yellow Morel · 2011 · Research Support, Non U.S. Gov'T · Natural product research

Antioxidant and NF-κB inhibitory constituents isolated from Morchella esculenta.

Morchella esculenta Pers. (Morchellaceae) was investigated for its antioxidant activity by measuring the intracellular reactive oxygen species in HT-29 colon cancer cells..

Niu-Chang-Chih · 2011 · Research Support, Non U.S. Gov'T · International journal of gynecological cancer: official journal of the International Gynecological Cancer Society

Antrodia camphorata induces apoptosis and enhances the cytotoxic effect of paclitaxel in human ovarian cancer cells.

INTRODUCTION: Antrodia camphorata is a Chinese herb. Recently, several reports demonstrated that it had growth-inhibiting effects on some cancer cells.

OncologyEnergy & fatigue

Cognition & nervesEnergy & fatigue

Mesima · 2011 · Research Support, Non U.S. Gov'T · Journal of nutritional science and vitaminology

Effects of Phellinus linteus Administration on Serotonin Synthesis in the Brain and Expression of Monocarboxylate Transporters in the Muscle during Exhaustive Exercise in Rats

This study was conducted to determine the effects of Phellinus linteus (PL) on serotonin synthesis in the brain and on the expression of monocarboxylate transporters (MCTs) in muscles during exhaustive exercise in rats..

Immune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2011 · Other · Evidence-based complementary and alternative medicine: eCAM

Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae).

Nerve crush injury is a well-established axonotmetic model in experimental regeneration studies to investigate the impact of various pharmacological treatments. Hericium erinaceus is a temperate mushroom but is now being cultivated in tropical Malaysia..

OncologyImmune supportEnergy & fatigueGut & microbiome

Mesima · 2010 · Research Support, Non U.S. Gov'T · Journal of medicinal food

An extract of Phellinus linteus grown on germinated brown rice inhibits inflammation markers in RAW264.7 macrophages by suppressing inflammatory cytokines, chemokines, and mediators and up-regulating antioxidant activity.

The immunomodulatory activity of an organic extract of Phellinus linteus grown on slightly germinated brown rice (PBR) was previously demonstrated. Here, we investigated the possible anti-inflammatory activity of the PBR extract by analyzing its effect on the expression of macrophage-derived cytokines, chemokines, and….

Enoki · 2010 · Research Support, Non U.S. Gov'T · Bioresource technology

Antioxidative activities of hydrophilic extracts prepared from the fruiting body and spent culture medium of Flammulina velutipes.

Antioxidative properties of hydrophilic extracts prepared from the fruiting body and spent culture medium of Flammulina velutipes were evaluated by monitoring the total reducing power ability (RPA) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity (RSA), together with antioxidative activities….

OncologyImmune supportEnergy & fatigueGut & microbiome

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Antrodia camphorata suppresses lipopolysaccharide-induced nuclear factor-kappaB activation in transgenic mice evaluated by bioluminescence imaging.

In an earlier study, we found that Antrodia camphorata inhibited the production of lipopolysaccharide (LPS)-induced cytokines, inducible nitric oxide synthase, and cyclooxygenase-2 by blocking nuclear factor-kappaB (NF-kappaB) activation in cultured RAW 264.7 macrophages..

Energy & fatigueSkin & hydration

Maitake · 2010 · Research Support, Non U.S. Gov'T · Archives of pharmacal research

Biological activities of Fructus arctii fermented with the basidiomycete Grifola frondosa.

Fructus arctii extract containing phenolic glycosides was cultured with Grifola frondosa mycelia to produce β-glucosidase and its biological activities were studied. This β-glucosidase converted the glycosides (arctiin and caffeic acid derivatives) into aglycones (arctigenin and caffeic acid)..

Turkey Tail · 2010 · Comparative Study · Artificial cells, blood substitutes, and immobilization biotechnology

Construction and comparison of Trametes versicolor laccase biosensors capable of detecting xenobiotics.

Amperometric biosensors using laccase from Trametes versicolor as a bioelement were developed for 2,4-dichloro phenoxy acetic acid (2,4-D). Laccase enzyme was immobilized by gelatin and glutaraldehyde onto a Clark oxygen probe and screen printed electrodes (SPEs)..

