MycoData

The understanding of the molecular mechanisms of the immune tolerance induced by the tumoral microenvironment is fundamental to prevent cancer development or to treat cancer patients using immunotherapy. Actually, there are investigations about "addressed-drugs" against cancer cells without affecting normal cells..

OncologyImmune support

High relevance

Cordyceps · 2014 · Review Article · Journal of functional foods

Recent advances in Cordyceps sinensis polysaccharides: Mycelial fermentation, isolation, structure, and bioactivities: A review.

Cordyceps (Ophiocordyceps sinensis) sinensis, the Chinese caterpillar fungus, is a unique and precious medicinal fungus in traditional Chinese medicine which has been used as a prestigious tonic and therapeutic herb in China for centuries. Polysaccharides are bioactive constituents of C..

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2026 · Review · Molecules (Basel, Switzerland)

Medicinal Mushrooms and Their Bioactive Compounds: From Traditional Use to Therapeutic Potential.

Medicinal mushrooms have become an important component of modern dietary supplementation and functional nutrition due to their diverse biological activities and long-standing use in traditional medicine..

OncologyImmune support

High relevance

Cordyceps · 2025 · Review · Frontiers in nutrition

Effects of fungal supplementation on endurance, immune function, and hematological profiles in adult athletes: a systematic review and meta-analysis.

Edible fungi are rich in a wide array of bioactive compounds, and a growing body of evidence suggests that they possess anti-inflammatory, antioxidant, antitumor, anti-aging, and other beneficial properties..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Niu-Chang-Chih · 2025 · Review · Naunyn-Schmiedeberg's archives of pharmacology

Unlocking the biological potential of methyl antcinate A: a new frontier in cancer and inflammation application.

Antrodia camphorata is a valued and scarce parasitic mushroom that exclusively proliferates on the inner cavity wall of the endangered tree Cinnamomum kanehirai Hay (Lauraceae), endemic to Taiwan..

OncologyImmune supportMetabolic healthLiver support

High relevance

Reishi · 2024 · Review · Mycology

Bibliometric, taxonomic, and medicinal perspectives of Ganoderma neo-japonicum Imazeki: A mini review.

Ganoderma, a traditional medicine in Asian countries, has been used to prevent and treat various ailments for centuries. Ganoderma neo-japonicum (synonym Ganoderma bambusicola), also known as purple Lingzhi, is a species that is currently underutilised when compared to Ganoderma lucidum (Lingzhi)..

OncologyImmune supportMetabolic healthLiver support

High relevance

Maitake · 2023 · Journal Article · Life sciences

Maitake α-glucan promotes differentiation of monocytic myeloid-derived suppressor cells into M1 macrophages.

AIMS: Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment and systemically accumulate in tumor-bearing hosts and patients with cancer, facilitating cancer progression..

OncologyImmune support

High relevance

Cordyceps · 2023 · Journal Article · International journal of medicinal mushrooms

Polysaccharide Elicitors Affect the Yield, Polysaccharide Synthase and Antibacterial Activity of Intracellular Polysaccharides from Submerged Culture of Cordyceps milifaris (Ascomycetes).

This study aimed to increase the yield of Cordyceps militaris intracellular polysaccharide (IPS) by adding elicitors. By comparing the effects of different elicitors on the IPS yield, three polysaccharide elicitors with significant promoting effect were screened out: Tween 80, pH, and vitamin B6 (VB6)..

Immune support

High relevance

Cordyceps · 2019 · Review Article · Molecules (Basel, Switzerland)

Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi.

Cordycepin(3'-deoxyadenosine), a cytotoxic nucleoside analogue found in Cordyceps militaris, has attracted much attention due to its therapeutic potential and biological value. Cordycepin interacts with multiple medicinal targets associated with cancer, tumor, inflammation, oxidant, polyadenylation of mRNA, etc..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Anti-Gastric Ulcer Activity of Polysaccharide Fraction Isolated from Mycelium Culture of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes).

Hericium erinaceus is a culinary-medicinal mushroom that is used in traditional medicine, in folk medicine, and as medicinal cuisine in Asian countries such as China, Japan, and Korea. H..

