MycoData

A chemical investigation on the fruiting bodies of Ganoderma lucidum led to the isolation and identification of five undescribed ergosteroids including two des-D-steroids (3 and 4) and one rare 6/6/7/5-fused carbon skeletal ergosterol (5) along with one 19-nor labdane-type diterpenoid (6)..

Immune support

High relevance

Enoki · 2024 · Journal Article · Food chemistry

Modulation of gut microbiota and metabolites by Flammulina velutipes polysaccharides during in vitro human fecal fermentation: Unveiling Bacteroides as a potential primary degrader.

Flammulina velutipes, a widely cultivated species of edible fungus, exhibits diverse functional activities attributed to its polysaccharides. In this study, we employed an in vitro model to investigate the impact of F..

Immune supportGut & microbiome

High relevance

Shiitake · 2024 · Journal Article · Microbiology and immunology

Modulatory effects of supplementation of Lentinula edodes mycelia extract and l-arginine on the therapeutic efficacy of immunogenic chemotherapy in colon cancer-bearing mice.

Some chemotherapeutic drugs can induce cancer cell death and enhance antitumor T-cell immunity in cancer-bearing hosts. Immunomodulatory reagents could augment such chemotherapy-induced effects..

OncologyImmune supportGut & microbiome

High relevance

Oyster Mushroom · 2024 · Research Article · Brazilian journal of microbiology: [publication of the Brazilian Society for Microbiology]

Multi-metal tolerant Porostereum umbrinoalutaceum isolated from Pleurotus ostreatus fruit body showing root colonization, growth promotion of chilli (Capsicum annuum L.) plant and antagonism against fungal pathogens.

Mushroom associated microbes could be utilized to improve crop productivity providing nutrients, plant growth promoting substances, production of hydrolytic enzymes and protecting plant from biotic and abiotic stress..

Gut & microbiome

High relevance

Shiitake · 2024 · Research Article · Foods (Basel, Switzerland)

Mushroom By-Products as a Source of Growth Stimulation and Biochemical Composition Added-Value of Pleurotus ostreatus, Cyclocybe cylindracea, and Lentinula edodes.

Spent mushroom substrates (SMSs) and mushroom basal bodies (MBBs) are significant by-products because of their nutrient content even after harvesting. This study aimed to evaluate the effect of these two by-products, derived from Agaricus bisporus (Ab) and Cyclocybe cylindracea (Cc) cultivation, as potential growth….

High relevance

Shiitake · 2024 · Journal Article · International journal of biological macromolecules

Near-gapless genome and transcriptome analyses provide insights into fruiting body development in Lentinula edodes.

Fruiting body development in macrofungi is an intensive research subject. In this study, high-quality genomes were assembled for two sexually compatible monokaryons from a heterokaryotic Lentinula edodes strain WX1, and variations in L.

Metabolic health

High relevance

Chaga · 2024 · Journal Article · Applied biochemistry and biotechnology

Necessity of Different Lignocellulose on Exopolysaccharide Synthesis and Its Hypoglycemic Activity In Vitro of Inonotus obliquus.

Current work proposes elm sawdust, poplar sawdust, pine sawdust, and cotton straw with different lignocellulose compositions and structures as the research objects to investigate the relationship between the hypoglycemic activity of mycelium polysaccharides from Inonotus obliquus and lignocellulose biodegradation..

Immune supportMetabolic health

High relevance

Lion's Mane · 2024 · Journal Article · Cell biochemistry and biophysics

Neuroprotective Effects of Dehydroepiandrosterone and Hericium erinaceus in Scopolamine-induced Alzheimer's Diseases-like Symptoms in Male Rats.

BACKGROUND: The neuroprotective effects of Dehydroepiandrosterone (DHEA) and Hericium erinaceus (H. erinaceus) mushroom extract against scopolamine-induced Alzheimer's disease-like symptoms in male Wistar rats were investigated.

Cognition & nerves

High relevance

Shiitake · 2024 · Journal Article · Journal of agricultural and food chemistry

Novel Catechol O-methyltransferases from Lentinula edodes Catalyze the Generation of Taste-Active Flavonoids.

Due to the increasing demand for natural food ingredients, including taste-active compounds, enzyme-catalyzed conversions of natural substrates, such as flavonoids, are promising tools to align with the principles of Green Chemistry..

