MycoData

Mushroom tumor on Flammulina velutipes has become the main disease during the off-season cultivation of F. velutipes while the causal organism has remained unknown..

Oncology

High relevance

Mesima · 2016 · Research Support, Non U.S. Gov'T · Nutrition research (New York, N.Y.)

Neuroprotective effects of the Phellinus linteus ethyl acetate extract against H2O2-induced apoptotic cell death of SK-N-MC cells.

Numerous studies have suggested that neuronal cells are protected against oxidative stress-induced cell damage by antioxidants, such as polyphenolic compounds. Phellinus linteus (PL) has traditionally been used to treat various symptoms in East Asian countries..

OncologyCognition & nervesEnergy & fatigue

High relevance

Chaga · 2016 · Research Support, Non U.S. Gov'T · Scientific reports

Regulation of Anticancer Styrylpyrone Biosynthesis in the Medicinal Mushroom Inonotus obliquus Requires Thioredoxin Mediated Transnitrosylation of S-nitrosoglutathione Reductase.

The medicinal macrofungus Inonotus obliquus widely utilized as folk medicine in Russia and Baltic countries is a source of phenylpropanoid-derived styrylpyrone polyphenols that can inhibit tumor proliferation. Insights into the regulatory machinery that controls I..

Oncology

High relevance

Mesima · 2016 · Research Support, Non U.S. Gov'T · Journal of microbiology (Seoul, Korea)

Species identity of Phellinus linteus (sanghuang) extensively used as a medicinal mushroom in Korea.

Sanghuang is a medicinal mushroom that has gained particular attention in Korea. It has been extensively studied for the past few decades as a natural immune booster and cancer suppressor..

OncologyImmune support

High relevance

Niu-Chang-Chih · 2015 · Journal Article · Fitoterapia

Anti-cancer agents derived from solid-state fermented Antrodia camphorata mycelium.

Three new ubiquinone derivatives, antrocamol LT1, antrocamol LT2, and antrocamol LT3, along with two known compounds, were isolated from Antrodia camphorata (Polyporaceae) mycelium. The structures of these compounds were established on the basis of extensive 1D and 2D NMR spectroscopic analyses..

Oncology

High relevance

Shiitake · 2015 · Journal Article · Biochemical and biophysical research communications

Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin.

Lentinula edodes mycelia solid culture extract (MSCE) contains several bioactive molecules, including some polyphenolic compounds, which exert immunomodulatory, antitumor, and hepatoprotective effects..

OncologyImmune supportLiver supportRespiratory

High relevance

Niu-Chang-Chih · 2015 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Antrodia camphorata Potentiates Neuroprotection against Cerebral Ischemia in Rats via Downregulation of iNOS/HO-1/Bax and Activated Caspase-3 and Inhibition of Hydroxyl Radical Formation.

Antrodia camphorata (A. camphorata) is a fungus generally used in Chinese folk medicine for treatment of viral hepatitis and cancer.

OncologyCognition & nervesEnergy & fatigueLiver support

High relevance

Maitake · 2015 · Journal Article · Food research international (Ottawa, Ont.)

Biological potential of extracts of the wild edible Basidiomycete mushroom Grifola frondosa

Partially purified polysaccharides (FP) and hot alkali extract (FNa) obtained from fruiting bodies of the wild basidiomycete Grifola frondosa were examined for their antimicrobial, antioxidant and cytotoxic activity..

OncologyImmune support

High relevance

Zhu Ling · 2015 · Journal Article · Journal of medicinal food

Khz (fusion product of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis in human colon carcinoma HCT116 cells, accompanied by an increase in reactive oxygen species, activation of caspase 3, and increased intracellular Ca²⁺.

Khz (a fusion mycelium of Ganoderma lucidum and Polyporus umbellatus mycelia) is isolated from ganoderic acid and P. umbellatus and it exerts antiproliferative effects against malignant cells.

OncologyEnergy & fatigueGut & microbiome

High relevance

Maitake · 2015 · Clinical Trial, Phase II · Cancer immunology, immunotherapy: CII

Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study.

BACKGROUND: Myelodysplastic syndromes (MDS) are characterized by ineffective erythropoiesis with dysplastic bone marrow leading to peripheral cytopenia, risk of infection, and progression to acute myelogenous leukemia..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Mesima · 2015 · Research Article · Journal of clinical medicine research

Potent Anticancer Effects of Bioactive Mushroom Extracts (Phellinus linteus) on a Variety of Human Cancer Cells.

