MycoData

The current study was designed to assess the anti-leishmanial effect of a semi-purified fraction of wild mushroom Grifola frondosa against Leishmania donovani, in vitro..

OncologyImmune support

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King Oyster · 2018 · Research Article · International journal of molecular sciences

Spatial Distribution of Glucan Type and Content between Caps and Stalks in Pleurotus eryngii: Impact on the Anti-inflammatory Functionality.

: Pleurotus eryngii is recognized for its prominent nutritional and medicinal value. In our study, we tested the effect of glucans on lipopolysaccharide (LPS)-induced production of TNF-α.

Immune supportGut & microbiome

High relevance

Chaga · 2018 · Journal Article · Carbohydrate polymers

Structural characterization of bioactive heteropolysaccharides from the medicinal fungus Inonotus obliquus (Chaga).

The aim of this paper was to perform a comprehensive characterization of polysaccharides isolated from the interior (IOI) and exterior (IOE) parts of the fungus Inonotus obliquus..

Immune support

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Cordyceps · 2018 · Research Article · RSC advances

Structural characterization of polysaccharides from Cordyceps militaris and their hypolipidemic effects in high fat diet fed mice.

Cordyceps militaris is a crude dietary therapeutic mushroom with high nutritional and medicinal values. Mushroom-derived polysaccharides have been found to possess antihyperglycemic and antihyperlipidemic activities..

Immune supportMetabolic healthLiver support

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King Oyster · 2018 · Journal Article · International journal of medicinal mushrooms

Structural Characterization of Polysaccharides of a Productive Strain of the Culinary-Medicinal King Oyster Mushroom, Pleurotus eryngii (Agaricomycetes), from Italy.

A preliminary biological investigation of the dry basidiomata of strain C-142-c of Pleurotus eryngii has shown significant antioxidant activity. Two different polysaccharides (PEPS-A1 and PEPS-A2) were isolated from the cultivated edible mushroom, P.

OncologyImmune support

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Cordyceps · 2018 · Journal Article · Food & function

Structural elucidation and immunostimulatory activity of a new polysaccharide from Cordyceps militaris.

A new polysaccharide (CMPB90-1) was isolated from cultured Cordyceps militaris by alkaline extraction. The chemical structure of CMPB90-1 was determined by analysis of physicochemical and spectral data..

OncologyImmune support

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Agarikon · 2018 · Journal Article · Carbohydrate polymers

Structure characterization of the mannofucogalactan isolated from fruit bodies of Quinine conk Fomitopsis officinalis.

The mannofucogalactan as a major component of water extract was obtained from fruit bodies of Fomitopsis officinalis by extraction with boiling water followed by deproteination, decoloration, and purification using anion-exchange chromatography and size exclusion chromatography..

Immune support

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Lion's Mane · 2018 · Research Article · Molecules (Basel, Switzerland)

The Prebiotic Activity of Simulated Gastric and Intestinal Digesta of Polysaccharides from the Hericium erinaceus.

Hericium erinaceus (HE) is a well-known edible and medicinal fungus widely grown in Asian countries. Polysaccharides from the Hericium erinaceus (HEP) are major biological macromolecules..

Immune supportGut & microbiome

High relevance

Reishi · 2018 · Journal Article · International journal of medicinal mushrooms

Triterpenes and Soluble Polysaccharide Changes in Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), During Fruiting Growth.

We analyzed the changes in triterpenes and soluble polysaccharides in Ganoderma lucidum strain G0119 during 4 growth phases in 3 regions of the fruiting bodies using reversed-phase high-performance liquid chromatography, and we also analyzed the soluble polysaccharides using high-performance size-exclusion….

Immune supportEnergy & fatigue

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Shiitake · 2017 · Journal Article · Journal of food biochemistry

1H NMR‐based metabolic investigation of the effect of Lentinula edodes‐derived polysaccharides on aged mice

Few comprehensive metabolic profiles of Lentinula edodes‐derived polysaccharides on mammalians have been reported to date. In previous studies, a novel heteropolysaccharide, named L2, obtained from L.

Immune supportEnergy & fatigueMetabolic health

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Cordyceps · 2017 · Journal Article · Natural product research

A new ribonucleotide from Cordyceps militaris.

One new ribonucleotide, 5'-(3''-deoxy-β-D-ribofuranosyl)-3'-deoxyadenosine (1), and 14 known compounds (2-15) were isolated from an ethanol extract of Cordyceps militaris..

Immune support

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Lion's Mane · 2017 · Journal Article · International journal of medicinal mushrooms

A Polysaccharide Isolated from Mycelia of the Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Induced Apoptosis in Precancerous Human Gastric Cells.