High relevance

Oyster Mushroom · 2024 · Journal Article · Bioscience, biotechnology, and biochemistry

Novel compound, pleuropyronine, and other polyketides isolated from the edible mushroom Pleurotus ostreatus suppress bacterial biofilm formation.

An increase in the number of drug-resistant microbes is a major threat to human health. Bacterial drug resistance is mostly mediated by biofilm formation.

Immune support

High relevance

Reishi · 2024 · Journal Article · Letters in applied microbiology

Optimization and scaling up of extracellular polysaccharide production by submerged culture of Ganoderma lucidum on starch-containing medium using response surface methodology and laboratory bioreactors of various designs.

Basidiomycetes, known for their production of bioactive compounds, traditionally use simple sugars for fermentation. However, their ability to degrade complex plant polysaccharides through enzyme secretion presents potential for the use of renewable raw materials..

Immune support

High relevance

Oyster Mushroom · 2024 · Research Article · Foods (Basel, Switzerland)

Optimization of Mushroom (Agaricus bisporus and Pleurotus ostreatus) By-Products Processing for Prospective Functional Flour Development.

Stems are a major by-product of mushroom production. This study optimizes the transformation of Agaricus bisporus stems (ABS) and Pleurotus ostreatus stems (POS) into flour.

Energy & fatigueSkin & hydration

High relevance

Lion's Mane · 2024 · Research Article · Frontiers in plant science

Optimization of substrate formulation for Hericium erinaceus by replacing wood by straw and their effect on enzyme activities.

INTRODUCTION: China is rich in straw resources. The utilization of straw in the cultivation of edible fungi partially resolves the resource conflicts between mushroom cultivation and forest industry and also contributes to environmental protection..

High relevance

Reishi · 2024 · Research Article · PeerJ

Optimization of ultrasonic-assisted debittering of Ganoderma lucidum using response surface methodology, characterization, and evaluation of antioxidant activity.

BACKGROUND: Ganoderma lucidum (G. lucidum) has gained increasing attention as a potential health care product and food source.

High relevance

Turkey Tail · 2024 · Journal Article · Journal of the science of food and agriculture

Optimizing the degradation of aflatoxin B1 in corn by Trametes versicolor and improving the nutritional composition of corn.

BACKGROUND: Corn, being an important grain, is prone to contamination by aflatoxin B1 (AFB1 ), and AFB1 -contaminated corn severely endangers the health of humans and livestock. Trametes versicolor, a fungus that can grow in corn, possesses the ability to directly degrade AFB1 through its laccase..

High relevance

Mesima · 2024 · Journal Article · Nanoscale

Oral exosome-like nanovesicles from Phellinus linteus suppress metastatic hepatocellular carcinoma by reactive oxygen species generation and microbiota rebalancing.

The biomedical application of nanotechnology in cancer treatment has demonstrated significant potential for improving treatment efficiencies and ameliorating adverse effects..

OncologyEnergy & fatigueGut & microbiomeLiver support

High relevance

Snow Fungus · 2024 · Journal Article · International journal of biological macromolecules

Oral food-derived whey protein isolate-Tremella fuciformis polysaccharides pickering emulsions with adhesive ability to delivery magnolol for targeted treatment of ulcerative colitis.

Magnolol (Mag) is a promising natural compound with therapeutic potential for ulcerative colitis (UC). Here we designed and fabricated an oral food-grade whey protein isolate-Tremella fuciformis polysaccharides (WPI-TFPS) stabilized pickering emulsions to encapsulate Mag (Mag-WPI-TFPS) for targeted treatment of UC..

Immune supportGut & microbiomeLiver support

High relevance

Reishi · 2024 · Journal Article · Journal of Environmental Management

Partitioning Ganoderma lucidum residue biochar differentially boosts anaerobic fermentation performance of cow manure via mediation of anaerobic microbiota assembly

Biochar is a promising strategy to solve the problem of low efficiency and ammonia inhibition during anaerobic digestion (AD). However, the correlation between biochar partitioning and its stimulatory effects on AD remains uncertain..

Energy & fatigueGut & microbiome

High relevance

Reishi · 2024 · Journal Article · Journal of environmental management

Partitioning Ganoderma lucidum residue biochar differentially boosts anaerobic fermentation performance of cow manure via mediation of anaerobic microbiota assembly.

Energy & fatigueGut & microbiome

High relevance

Mesima · 2024 · Research Article · Cancer immunology, immunotherapy: CII

Phellinus linteus activates Treg cells via FAK to promote M2 macrophage polarization in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the most prevalent malignant tumor worldwide. Within HCC's tumor microenvironment, focal adhesion kinase (FAK) plays a critical role..