OncologyImmune supportCognition & nerves

High relevance

Niu-Chang-Chih · 2015 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Anti-inflammatory effects of Antrodia camphorata, a herbal medicine, in a mouse skin ischemia model.

ETHNOPHARMACOLOGICAL EVIDENCE: Antrodia camphorata, a highly valued polypore mushroom native only to Taiwan, has been traditionally used as a medicine for anti-inflammation..

Immune supportSkin & hydration

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Antihyperlipidemic and hepatoprotective activities of residue polysaccharide from Cordyceps militaris SU-12.

Cordyceps militaris has been artificially cultivated in China, and the great amounts of produced medium residue were discarded after the harvest. The aims of this work were to analyze the structure of the residue polysaccharide (RPS) of C..

Immune supportMetabolic healthLiver support

High relevance

King Oyster · 2015 · Research Support, Non U.S. Gov'T · Microbiological research

Characterization of the wzc gene from Pantoea sp. strain PPE7 and its influence on extracellular polysaccharide production and virulence on Pleurotus eryngii.

To characterize of the pathogenicity gene from the soft rot pathogen Pantoea sp. PPE7 in Pleurotus eryngii, we constructed over 10,000 kanamycin-resistant transposon mutants of Pantoea sp.

Immune support

High relevance

Chaga · 2015 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal "mushroom".

ETHNOPHARMACOLOGICAL RELEVANCE: In Russian traditional medicine, an extract from the mushroom Inonotus obliquus (Fr.) Pil´at is used as an anti-tumor medicine and diuretic. It has been reported that Inonotus obliquus has therapeutic effects, such as anti-inflammatory, immuno-modulatory and hepatoprotective effects..

OncologyImmune supportLiver support

High relevance

Almond Mushroom · 2015 · Research Support, Non U.S. Gov'T · Molecular medicine reports

Chitosan oligosaccharides in combination with Agaricus blazei Murill extract reduces hepatoma formation in mice with severe combined immunodeficiency.

Chitosan and Agaricus blazei Murill (ABM) extracts possess antitumor activities. The aim of the present study was to investigate whether chitosan, ABM extract or the two in combination were effective against tumors in tumor‑bearing mice..

OncologyImmune supportLiver support

High relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · Molecular medicine reports

Composition and antioxidant activity of water-soluble oligosaccharides from Hericium erinaceus.

Oligosaccharide are carbohydrate molecules, comprising repeating units joined together by glycosidic bonds. In recent years, an increasing number of oligosaccharides have been reported to exhibit various biological activities, including antitumor, immune-stimulation and antioxidation effects..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Almond Mushroom · 2015 · Research Support, Non U.S. Gov'T · Malaria journal

Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria.

BACKGROUND: Cerebral malaria (CM) is debilitating and sometimes fatal. Disease severity has been associated with poor treatment access, therapeutic complexity and drug resistance and, thus, alternative therapies are increasingly necessary..

Immune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Natural product communications

Ergosterol of Cordyceps militaris Attenuates LPS Induced Inflammation in BV2 Microglia Cells.

Different solvent extracts of Cordyceps militaris stroma powder were tested for cell viability and inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS) triggered BV2 microglia cells. Chemical investigation of the ethyl acetate fraction resulted in an enriched ergosterol sub-fraction CE3..

OncologyImmune support

High relevance

Chaga · 2015 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer.

AIM OF THE STUDY: In this study, we examined the effect of different fractions and components of Chaga mushroom (Inonotus Obliquus) on viability and apoptosis of colon cancer cells. Among them, one component showed the most effective growth inhibition and was identified as ergosterol peroxide by NMR analysis..

OncologyImmune supportGut & microbiome

High relevance

Shiitake · 2015 · Research Support, Non U.S. Gov'T · Gene

Expression and functional analysis of novel molecule - Latcripin-13 domain from Lentinula edodes C91-3 produced in prokaryotic expression system.

The shiitake mushroom Lentinula edodes has health benefits and is used to treat various diseases due to its immunomodulatory and antineoplastic properties. In the present study, the Latcripin-13 domain, isolated from L.

OncologyImmune supportRespiratory

High relevance

Maitake · 2015 · Research Support, Non U.S. Gov'T · Food & function

Hypoglycemic effects of Grifola frondosa (Maitake) polysaccharides F2 and F3 through improvement of insulin resistance in diabetic rats.

