MycoData

Flammulina velutipes residue (FVR) was valorized into a functional feed additive targeting multi-drug resistant (MDR) Escherichia coli B2 (E. coli B2) via multi-strain co-fermentation..

Immune supportGut & microbiome

High relevance

Lion's Mane · 2026 · Research Article · Foods (Basel, Switzerland)

Valorization of Hericium erinaceus By-Products for β-Glucan Recovery via Pulsed Electric Field-Assisted Alkaline Extraction and Prebiotic Potential Analysis.

Hericium erinaceus is a well-known edible fungus rich in β-glucans, widely recognized for its immune-boosting and prebiotic properties. This study used a pulsed electric field (PEF) combined with alkaline extraction to improve β-glucan yield from H.

Immune supportGut & microbiome

High relevance

Reishi · 2026 · Journal Article · Carbohydrate polymers

Virus-inspired Ganoderma lucidum polysaccharide-functionalized adjuvant with pseudo-zwitterionic interface for potentiated nasal immunization.

Intranasal vaccination is promising against respiratory infections but hindered by the mucus barrier. To overcome the adhesion-penetration dilemma, we developed a virus-inspired hybrid nanoparticle (GHNP) by functionalizing a cationic polymer/lipid core (HNP) with Ganoderma lucidum polysaccharide (GLP)..

Immune supportLiver supportRespiratory

High relevance

Lion's Mane · 2026 · Journal Article · International journal of biological macromolecules

β-Glucan-rich Hericium erinaceus hot-water extract ameliorates acute colitis by suppressing inflammation, preserving the epithelial barrier, and modulating gut microbiota ecosystem.

Inflammatory bowel disease (IBD) is a chronic disorder marked by mucosal barrier disruption, immune imbalance, and gut dysbiosis. Polysaccharide-enriched extracts of Hericium erinaceus (HE) have shown anti-colitic effects, but the role of its β-glucan-rich water extract (HE-HW) remains unclear..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Turkey Tail · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

A Chromosome-Scale Genome of Trametes versicolor and Transcriptome-Based Screening for Light-Induced Genes That Promote Triterpene Biosynthesis.

Trametes versicolor is an important fungus with medicinal properties and a significant role in lignocellulose degradation. In this study, we constructed a high-quality chromosome-level genome of T.

Metabolic health

High relevance

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

A glucan from Ganoderma lucidum: Structural characterization and the anti-inflammatory effect on Parkinson's disease via regulating dysfunctions of intestinal microecology and inhibiting TLR4/MyD88/NF-κB signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Curtis) P. Karst (G.

Immune supportCognition & nervesGut & microbiome

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

A glucomannan from defatted Ganoderma lucidum spores: structural characterization and immunomodulatory activity via activating TLR4/MyD88/NF-κB signaling pathway.

Ganoderma lucidum spores are tiny mature germ cells ejected from the abaxial side of the pileus and were responsible for multiple pharmacological properties. The defatted G.

OncologyImmune supportMetabolic health

High relevance

Shiitake · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

A Model of the Current Geographic Distribution and Predictions of Future Range Shifts of Lentinula edodes in China Under Multiple Climate Change Scenarios.

Due to its ecological functions, huge economic benefits, and excellent nutritional and physiological activities, Lentinula edodes is a very popular edible fungus in Asia, especially in China. Changes in the distribution and population of wild L..

High relevance

Oyster Mushroom · 2025 · Research Article · Membranes

A Model-Driven Approach to Assessing the Fouling Mechanism in the Crossflow Filtration of Laccase Extract from Pleurotus ostreatus 202.

Membrane technology is primarily used for the separation and purification of biotechnological products, which contain proteins and enzymes. Membrane fouling during crossflow filtration remains a significant challenge..

High relevance

Reishi · 2025 · Research Article · Frontiers in chemistry

A new lanostane-type triterpene with lipid-lowering activity from Ganoderma lucidum and an additional analogue.

Non-alcoholic fatty liver disease (NAFLD) represents a chronic liver disorder with widespread global prevalence, primarily attributed to hepatic lipid accumulation, oxidative stress, and inflammatory responses..

Immune supportMetabolic healthLiver support

High relevance

Lion's Mane · 2025 · Research Article · International journal of medical sciences

A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation.

Hericium erinaceus, renowned for its pharmaceutical potential, is particularly notable for its isolated diterpenoid derivative, erinacine S. Colorectal cancer (CRC) is one of the most prevalent cancers, characterized by CSC that contribute to chemoresistance and sustained tumor growth..