OncologyImmune supportLiver support

High relevance

Enoki · 2024 · Research Article · Food chemistry: X

Physicochemical properties and fermentation characteristics of a novel polysaccharide degraded from Flammulina velutipes residues polysaccharide.

Flammulina velutipes (F. velutipes) residues polysaccharide (FVRP) is a high molecular weight polysaccharide with diverse bioactivities extracted from F.

Immune supportGut & microbiome

High relevance

Lion's Mane · 2024 · Journal Article · Food Hydrocolloids

Physicochemical properties of polysaccharides from Hericium erinaceus by steam explosion pretreatment and its effects on human gut microbiota

Crude polysaccharides (HEP) extracted from Hericium erinaceus (H. erinaceus) using hot water soaking were focused in this study.

Immune supportGut & microbiome

High relevance

Oyster Mushroom · 2024 · Research Article · Current research in food science

Pleurotus ostreatus is a promising candidate of an edible 3D printing ink: Investigation of printability and characterization.

The 3D printing (3DP) technology shows great potential in the food industry, but the development of edible ink is currently insufficient. Pleurotus ostreatus (P.

High relevance

Oyster Mushroom · 2024 · Journal Article · Environmental pollution (Barking, Essex: 1987)

Pleurotus ostreatus polysaccharide-mediated modulation of skin damage caused by microcystin-LR in tadpoles.

In this study, we aimed to evaluate the effect of dietary supplementation with edible mushroom (Pleurotus ostreatus)-derived polysaccharides on microcystin leucine-arginine (MC-LR)-induced skin damage in Pelophylax nigromaculatus tadpoles..

OncologyImmune supportGut & microbiomeSkin & hydration

High relevance

Lion's Mane · 2024 · Research Article · Poultry science

Polysaccharide from Hericium erinaceus improved laying performance of aged hens by promoting yolk precursor synthesis and follicle development via liver-blood-ovary axis.

Little information is available on the effect of Hericium erinaceus polysaccharides (HEP) on laying hens, especially on improving liver and ovarian health and function..

Immune supportEnergy & fatigueMetabolic healthLiver support

High relevance

Reishi · 2024 · Journal Article · Carbohydrate polymers

Polysaccharide structure evaluation of Ganoderma lucidum from different regions in China based on an innovative extraction strategy

The polysaccharides and triterpenes are important functional components of Ganoderma lucidum, but traditional preparation process of G. lucidum functional components can only realize the preparation of single functional component, which has poor targeting and low efficiency..

Immune support

High relevance

Reishi · 2024 · Journal Article · Carbohydrate polymers

Polysaccharide structure evaluation of Ganoderma lucidum from different regions in China based on an innovative extraction strategy.

Immune support

High relevance

Maitake · 2024 · Journal Article · International journal of biological macromolecules

Polysaccharide with anticancer activity from Grifola frondosa cultured in industrial wastewater of Agaricus bisporus.

Culture conditions for Grifola frondosa using Agaricus bisporus industrial wastewater as a medium were optimized using Plackett-Burman and Box-Behnken methodologies. Plackett-Burman screening identified culture temperature, shaking speed, and wastewater solubility as the key factors influencing G.

OncologyImmune supportMetabolic healthLiver support

High relevance

Reishi · 2024 · Journal Article · International journal of biological macromolecules

Polysaccharides extraction from Ganoderma lucidum using a ternary deep eutectic solvents of choline chloride/guaiacol/lactic acid.

In this study, a purposefully formulated ternary deep eutectic solvents (DESs), consisting of choline chloride, guaiacol, and lactic acid in a molar ratio of 1:1:1, was synthesized for the extraction of polysaccharides from Ganoderma lucidum..

Immune supportEnergy & fatigueMetabolic health

High relevance

Lion's Mane · 2024 · Journal Article · International journal of biological macromolecules

Polysaccharides from an edible mushroom, Hericium erinaceus, alleviate ulcerative colitis in mice by inhibiting the NLRP3 inflammasomes and reestablish intestinal homeostasis.

This study aimed to assess the effects of polysaccharides extracted from Hericium erinaceus fruiting bodies (HEFPs) on the inflammatory response to oxidative stress in a mouse model of ulcerative colitis (UC) induced by ingestion of dextran sodium sulfate..