Our laboratory has previously demonstrated that Grifola frondosa polysaccharides (GFPs) showed hypoglycemic effects. This study aimed to investigate which polysaccharide-enriched fractions of GFPs were the main active constituents, and to disclose their hypoglycemic mechanism..

Immune supportMetabolic healthLiver support

High relevance

King Oyster · 2015 · Research Support, Non U.S. Gov'T · ACS applied materials & interfaces

MicroRNA Replacing Oncogenic Klf4 and c-Myc for Generating iPS Cells via Cationized Pleurotus eryngii Polysaccharide-based Nanotransfection.

Induced pluripotent stem cells (iPSCs), resulting from the forced expression of cocktails out of transcription factors, such as Oct4, Sox2, Klf4, and c-Myc (OSKM), has shown tremendous potential in regenerative medicine..

Immune support

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Protective Efficacy of the Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes), from India in Neuronal Hippocampal Cells against Hypoxia.

This study demonstrated the protective efficiency of extracts of the Indian variety of Ophiocordyceps sinensis (=Cordyceps sinensis) (CSEs) in HT22 (murine hippocampal) cells under hypoxic conditions..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Molecular medicine reports

Purification of polysaccharides from Cordyceps militaris and their anti‑hypoxic effect.

Acute mountain sickness, one of the most common altitude diseases, causes lung and brain injury. The present study aimed to investigate the anti‑hypoxic effect of purified polysaccharides extracted from Cordyceps militaris..

Immune supportCognition & nervesRespiratory

High relevance

Maitake · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Submerged-Culture Mycelia and Broth of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes) Alleviate Type 2 Diabetes-Induced Alterations in Immunocytic Function.

Type 2 Diabetes mellitus (T2DM), a disease with impaired glucose, protein and lipid metabolism, low-grade chronic inflammation, and immune dysfunction, is a global public health crisis. We previously demonstrated that Grifola frondosa has bioactivities in improving glycemic responses in diabetic rats..

OncologyImmune supportMetabolic health

High relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages.

Chronic low-grade inflammation in the adipose tissue accompanying obesity is thought to be an underlying driver of metabolic diseases. In this study, we aimed to investigate the efficacy of Hericium erinaceus on adipose tissue inflammation.

OncologyImmune supportMetabolic health

High relevance

Almond Mushroom · 2015 · Research Support, Non U.S. Gov'T · Journal of medicinal food

The polar high molecular weight fraction of the Agaricus blazei Murill extract, AndoSan™, reduces the activity of the tumor-associated protease, legumain, in RAW 264.7 cells.

AndoSan™ is an extract of Agaricus blazei Murill (AbM; 82.4%), Hericium erinaceum (14.7%), and Grifola frondosa (2.9%). The main ingredient of AndoSan, AbM, is rich in different forms of β-glucans..

OncologyImmune supportMetabolic health

High relevance

Chaga · 2014 · English Abstract · Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

[Prevention of Inonotus obliquus polysaccharides for high power microwave radiation induced testicular injury in rats: an experimental research].

OBJECTIVE: To investigate the effect of Inonotus obliquus polysaccharides on testicular injury induced by exposure to high power microwave (HPM) in rats. METHODS: A total of 30 male Wistar rats were randomly divided into 5 groups, i.e., the normal control group, the microwave radiation model group, the treatment….

Immune supportEnergy & fatigueMetabolic health

High relevance

Maitake · 2014 · Research Support, Non U.S. Gov'T · Glycoconjugate journal

A polysaccharide from Grifola frondosa relieves insulin resistance of HepG2 cell by Akt-GSK-3 pathway.

Grifola frondosa is an important fungal research resource. However, there was little report about hyperglycemic activity of Grifola frondosa polysaccharide on insulin resistance in vitro..

Immune supportMetabolic health

High relevance

Almond Mushroom · 2014 · Research Support, Non U.S. Gov'T · Molecules (Basel, Switzerland)

Agaricus blazei hot water extract shows anti quorum sensing activity in the nosocomial human pathogen Pseudomonas aeruginosa.

