MycoData

Reishi · 2026 · Journal Article · Carbohydrate polymers

Polysaccharide from Ganoderma lucidum-fermented wheat pericarp: Purification, structural features, and lipid-lowering mechanisms

This study purified and characterized a polysaccharide derived from wheat pericarp via solid-state fermentation (SSF) with Ganoderma lucidum, and evaluated its lipid-lowering effects using an oleic acid (OA)-induced HepG2 cell model..

Reishi · 2026 · Journal Article · Carbohydrate polymers

Polysaccharide from Ganoderma lucidum-fermented wheat pericarp: Purification, structural features, and lipid-lowering mechanisms.

Immune supportSkin & hydration

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Preparation and In Vitro Bioactivity Evaluation of Ganoderma lucidum Melanin-Stabilized Selenium Nanoparticles.

Selenium nanoparticles (SeNPs), a highly promising candidate as a nutrient fortificant and food additive, face challenges in stability and biosafety. These limitations hinder their application in the food industry.

Oyster Mushroom · 2026 · Journal Article · Journal of microbiological methods

Preparation of multi-enzyme cocktail from antagonistic Pleurotus ostreatus mycelia grown in broth containing dead fungal tissue and its potential application for isolating protoplast of filamentous fungi.

Protoplast generation is a prerequisite for fungal genetic manipulation, yet dependence on costly and variable commercial lysing enzymes limits its accessibility..

OncologyImmune supportLiver support

Lion's Mane · 2026 · Journal Article · Journal of the science of food and agriculture

Preparation, characterization and immune enhancement study of Hericium erinaceus polysaccharide-loaded polyethyleneimine-modified poly(lactic-co-glycolic acid) nanoparticles.

BACKGROUND: Hericium erinaceus polysaccharides (HEPs) exhibit remarkable immunomodulatory properties but are hampered by poor oral bioavailability. To overcome these limitations, this study developed and optimized HEP-loaded polyethyleneimine (PEI)-modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles….

Snow Fungus · 2026 · Journal Article · International journal of biological macromolecules

Preparation, characterization, antioxidant activity evaluation and application of high-thickening instant Tremella fuciformis polysaccharide products under the IDDSI framework.

Tremella fuciformis polysaccharides (TP), a natural polysaccharide with dual medicinal and edible values, possesses excellent gelling properties, water-holding capacity, and biological activities, rendering it a promising thickening agent for dysphagia-friendly foods..

OncologyImmune supportEnergy & fatigueLiver support

Reishi · 2026 · Journal Article · Journal of ethnopharmacology

Protective effects of Ganoderma lucidum polysaccharide peptides against cisplatin-induced toxicity.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum) has been used in traditional Chinese medicine for centuries to enhance vitality and support organ function.

Oyster Mushroom · 2026 · Research Article · Archives of microbiology

Putative transcription factor Skn7 is involved in cell wall formation, oxidative stress response, and hydrophobin gene expression in Pleurotus ostreatus.

The functions of the transcription factor Skn7 in regulating cell wall synthesis and oxidative stress response have been investigated in ascomycetes and a few basidiomycetes. We identified and disrupted the putative skn7 gene in Pleurotus ostreatus, a basidiomycete..

Yellow Morel · 2026 · Research Article · BMC plant biology

Regulatory effects of winter Morchella esculenta cultivation on the summer maize phyllosphere microbiome and plant health-related traits.

In response to the intensifying demand for reduced fertilizer use and increased climate instability, the strategic incorporation of cover crops to improve the maize (Zea mays L.) phyllosphere microenvironment and leaf functional traits has emerged as an important approach for sustaining and enhancing crop….

Oyster Mushroom · 2026 · Journal Article · Fungal biology

Role of the putative transcription factor Rim101 in pH/oxidative stress response and cell wall structure formation in the white-rot fungus Pleurotus ostreatus.

The transcription factor Rim101 regulates various cellular functions in fungi, including maintaining cell homeostasis, regulating redox processes, and transmembrane transport, in response to environmental pH changes and redox stress. White-rot fungi encounter various environmental stresses during wood degradation..

Immune supportEnergy & fatigueMetabolic health

Reishi · 2026 · Research Article · Journal of nanobiotechnology

ROS-responsive Ganoderma lucidum polysaccharide nanocomposite targeting prosenescent oxidative stress niche for structural and functional diabetic tendon regeneration.