OncologyImmune supportEnergy & fatigueGut & microbiome

Maitake · 2010 · Research Support, Non U.S. Gov'T · Experimental & molecular medicine

Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling.

TNF-alpha is a major cytokine involved in inflammatory bowel disease (IBD). In this study, water extract of Grifola frondosa (GFW) was evaluated for its protective effects against colon inflammation through the modulation of TNF-alpha action..

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Chemical research in toxicology

Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway.

We investigated the effects of antcin A, antcin C, and methyl antcinate A (MAA) isolated from Antrodia camphorata on the proliferation of human liver cancer cell lines Huh7, HepG2, and Hep3B and the normal cell rat hepatocytes..

OncologyEnergy & fatigueSkin & hydration

Niu-Chang-Chih · 2009 · Research Support, Non U.S. Gov'T · International heart journal

A novel inhibitory effect of Antrodia camphorata extract on vascular smooth muscle cell migration and neointima formation in mice.

Antrodia camphorata (AC) is a well-known traditional Chinese medicine that has been shown to inhibit proliferation and migration of cancer cells. We examined whether AC could inhibit rat aortic smooth muscle cell (RASMC) proliferation and migration and evaluated its effect on neointima formation in mouse carotid….

Energy & fatigueLiver support

Mesima · 2009 · Research Support, Non U.S. Gov'T · BMB reports

Anti-oxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage.

Anti-oxidative effect of Phellinus linteus (P. linteus) and red ginseng extracts on DNA damage induced by reactive oxygen species (ROS) were investigated in this study.

Maitake · 2009 · Patent · journal metadata

Preparation method of r grifola frondosa compost

The invention relates to a preparation method of grifola frondosa compost which comprises the following components by weight percent: 45 percent to 55 percent of cotton seed hulls, 4 percent to 12 percent of soybean cake, 3 percent to 9 percent of corn flour, 4 percent to 12 percent of corncob, 3 percent to 9 percent….

Energy & fatigueMetabolic health

Turkey Tail · 2009 · Research Support, Non U.S. Gov'T · Preparative biochemistry & biotechnology

Pyranose 2-oxidase (P2O): production from trametes versicolor in stirred tank reactor and its partial characterization.

Optimization of pyranose-2-oxidase (P2O) production conditions from Trametes versicolor was carried out in shaking cultures containing glucose, malt, and yeast extracts; the optimum concentration values were found to be 1.5% glucose, 1.0% yeast extract, and 1.0% malt extract, pH 5.0, temperature, 26 degrees C, and….

Zhu Ling · 2009 · Research Support, Non U.S. Gov'T · Die Pharmazie

Qualitative and quantitative analysis of the diuretic component ergone in Polyporus umbellatus by HPLC with fluorescence detection and HPLC-APCI-MS/MS.

Polyporus umbellatus is a widely used anti-aldosteronic diuretic in Traditional Chinese medicine (TCM). A new, sensitive and selective high-performance liquid chromatography-fluorescence detector (HPLC-FLD) and high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry….

Enoki · 2009 · Research Support, Non U.S. Gov'T · Zeitschrift fur Naturforschung. C, Journal of biosciences

Selenium accumulation in mycelia of Flammulina velutipes during fermentation determined by RP-HPLC.

A method to estimate the content of selenium in organics was introduced based on reversed phase-high performance liquid chromatography (RP-HPLC).The maximum absorption peak of piazselenol was at 330 nm and the optimized temperature and pH value were 40 degrees C and 2.8, respectively..

Turkey Tail · 2008 · Research Support, Non U.S. Gov'T · Bioresource technology

Characterization of Trametes versicolor laccase for the transformation of aqueous phenol.

Laccase (oxygen oxidoreductase, EC 1.10.3.2) from Trametes versicolor was thoroughly characterized in terms of its catalytic stability and its effectiveness as a biocatalyst under various reaction conditions when using phenol as a model substrate..

OncologyImmune supportEnergy & fatigueLiver support

Chaga · 2008 · Research Support, Non U.S. Gov'T · Current microbiology

Identification of Inonotus obliquus and analysis of antioxidation and antitumor activities of polysaccharides.