The edible mushroom Agaricus blazei Murill is known to induce protective immunomodulatory action against a variety of infectious diseases. In the present study we report potential anti-quorum sensing properties of A.

Immune supportEnergy & fatigue

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Antioxidant activity of polysaccharide extracted from Pleurotus eryngii using response surface methodology.

Ultrasonic technology was applied for polysaccharide extraction from the fruiting bodies of P. Eryngii, and response surface methodology (RSM) was used to optimize the effects of processing parameters on polysaccharide extraction yield..

Immune supportEnergy & fatigue

High relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

Antioxidant and immunomodulatory activities of a polysaccharide from Flammulina velutipes.

OBJECTIVE: To evaluate the antioxidant and immunomodulatory activities of a unique polysaccharide from the medicinal fungus Flammulina velutipes in vitro. METHODS: Using water extraction and alcohol precipitation, crude polysaccharides were obtained..

OncologyImmune supportEnergy & fatigue

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Journal of the science of food and agriculture

Antiproliferative and immunostimulatory activity of a protein from Pleurotus eryngii.

BACKGROUND: Currently, the use of mushrooms as functional foods, nutraceuticals or phytopharmaceuticals source has risen. In contrast, the possible cellular cytotoxicity and immunostimulatory activity of Pleurotus eryngii (DC.

OncologyImmune supportLiver supportRespiratory

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Changes in chemical components and cytotoxicity at different maturity stages of Pleurotus eryngii fruiting body.

The present study investigated the changes of the chemical components and cytotoxicity potency at 5 developmental stages of Pleurotus eryngii fruiting body. The carbohydrate and protein contents increased along the maturity of fruiting body while fat content decreased..

OncologyImmune support

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Food & function

Chemical composition of Pleurotus eryngii polysaccharides and their inhibitory effects on high-fructose diet-induced insulin resistance and oxidative stress in mice.

High intake of dietary fructose exerts a number of adverse metabolic effects. The present study investigates the preventive effects of Pleurotus eryngii polysaccharides (PEP), which showed powerful antioxidant activity in vitro, on insulin resistance and oxidative stress in mice fed a high-fructose diet..

Immune supportMetabolic healthLiver support

High relevance

Almond Mushroom · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Drying effects on the antioxidant properties of polysaccharides obtained from Agaricus blazei Murrill.

Three polysaccharides (ABMP-F, ABMP-V, ABMP-A) were obtained from Agaricus blazei Murrill via methods such as freeze drying, vacuum drying and air drying, respectively..

Immune support

High relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · TheScientificWorldJournal

Effect of Antrodia camphorata on inflammatory arterial thrombosis-mediated platelet activation: the pivotal role of protein kinase C.

Antrodia camphorata is a rare Taiwanese medicinal mushroom. Antrodia camphorata extract has been reported to exhibit antioxidant, anti-inflammation, antimetastasis, and anticancer activities and plays a role in liver fibrosis, vasorelaxation, and immunomodulation..

OncologyImmune supportMetabolic healthLiver support

High relevance

Almond Mushroom · 2014 · Comparative Study · Biological trace element research

Effects of selenium-enriched Agaricus blazei Murill on liver metabolic dysfunction in mice, a comparison with selenium-deficient Agaricus blazei Murill and sodium selenite.

In the present study, we investigated the effects of Se-enriched Agaricus blazei Murill (Se-AbM) on liver injury in mice induced by acute alcohol administration. Mice received ethanol (5 g/kg body weight (BW)) by gavage every 12 h for a total of 3 doses.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · BioMed research international

Hypolipidemic and antioxidant activity of enoki mushrooms (Flammulina velutipes).

According to the literatures, Flammulina velutipes contains biologically active components such as dietary fiber, polysaccharide, and mycosterol, whose effects in reducing blood sugar, blood pressure, and cholesterol have been proven..

Immune supportMetabolic healthLiver support

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Immunopotentiation of Pleurotus eryngii (DC. ex Fr.) Quel.

ETHNOPHARMACOLOGICAL RELEVANCE: Pleurotus eryngii (DC. ex Fr.) Quel has been collected from the wild, cultivated and used in traditional medicines to treat various disorders and diseases since antiquity..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Shiitake · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Lentinan degradation in the Lentinula edodes fruiting body during postharvest preservation is reduced by downregulation of the exo-β-1,3-glucanase EXG2.

