MycoData

Cancer cachexia is a syndrome characterized by profound weight loss, muscle wasting, and metabolic disturbance in cancer patients. Cancer-associated cachexia represents significant biological and clinical challenges that profoundly affect human health..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2026 · Research Article · Pharmaceutics

Ganoderma lucidum Polysaccharide Potentiates mRNA-LNP Efficacy: Synergizing Oxidative Stress Mitigation with Innate Immune Modulation.

Background/Objectives: As a primary mRNA delivery platform, lipid nanoparticles (LNPs) often induce oxidative stress that compromises mRNA translation efficiency. Natural polysaccharides are known for their antioxidant properties..

OncologyImmune supportLiver support

High relevance

Reishi · 2026 · Research Article · Materials today. Bio

Ganoderma lucidum polysaccharide-decorated extracellular vesicle enables synergistical antitumor immunotherapy.

Ganoderma lucidum polysaccharide (GLP) holds considerable promise for tumor therapy, but its clinical application is limited by its poor tumor-targeting capability..

OncologyImmune supportLiver supportRespiratory

High relevance

Reishi · 2026 · Journal Article · Journal of agricultural and food chemistry

Ganoderma lucidum Polysaccharides Alleviate High-Fat Diet-Induced Obesity by Promoting Lipolysis and Inhibiting Inflammation through Lactobacillus johnsonii-Butyrate Axis.

Ganoderma lucidum polysaccharides (GLPs) exert antiobesity effects that are linked to gut-microbiota modulation, yet the underlying mechanisms remain elusive. Here, we show that GLPs raise the fecal butyrate level, which in turn inhibits high-fat diet (HFD)-induced weight gain, fat accumulation, adipocyte hypertrophy,….

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2026 · Journal Article · Journal of ethnopharmacology

Ganoderma lucidum polysaccharides alleviate non-alcoholic fatty liver disease by modulating gut microbiota against TLR4/NF-κB/MAPK pathway and activating AMPK pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Leyss. ex Fr.) Karst has been a revered traditional Chinese medicinal herb, widely used in folk medicine to treat various metabolic diseases due to its remarkable bioactivities.

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2026 · Research Article · International journal of molecular medicine

Ganoderma lucidum polysaccharides improve liver metabolic disorders by modulating gut microbiota of ovariectomized mice.

The morbidity of cardiovascular disease in postmenopausal patients increases due to the lack of estrogen protection. One of the most common conditions is hyperlipidemia characterized by abnormally elevated low‑density lipoprotein cholesterol (LDL‑C) and total cholesterol (TC)..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Ganoderma lucidum Triterpenoids Suppress Adipogenesis and Obesity via PRKCQ Activation: An Integrated In Vivo, In Vitro, and Systems Pharmacology Study.

Ganoderma lucidum triterpenoids (GLTs) exhibit potential anti-obesity activity. However, their mechanism remains unclear.

Cognition & nervesMetabolic health

High relevance

Reishi · 2026 · Journal Article · Molecular pharmaceutics

Ganoderma lucidum-Derived Nanovesicles Attenuate Multiorgan Senescence via Modulation of Oxidative Stress and Inflammation.

Aging is a complex and multifactorial biological process characterized by cellular senescence and is a major risk factor for numerous age-related diseases. Developing safe and effective anti-aging interventions remains a significant challenge..

Immune supportEnergy & fatigueLiver supportSkin & hydration

High relevance

Reishi · 2026 · Journal Article · Biotechnology letters

Gene expression profiling to elucidate the promotive effects of the volatile organic compound 3-octanone on the mycelial growth of Ganoderma lucidum

To investigate the effects of fungal volatile organic compounds (FVOCs) on the mycelial growth of Ganoderma lucidum, and to elucidate the molecular mechanisms underlying the growth-promoting effect of 3-octanone. G..

Immune supportGut & microbiome

High relevance

Reishi · 2026 · Research Article · Biotechnology letters

Gene expression profiling to elucidate the promotive effects of the volatile organic compound 3-octanone on the mycelial growth of Ganoderma lucidum.

Immune supportGut & microbiome

High relevance

Zhu Ling · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Genetic-Geographic-Chemical Framework of Polyporus umbellatus Reveals Lineage-Specific Chemotypes for Elite Medicinal Line Breeding.

Polyporus umbellatus is a valuable fungus with both dietary and medicinal applications. However, heterogeneous germplasm and chemical variability constrain its sustainable use.