Diabetic patients exhibit higher tendon injury incidence, with elevated risks of healing failure and re-rupture than healthy individuals, posing major clinical challenges. Tendon stem/progenitor cells (TSPCs) are crucial for tendon homeostasis maintenance, and their senescence underlies regenerative impairment..

Reishi · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Sandwich Mycelium-Based Composite Panels Fabricated with a Lightweight Core from Forest Waste Using Ganoderma lucidum and Pleurotus ostreatus.

The present study aims to determine the properties of sandwich mycelium-based composite panels (sandwich-MBC-panel) fabricated with a lightweight core of mycelium-based composites (MBCs) of Ganoderma lucidum and Pleurotus ostreatus and veneers of Gmelina arborea and Vochysia guatemalensis wood..

Immune supportGut & microbiome

Lion's Mane · 2026 · Journal Article · Poultry science

Selenium-modified Hericium erinaceus polysaccharides improves intestinal immunity and ND vaccine responses in chickens.

This study aimed to investigate the immunomodulatory effects of selenium-modified Hericium erinaceus polysaccharides on intestinal immunity and Newcastle disease (ND) vaccine responses in chickens..

Reishi · 2026 · Journal Article · Journal of separation science

Separation of Lower Polarity Components From Ganoderma lucidum Spores by a Combined Approach of Ultra-High Pressure Extraction and pH-Zone-Refining Counter-Current Chromatography.

An integrated strategy combining ultra-high pressure-assisted extraction and pH-zone-refining counter-current chromatography was developed for the efficient extraction and separation of the lower polar constituents from Ganoderma lucidum spores..

Reishi · 2026 · Journal Article · Phytochemistry

Seven undescribed metabolites from Ganoderma lucidum-derived endophytic Talaromyces sp. GLQ04 and their anti-DLBCL (diffuse large B-cell lymphoma) activities.

Seven undescribed metabolites and four known compounds were isolated from a Ganoderma lucidum-derived endophytic fungus Talaromyces sp. GLQ04.

Oncology

Reishi · 2026 · Journal Article · Chemistry & biodiversity

Six Undescribed Lanostane-Type Triterpenoids From Ganoderma lucidum.

Six previously undescribed lanostane triterpenoids (1-6), together with 21 known analogues (7-27) were isolated from the fruiting bodies of the medicinal fungus Ganoderma lucidum. Compounds 1-3 are lucidenate-type triterpenoids, whereas compounds 4-6 are ganoderate-type derivatives..

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Solid-State Fermentation of Jatropha curcas Cake by Pleurotus ostreatus or Ganoderma lucidum Mycelium to Determine Multi-Bioactivities.

Non-toxic Jatropha curcas cake is a by-product rich in protein that can be used in the food industry. Proteolytic kinetics were used to identify and quantify its antioxidant, antidiabetic, angiotensin-converting enzyme inhibitory, and hypocholesterolemic capacities.

Metabolic health

Lion's Mane · 2026 · Journal Article · International journal of biological macromolecules

Strategic ultrasonic degradation enhances immunomodulatory and hypolipidemic activities of Hericium Erinaceus β-glucan.

Bioactive β-glucans from Hericium erinaceus possess health benefits, yet the structure-function relationships of these polysaccharides remain incompletely elucidated. This study employed an ultrasonic degradation strategy to modify a high-molecular-weight β-glucan (H6PC20, 2.39 × 106 g/mol) from its fruiting bodies..

Lion's Mane · 2026 · Journal Article · Biotechnology and applied biochemistry

Structural Characterization and Anti-Inflammatory Activities of Polysaccharide From Hericium erinaceus Mycelium.

A novel heteropolysaccharide named HEP-S was separated from the mycelium of Hericium erinaceus using hot water extraction. The structure of HEP-S (2.45 × 106 Da) is mainly composed of →4,6)-α-D-Glcp(1→, →2)-α-D-Manp(1→, →4)-α-D-Glcp(1→, →3,6)-β-D-Glcp(1→, T-β-D-Galp(1→, and →4)-β-D-Galp(1→..

Maitake · 2026 · Journal Article · Carbohydrate polymers

Structural characterization and antitumor activity via immune modulation of an α-glucan from Grifola frondosa.