OncologyImmune supportCognition & nerves

High relevance

Reishi · 2025 · Journal Article · Carbohydrate polymers

A novel galactoglucan from Ganoderma lucidum ameliorates ethanol-induced gastric ulcers by modulating FAK-MAPK signaling pathway

Gastric ulcer (GU) is a prevalent gastrointestinal disorder that significantly impacts patients' quality of life. Current treatments, including proton pump inhibitors and H₂ receptor antagonists, often present limitations such as adverse side effects and incomplete healing, highlighting the urgent need for new….

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Carbohydrate polymers

A novel galactoglucan from Ganoderma lucidum ameliorates ethanol-induced gastric ulcers by modulating FAK-MAPK signaling pathway.

Gastric ulcer (GU) is a prevalent gastrointestinal disorder that significantly impacts patients' quality of life. Current treatments, including proton pump inhibitors and H2 receptor antagonists, often present limitations such as adverse side effects and incomplete healing, highlighting the urgent need for new….

Immune supportMetabolic healthGut & microbiome

High relevance

Maitake · 2025 · Journal Article · International journal of biological macromolecules

A novel water-soluble antibacterial films of gelatin/carboxymethyl cellulose sodium incorporated with Grifola frondosa polysaccharides and pearl powder for fruit preservation.

Grifola frondosa polysaccharides (GFG) is a polysaccharide-protein complex, rich in hydrophilic groups, and has antioxidant and antibacterial biological activities. Nano-pearl powder (PP) with a large amount of calcium carbonate can be used as a chelating agent, antioxidant, and antibacterial agent..

Immune supportEnergy & fatigue

High relevance

Shiitake · 2025 · Research Article · Frontiers in oncology

A placebo-controlled study of the doses and efficacy of Lentinula edodes mycelia for oxaliplatin-induced peripheral neuropathy in colorectal cancer.

INTRODUCTION: Preclinical studies have demonstrated the potential of Lentinula edodes mycelium (L.E.M.) extract for managing oxaliplatin-induced peripheral neuropathy (OIPN). The efficacy and optimal dosage of L.E.M.

OncologyCognition & nerves

High relevance

Enoki · 2025 · Research Article · Foods (Basel, Switzerland)

Activity Analysis and Inhibition Mechanism of Four Novel Angiotensin I-Converting Enzyme Inhibitory Peptides Prepared from Flammulina velutipes by Enzymatic Hydrolysis.

In order to innovatively develop high-activity ACE inhibitory peptides from edible fungi, the conditions for a double-enzymatic hydrolysis preparation of ACE inhibitory peptides from Flammulina velutipes were optimized by response surface methodology..

Energy & fatigueMetabolic health

High relevance

Almond Mushroom · 2025 · Journal Article · Combinatorial chemistry & high throughput screening

Agaricus blazei Murill Extract (FA-2-b-β) Induces Ferroptosis in Diffuse Large B-Cell Lymphoma via the Nrf2/Ho-1 Pathway.

INTRODUCTION: Ferroptosis is a recently identified iron-dependent programmed cell death closely linked to the progression of diffuse large B-cell lymphoma (DLBCL)..

OncologyEnergy & fatigue

High relevance

Shiitake · 2025 · Journal Article · Bioresource Technology Reports

Agro-industrial waste valorization through solid-state fermentation by Lentinula edodes for high-protein and β-glucans flour development for human diet: Chemical characterization, drying kinetics evaluation, and bioaccessibility

This study aimed to develop a high-protein and β-glucans flour for the human diet through the solid-state fermentation of peach palm shells by Lentinula edodes. Six biomasses were produced to analyze the effects of cultivation substrate on the physicochemical properties, using soya bran, cassava bagasse, and sorghum….

Gut & microbiome

High relevance

Reishi · 2025 · Journal Article · Plant Foods Hum Nutr

Alcoholic Extracts from the Ganoderma Lucidum Fermentation Product Alleviated Ethanol-Induced Liver Injury, Gut Leakiness, and Gut Dysbiosis in Mice

The hepatoprotective effect of the alcoholic extracts of Ganoderma lucidum fermentation products (GFE) was investigated. C57BL/6 mice were pretreated with GFE for 7 days and then subjected to the chronic-binge ethanol feeding model..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Enoki · 2025 · Journal Article · International journal of biological macromolecules

Alkaline-heat treatment Flammulina velutipes polysaccharides/sodium carboxymethyl cellulose biodegradable composite film for fresh-cut cantaloupe preservation.

As concerns about the safety and sustainability of plastic wrap grow, the development of biodegradable film for use in fresh-cut fruits and vegetables has become an inevitable trend..

