MycoData
Medicinal fungi research database
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Species record
Oyster Mushroom
Pleurotus ostreatus
- Studies
- 1,947
- Avg relevance
- 53
- Latest
- 2026
Species record
Reishi · Lingzhi
Ganoderma lucidum
- Studies
- 1,830
- Avg relevance
- 60
- Latest
- 2026
Species record
Turkey Tail · Yun Zhi
Trametes versicolor
- Studies
- 1,828
- Avg relevance
- 41
- Latest
- 2026
Species record
Shiitake · Hua Gu
Lentinula edodes
- Studies
- 1,766
- Avg relevance
- 60
- Latest
- 2026
Species record
Cordyceps · Scarlet Club
Cordyceps militaris
- Studies
- 1,635
- Avg relevance
- 67
- Latest
- 2026
Species record
Cordyceps · Caterpillar Fungus
Ophiocordyceps sinensis
- Studies
- 1,576
- Avg relevance
- 59
- Latest
- 2026
Species record
Almond Mushroom · ABM
Agaricus blazei
- Studies
- 1,441
- Avg relevance
- 54
- Latest
- 2026
Species record
Enoki · Winter Mushroom
Flammulina velutipes
- Studies
- 1,403
- Avg relevance
- 47
- Latest
- 2026
Species record
King Oyster · Eryngii
Pleurotus eryngii
- Studies
- 1,278
- Avg relevance
- 60
- Latest
- 2026
Species record
Maitake · Hen of the Woods
Grifola frondosa
- Studies
- 1,276
- Avg relevance
- 48
- Latest
- 2026
Species record
Snow Fungus · Silver Ear
Tremella fuciformis
- Studies
- 1,052
- Avg relevance
- 29
- Latest
- 2026
Species record
Lion's Mane · Yamabushitake
Hericium erinaceus
- Studies
- 862
- Avg relevance
- 67
- Latest
- 2026
Species record
Chaga
Inonotus obliquus
- Studies
- 738
- Avg relevance
- 65
- Latest
- 2026
Species record
Mesima · Sanghwang
Phellinus linteus
- Studies
- 722
- Avg relevance
- 58
- Latest
- 2026
Species record
Niu-Chang-Chih
Antrodia camphorata
- Studies
- 496
- Avg relevance
- 63
- Latest
- 2026
Species record
Nameko · Nametake
Pholiota microspora
- Studies
- 421
- Avg relevance
- 29
- Latest
- 2026
Species record
Yellow Morel
Morchella esculenta
- Studies
- 392
- Avg relevance
- 42
- Latest
- 2026
Species record
Zhu Ling · Umbrella Polypore
Polyporus umbellatus
- Studies
- 263
- Avg relevance
- 55
- Latest
- 2026
Species record
Wood Ear · Kikurage
Auricularia auricula-judae
- Studies
- 254
- Avg relevance
- 51
- Latest
- 2026
Species record
Agarikon · Quinine Conk
Fomitopsis officinalis
- Studies
- 47
- Avg relevance
- 55
- Latest
- 2026
Articles
17,669 results
Showing 201–250 of 17,669
Chaga · 2025 · Journal Article · Meat science
Effects of dietary Inonotus obliquus fermentation products supplementation on meat quality and antioxidant capacity of finishing pigs.
This study aimed to investigate the supplementation of finishing pigs with Inonotus obliquus fermentation products (IOFP) on the meat quality, amino acid and fatty acid composition, muscle fiber characteristics, and antioxidant capacity..
Cordyceps · 2025 · Journal Article · International journal of biological macromolecules
Effects of ethanol extracts of Lycium chinense berry fruit on the production, structure and bioactivity of exopolysaccharides in Cordyceps militaris.
The addition of ethanol extracts from traditional Chinese medicine effectively promotes the production of exopolysaccharides (EPSs) through liquid fermentation of fungi. The impact of these extracts on the structure and activity of EPSs warrants further investigation..
Enoki · 2025 · Review · Journal of the science of food and agriculture
Effects of Flammulina velutipes powder on the emulsion properties of chicken myofibrillar protein under low-salt conditions.
This study aimed to investigate the influence of varying concentrations of Flammulina velutipes powder (FVP) (0, 4, 8, 12, 16, and 20 g L-1, based on FVP weight per liter of emulsion) on the stability, rheological properties, microstructure, and interfacial protein content of chicken myofibrillar protein (MP)….