Hericium erinaceus is typically used in traditional Chinese medicine for mucosal protection, healing of gastric ulcers, and treatment of gastritis. We purified from the cultured mycelia of H..

OncologyImmune support

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King Oyster · 2017 · Journal Article · International immunopharmacology

Activity-guided isolation and structural identification of immunomodulating substances from Pleurotus eryngii byproducts.

A two-step extraction process was used to investigate the bioactive substances from the byproducts of the fungus Pleurotus eryngii. Methanol extraction followed by extraction using different polar solvents coupled with silica column chromatography was carried out to separate the bioactive components..

OncologyImmune support

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King Oyster · 2017 · Journal Article · Carbohydrate polymers

Anti-hyperlipidemic and antioxidant effects of alkali-extractable mycelia polysaccharides by Pleurotus eryngii var. tuolensis.

In this study, we noted that the Al-MPS from Pleurotus eryngii var. tuolensis provoked pharmacological effects on blood lipid profiles and oxidative stress.

Immune supportMetabolic healthLiver support

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Cordyceps · 2017 · Research Article · Food science and biotechnology

Anti-inflammatory effect of the extract from fermented Asterina pectinifera with Cordyceps militaris mycelia in LPS-induced RAW264.7 macrophages.

In our previous work, Asterina pectinifera was fermented with Cordyceps militaris mycelia to improve its bioactivities and was reported to have strong antioxidant activities. The aim of the current study was to investigate its anti-inflammatory effect and mechanisms of action..

Immune supportEnergy & fatigue

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Shiitake · 2017 · Journal Article · Journal of food processing and preservation

Anti‐Inflammatory and Antioxidant Properties of Pulsed Light Irradiated Lentinula edodes

Intense pulsed light irradiation is used in food decontamination and in production of mushrooms with high level of ergocalciferol. Lentinula edodes (Berk.) Pegler, shiitake, was freeze‐dried and milled into powder and irradiated with 20, 40 and 60 pulses of pulsed light at a distance of 6 cm and the irradiation energy….

OncologyImmune supportEnergy & fatigue

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Cordyceps · 2017 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Anticancer Efficacy of Cordyceps militaris Ethanol Extract in a Xenografted Leukemia Model.

Cordyceps militaris is used widely as a traditional medicine in East Asia. Although a few studies have attempted to elucidate the anticancer activities of C.

OncologyImmune support

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King Oyster · 2017 · Research Article · BMC complementary and alternative medicine

Antihyperlipidaemic and hepatoprotective activities of acidic and enzymatic hydrolysis exopolysaccharides from Pleurotus eryngii SI-04.

BACKGROUND: Hyperlipidaemia is the major risk factor contributing to the development and progression of atherosclerosis, fatty liver and cerebrovascular disease. Pleurotus eryngii (P..

Immune supportMetabolic healthLiver support

High relevance

King Oyster · 2017 · Journal Article · International journal of biological macromolecules

Antioxidant and anti-hyperlipidemic effects of mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis.

The aims of this work were designed to investigate the hepatoprotective and antioxidant effects of acidic- and alkali-extractable mycelia zinc polysaccharides (AcMZPS, AlMZPS) from Pleurotus eryngii var. tuoliensis on high-fat-high-cholesterol emulsion-induced hyperlipidemic mice..

Immune supportMetabolic healthLiver support

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King Oyster · 2017 · Journal Article · International journal of biological macromolecules

Antioxidant, antitumor and immunostimulatory activities of the polypeptide from Pleurotus eryngii mycelium.

The objective of this study was to investigate the antioxidant, antitumor and immunological activities of the polypeptide from Pleurotus eryngii mycelium (PEMP). The ability of the polypeptide to stimulate Ana-1 macrophages to englobe neutral red, secrete NO, H2O2, TNF-α, and IL-6, increase TLR2 and TLR4 expression….

OncologyImmune supportSkin & hydrationRespiratory

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Maitake · 2017 · Journal Article · Nutrition and cancer

Antitumoral Effects of D-Fraction from Grifola Frondosa (Maitake) Mushroom in Breast Cancer.

D-Fraction is protein-bound β-1,6 and β-1,3 glucans (proteoglucan) extracted from the edible and medicinal mushroom Grifola frondosa (Maitake). The antitumoral effect of D-Fraction has long been exclusively attributed to their immunostimulatory capacity..