Immune support

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Alternative splicing of Gllac7 regulate lignin degradation in Ganoderma lucidum.

Laccases are key enzymes involved in lignin degradation in the white-rot fungus Ganoderma lucidum. Gllac7, which exists as two alternative splice isoforms, Gllac7.1 and Gllac7.2, plays a significant role in the lignin degradation process in G.

Metabolic health

High relevance

Wood Ear · 2025 · Journal Article · International journal of biological macromolecules

An environment-friendly strategy for direct characterization of polysaccharides in Auricularia auricula-judae by ATR-FTIR spectra and chemometrics.

The traditional polysaccharide component analysis often depends on utilization of chemical reagents, which pose potential threats to human health and environmental safety..

Immune support

High relevance

Cordyceps · 2025 · Research Article · Journal of pharmacy & bioallied sciences

Analysis and Evaluation of Volatile Chemical Components of Wild Ophiocordyceps sinensis and Its Mycelia in Xizang, China.

BACKGROUND: As a rare traditional Chinese medicinal material, Ophiocordyceps sinensis is subject to counterfeiting in the market due to its limited distribution and insufficient supply and demand. Therefore, conducting research on its volatile components is of great significance for identifying authenticity..

Energy & fatigue

High relevance

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Analysis of Amino Acid and Derivative Diversity and Antioxidant Capacity in Ophiocordyceps sinensis and Its Substitutes.

In this study, we used liquid chromatography-tandem mass spectrometry (LC-MS/MS) combined with multivariate statistical analysis to conduct comprehensive qualitative and quantitative profiling of amino acids and their derivatives in wild Ophiocordyceps sinensis (O..

Immune support

High relevance

Snow Fungus · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Analysis of Microbial Community Structure and Cultivation Performance Assessment in Tremella fuciformis Liquid Inoculum.

Liquid inoculum is widely adopted in the mushroom industry, yet preparing Tremella fuciformis liquid inoculum remains challenging due to its complex microbial community and dimorphic growth. This study aimed to establish a reliable protocol for T.

Energy & fatigue

High relevance

Shiitake · 2025 · Journal Article · International journal of biological macromolecules

Anti-hyperuricemia effects of a polysaccharide-protein complex from Lentinula edodes mediated by gut-kidney axis.

In order to investigate the effects of Lentinula edodes (L. edodes) on hyperuricemia, a polysaccharide-protein complex (LEPP) was prepared and characterized, and the activity was also systematically studied..

Immune supportGut & microbiome

High relevance

Wood Ear · 2025 · Research Article · Ultrasonics sonochemistry

Anti-inflammatory and gut microbiota regulatory effects of ultrasonic degraded polysaccharides from Auricularia auricula-judae in DSS-induced colitis mice.

Auricularia auricula-judae is a widely cultivated mushroom species known for its edible and medicinal properties. Polysaccharides have been the focus of research because of their potential bioactivities; nonetheless, the structural complexity and molecular weight have hindered a complete understanding of their….

Immune supportGut & microbiome

High relevance

Lion's Mane · 2025 · Research Article · BMB reports

Anti-inflammatory effects of Hericium erinaceus hot water extract via the JAK1/STAT3 pathway in LPS-stimulated RAW 264.7 macrophages.

Several individual bioactive compounds isolated from Hericium erinaceus exhibit various physiological and biochemical activities, including neuroprotective, neurotrophic, gastrointestinal protective, immunoregulatory, and anti-inflammatory effects. However, the specific anti-inflammatory effects of H..

Immune supportCognition & nervesEnergy & fatigueGut & microbiome

High relevance

Zhu Ling · 2025 · Research Article · Computational and structural biotechnology journal

Anticancer effects and mechanisms of Pulsatilla chinensis, Bupleurum chinense and Polyporus umbellatus on human lung carcinoma and hepatoma cells.

Herbs are extensively utilized in Traditional Chinese Medicine (TCM) for lung and liver cancer treatment, but the mechanisms behind these herbs remain largely unknown. Here, high-throughput transcriptomic analysis technology was used to uncover molecular mechanisms of herbal treatment..

OncologyImmune supportCognition & nervesLiver support

High relevance

Turkey Tail · 2025 · Journal Article · Molecular biology reports

Anticancer potential of purified laccase enzyme from Trametes versicolor: specific cytotoxicity against thyroid and endometrial cancer cells.

BACKGROUND: Cancer is one of the leading causes of death worldwide, highlighting the need to develop novel therapeutic strategies that are more effective and have fewer side effects than conventional treatments. Enzymatic cancer therapy is a promising approach due to its high specificity and minimal toxicity..