Reishi · 2025 · Journal Article · International journal of biological macromolecules
Effects of Ganoderma lucidum fermentation on the structure of Tartary buckwheat polysaccharide and its impact on gut microbiota composition.
Fermentation modifies plant polysaccharides and enhances their bioactivity. In this study, polysaccharides were extracted from Ganoderma lucidum-fermented (FBP) and non-fermented (NBP) Tartary buckwheat.
King Oyster · 2025 · Research Article · Biomedicines
Effects of In Vitro Fermented Pleurotus eryngii on Intestinal Barrier Integrity and Immunomodulation in a Lipopolysaccharide-Induced Colonic Model.
Background: This study investigates the impact of fermentation supernatants (FSs) from Pleurotus eryngii whole mushrooms (PEWS), as well as its subcomponents, digested (PEWSD) and extracted (PEWSE) forms, on intestinal barrier function and immune modulation in lipopolysaccharide (LPS) -stimulated Caco-2 cells..
Reishi · 2025 · Journal Article · International journal of medicinal mushrooms
Effects of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Triterpene on Motor and Spatial Learning Disorders in 5xFAD Mice.
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that gradually destroys cognitive, memory, and thinking skills. Although increasing evidence has demonstrated that Ganoderma lucidum triterpenoids (GLT) can ameliorate the motor and spatial learning disorders of AD, the underlying mechanism remains….
Cordyceps · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire
Effects of selenium enrichment on the nutritional components, metabolites, and flavor volatiles of fermented Cordyceps militaris juice
Selenium (Se) enrichment changes the nutritional composition and secondary metabolites of Cordyceps militaris (CM), but its effect on the fermentation process of CM is still unclear..
Almond Mushroom · 2025 · Research Article · Scientific reports
Effects of selenium nanoparticles on cadmium uptake, selenium transformation, and metabolomics in Agaricus Blazei murill.
Selenium nanoparticles (Se NPs) primarily reduce cadmium content in plants. However, the mechanism by which Se NPs affect the Cd content in edible mushrooms is unknown.
Turkey Tail · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire
Effects of Trametes versicolor fermented Rosa roxburghii Tratt and Coix seed complex on the physicochemical properties, microstructure, and shelf-life prediction of yogurt
Edible fungi fermentation enhances flavor and physicochemical properties of raw materials, yet its application in yogurt is underexplored. This study investigated changes in flavor, physicochemical properties, rheological, and structural characteristics of yogurt made with a Rosa roxburghii Tratt and Coix seed complex….
Cordyceps · 2025 · Research Article · Mycoscience
Efficient generation of uridine/uracil auxotrophic mutants in homokaryotic Cordyceps militaris strains for constructing a food-grade expression platform.
Cordyceps militaris is a well-known medicinal mushroom widely exploited in traditional medicine and nutraceuticals. In this study, we aim to establish a new platform for improving the production of beneficial ingredients in this fungus..
Chaga · 2025 · Research Article · International journal of molecular sciences
Elucidating the Anti-Diabetic Mechanisms of Mushroom Chaga (Inonotus obliquus) by Integrating LC-MS, Network Pharmacology, Molecular Docking, and Bioinformatics.
Diabetes mellitus is characterized by insulin resistance, impaired glucose homeostasis, and dysregulated glucose metabolism, leading to complications. Inonotus obliquus (Chaga) has shown potential anti-diabetic effects, but the bioactive compounds and molecular targets remain unclear..
Oyster Mushroom · 2025 · Journal Article · Innovative Food Science and Emerging Technologies
Enhanced extraction of Pleurotus ostreatus polysaccharides via plasma-ultrasound synergy: Kinetics modeling and functional characterization
The limitations of traditional extraction methods in terms of efficiency and environmental sustainability have highlighted the urgent need for advancements in extraction technology..
Reishi · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire
Enhancement of grindability and physicochemical properties of Ganoderma lucidum through steam explosion and its impact on quality characteristics of wheat dough
Steam explosion (SE) was applied to enhance the grinding performance and physicochemical properties of Ganoderma lucidum (GL), and the effects of steam-exploded Ganoderma lucidum powders (SGL) on quality characteristics of wheat dough were investigated..
Oyster Mushroom · 2025 · Research Article · BMC plant biology
Enhancing Pearl oyster mushroom (Pleurotus ostreatus (Jacq.) P. Kumm) performance by evaluating the influence of potassium humate and wheat straw on yield and biochemical attributes.