Inonotus obliquus, a wild wood-decay fungus which grows on Betula trees in cool climates, has a variety of biological activities that the scientific community is paying more and more attention to. However, the research work is moving at a snail's pace..

Niu-Chang-Chih · 2008 · Patent · journal metadata

NOVEL ANTI-FATIGUE CYCLOHEXENONE COMPOUNDS FROM ANTRODIA CAMPHORATA

The present invention relates to a compound of Antrodia camphorata used to delay physiological fatigue, in particular to a extract isolated from Antrodia camphorata4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, and its use in delaying fatigue..

Niu-Chang-Chih · 2008 · Patent · journal metadata

NOVEL CYCLOHEXENONE COMPOUNDS FROM ANTRODIA CAMPHORATA AND APPLICATION THEREOF

A cyclohexenone compound is provided to suppress the growth of cancer cells such as breast cancer, liver cancer, and prostatic cancer, and to ensure antioxidant activities..

Turkey Tail · 2008 · Research Support, Non U.S. Gov'T · Bulletin of environmental contamination and toxicology

Prediction of biodegradation rate constants of hydroxylated polychlorinated biphenyls by fungal laccases from Trametes versicolor and Pleurotus ostreatus.

Quantitative structure-activity relationship (QSAR) models for fungal laccase-catalyzed degradation of different hydroxylated polychlorinated biphenyls (OH-PCBs) were developed using some fundamental quantum chemical descriptors..

Turkey Tail · 2007 · Research Support, Non U.S. Gov'T · Canadian journal of microbiology

Decoloration of Amaranth by the white-rot fungus Trametes versicolor. Part II. Verification study.

The involvement of lignin peroxidase (LiP) in the decoloration of the mono-azo substituted napthalenic dye Amaranth was investigated with pure enzymes and whole cultures of Trametes versicolor..

Immune supportCognition & nervesEnergy & fatigue

Snow Fungus · 2007 · Research Support, Non U.S. Gov'T · Biological & pharmaceutical bulletin

Effect of Tremella fuciformis on the Neurite Outgrowth of PC12h Cells and the Improvement of Memory in Rats

We investigated the neuritogenic effects of Tremella fuciformis (TF), which has been valued in traditional Chinese medicine as a remedy with nutritive and tonic actions, on PC12h cells..

OncologyImmune supportEnergy & fatigue

Chaga · 2007 · Research Support, Non U.S. Gov'T · Journal of medicinal food

Ethanol extract of Inonotus obliquus inhibits lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells.

Inonotus obliquus (Pers.:Fr.) Pil. is a white rot fungus that belongs to the family Hymenochaetaceae of Basidiomycetes.

OncologyImmune supportEnergy & fatigueLiver support

Maitake · 2007 · Research Support, Non U.S. Gov'T · Toxicology in vitro: an international journal published in association with BIBRA

Induction of apoptosis in SGC-7901 cells by polysaccharide-peptide GFPS1b from the cultured mycelia of Grifola frondosa GF9801.

The biological function of GFPPS1b, a novel polysaccharide-peptide isolated from cultured mycelia of Grifola frondosa GF9801, was well investigated. GFPS1b has anti-tumor activity and can significantly inhibit the proliferation of SGC-7901 cells, whereas slightly influences the growth of human normal liver cell line….

Niu-Chang-Chih · 2007 · Research Support, Non U.S. Gov'T · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Inhibition of cyclooxygenase-2 and induction of apoptosis in estrogen-nonresponsive breast cancer cells by Antrodia camphorata.

The objective of this study was to investigate the fermented culture broth of Antrodia camphorata (A. camphorata) to induce apoptosis and inhibit cyclooxygenase-2 (COX-2) in estrogen-nonresponsive (MDA-MB-231) human breast cancer cells.

OncologyEnergy & fatigue

Mesima · 2007 · Research Support, Non U.S. Gov'T · Phytotherapy research: PTR

Protective effects of Phellinus linteus extract against iron overload-mediated oxidative stress in cultured rat hepatocytes.

Phellinus linteus (PL) mushroom has been reported to possess antioxidant activity. The present study was designed to investigate whether an ethanol extract obtained from PL might ameliorate oxidative stress and enhance antioxidant enzyme activities in primary rat hepatocytes, which were overloaded with iron using….