BACKGROUND: Although several therapeutic options are currently available for patients with various cancers, the outcomes are often disappointing and a more effective modality needs to be promptly established..

OncologyCognition & nervesLiver supportRespiratory

High relevance

Mesima · 2015 · Journal Article · Journal of investigative medicine: the official publication of the American Federation for Clinical Research

The Effects of Phellinus linteus Polysaccharide Extracts on Cholesterol Efflux in Oxidized Low-Density Lipoprotein-Loaded THP-1 Macrophages.

The removal of excess cellular cholesterol is critical for maintaining cellular cholesterol homeostasis. Phellinus linteus polysaccharide extracts (PLPEs) is an immunomudulatory agent with a molecular weight of 153 kd..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Chaga · 2015 · Journal Article · Fitoterapia

Triterpenoids from Inonotus obliquus and their antitumor activities.

Three new lanostane-type triterpenes, inonotusanes A-C (1-3), and a new naturally occurring one, 3β-hydroxy-25,26,27-trinorlanosta-8,22E-dien-24-oic acid (4), together with sixteen known triterpenoids (5-20), including 13 lanostane derivatives, 2 lupanes and 1 oleanane-type triterpene were isolated from the sclerotia….

Oncology

High relevance

Mesima · 2014 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Chemical characterization of the medicinal mushroom Phellinus linteus (Berkeley & Curtis) Teng and contribution of different fractions to its bioactivity

Mushrooms are widely appreciated for their organoleptic qualities, being also recognized as good sources of bioactive compounds that provide antioxidant, antimicrobial and cytotoxic activities..

OncologyImmune support

High relevance

Lion's Mane · 2014 · Journal Article · Biological & pharmaceutical bulletin

Mutagenesis of the Novel Hericium erinaceus Ribonuclease, RNase He1, Reveals Critical Responsible Residues for Enzyme Stability and Activity

Here, we determined the sequence of a cDNA encoding a guanylic acid-specific ribonuclease (RNase He1) from Hericium erinaceus that exhibits high sequence identity (59%) with RNase Po1, an enzyme with anti-cancer activity and which is found in Pleurotus ostreatus..

Oncology

High relevance

Mesima · 2014 · Research Article · Immune network

Phellinus linteus Extract Exerts Anti-asthmatic Effects by Suppressing NF-κB and p38 MAPK Activity in an OVA-induced Mouse Model of Asthma.

Phellinus linteus has been used as a traditional herbal medicine in Asian countries and is known to have anti-tumor, immunomodulatory, anti-inflammatory, and anti-allergic activities. However, the protective effects of P.

OncologyImmune supportRespiratory

High relevance

Niu-Chang-Chih · 2013 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Antrodia camphorata Grown on Germinated Brown Rice Suppresses Melanoma Cell Proliferation by Inducing Apoptosis and Cell Differentiation and Tumor Growth.

Antrodia camphorata grown on germinated brown rice (CBR) was prepared to suppress melanoma development. CBR extracts were divided into hexane, EtOAc, BuOH, and water fractions.

OncologySkin & hydration

High relevance

Niu-Chang-Chih · 2013 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Ethanol Extract of Antrodia camphorata Grown on Germinated Brown Rice Suppresses Inflammatory Responses in Mice with Acute DSS-Induced Colitis.

The anti-inflammatory activity of Antrodia camphorata (AC) grown on germinated brown rice (CBR) extract was evaluated in vitro and in vivo. CBR suppressed the release of nitric oxide (NO) and prostaglandin (PG) E2 from lipopolysaccharide-(LPS-)stimulated RAW264.7 cells..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Yellow Morel · 2013 · Journal Article · Biotechnology letters

Induction of apoptosis in HepG2 cells by polysaccharide MEP-II from the fermentation broth of Morchella esculenta

A novel polysaccharide, MEP-II, isolated from the fermentation broth of Morchella esculenta inhibited the proliferation of human hepatoma cell line (HepG2) through an apoptotic pathway..

OncologyImmune supportEnergy & fatigueLiver support

High relevance

Niu-Chang-Chih · 2013 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Inhibition of Helicobacter pylori CagA-Induced Pathogenesis by Methylantcinate B from Antrodia camphorata.