This study investigated the effects of various combinations of potassium humate and raw wheat straw (RWS) treatments on the growth, yield, and quality of Pleurotus ostreatus (Jacq.) P. Kumm across two growing seasons..
King Oyster · 2025 · Research Article · Antioxidants (Basel, Switzerland)
Enhancing the Nutritional and Health-Related Properties of Taralli Through the Use of Pleurotus eryngii: Focus on Antioxidant and Anti-Inflammatory Properties.
In this study, a portion of whole durum wheat semolina was replaced with Pleurotus eryngii powder (PeP) at concentrations of 5% and 10% (w/w) to produce two taralli variants, TPE5 and TPE10. The impact of PeP on the technological, chemical, physical, and sensory properties of taralli was evaluated..
Cordyceps · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire
Enhancing the physicochemical and textural properties of goat milk yogurt using Cordyceps militaris polysaccharide and polymerized whey protein composite hydrogels
This study investigated the physicochemical and textural improvement of goat milk yogurt using composite hydrogels prepared from polymerized whey protein (PWP, 10 %, w/v) and Cordyceps militaris polysaccharides (CMP, 0–6 %, w/v)..
Oyster Mushroom · 2025 · Research Article · Journal of fungi (Basel, Switzerland)
Enhancing the Yield of Pleurotus ostreatus Through the Addition of Nucleotides and Nucleosides.
Pleurotus ostreatus is a mushroom species renowned for its abundant nutritional and medicinal properties. Nevertheless, the yield of its fruiting bodies has long remained at a standstill, making it arduous to achieve substantial improvements..
Oyster Mushroom · 2025 · Preprint · journal metadata
Establishment of a Congenic Strain for the Oyster Mushroom Reveals the Structure and Evolution of Mating-Type Loci
Pleurotus ostreatus, a widely cultivated edible oyster mushroom, is an ecologically versatile species with applications in biotechnology, agriculture, and food production. It functions as a decomposer and in nutrient-limited conditions it enhances its survival by using a potent toxin to prey on nematodes..
Yellow Morel · 2025 · Research Article · Journal of food science
Evaluating the antioxidant, anti-inflammatory, and neuroprotective potential of fruiting body and mycelium extracts from edible yellow morel (Morchella esculenta L. Pers.).
SCOPE: This study aimed to assess the antioxidant, anti-inflammatory, and acetylcholinesterase activities of fruiting bodies (FB) and mycelium (M) extracts of Morchella esculenta L. collected from various regions of Pakistan..
Reishi · 2025 · Research Article · BMC biotechnology
Evaluation of the pharmacological potential of Ganoderma lucidum against haemorrhagic and anticoagulant activities of Echis ocellatus venom.
BACKGROUND: Echis ocellatus is a highly venomous snake that can cause serious medical complications due to the presence of toxic proteins in its venom. These proteins, such as echicetin and phospholipase A2 (PLA2), often cause severe pathophysiology in snakebite victims..
Oyster Mushroom · 2025 · Journal Article · Environmental monitoring and assessment
Exploring bioremediation potential: sustainable treatment of landfill leachate with oyster mushroom (Pleurotus ostreatus) grown on different agro-industrial waste.
Landfill leachate poses significant environmental risks due to its high concentrations of heavy metals and harmful physicochemical properties, which threaten ecosystems and human health..
Enoki · 2025 · Journal Article · Food chemistry
Exploring the effect of pH-shifting on the gel properties and interaction of heat-induced Flammulina velutipes polysaccharide-porcine myofibrillar protein for improving the quality of Flammulina velutipes-pork patties.
This study primarily investigated the impact of pH-shifting on the gel properties of Flammulina velutipes polysaccharide (FVP)-porcine myofibrillar protein (MPs) gels, aiming to improve the quality of Flammulina velutipes-pork patties..
King Oyster · 2025 · Journal Article · International journal of medicinal mushrooms
Exploring the Potential of Spent Pleurotus eryngii (Agaricomycetes) Substrate to Cultivate Pleurotus florida with Enhanced Productivity, Nutritional Profile, and Therapeutic Potential.
Every year, several mushroom farms create a significant volume of discarded mushroom substrate. To make use of spent mushroom substrate, Pleurotus florida was grown on wheat straw that had been supplemented in varying amounts with one year old spent substrate of Pleurotus eryngii, wheat bran, and CaCo3..
Reishi · 2025 · Review · International journal of biological macromolecules
Extraction, purification, structural characterization, biological activity, mechanism of action and application of polysaccharides from Ganoderma lucidum: A review.