Oncology

High relevance

Oyster Mushroom · 2025 · Journal Article · International journal of medicinal mushrooms

Antihyperlipidemic Effect of Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) Extract in Rats with Postnatal Sucrose Consumption Whose Mothers Also Consumed Sucrose.

Male offspring of rats whose mothers consumed sucrose (5% solution) during gestation and lactation were also given the sucrose solution instead of drinking water for 3 months, and subsequently, for 1 month, they were given an aqueous extract obtained from dehydrated fruiting bodies of Pleurotus ostreatus..

Metabolic health

High relevance

Yellow Morel · 2025 · Journal Article · Bioorganic chemistry

Antioxidant and immunomodulatory effects of acetylated Morchella esculenta polysaccharide in DSS-induced ulcerative colitis mice.

This study follows the current attempt to discover and develop natural therapeutic substances for counteracting ulcerative colitis. Commercial Morchella esculenta polysaccharide after deproteinization (yielding MP) was hydrolyzed with commercial snailase (yielding EMP) then acetylated (yielding AEMP)..

Immune supportGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Journal of medicinal food

Antioxidant Properties of Mexican Ganoderma lucidum Extracts in Obese C57BL/6 Mice Fed with a High-Fat and Sugar Diet.

Oxidative stress is a key factor of comorbidities in obesity. A Mexican genotype of the medicinal mushroom Ganoderma lucidum (Gl) contains bioactive compounds showing antioxidant, hypocholesterolemic, anti-inflammatory, anticancer, and prebiotic properties..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Research Article · Foods (Basel, Switzerland)

AOX Affects the Synthesis of Polysaccharides by Regulating the Reactive Oxygen Species in Ganoderma lucidum.

Alternative oxidase (AOX) is a terminal oxidase in the mitochondrial electron transport chain that does not contribute to the generation of ATP. It plays a critical role in maintaining the balance between reactive oxygen species (ROS) production and intracellular redox homeostasis within the mitochondria..

Immune supportEnergy & fatigue

High relevance

Wood Ear · 2025 · Journal Article · International journal of food microbiology

Assessing safety risks associated with Burkholderia gladiolus in soaked Auricularia auricula-judae: One instant predictive model study.

Soaked Auricularia auricula-judae (A. auricula-judae) serves as a significant vehicle for foodbome disease caused by Burkholderia gladiol.

High relevance

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Association of α-Klotho with anti-aging effects of Ganoderma lucidum in animal models.

ETHNOPHARMACOLOGICAL RELEVANCE: Aging is a complex, universal process characterized by structural and functional decline across multiple organs. Ganoderma lucidum (G.

Immune supportEnergy & fatigueGut & microbiomeLiver support

High relevance

Oyster Mushroom · 2025 · Research Article · IMA fungus

Asymmetric mitonuclear interactions trigger transgressive inheritance and mitochondria-dependent heterosis in hybrids of the model system Pleurotus ostreatus.

Mitonuclear interactions are crucial in governing mitochondrial function, development and responses to stress in eukaryotic organisms. In this study, we explored how varying mitochondrial haplotypes affect the phenotype and oxidative stress response using hybrids of the basidiomycete Pleurotus ostreatus (P..

Energy & fatigue

High relevance

Reishi · 2025 · Research Article · Microbial cell factories

ATP deficiency triggers ganoderic acids accumulation via fatty acid β-oxidation pathway in Ganoderma lucidum.

BACKGROUND: Ganoderic acids (GAs), recognized as significant triterpenoid bioactive components in Ganoderma lucidum, exhibit a broad spectrum of pharmacological activities, including immunomodulation, anti-cancer, and anti-aging properties..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Reishi · 2025 · Journal Article · Phytochemistry

Baoslingzhines Q-X: Structurally previously undescribed trace phenolic meroterpenoids from Ganoderma lucidum and their biological activities toward renal fibrosis and cytotoxicity.

Eight previously undescribed phenolic meroterpenoids baoslingzhines Q-X (1-8) including three enantiomeric (±)-baoslingzhines Q-S (1-3) harboring a 2-methylbenzofuran moiety, two trinormeroterpenoids baoslingzhines T and U (4 and 5) containing a 5-methylbenzyl motif as a connection point with another ring, an alkaloid….

OncologySkin & hydration

High relevance

Chaga · 2025 · Journal Article · Journal of ethnopharmacology

Betulinic acid from Inonotus obliquus ameliorates T2DM by modulating short-chain fatty acids producing bacteria and amino acids metabolism in db/db mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus has also been used as a traditional folk medicine in Europe and Northeastern China to treat metabolic diseases. Betulinic acid (BA) is a major ingredient with anti-diabetic property derived from I.