Immune supportMetabolic health

High relevance

Maitake · 2026 · Journal Article · Journal of the science of food and agriculture

Grifola frondosa polysaccharide ameliorates adenine-induced CKD by inhibiting TGF-β1/Smad signaling pathway in mice.

BACKGROUND: Chronic kidney disease (CKD) is pathologically characterized by oxidative stress, inflammation, and renal fibrosis, yet effective therapeutic interventions for this condition remains limited. Grifola frondosa polysaccharide (GFP), an active component derived from the edible and medicinal mushroom G..

OncologyImmune supportMetabolic health

High relevance

Reishi · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Heat-Stress Induced Apoptosis: A New Biotechnological Strategy to Enhance Ganoderic Acids Production in Ganoderma lucidum.

Ganoderma lucidum is a medicinal fungus widely utilized in traditional medicine and functional foods. Its primary bioactive constituents are ganoderic acids (GAs), a group of triterpenoid compounds..

Oncology

High relevance

Lion's Mane · 2026 · Research Article · Food science & nutrition

Hericium erinaceus Extracts Exert Gastroprotective Effects Through Modulation of the Gut Microbiota and Metabolites.

Hericium erinaceus (H. erinaceus) is a traditional edible and medicinal fungus with a long history of use in gastrointestinal protection.

Metabolic healthGut & microbiome

High relevance

Oyster Mushroom · 2026 · Journal Article · World journal of microbiology & biotechnology

Heterologous expression and interfacial activity evaluation of Pleurotus ostreatus hydrophobin Vmh2 mutants in Tremella fuciformis.

Hydrophobins are exceptional amphiphilic proteins, yet their industrial adoption is hindered by a dual "production-performance" bottleneck: low natural yields and fixed interfacial properties..

Energy & fatigue

High relevance

Reishi · 2026 · Journal Article · International journal of biological macromolecules

Hydrogen sulfide maintains redox homeostasis and suppresses ganoderic acids biosynthesis under heat stress via persulfidating thioredoxin 1 in Ganoderma lucidum.

Hydrogen sulfide (H2S) is regarded as a novel gaseous signalling molecule with multiple physiological functions. Recently, the identification of persulfidated proteins has become a new hotspot in the analysis of the underlying mechanism of H2S..

High relevance

Shiitake · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Identification of Candidate Genes Associated with the Pileus-Deficient Phenotype in Lentinula edodes Through Comparative Genomic and Transcriptomic Analyses.

This study aimed to elucidate the molecular mechanisms underlying phenotypic divergence between two Lentinula edodes strains, Le_L and Le_S, which exhibit distinct fruiting body morphologies..

Metabolic health

High relevance

Cordyceps · 2026 · Journal Article · Analytical and bioanalytical chemistry

Identification of geographical origins of Ophiocordyceps sinensis (Berk.) via machine learning-assisted surface-enhanced Raman spectroscopy.

Ophiocordyceps sinensis (Berk.) is a functional food with health. O.

Cognition & nervesEnergy & fatigue

High relevance

Reishi · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Impact of Ganoderma lucidum fermentation and micro-pressure pulping on the structure, metabolism, and bioactivity of sugarcane bagasse.

Sugarcane bagasse (SB) is a typical lignocellulosic agricultural by-product with limited nutritional utilization due to its compact structure. This study investigated the effects of Ganoderma lucidum fermentation (GF) and micro-pressure pulping (MP) on the structural characteristics, metabolic profiles, and….

Metabolic health

High relevance

Lion's Mane · 2026 · Research Article · Foods (Basel, Switzerland)

Impact of Ginger Straw on Cultivation and Quality of Pleurotus geesteranus and Hericium erinaceus.

Against the backdrop of China's booming edible fungi industry, shortages and price hikes of traditional cultivation substrates have emerged as critical bottlenecks. Meanwhile, the disposal of a large amount of ginger straw produced during the ginger cultivation process is also a major challenge..

High relevance

Snow Fungus · 2026 · Journal Article · Ultrasonics sonochemistry

Impact of ultrasound-assisted enzymatic extraction on the structural and functional properties of Tremella fuciformis polysaccharide and its application in almond-based milk.

Ultrasound, when combined with enzymatic hydrolysis, distinctly influences the macromolecular structure of Tremella fuciformis polysaccharide, yielding a polysaccharide with improved functional properties..