The bacterial pathogen Helicobacter pylori (Hp) is the leading risk factor for the development of gastric cancer. Hp virulence factor, cytotoxin-associated gene A (CagA) interacted with cholesterol-enriched microdomains and leads to induction of inflammation in gastric epithelial cells (AGS)..

OncologyImmune supportMetabolic health

High relevance

Mesima · 2013 · Research Article · Chinese medicine

Phellinus linteus polysaccharide extracts increase the mitochondrial membrane potential and cause apoptotic death of THP-1 monocytes.

BACKGROUND: The differentiation resp. death of human monocytic THP-1 cells induced by polysaccharide extracts of the medicinal mushrooms Phellinus linteus, Agaricus bisporus and Agaricus brasiliensis have been studied..

OncologyImmune supportEnergy & fatigue

High relevance

Maitake · 2013 · Journal Article · International journal of biological macromolecules

Purification and partial characterization of a novel anti-tumor glycoprotein from cultured mycelia of Grifola frondosa.

A novel glycoprotein GFG-3a with the molecular weight of 88.01kDa and potent anti-tumor activity was isolated from the cultured mycelia of Grifola frondosa GF9801. GFG-3a was heat-sensitive with the decreasing anti-proliferative activity after treated from 56°C to 100°C for 10-120min..

OncologyMetabolic health

High relevance

Enoki · 2012 · Journal Article · Food chemistry

Bioactive sesquiterpenoids from the solid culture of the edible mushroom Flammulina velutipes growing on cooked rice.

The edible mushroom Flammulina velutipes was cultivated on cooked rice. Six new cuparene sesquiterpenes, enokipodins E-J (1-6), and two new sterpurane sesquiterpenes, sterpurols A (10) and B (11), with four known sesquiterpenes, 2,5-cuparadiene-1,4-dione (7), enokipodins B (8) and D (9), and sterpuric acid (12), were….

Oncology

High relevance

Niu-Chang-Chih · 2012 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Inhibition of Cell Growth and Induction of Apoptosis by Antrodia camphorata in HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway.

Previously, we demonstrated that a submerged fermentation culture of Antrodia camphorata (AC) promotes cell-cycle arrest and apoptosis in human estrogen receptor-positive/negative breast cancer cells. However, whether AC is effective against HER-2/neu-overexpressing breast cancers has not been thoroughly elucidated..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Zhu Ling · 2012 · Research Article · PloS one

Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species.

Khz is a compound derived from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia that inhibits the growth of cancer cells. The results of the present study show that Khz induced apoptosis preferentially in transformed cells and had only minimal effects on non-transformed cells..

OncologyEnergy & fatigue

High relevance

Turkey Tail · 2012 · Research Article · ISRN oncology

Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer.

Introduction. Orally administered preparations from the Trametes versicolor (Tv) mushroom have been hypothesized to improve immune response in women with breast cancer after standard chemotherapy and radiotherapy.

OncologyImmune support

High relevance

Niu-Chang-Chih · 2012 · Journal Article · Food chemistry

Protective effect of antrosterol from Antrodia camphorata submerged whole broth against carbon tetrachloride-induced acute liver injury in mice

The hepatoprotective potential of antrosterol (ergostatrien-3Î²-ol, ST1) from Antrodia camphorata (AC) against carbon tetrachloride (CClâ)-induced liver damage was evaluated in preventive models in mice..

OncologyImmune supportEnergy & fatigueLiver support

High relevance

Enoki · 2012 · Journal Article · Carbohydrate polymers

Purification, characterization and anti-proliferation activity of polysaccharides from Flammulina velutipes

A polysaccharide was isolated from Flammulina velutipes (FVP) using ultrasonic-assisted extraction, and then further purified by DEAE cellulose-52 chromatography and Sephadex G-100 size-exclusion chromatography to afford FVP-1 and FVP-2..

OncologyImmune supportCognition & nervesSkin & hydration

High relevance

Maitake · 2012 · Journal Article · Journal of leukocyte biology

Soluble β-glucan from Grifola frondosa induces proliferation and Dectin-1/Syk signaling in resident macrophages via the GM-CSF autocrine pathway.

MD-Fraction, a highly purified, soluble β-(1,3) (1,6)-glucan obtained from Grifola frondosa (an oriental edible mushroom), has been reported to inhibit tumor growth by modulating host immunity..