OncologyImmune supportRespiratory

High relevance

Niu-Chang-Chih · 2017 · Journal Article · Environmental toxicology

Antrodia camphorata attenuates cigarette smoke-induced ROS production, DNA damage, apoptosis, and inflammation in vascular smooth muscle cells, and atherosclerosis in ApoE-deficient mice.

Cigarette smoke exposure activates several cellular mechanisms predisposing to atherosclerosis, including oxidative stress, dyslipidemia, and vascular inflammation..

OncologyImmune supportEnergy & fatigueMetabolic health

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Cordyceps · 2017 · Journal Article · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Broad-spectrum immunoaffinity cleanup for the determination of aflatoxins B1, B2, G1, G2, M1, M2 in Ophiocordyceps sinensis and its pharmaceutical preparations by ultra performance liquid chromatography tandem mass spectrometry.

An ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the simultaneous determination of aflatoxins B1, B2, G1, G2, M1 and M2 (AFB1, AFB2, AFG1, AFG2, AFM1 and AFM2) in Ophiocordyceps sinensis and its pharmaceutical preparations..

Immune supportEnergy & fatigue

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Enoki · 2017 · Journal Article · Journal of food science

Characteristics and Rheological Properties of Polysaccharide Nanoparticles from Edible Mushrooms (Flammulina velutipes).

Nanotechnology has become relevant in the food-related industries, and edible mushrooms can be a potential raw material for providing satisfied edible nanomaterial..

Immune support

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King Oyster · 2017 · Research Article · The plant pathology journal

Characterization of the rcsA Gene from Pantoea sp. Strain PPE7 and Its Influence on Extracellular Polysaccharide Production and Virulence on Pleurotus eryngii.

RcsA is a positive activator of extracellular polysaccharide (EPS) synthesis in the Enterobacteriaceae. The rcsA gene of the soft rot pathogen Pantoea sp.

Immune support

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Cordyceps · 2017 · Research Article · Oncotarget

Cordycepin and a preparation from Cordyceps militaris inhibit malignant transformation and proliferation by decreasing EGFR and IL-17RA signaling in a murine oral cancer model.

Cordyceps militaris (CM) and its active ingredient cordycepin have been reported to inhibit tumor growth, but the mechanisms are not fully understood. This study used a mouse model for oral cancer and a cell line, 4NAOC-1 derived from the model to study the mechanisms..

OncologyImmune support

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Cordyceps · 2017 · Journal Article · Journal of ethnopharmacology

Cordycepin-enriched WIB-801C from Cordyceps militaris improves functional recovery by attenuating blood-spinal cord barrier disruption after spinal cord injury.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps militaris is an ingredient of traditional Chinese medicine and have been widely used for inflammatory diseases and cancer. Cordycepin is one of the major bioactive components of Cordyceps militaris, and has been known to have anti-inflammatory and anti-oxidant effects..

OncologyImmune supportCognition & nerves

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Cordyceps · 2017 · Research Article · Heliyon

Cordyceps militaris improves the survival of Dahl salt-sensitive hypertensive rats possibly via influences of mitochondria and autophagy functions.

The genus Cordyceps and its specific ingredient, cordycepin, have attracted much attention for multiple health benefits and expectations for lifespan extension. We analyzed whether Cordyceps militaris (CM), which contains large amounts of cordycepin, can extend the survival of Dahl salt-sensitive rats, whose survival….

Immune supportCognition & nervesEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2017 · Journal Article · International journal of medicinal mushrooms

Effect of Pulsed Light Irradiation on Bioactive, Nonvolatile Components and Antioxidant Properties of Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes).

The caterpillar medicinal mushroom Cordyceps militaris contains many bioactive components, such as adenosine, cordycepin, and polysaccharides. In this study, C.

Immune support

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Niu-Chang-Chih · 2017 · Journal Article · Journal of ethnopharmacology

Effects of antrosterol from Antrodia camphorata submerged whole broth on lipid homeostasis, antioxidation, alcohol clearance, and anti-inflammation in livers of chronic-alcohol fed mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Antrodia camphorata is a functional fungus in Taiwan and owns several pharmacological functions. Antrosterol, a bioactive constitute of sterols in edible Antrodia camphorata submerged whole broth, can protect liver from CCl4 damage via enhancing antioxidant and anti-inflammatory….

Immune supportMetabolic healthLiver support

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Cordyceps · 2017 · Journal Article · Journal of the science of food and agriculture

Evaluation of different agricultural wastes for the production of fruiting bodies and bioactive compounds by medicinal mushroom Cordyceps militaris

BACKGROUND: In commercial production of Cordyceps militaris (a famous Chinese medicine), cereal grains are usually utilized as cultivation substrates. This study aimed to evaluate the efficiency of agricultural wastes as substitute materials in the low‐cost production of C.