Immune supportEnergy & fatigueSkin & hydration

High relevance

Reishi · 2026 · Research Article · Molecules (Basel, Switzerland)

In Vitro and In Vivo Evaluation of the Skincare Bioactivity of β-1,3;1,6-Glucans-Rich Ganoderma lucidum Polysaccharides.

Extracted from Ganoderma lucidum mycelium, the developed β-1,3;1,6-glucan rich polysaccharides have the potential to be used during the industrial production of health food products due to their inhibition of metabolic syndrome, immunomodulatory and antitumor activities and other health benefits..

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Chaga · 2026 · Research Article · Foods (Basel, Switzerland)

Inonotus obliquus Polysaccharides Prevent High-Fat Diet-Induced Obesity in Mice Related to Reshaping Gut Microbiota.

Obesity development is linked to disturbances in the gut microbiota. Inonotus obliquus polysaccharides (IOPs) have potential therapeutic efficacy in alleviating metabolic disorders.

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Cordyceps · 2026 · Journal Article · Food chemistry

Integrated metabolomics to systematically monitor quality indicators and metabolic dynamics in stored Ophiocordyceps sinensis.

Ophiocordyceps sinensis, a highly valued medicinal fungus, requires proper storage to maintain its commercial quality. To elucidate the underlying mechanisms of O.

Metabolic health

High relevance

Reishi · 2026 · Journal Article · International journal of biological macromolecules

Intestinal epithelial protection and gut microbiota modulation by Ganoderma lucidum proteoglycan are associated with its hypoglycemic potential in type 2 diabetes.

The interplay between gut microbiota, oxidative stress, and intestinal barrier integrity is increasingly recognized as a driving force in the progression of type 2 diabetes mellitus..

OncologyMetabolic healthGut & microbiome

High relevance

Shiitake · 2026 · Journal Article · Food chemistry

Lentinula edodes-derived exosome-like nanoparticles improve curcumin stability and biotransformation via gut microbiota interactions.

Exosome-like nanoparticles (ELNs) from edible sources are emerging as natural carriers for stabilizing bioactive compounds. This study investigated Lentinula edodes-derived ELNs (LeELNs) as a delivery system for curcumin..

Gut & microbiomeLiver support

High relevance

Oyster Mushroom · 2026 · Research Article · Food science & nutrition

Ligninolytic Enzyme Content of Mushroom Pleurotus ostreatus and Agaricus bisporus Extracts and In Vitro Rumen Fermentation of Fungal Extract-Treated Wheat Straw.

Mushrooms get nutrients from the soil fibrous substrates by producing enzymes (mainly laccases and manganese peroxidases) via the radical apparatus to attack lignin and cellulose..

High relevance

Snow Fungus · 2026 · Journal Article · Food chemistry

Mechanism of pH-driven gelation in Tremella fuciformis polysaccharide-soy protein isolate composite systems.

The gelling properties of soy protein isolate (SPI) are limited, but can be enhanced by adding polysaccharides, with their interactions strongly influenced by pH. This paper explored the effects of pH (5-9) on gel mechanisms of Tremella fuciformis polysaccharide (TFP)-SPI complexes..

Immune support

High relevance

Maitake · 2026 · Research Article · Food chemistry: X

Mechanistic insights into Grifola frondosa-driven fermentation of Rice-wheat bran: Metabolomic profiling, molecular dynamics, and enhanced antioxidant efficacy.

Rice bran (RB) and wheat bran (WB) are rich in bioactives but poorly utilized due to limited bioaccessibility. Here, a fungal fermentation strategy was developed to valorize RB-WB blends.

OncologyImmune supportEnergy & fatigue

High relevance

Reishi · 2026 · Research Article · BMC plant biology

Metabolomics analysis functional metabolites shaped by Ganoderma lucidum fermentation of daylily.

Edible fungi fermentation is an effective strategy for enhancing the functional value of traditional foods, while postbiotics offer multiple health benefits, primarily produced through heating..

Metabolic health

High relevance

Lion's Mane · 2026 · Journal Article · International journal of biological macromolecules

Metabolomics study on Hericium erinaceus polysaccharides in intervening ethanol induced gastric ulcer in mice.

Based on previous evidence indicating the gastroprotective potential of Hericium erinaceus polysaccharides (HEP), this study aimed to evaluate their protective effects against ethanol-induced gastric ulcers in mice and characterize the associated serum metabolic changes using an untargeted metabolomics approach..