OncologyImmune support

High relevance

Niu-Chang-Chih · 2012 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Triterpenoid-Rich Extract from Antrodia camphorata Improves Physical Fatigue and Exercise Performance in Mice.

Antrodia camphorata (AC) is an endemic mushroom that grows in Taiwan. We investigated the fatigue-alleviating effects of AC on endurance capacity in swim-exercised and weight-loading mice..

OncologyEnergy & fatigueMetabolic healthLiver support

High relevance

Wood Ear · 2011 · Research Article · Toxicological research

Comparative Antitumor Activity of Different Solvent Fractions from an Auricularia auricula-judae Ethanol Extract in P388D1 and Sarcoma 180 Cells.

The objective of this study was to evaluate and compare the antitumor activity of different solvent fractions (ethanol, dichloromethane, ethyl acetate, butanol and water) of the Auricularia auricula-judae 70% ethanol extract on the P388D1 macrophage and sarcoma 180 cells..

OncologyImmune support

High relevance

Lion's Mane · 2011 · Journal Article · Journal of agricultural and food chemistry

Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice.

We investigated antitumor effects of the following four extracts of freeze-dried Hericium erinaceus mushrooms in Balb/c mice intracutaneously transplanted on the backs with CT-26 colon cancer cells: HWE, hot water extraction by boiling in water for 3 h; MWE, microwaving in 50% ethanol/water at 60 W for 3 min; and ACE….

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Chaga · 2011 · Research Article · Molecules and cells

Immunostimulating activity by polysaccharides isolated from fruiting body of Inonotus obliquus.

In this study, we investigated the immunostimulating activity of polysaccharides isolated from fruiting body of Inonotus obliquus (PFIO). Additionally, the signaling pathway of PFIO-mediated macrophage activation was investigated in RAW264.7 macrophage cells..

OncologyImmune support

High relevance

Chaga · 2011 · Research Article · Molecules and cells

Inonotus obliquus protects against oxidative stress-induced apoptosis and premature senescence.

In this study, we investigated the cytoprotective effects of Inonotus obliquus against oxidative stress-induced apoptosis and premature senescence. Pretreatment with I.

OncologySkin & hydration

High relevance

Mesima · 2011 · Journal Article · Journal of ethnopharmacology

Orally administered mycelial culture of Phellinus linteus exhibits antitumor effects in hepatoma cell-bearing mice.

AIM OF THE STUDY: The aim of this study was to evaluate the anticancer effect of a mycelial culture from Phellinus linteus PL-7 (MCPL-7) and to elucidate its potential mechanism in vivo. MATERIALS AND METHODS: SCID CB-17 mice received a transplant of Hep3B cells followed by daily MCPL-7 administrations for 8 weeks..

OncologyImmune supportLiver support

High relevance

Maitake · 2011 · Journal Article · World journal of microbiology & biotechnology

Production of exopolysaccharides by submerged mycelial culture of Grifola frondosa TFRI1073 and their antioxidant and antiproliferative activities

The exopolysaccharide (EPS) extract of a newly screened Grifola frondosa TFRI1073 was evaluated antioxidant activity, including superoxide anion scavenging activity and reducing power, and the antiproliferative activities by using lung (A549 cells) and breast (MDA-MD-231 cells) cancer cell line..

OncologyImmune supportRespiratory

High relevance

Maitake · 2010 · Journal Article · Mycoscience

Effect of a hot water-soluble extraction from Grifola frondosa on the viability of a human monocyte cell line exposed to mitomycin C

The effects of a hot water-soluble extract of Grifola frondosa on the viability of multiple immune cell lines were examined in vitro. The extract and the 1000-cut extract, a low molecular weight fraction, improved the viability of a human monocyte cell line, THP-1, treated by the anticancer drug mitomycin C..

OncologyImmune support

High relevance

Lion's Mane · 2010 · Journal Article · Cancer letters

Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells.

It has been demonstrated that the Hericium erinaceus (HE) mushroom, which primarily consists of polysaccharides, possesses anti-tumor activities. However, the mechanisms by which HE inhibits human hepatocellular carcinoma growth remain unknown..

OncologyImmune supportLiver support

High relevance

Mesima · 2010 · Journal Article · Archives of pharmacal research

Hispidin produced from Phellinus linteus protects pancreatic beta-cells from damage by hydrogen peroxide.