Immune support

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Cordyceps · 2017 · Journal Article · Applied biochemistry and biotechnology

Functional Analysis of Ribonucleotide Reductase from Cordyceps militaris Expressed in Escherichia coli.

Cordyceps militaris produces cordycepin (3'-deoxyadenosine), which has various activities, including anti-oxidant, anti-tumoral, anti-viral, and anti-inflammatory. Ribonucleotide reductase (RNR) seems to be a candidate to produce cordycepin in C..

OncologyImmune supportMetabolic healthRespiratory

High relevance

Maitake · 2017 · Research Article · International journal of molecular medicine

Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway.

Grifola frondosa, a type of food and medical fungus, has been shown to exhibit various pharmacological activities, including anticancer effects. As the most typical cancer diagnosed among female patients, breast cancer remains a huge concern threatening human health globally..

OncologyImmune supportEnergy & fatigue

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King Oyster · 2017 · Journal Article · Carbohydrate polymers

Hepatoprotection of enzymatic-extractable mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis.

The purpose of this work was designed to investigate the hepatoprotective and antioxidant effects of enzymatic-extractable mycelia zinc polysaccharides (En-MZPS) from Pleurotus eryngii var. tuoliensis on the hyperlipidemic mice induced by high-fat-high-cholesterol emulsion (HFHCM)..

Immune supportMetabolic healthLiver support

High relevance

Cordyceps · 2017 · Research Article · Marine drugs

Higher Anti-Liver Fibrosis Effect of Cordyceps militaris-Fermented Product Cultured with Deep Ocean Water via Inhibiting Proinflammatory Factors and Fibrosis-Related Factors Expressions.

Deep ocean water (DOW) has been shown to enhance the functional components of fungi, resulting in increased health benefits. Therefore, using DOW for culturing fungi can enhance the cordycepin and adenosine of Cordyceps militaris (CM) and its protective effects on the liver..

Immune supportEnergy & fatigueLiver supportSkin & hydration

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King Oyster · 2017 · Journal Article · International journal of medicinal mushrooms

Immunomodulatory Effects of Extracellular β-Glucan Isolated from the King Oyster Mushroom Pleurotus eryngii (Agaricomycetes) and Its Sulfated Form on Signaling Molecules Involved in Innate Immunity.

The aim of this study was to determine, using murine RAW 264.7 macrophages, the immunomodulatory effect of extracellular β-glucan isolated from Pleurotus eryngii (PEBG) and its sulfated derivative (PEBG-S) on signaling molecules implicated in host innate immunity..

OncologyImmune supportEnergy & fatigue

High relevance

King Oyster · 2017 · Journal Article · Food & function

In vitro and in vivo inhibitory effects of a Pleurotus eryngii protein on colon cancer cells.

Edible mushrooms have been considered as a good source of bioactive components with various health benefits. Our previous study demonstrated the identity of a novel protein from Pleurotus eryngii, namely PEP, and its anti-inflammatory activities..

OncologyImmune supportGut & microbiome

High relevance

King Oyster · 2017 · Journal Article · Food & function

In vivo fermentation of a Pleurotus eryngii polysaccharide and its effects on fecal microbiota composition and immune response.

A novel, homogeneous Pleurotus eryngii polysaccharide (PEP) (molecular weight 426 kDa, purity 91.25 ± 3.14%) which mainly consisted of glucose with β-type glycosidic linkages was used to investigate in vivo fermentation behavior and effects on immune response in mice..

Immune supportMetabolic healthGut & microbiome

High relevance

King Oyster · 2017 · Journal Article · Food & function

Isolation of a novel bioactive protein from an edible mushroom Pleurotus eryngii and its anti-inflammatory potential.

Edible mushrooms are rich sources of bioactive components. In this study, a bioactive protein, PEP, was isolated from an edible mushroom, Pleurotus eryngii, through (NH4)2SO4 precipitation and ion-exchange chromatography..

Immune supportGut & microbiome

High relevance

Maitake · 2017 · Journal Article · Carbohydrate polymers

Isolation, purification, structural analysis and immunostimulatory activity of water-soluble polysaccharides from Grifola Frondosa fruiting body.

A new polysaccharide had been successfully isolated from maitake mushroom (Grifola Frondosa)-GFP. HPLC and Monosaccharide analysis showed that the average molecular weight of GFP was 155kDa and it was mainly composed of rhamnose, xylose, mannose, glucose, molar ratio of 1.00: 1.04: 1.11: 6.21..