Immune supportMetabolic health

High relevance

Oyster Mushroom · 2026 · Journal Article · International journal of medicinal mushrooms

Modulatory Effect of Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) Extract on uspA Gene Expression and Antibiotic Susceptibility of Staphylococcus aureus Exposed to Antibiotic Stress.

Mushrooms have been found to be one of the main sources of nutrients to man, but their nutraceutical approach to life science is still being studied. The proposed concept that mushrooms serve both as food and medicine has placed mushrooms as nutraceuticals..

High relevance

Oyster Mushroom · 2026 · Research Article · Applied microbiology and biotechnology

Molecular breeding alters mycelium material properties in the white-rot fungus Pleurotus ostreatus.

Mycelium-based materials derived from white-rot fungi have attracted increasing attention as sustainable and eco-friendly alternatives to conventional products. However, their mechanical strength and durability remain relatively inferior..

Energy & fatigue

High relevance

Yellow Morel · 2026 · Journal Article · Food chemistry

Morchella esculenta protein‑sodium alginate composite gels: Properties and formation mechanism.

Given the environmental and resource constraints associated with animal-derived foods, exploring alternative protein systems has become crucial for developing sustainable food structures..

High relevance

Lion's Mane · 2026 · Journal Article · Journal of biotechnology

Morphological and molecular characterization of Mexican Hericium erinaceus strains.

Hericium erinaceus is an edible and medicinal fungus recognized for its antimicrobial, antioxidant, anticancer, neuroprotective, and immunomodulatory properties. Despite its biological and biotechnological relevance, reports of this species in Mexico remain limited, with only one previous molecularly confirmed record….

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Oyster Mushroom · 2026 · Research Article · Plants (Basel, Switzerland)

Morphological Characterization and Metabolomic Analysis of the Inhibitory Effects of Pleurotus ostreatus Mycelium on Triticum aestivum L. Growth and Development.

With the continuous expansion of Pleurotus ostreatus cultivation, substantial quantities of post-harvest spent mushroom substrate (SMS) are generated. Improper disposal of this organic waste poses potential threats to soil health, including contamination and ecological imbalance..

Energy & fatigueGut & microbiome

High relevance

Reishi · 2026 · Research Article · Scientific reports

Multi-dimensional immunoprotection of Ganoderma lucidum spore oil in immunosuppressed mice via microbiome-proteome-metabolome network analysis.

Ganoderma lucidum has a long-standing history of use as a medicinal mushroom, with its spore oil (GLSO) extracted from broken cell walls using CO2 supercritical extraction..

Immune supportGut & microbiome

High relevance

Reishi · 2026 · Research Article · Journal of agricultural and food chemistry

Multiomics Analysis across the Life Cycle Identifies Zn2Cys6_61 as a Target for Enhancing Triterpenoid Production in Ganoderma lucidum.

Ganoderic acids (GAs) are high-value lanostane-type triterpenoids derived from Ganoderma lucidum (G. lucidum) with broad applications in functional foods and nutraceuticals, yet their low natural abundance limits industrial production..

High relevance

Reishi · 2026 · Research Article · Applied microbiology and biotechnology

N-Glycosylation of Band 3 is essential for the binding of Ganoderma lucidum immunomodulatory protein rLZ-8.

Fungal immunomodulatory proteins (FIPs) are considered potential therapeutic candidates due to their immunomodulatory and anti-cancer activities. Meanwhile, they are capable of agglutinating mammalian red blood cells in a manner similar to lectins..

OncologyImmune support

High relevance

Oyster Mushroom · 2026 · Research Article · Molecules (Basel, Switzerland)

Non-Volatile Bioactive Properties of Mushroom Extracts (Agaricus bisporus and Pleurotus ostreatus).

Sustainable food processing and zero-waste management of by-products require the search for natural functional ingredients that can be used in finished food products. Edible mushrooms are a rich source of non-volatile bioactive compounds, but their functionality in complex food matrices remains poorly understood..

High relevance

Oyster Mushroom · 2026 · Research Article · Foods (Basel, Switzerland)

Nutritional Improvement of Sugar-Snap Cookies Supplemented with Ganoderma sessile and Pleurotus ostreatus Solid-State Fermentation Flours.

Wheat and rice are major sources of human nutrition worldwide. Solid-state fermentation (SSF) with lignocellulolytic mushrooms can enhance their nutritional value and increase their functional properties.