Immune supportGut & microbiome

High relevance

Lion's Mane · 2024 · Journal Article · International journal of biological macromolecules

Polysaccharides from Hericium erinaceus and its immunomodulatory effects on RAW 264.7 macrophages.

This study aimed to optimize the extraction of Hericium erinaceus polysaccharides (HEP) using ultrasound-assisted enzymatic extraction combined with Plackett-Burman design (PBD) and response surface methodology (RSM)..

Immune support

High relevance

Mesima · 2024 · Journal Article · International journal of biological macromolecules

Polysaccharides from Phellinus linteus attenuate type 2 diabetes mellitus in rats via modulation of gut microbiota and bile acid metabolism.

Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder. Polysaccharides from Phellinus linteus (PLP) have been found to have anti-diabetes effects, but the mechanism has not been elucidated..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Turkey Tail · 2024 · Research Article · Microorganisms

Polysaccharides from Trametes versicolor as a Potential Prebiotic to Improve the Gut Microbiota in High-Fat Diet Mice.

Polysaccharides derived from Trametes versicolor have been found to exhibit hypolipidemic activity in hyperlipidemic mice, but the mechanism by which they modulate intestinal flora is still unclear..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Maitake · 2024 · Journal Article · Journal of food science

Positive effect of peptide-calcium chelates from Grifola frondosa on a mouse model of senile osteoporosis.

Calcium supplementation has been shown to be efficacious in mitigating the progression of senile osteoporosis (SOP) and reducing the incidence of osteoporotic fractures resulting from prolonged calcium shortage..

Metabolic healthSkin & hydration

High relevance

Oyster Mushroom · 2024 · Journal Article · International journal of biological macromolecules

PoSnf1 affects cellulose utilization through interaction with cellobiose transporter in Pleurotus ostreatus.

Pleurotus ostreatus is one of the most cultivated edible fungi worldwide, but its lignocellulose utilization efficiency is relatively low (<50 %), which eventually affects the biological efficiency of P. ostreatus..

Energy & fatigue

High relevance

Oyster Mushroom · 2024 · Journal Article · International journal of biological macromolecules

Preparation, physicochemical and biological evaluation of chitosan Pleurotus ostreatus polysaccharides active films for food packaging.

The aim of this study was to create CS-POP composite films by blending Pleurotus ostreatus stalk polysaccharides (POP) and chitosan (CS). The effects of adding different concentrations (0 %, 0.25 %, 0.5 %, 0.75 %, and 1 %) of POP on the mechanical, barrier, and optical properties of the CS films were investigated..

Immune support

High relevance

Oyster Mushroom · 2024 · Journal Article · Food Research International

Preparation, structural characterization and neuroprotective effects to against H2O2-induced oxidative damage in PC12 cells of polysaccharides from Pleurotus Ostreatus

Pleurotus ostreatus is one of the most common edible and medicinal fungi in life, and its polysaccharide has been a hot research topic in recent years. In this paper, a new intracellular polysaccharide component named P.

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Snow Fungus · 2024 · Journal Article · International journal of biological macromolecules

Pressure-controlled steam explosion as pretreatment for efficient extraction of Tremella fuciformis polysaccharide: Structure and bioactivity.

Tremella fuciformis (TF) is a mushroom with rich nutritional and medicinal value. This study aimed to develop an efficient extraction technique for TF polysaccharide (TFP) to enhance its health benefits..

Immune supportMetabolic healthSkin & hydration

High relevance

Turkey Tail · 2024 · Journal Article · Journal of agricultural and food chemistry

Production of a Cheese-Like Aroma via Fermentation of Plant Proteins and Coconut Oil with the Basidiomycetes Cyclocybe aegerita and Trametes versicolor.

Cheese is one of the most common dairy products and is characterized by its complex aroma. However, in times of climate change and resource scarcity, the possibility to mimic the characteristic cheese-like aroma from plant-based sources is in demand to offer alternatives to cheese..

High relevance

Oyster Mushroom · 2024 · Journal Article · International journal of medicinal mushrooms

Progression Over Time of Nutritional Content and Antioxidant Activity of Grains Fermented with the Medicinal Mushrooms Pleurotus ostreatus and Ganoderma sessile (Agaricomycetes).

Solid-state fermentation of cereals with edible fungi is a promising strategy for producing functional flours. Hypothetically, the nutritional and functional properties of these flours could be modulated by manipulating substrate composition, fungal species, and incubation conditions..