Lentinan from Lentinula edodes fruiting bodies (shiitake mushrooms) is a valuable β-glucan for medical purposes based on its anticancer activity and immunomodulating activity. However, lentinan content in fruiting bodies decreases after harvesting and storage due to an increase in glucanase activity..

OncologyImmune support

High relevance

Snow Fungus · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Molecular cloning and function characterization of a new macrophage-activating protein from Tremella fuciformis.

Silver ear mushroom ( Tremella fuciformis ) is an edible fungus with health benefits. In this study, we purified a new T.

Immune support

High relevance

Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · International journal of molecular sciences

Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine.

Hericium erinaceus, an edible mushroom, has been demonstrated to potentiate the effects of numerous biological activities. The aim of this study was to investigate whether H..

OncologyImmune supportCognition & nerves

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Purification, characterization and antitumor activity of polysaccharides from Pleurotus eryngii residue.

A novel water-soluble polysaccharide from Pleurotus eryngii residue was isolated and further purified by DEAE cellulose-52 chromatography and Sephadex G-100 size-exclusion chromatography to yield PEPE-1, PEPE-2 and PEPE-3. Molecular weights were determined by high-performance size-exclusion chromatography (HPSEC)..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

The excreted polysaccharide of Pleurotus eryngii inhibits the foam-cell formation via down-regulation of CD36.

Previous study has verified the polysaccharide from the fruiting body of Pleurotus eryngii (PEPE) is capable of decreasing the lipid content in both of cell-line and mouse model. However, little is known about underlying mechanisms and whether this bioactive polysaccharide exists in submerged culture..

Immune supportMetabolic healthGut & microbiome

High relevance

Almond Mushroom · 2014 · Research Support, Non U.S. Gov'T · BioMed research international

The protective effect of Agaricus blazei Murrill, submerged culture using the optimized medium composition, on alcohol-induced liver injury.

Agaricus blazei Murrill (ABM), an edible mushroom native to Brazil, is widely used for nonprescript and medicinal purposes. Alcohol liver disease (ALD) is considered as a leading cause for a liver injury in modern dietary life, which can be developed by a prolonged or large intake of alcohol..

Immune supportMetabolic healthLiver support

High relevance

Chaga · 2013 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Aqueous extract from a Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), prevents herpes simplex virus entry through inhibition of viral-induced membrane fusion.

Chaga medicinal mushroom, Inonotus obliquus, a popular prescription in traditional medicine in Europe and Asia, was used to reduce inflammation in the nasopharynx and to facilitate breathing. The aqueous extract from I..

OncologyImmune supportRespiratory

High relevance

Maitake · 2013 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Characterization of a novel maitake (Grifola frondosa) protein that activates natural killer and dendritic cells and enhances antitumor immunity in mice.

Grifola frondosa, also known as maitake, is a culinary mushroom with immune-enhancing and antitumor effects. Numerous studies have investigated the activity of maitake polysaccharide extracts, but studies of maitake proteins are scarce.

OncologyImmune support

High relevance

King Oyster · 2013 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Characterization of polysaccharides with marked inhibitory effect on lipid accumulation in Pleurotus eryngii.

Mushrooms have a great potential for the production of useful bioactive metabolites. To explore the bioactive compounds from edible mushrooms for interfering with the development of macrophage-derived foam cells, which is recognized as the hallmark of early atherosclerosis, eight types of mushrooms polysaccharides had….

Immune supportMetabolic health

High relevance

Cordyceps · 2013 · Comparative Study · Journal of ethnopharmacology

Comparisons on enhancing the immunity of fresh and dry Cordyceps militaris in vivo and in vitro.

ETHNOPHARMACOLOGICAL RELEVANCE: The immunomodulatory capacities of fresh Cordyceps militaris (FCM) and dry Cordyceps militaris (DCM) were compared. MATERIALS AND METHODS: In vivo immunomodulatory assay, different doses of FCM and DCM were orally administrated over a period of 15 days in a cyclophosphamide (CY) induced….

Immune support