Gut & microbiome

High relevance

Reishi · 2026 · Research Article · PloS one

Optimization of a natural fermentative medium for submerged mycelial culture of Ganoderma lucidum and the nutritional and bioactive composition of the cultured food-grade mycelia.

Ganoderma lucidum is a famous traditional Chinese medicinal fungus with health-promoting and pharmacological properties. The present study aimed to provide a liquid medium for G..

Immune support

High relevance

Shiitake · 2026 · Research Article · Scientific reports

Oral Lentinula edodes mycelia extract enhances the antitumor effect of radiotherapy via gut-associated activation of dendritic and cytotoxic T cells.

Oral administration of Lentinula edodes mycelia extract (L.E.M.) has been shown to stimulate systemic T cell-mediated antitumor immunity and inhibit tumor growth in mice, suggesting its potential to modulate host immune responses. However, the route of this systemic antitumor effect remains unclear..

OncologyImmune supportCognition & nervesGut & microbiome

High relevance

Snow Fungus · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Orchestrating the oriented fibrous architecture in high-moisture soy protein extrudates via Tremella fuciformis stem dietary fiber.

Plant-based meat alternatives have attracted increasing attention due to their sustainability and health benefits. However, high-moisture extrusion technology for soy protein often faces limitations in precisely controlling fibrous structure and texture..

High relevance

Lion's Mane · 2026 · Journal Article · International journal of clinical pharmacology and therapeutics

Peripheral nerve regeneration and synergistic pharmacology using Hericium erinaceus, lithium, and vitamin B12: The triple neuromodulatory axis hypothesis.

BACKGROUND: Peripheral nerve injuries (PNI) frequently result in incomplete functional recovery, creating a significant translational gap despite advances in surgical techniques. While Hericium erinaceus (H..

Cognition & nervesMetabolic health

High relevance

Mesima · 2026 · Research Article · American journal of cancer research

Phellinus linteus polysaccharides inhibit castration-resistant prostate cancer progression possibly via dual modulation of PIK3R1 and PGC-1α: a preclinical evaluation.

Castration-resistant prostate cancer (CRPC) remains a major challenge due to limited treatment options and frequent therapeutic resistance. This study demonstrates that Phellinus linteus polysaccharides (PLP), both in the form of drug-loaded serum and as a purified extract, exhibit potent anti-CRPC activity through a….

OncologyImmune supportEnergy & fatigueLiver support

High relevance

Lion's Mane · 2026 · Journal Article · Innovative Food Science and Emerging Technologies

Physical field extraction: The role of pH control in enhancing the efficiency and quality of Hericium erinaceus mycelium protein

There is growing interest in edible mushroom mycelia as a sustainable alternative protein source. However, the robust cell walls and complex cell matrix pose significant extraction challenges, and research on how combined physical and alkaline extraction techniques impact the structural and functional characteristics….

High relevance

Oyster Mushroom · 2026 · Journal Article · Food chemistry

Physicochemical and digestive properties of low-sodium bread enriched with Agaricus bisporus and Pleurotus ostreatus co-products.

The work explored the use of Agaricus bisporus (ABSF) and Pleurotus ostreatus (POSF) co-products as functional ingredients to partially or fully replace NaCl in bread (eight formulations, 0.5-6%; 50-100% replacement). Chemical, physicochemical, sensory, and in vitro digestion analyses were performed..

Metabolic healthGut & microbiome

High relevance

Lion's Mane · 2026 · Journal Article · Colloids and surfaces. B, Biointerfaces

Physicochemical properties and immunological effects of macrophage membrane-coated PLGA nanoparticles loaded with Hericium erinaceus polysaccharides.

In this study, we developed biomimetic Hericium erinaceus polysaccharides PLGA nanoparticles (NPs) coated with macrophage membrane (MM-PLGA-HEP) and examined their immune activity in vitro and in vivo..

OncologyImmune supportLiver support

High relevance

Oyster Mushroom · 2026 · Research Article · Frontiers in pharmacology

Pleurotus ostreatus ethanolic extract exerts anti-cancer effects via PI3K/Akt/mTOR pathway modulation in DMBA-NMU induced breast cancer in female Sprague Dawley rats.

Hormone receptor-positive Breast Cancer (BC) driven by PI3K/Akt/mTOR signaling remains a major therapeutic challenge, particularly in settings where conventional chemotherapy causes severe systemic and reproductive toxicity..

OncologyImmune support