Grifola frondosa is a valued edible and medicinal fungus whose polysaccharides are key bioactive components, yet the identification of specific homogeneous effectors and their detailed immunomodulatory mechanisms remains a critical focus of research. In this study, polysaccharide fractions were isolated from G..

OncologyImmune support

Immune supportMetabolic healthLiver support

Reishi · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Structural characterization, lipid-lowering activity, and emulsifying properties of polysaccharides derived from wheat pericarp via Ganoderma lucidum solid-state fermentation.

The biotransformation of agricultural by-products through fungal solid-state fermentation (SSF) represents a sustainable and efficient strategy for enhancing the functional properties of plant polysaccharides..

Immune supportGut & microbiome

Shiitake · 2026 · Research Article · NPJ science of food

Structural divergence of lentinula edodes polysaccharides is associated with distinct anti-hyperuricemia pathways.

Lentinula edodes (L. edodes) polysaccharides hold therapeutic potential for hyperuricemia (HUA), but their mechanisms remain unclear.

Gut & microbiomeSkin & hydration

Maitake · 2026 · Research Article · Gels (Basel, Switzerland)

Structural, Interfacial, Gelling, and Digestive Properties of Protein from Grifola frondosa Fruiting Body.

Culture medium formulation influences mushroom yield and composition, but its effect on the properties of edible fungal protein remains unclear. To explore the functional and nutritional properties of proteins from Grifola frondosa (GF) fruiting bodies, the study examined the structural, interfacial, gelling, and….

Oyster Mushroom · 2026 · Journal Article · Journal of food engineering

Surplus bread fermentation by Pleurotus ostreatus monitored by magnetic resonance imaging

This study addresses circular approaches to reuse food surpluses and losses, focusing on starchy products like bread that are fermented by fungi to produce a nutrient-rich biomass..

Immune supportEnergy & fatigue

Snow Fungus · 2026 · Journal Article · Food Research International

Synergistic emulsions of Tremella fuciformis polysaccharide and sodium caseinate enable melt-resistance and inhibit ice crystals in low-fat ice cream

The potential health risks of excessive fat intake have increased the demand for low-fat ice cream. However, reducing the fat content often compromises the flavor..

Immune supportEnergy & fatigue

Snow Fungus · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Synergistic emulsions of Tremella fuciformis polysaccharide and sodium caseinate enable melt-resistance and inhibit ice crystals in low-fat ice cream.

The potential health risks of excessive fat intake have increased the demand for low-fat ice cream. However, reducing the fat content often compromises the flavor..

Reishi · 2026 · Journal Article · Phytopathologische Zeitschrift

Systemic Effect of Ganoderma lucidum Filtrate on Septoria Leaf Spot and Pycnidia Formation by Septoria lycopersici

This study aimed to evaluate the potential of the mycelial growth filtrate (MGF) from Ganoderma lucidum in providing systemic protection to tomato plants against Septoria lycopersici‐induced leaf spot and inhibiting the production of reproductive structures by the phytopathogen..

Energy & fatigueMetabolic healthLiver support

Shiitake · 2026 · Research Article · Microbiology spectrum

The alterations of the synthetic pathway and metabolic flux of auxin indole-3-acetic acid govern thermotolerance in Lentinula edodes mycelia subjected to heat stress.

Heat stress poses a significant constraint on the annual production of Lentinula edodes (L. edodes), a challenge that has been intensified by global warming.

OncologyImmune supportMetabolic healthGut & microbiome

Enoki · 2026 · Research Article · International journal of molecular sciences

The Brown Strain of Flammulina velutipes Singer Attenuates 5-Fluorouracil-Induced Intestinal Injury by Suppressing Inflammation, Oxidative Stress, and Barrier Disruption via Modulation of Epithelial-Mesenchymal Transition and Tight Junction Integrity.

5-Fluorouracil (5-FU) remains a cornerstone chemotherapeutic for colorectal cancer, exerting its antitumor effects primarily through disruption of DNA and RNA synthesis and subsequent induction of apoptosis. Nonetheless, its clinical efficacy is often compromised by prominent adverse effects, particularly mucositis..

Cognition & nervesMetabolic health

Lion's Mane · 2026 · Journal Article · Biological trace element research

The Chronic Metabolic Fingerprint of Canine Anxiety: Hair Trace Element Dyshomeostasis and the Dissociation of Behavioral Recovery via Hericium erinaceus.