Metabolic healthGut & microbiomeLiver support

High relevance

Oyster Mushroom · 2025 · Research Article · Current research in food science

Bioactive properties of selenium-enriched polysaccharides extracted from Pleurotus ostreatus using ultrasonic-assisted extraction.

Mushrooms are well recognized as functional foods owing to their rich nutritional and medicinal properties, particularly polysaccharides with notable therapeutic potential..

OncologyImmune supportMetabolic healthRespiratory

High relevance

Oyster Mushroom · 2025 · Research Article · Scientific reports

Biochemical characterization of a novel purified lectin extracted from Pleurotus ostreatus mushroom for its antiviral activity.

Viruses are responsible for numerous serious outbreaks and pandemics worldwide. In this context, lectins, which are carbohydrate-binding proteins, have garnered attention due to their antiviral properties against RNA and DNA viruses..

Respiratory

High relevance

Mesima · 2025 · Research Article · Current issues in molecular biology

Bioconversion of Chamaecyparis obtusa Leaves with Phellinus linteus Mycelium Modulates Antioxidant and Anti-Inflammatory Activities.

Chamaecyparis obtusa (Hinoki cypress) has been extensively studied for its leaves and bark, which are known to contain high levels of polyphenols and flavonoids with potent bioactivities. In this study, the phytochemical transformation and changes in bioactivity of C..

OncologyImmune support

High relevance

Turkey Tail · 2025 · Journal Article · Bioprocess and biosystems engineering

Biological pretreatment of wheat straw using Trametes versicolor for enhanced cellulase production in solid-state fermentation.

Wheat straw is a renewable biomass with potential for bioethanol and biorefinery applications, offering potential value-added products such as enzymes and oligosaccharides. However, its complex lignocellulosic structure, costly pretreatment requirements, and formation of inhibitory compounds hinder its utilization..

High relevance

Snow Fungus · 2025 · Journal Article · International journal of biological macromolecules

Biomacromolecular composite microspheres based on sodium alginate and tremella fuciformis polysaccharide for enhanced protection and delivery of camellia oil: A comprehensive study in simulated digestion.

This study presents the development of a novel polysaccharide biomolecule composite microsphere system based on sodium alginate (SA) and tremella fuciformis polysaccharide (TFP) for the encapsulation and controlled release of camellia oil (CO)..

Immune supportEnergy & fatigueGut & microbiomeLiver support

High relevance

Mesima · 2025 · Journal Article · Journal of photochemistry and photobiology. B, Biology

Biophysical effects of Phellinus Linteus on hepatocellular carcinoma cells studied by atomic force microscopy.

Precisely quantifying cancer cell morphology and physical properties is crucial for advancing cancer therapeutics, drug screening, and pharmacological assessment..

OncologyLiver support

High relevance

Turkey Tail · 2025 · Research Article · International journal of molecular sciences

Biopolymers of Polycaprolactone Loaded with Caffeic Acid and Trametes versicolor Extract Induced Proliferation in Human Coronary Artery Endothelial Cells and Inhibited Platelet Activity.

In atherosclerosis, the proliferation and migration of endothelial and smooth muscle cells (SMCs) and platelet activation alter endothelial function. Naturally occurring substances, such as caffeic acid (CA) and Trametes versicolor extract (TvE), have medicinal properties and are traditionally used for their….

Immune supportEnergy & fatigueLiver support

High relevance

Lion's Mane · 2025 · Research Article · Foods (Basel, Switzerland)

Biopreservation of Hericium erinaceus By-Products via Lactic Acid Fermentation: Effects on Functional and Technological Properties.

Lactic acid fermentation is an effective strategy for food preservation and functional enhancement. This study evaluated the fermentation of Hericium erinaceus by-products using Lactoplantibacillus plantarum and Lactocaseibacillus rhamnosus, assessing microbial stability, physicochemical parameters, phenolic content,….

High relevance

Shiitake · 2025 · Journal Article · Food Chemistry

Blue light attenuated the umami loss of postharvest Lentinula edodes during spore discharge: Crucial roles of energy status

Postharvest Lentinula edodes face significant umami quality decline during spore release. Light is a novel strategy for enhancing the flavor of edible mushrooms.

Energy & fatigue

High relevance

Oyster Mushroom · 2025 · Journal Article · International journal of medicinal mushrooms

Boosting Nutritional Proficiency of Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes): A Selenium and Zinc Fortification Exploration.

The present study was aimed at evaluating the nutritional characteristics of bio-enriched oyster mushrooms. Cereal, leguminous and oilseed waste was used as substrates..