High relevance

Reishi · 2024 · Research Article · BMC complementary medicine and therapies

Protective effect of Ganoderma lucidum-fermented crop extracts against hydrogen peroxide- or β-amyloid-induced damage in human neuronal SH-SY5Y cells.

BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of stacked β-amyloid peptides in the brain and associated with the generation of oxidative stress. So far, there is no cure for AD or a way to stop its progression..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Chaga · 2024 · Research Article · Heliyon

Protective effect of Inonotus obliquus polysaccharide on MGO-induced nonenzymatic glycation fibroblasts.

BACKGROUND: The nonenzymatic glycation of fibroblasts causes functional downregulation and behavioral disorders in the skin. METHODS: To investigate the effect of Inonotus obliquus on the nonenzymatic glycation of skin, we examined the inhibition of advanced glycation end products (AGEs) using four extraction methods:….

Immune supportEnergy & fatigueMetabolic healthSkin & hydration

High relevance

Chaga · 2024 · Journal Article · International journal of biological macromolecules

Protective effect of Inonotus obliquus polysaccharide on mice infected with Neospora caninum.

The study aimed to explore the protective effects of Inonotus obliquus polysaccharide (IOP) on Neospora caninum (N. caninum) infection.

OncologyImmune supportCognition & nervesLiver support

High relevance

Reishi · 2024 · Research Article · Frontiers in pharmacology

Protective effects of Ganoderma lucidum spores on estradiol benzoate-induced TEC apoptosis and compromised double-positive thymocyte development.

Backgroud: Thymic atrophy marks the onset of immune aging, precipitating developmental anomalies in T cells. Numerous clinical and preclinical investigations have underscored the regulatory role of Ganoderma lucidum spores (GLS) in T cell development..

OncologyImmune support

High relevance

Oyster Mushroom · 2024 · Research Article · 3 Biotech

Purification, characterization of laccase from Pleurotus ostreatus HK35, and optimization for congo red biodecolorization using Box-Behnken design.

UNLABELLED: This study is the first report on purification, characterization, and application of laccase derived from the white-rot fungus, Pleurotus ostreatus HK35 (Hungary strain), in Congo Red decolorization..

High relevance

Oyster Mushroom · 2024 · Research Article · PloS one

Quantitative trait loci analysis for molecular markers linked to agricultural traits of Pleurotus ostreatus.

Pleurotus ostreatus is a global mushroom crop with nutritional and medicinal benefits. However, the genetic basis of several commercial traits remains unknown.

High relevance

Reishi · 2024 · Journal Article · Journal of agricultural and food chemistry

Rapid Discovery of Aβ42 Fibril Disintegrators from Ganoderma lucidum via Ligand Fishing and Their Neuroprotective Effects on Alzheimer's Disease.

An amyloid-β (Aβ) fibril is a vital pathogenic factor of Alzheimer's disease (AD). Aβ fibril disintegrators possess great potential to be developed into novel anti-AD agents..

OncologyCognition & nerves

High relevance

Cordyceps · 2024 · Research Article · Current research in food science

Rapid discrimination between wild and cultivated Ophiocordyceps sinensis through comparative analysis of label-free SERS technique and mass spectrometry.

Ophiocordyceps sinensis is a genus of ascomycete fungi that has been widely used as a valuable tonic or medicine. However, due to over-exploitation and the destruction of natural ecosystems, the shortage of wild O.

Cognition & nervesEnergy & fatigueMetabolic health

High relevance

Zhu Ling · 2024 · Journal Article · Phytochemical analysis: PCA

Rapid screening, isolation, and activity evaluation of potential xanthine oxidase inhibitors in Polyporus umbellatus and mechanism of action in the treatment of gout.

INTRODUCTION: Studies show that Polyporus umbellatus has some pharmacological effects in enhancing immunity and against gout. OBJECTIVES: We aimed to establish new techniques for extraction, biological activity screening, and preparation of xanthine oxidase inhibitors (XODIs) from P.

Immune support

High relevance

Oyster Mushroom · 2024 · Journal Article · Preparative biochemistry & biotechnology

Recovery and partial purification of fibrinolytic protease from Pleurotus ostreatus and P. eryngii and cytotoxic and antioxidant activity of their extracts.

Mushrooms are a source of primary and secondary metabolites. Little is known about the most suitable conditions for production of mushrooms by submerged fermentation..

Oncology