Canine anxiety is a complex welfare issue involving neuro-endocrine dysregulation. While acute stress biomarkers are widely used, the chronic metabolic consequences of anxiety remain under-investigated.

OncologyImmune supportEnergy & fatigue

Chaga · 2026 · Research Article · Frontiers in veterinary science

The effects of polysaccharides from Inonotus obliquus, artemisinin, and dihydroartemisinin on the reproductive system of male mice infected with Neospora caninum.

The present study investigated the protective effects of Inonotus obliquus polysaccharides (IOPs), artemisinin, and dihydroartemisinin (DHA) on Neospora caninum-induced damage of the reproductive system in male BALB/c mice..

Immune supportCognition & nervesGut & microbiome

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

The Ganoderma lucidum and Rosa roxburghii Tratt Formulation Prevents Depressive-like Behaviors in Mice by Modulating Tryptophan Metabolism via the Gut-Brain Axis and Upregulating the BDNF/TrkB/PI3K/AKT Pathway.

Depression is a common mental disorder that substantially impairs patients' daily life and work. To identify natural and safe preventive options, we investigated the preventive effect and underlying mechanism of the Ganoderma lucidum and Rosa roxburghii Tratt formula (GLRRTF) on depression..

Reishi · 2026 · Research Article · Genes

The Genome-Wide Identification and Expression Profiling of the HSF Gene Family in Ganoderma lucidum Under Temperature Stress.

OBJECTIVE: In this study, the heat shock transcription factor (HSF) gene family in Ganoderma lucidum was systematically characterized. Using genomic and transcriptomic data, we identified HSF family members and investigated their expression patterns under temperature stress and their potential regulatory roles in….

Immune supportEnergy & fatigueSkin & hydration

Oyster Mushroom · 2026 · Journal Article · Meat science

The improving effect of Pleurotus ostreatus polysaccharide-EGCG active preservative films on the functional properties of myofibrillar proteins in refrigerated pork.

This study aimed to investigate the effects of chitosan (CS) /collagen (Clg) films loaded with Pleurotus ostreatus polysaccharide-EGCG conjugates (POP-EGCG) and ε-Polylysine (ε-PL, PL) on the functional properties of myofibrillar proteins (MPs) in refrigerated pork..

Oyster Mushroom · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

The Interference of Mnsod3 Enhances the Tolerance of Pleurotus ostreatus Mycelia to Abiotic Stress by Reshaping the Cell Wall.

In recent years, the response mechanism of Pleurotus ostreatus to abiotic stress has received widespread attention. MnSOD is an important antioxidant enzyme that has been widely studied in animals and plants because of its functions..

Skin & hydration

OncologyImmune supportGut & microbiome

Reishi · 2026 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

The paradox of potency: Insights into emergent mechanisms of Ganoderma lucidum's antitumor effects.

BACKGROUND: An arms race between cancer cells and therapeutic pressure fuels drug resistance, immune evasion, and tumor heterogeneity, hindering therapy. Ganoderma lucidum (G.

OncologyImmune supportEnergy & fatigueGut & microbiome

Reishi · 2026 · Journal Article · Molecular and cellular biochemistry

The role of mitochondrial regulation in macrophage polarization by Ganoderma lucidum polysaccharide for the treatment of colitis-associated colorectal cancer.

Colorectal cancer (CRC) is a common malignant tumor of the digestive tract. Ganoderma lucidum polysaccharide (GLP) has shown significant potential in regulating macrophage polarization and treating CRC..

Metabolic healthLiver support

Reishi · 2026 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Therapeutic potential of the medicinal mushroom Ganoderma lucidum in metabolic syndrome: Antioxidant, hypoglycemic, and hepatoprotective activities.

The objective of this study was to investigate the impact of Ganoderma lucidum mycelium on biochemical parameters altered in rats with fructose-induced metabolic syndrome..

Turkey Tail · 2026 · Journal Article · International journal of food microbiology

Trametes versicolor mycelium fermenting whole kidney beans into tempeh-like product.

This research explored the feasibility of using Trametes versicolor mycelium as a culture for fermenting kidney beans into tempeh-like products within 5 days, with citric acid (0, 3, and 6%, w/w; dry bean basis) applied as an abiotic stressor to enhance bioactive compound synthesis. The results showed that T..

Shiitake · 2026 · Journal Article · Fungal biology

Transcriptomic analysis of the dynamic changes in polysaccharide biosynthesis metabolism in Lentinula edodes throughout liquid fermentation.