Phellinus linteus, which is a traditional medicinal mushroom used in Asian countries for the treatment of various diseases, has attracted a lot of attention due to its antioxidant, anti-inflammatory, anti-mutagenicity, and cell-mediated immunity properties in addition to its ability to inhibit tumor growth and….

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Niu-Chang-Chih · 2010 · Journal Article · Food chemistry

Inhibitory effect of Antrodia camphorata constituents on the Helicobacter pylori-associated gastric inflammation

Helicobacter pylori infection plays a crucial role in the pathogenesis of peptic ulcer, and gastric cancer. Among the 13 chemical constituents isolated from fruiting bodies of Antrodia camphorata, methyl antcinate B (4), antcins K (10) and A (12) displayed potential anti-H..

OncologyImmune support

High relevance

Chaga · 2010 · Journal Article · International journal of biological macromolecules

Optimization of ultrasonic/microwave assisted extraction (UMAE) of polysaccharides from Inonotus obliquus and evaluation of its anti-tumor activities.

Recently, the use of ultrasonic and microwave has attracted considerable interest as an alternative approach to the traditional extraction methods. In this paper, in order to maximize the yield and purity of polysaccharides from Inonotus obliquus, response surface methodology (RSM) was employed to optimize the….

OncologyImmune support

High relevance

Niu-Chang-Chih · 2010 · Journal Article · Bioorganic & medicinal chemistry

Structure and functions of gamma-dodecalactone isolated from Antrodia camphorata for NK cell activation.

The preserved fungal species Antrodia camphorata has diverse health-promoting effects and has been popularly used in East Asia as a traditional herb. We isolated a volatile compound from the culture medium of A.

OncologyImmune support

High relevance

Mesima · 2009 · Research Article · Mycobiology

Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model.

The antitumor effects of Phellinus linteus extract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model. When administered orally (250~1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Maitake · 2009 · Journal Article · Journal of agricultural and food chemistry

Characterization and antitumor effect of a novel polysaccharide from Grifola frondosa.

A novel polysaccharide, MZF, with a molecular mass of 23 kDa was isolated from Grifola frondosa. Results from methylation and (1)H NMR led to the conclusion that MZF is a heteropolysaccharide consisting of -->6)-alpha-D-Galp-(1--> (36.2%), -->3)-alpha-L-Fucp-(1--> (14.5%), -->6)-alpha-D-Manp-(1--> (9.4%),….

OncologyImmune supportGut & microbiome

High relevance

Chaga · 2009 · Journal Article · Journal of bioscience and bioengineering

Comparative study of antioxidant activity and antiproliferative effect of hot water and ethanol extracts from the mushroom Inonotus obliquus.

The medicinal mushroom Inonotus obliquus is a traditional and widely used multi-functional fungus. Hot water (50 degrees C, 70 degrees C, and 80 degrees C) and ethanol crude extracts of I..

OncologyImmune supportGut & microbiome

High relevance

Niu-Chang-Chih · 2009 · Journal Article · Food chemistry

Immunostimulatory effect of Antrodia camphorata extract on functional maturation of dendritic cells

Dendritic cells (DCs) are now recognised as the most potent professional antigen presenting cells (APCs) involved in initiating primary immune responses. The medicinal mushroom Antrodia camphorata (AC) is one of the most popular chemopreventive mushrooms in Taiwan..

OncologyImmune support

High relevance

Lion's Mane · 2009 · Journal Article · Journal of microbiology and biotechnology

Study of macrophage activation and structural characteristics of purified polysaccharides from the fruiting body of Hericium erinaceus.

Most, if not all, Basidiomycetes mushrooms have biologically active polysaccharides showing potent antitumor activity with immunomodulating properties. These polysaccharides have various chemical compositions and belong primarily to the beta-glucan group..

OncologyImmune support

High relevance

Lion's Mane · 2009 · Journal Article · Carbohydrate polymers

Study on macrophage activation and structural characteristics of purified polysaccharides from the liquid culture broth of Hericium erinaceus

Recently, a number of bioactive molecules, including antitumor agents, have been identified in various higher basidiomycetes mushrooms. Polysaccharides are the best known and most potent mushroom derived substances that display immuno-pharmacological properties..

OncologyImmune support