Immune supportMetabolic health

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King Oyster · 2017 · Research Article · International journal of molecular sciences

Olive Mill Waste Enhances α-Glucan Content in the Edible Mushroom Pleurotus eryngii.

Mushroom polysaccharides are edible polymers that have numerous reported biological functions; the most common effects are attributed to β-glucans. In recent years, it became apparent that the less abundant α-glucans also possess potent effects in various health conditions..

Immune support

High relevance

King Oyster · 2017 · Journal Article · Journal of food processing and preservation

Preparation and Antioxidant Activities of Oligosaccharides Derived from Pleurotus eryngii Polysaccharides

Pleurotus eryngii oligosaccharides (PEOs) were prepared by hydrolyzing P. eryngii polysaccharides with hydrogen peroxide (H₂O₂).

Immune support

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Maitake · 2017 · Research Article · Iranian journal of pharmaceutical research: IJPR

Purification, Characterization and Antioxidant Activities of Enzymolysis Polysaccharide from Grifola frondosa.

Our previous study revealed that the antioxidant activity of polysaccharide (coded as FGFP) extracted from Grifola frondosa by enzymolysis treatment was significantly superior than that (coded as GFP) extracted by boiling-water..

Immune supportMetabolic health

High relevance

Almond Mushroom · 2017 · Journal Article · Food & function

Regulation of RAW 264.7 cell-mediated immunity by polysaccharides from Agaricus blazei Murill via the MAPK signal transduction pathway.

Agaricus blazei Murill (ABM) is a common anticancer folk remedy. Its active ingredients, i.e., polysaccharides, have been isolated and exhibit indirect tumor-suppressing activity via immunological activation.

OncologyImmune support

High relevance

King Oyster · 2017 · Journal Article · Carbohydrate polymers

Safe therapeutics of murine melanoma model using a novel antineoplasic, the partially methylated mannogalactan from Pleurotus eryngii.

A heteropolysaccharide was isolated by cold aqueous extraction from edible mushroom Pleurotus eryngii ("King Oyster") basidiocarps and its biological properties were evaluated. Structural assignments were carried out using mono- and bidimensional NMR spectroscopy, monosaccharide composition, and methylation analyses..

OncologyImmune supportMetabolic health

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Shiitake · 2017 · Journal Article · International journal of food science & technology

Secondary metabolism associated with softening of shiitake mushroom (Lentinula edodes) induced by O2 depletion and CO2 accumulation

It is difficult to preserve fresh shiitake mushroom (Lentinula edodes (Berk.) sing) partly because of the rapid deterioration of texture (softening or lignification)..

Immune support

High relevance

Maitake · 2017 · Journal Article · Carbohydrate polymers

Structural elucidation and antioxidant activity a novel Se-polysaccharide from Se-enriched Grifola frondosa.

Se-GFP-22, a heteropolysaccharide, with a weight-average Mw of 4.13×106Da, was purified from the crude Se-polysaccharide (Se-GFP) isolated from fruit bodies of Se-enriched Grifola frondosa. Selenium was accumulated efficiently in Grifola frondosa during cultivation with Na2SeO3..

Immune support

High relevance

Cordyceps · 2017 · Journal Article · Carbohydrate polymers

Structural elucidation and immunostimulatory activity of polysaccharide isolated by subcritical water extraction from Cordyceps militaris.

Water-soluble polysaccharides were obtained from Cordyceps militaris (C. militaris) (CMP) by subcritical water extraction (SWE).

Immune supportMetabolic health

High relevance

King Oyster · 2017 · Journal Article · International journal of medicinal mushrooms

Sulfation of the Extracellular Polysaccharide Produced by the King Oyster Culinary-Medicinal Mushroom, Pleurotus eryngii (Agaricomycetes), and Its Antioxidant Properties In Vitro.

Extracellular polysaccharide from Pleurotus eryngii was sulfated; the optimum reaction conditions used pyridine as the reaction solvent, a temperature of 80°C, and a reaction time of 90 minutes..

Immune support

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King Oyster · 2017 · Journal Article · Food chemistry

Sulphonated modification of polysaccharides from Pleurotus eryngii and Streptococcus thermophilus ASCC 1275 and antioxidant activities investigation using CCD and Caco-2 cell line models.

Polysaccharides extracted from Pleurotus eryngii (PEPS) and Streptococcus thermophilus ASCC 1275 (EPS) were sulphonated and their composition determined. Antioxidant activities of crude and sulphonated polysaccharides (S.PEPS and S.EPS) were investigated using the ABTS radical scavenging test and CCD and Caco-2 cell….

Immune supportEnergy & fatigue