Lentinula edodes, a mushroom valued both nutritionally and medicinally, produces polysaccharides as its principal bioactive compounds, known for their significant pharmacological effects. However, low yields have limited their large-scale industrial application..

Immune supportCognition & nervesMetabolic health

Cordyceps · 2026 · Research Article · BMC microbiology

Transcriptomic and metabolomic insights into the long-term survival strategies of Ophiocordyceps sinensis following host immune perturbation.

BACKGROUND: Ophiocordyceps sinensis is a premier medicinal fungus with a unique slow-killing parasitic strategy, yet the molecular basis of its long-term persistence in host hemocoel remains elusive..

Shiitake · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Transcriptomic and Physiological Profiling Reveals Metabolic Determinants and Key Regulatory Hubs of Fruiting Body Degeneration in Lentinula edodes.

Frequent strain degeneration during subcultivation, characterized by impaired sporulation and fruiting body formation, represents a major constraint in fungal agricultural production..

Metabolic health

Shiitake · 2026 · Research Article · Frontiers in fungal biology

Transcriptomic insights into common defense mechanisms of Pleurotus ostreatus, Agaricus bisporus, and Lentinula edodes against Pseudomonas tolaasii-induced browning.

This study investigated gene expression patterns associated with the browning of mushroom fruiting bodies caused by Pseudomonas tolaasii infection. To address this, Pleurotus ostreatus, Agaricus bisporus, and Lentinula edodes were inoculated with P..

Skin & hydration

Shiitake · 2026 · Research Article · Current issues in molecular biology

Treatment of Mesenchymal Stem Cell-Derived Extracellular Vesicles with Extract of Cultured Lentinula edodes Modulates Breast Cancer Stem Cells and MicroRNA Reprogramming.

Breast carcinoma represents the most frequent malignancy in women in Canada, and intrinsic or acquired drug resistance significantly increases the risk of recurrence and metastasis..

Oncology

Snow Fungus · 2026 · Research Article · European journal of translational myology

Tremella fuciformis polysaccharide: enhancing ischemic hypoxic adaptation of mesenchymal stem cells.

Human Placenta-Derived Mesenchymal Stem Cells (HP-MSCs) are recognized for their potential in treating various diseases due to their multidirectional differentiation and immunomodulatory abilities. However, the therapeutic efficacy is often compromised in ischemic and hypoxic environments..

OncologyImmune support

Energy & fatigueMetabolic health

Lion's Mane · 2026 · Research Article · Molecules (Basel, Switzerland)

Ultrasound-Assisted Extraction of Polyphenols from Hericium erinaceus: Optimization, Bioactivities and LC-MS-Based Chemical Profiling.

In this study, the Box-Behnken Design (BBD) was adopted to optimize the ultrasound-assisted extraction (UAE) conditions of polyphenols from Hericium erinaceus (H. erinaceus) on the basis of single-factor experiments, with extraction time, solid-liquid ratio and ethanol concentration as the key investigation factors..

Reishi · 2026 · Journal Article · International journal of biological macromolecules

Unique synergistic and compensatory interaction between β-1,3-glucosyltransferase isoenzyme in Ganoderma lucidum polysaccharide biosynthesis.

Two β-1,3-glucosyltransferase isoenzymes, designated GL20535 and GL24465, are present in Ganoderma lucidum polysaccharide (GLPS) biosynthesis. Previous studies have demonstrated that the expression level of gl20535 significantly influences the yield of GLPS, and silencing gl20535 results in upregulation of gl24465..

Shiitake · 2026 · Journal Article · Food chemistry

Unraveling the spatial chemical heterogeneity of Lentinula edodes: Integrative metabolomics and machine learning for cultivar and origin classification.

As a major edible mushroom, Lentinula edodes requires accurate cultivar and origin authentication. Conventional homogenate-based metabolomics obscures spatial chemical information..

Cognition & nerves

Shiitake · 2026 · Research Article · RSC advances

Unusual prenylated phenols with antioxidant and immunosuppressive activities from the edible mushroom Lentinula edodes.

Prenylated phenols, the primary class of mushroom-derived meroterpenoids, exhibit significant structural diversity and biological activities. Two new prenylated phenols (1 and 2), along with four aromatic derivatives, were isolated from the wild mushroom Lentinula edodes for the first time..