Ganoderma lucidum is a traditional tonic medicine in China, known as the "fairy grass" and "spiritual grass". It contains various chemical components, such as polysaccharides, triterpenoids, alkaloids, nucleosides, sterols, and acid compounds, which have the effects of tonifying qi and calming the mind, stopping cough….
Shiitake · 2025 · Journal Article · Journal of Applied Entomology
First Record of Zygothrica Wiedemann, 1830 (Diptera: Drosophilidae) Species Infesting Shiitake Mushrooms (Lentinula edodes (Berk.) Pegler) on a Log Farm in the Atlantic Forest, Brazil
We document the first observation of a severe shiitake mushroom infestation by several native Neotropical Zygothrica species (Drosophilidae, Diptera) under natural conditions. This infestation occurred in an agroforestry model, a medium‐scale, log‐based shiitake mushroom production culture..
Enoki · 2025 · Research Article · Journal of dental sciences
Flammulina velutipes polysaccharides exhibit potent antioxidant and anti-pyroptotic properties in diabetes-associated periodontitis: A preliminary in vitro study.
BACKGROUND/PURPOSE: Diabetes-associated periodontitis (DAP) is a complicated illness characterized by elevated oxidative stress and a pro-inflammatory response. There is a bidirectional relationship between diabetes and periodontitis..
Enoki · 2025 · Journal Article · International journal of biological macromolecules
Flammulina velutipes protein-Flammulina velutipes soluble polysaccharide-tea polyphenols particles stabilized Pickering emulsions for the delivery of β-carotene.
The delivery vehicles based on protein-polysaccharide-polyphenol are promising methods to encapsulate bioactive components with the aim of improving their solubility and bioavailability..
Cordyceps · 2025 · Research Article · Food science of animal resources
Flavorzyme Hydrolyzed Cordyceps militaris Mushroom Enhanced Quality and Functional Properties of Chicken Breast Meat during Storage.
This study aimed to reveal improvement on functional properties and quality attributes of chicken meat through the utilization of flavourzyme hydrolyzed Cordyceps militaris mushroom extract (CMs) during cold storage (9 days)..
Shiitake · 2025 · Research Article · PloS one
Formulation of silages from spent mushroom substrates of Pleurotus ostreatus and Lentinula edodes: Organoleptic properties, phenolic content, in vitro digestibility, gas production and ruminal kinetics.
To fulfill the global demand for sustainable livestock production and the implementation of circular economy models, the search for alternative feed sources to lower production cost has increased significantly. The use of agro-industrial waste has proven to be a low-cost strategy for animal feed..
Yellow Morel · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire
From byproduct to taste enhancer: Effective preparation of γ-glutamyl peptides from Morchella esculenta stipes and their mechanism of taste enhancement
Long-term consumption of high-salt diets can lead to an increased risk of cardiovascular diseases. γ-Glutamyl peptides (GGP) display a taste-enhancing effect, which contributes to salt reduction.
Cordyceps · 2025 · Journal Article · Journal of agricultural and food chemistry
Functional Characterization of a β-1,3-Glucanosyltransferase CmGel4 in Cordyceps militaris Using a Precise CRISPR-Cas9 Genome-Editing System.
Cordyceps militaris polysaccharides, especially β-glucans, have presented significant antitumor, hypoglycemic, and immunomodulatory activities. However, the enzymes involved in the branching formation of C.
Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)
Fusarium pseudonygamai Promotes Blastospore Transformation in Ophiocordyceps sinensis: Insights into Microbial Interaction and Key Mechanisms.
Chinese cordyceps, a highly valued traditional medicine, is formed when the fungal parasite Ophiocordyceps sinensis infects an underground caterpillar (Thitarodes). This interaction progresses slowly, as the larvae have a long developmental period and the fungus requires several months to complete its growth..
Reishi · 2025 · Journal Article · Fitoterapia
Ganoderma lucidum extract reduces skin aging by reducing mitochondrial stress and controlling mitochondrial numbers.
Mitochondrial dysfunction is one of the important signs of cellular and even individual aging. Ganoderma lucidum is a common edible and medicinal mushroom, widely used as a functional food in Asia.
Reishi · 2025 · Journal Article · Journal of ethnopharmacology
Ganoderma lucidum polysaccharide alleviates cognitive dysfunction by inhibiting neuroinflammation via NLRP3/NF-κB signaling pathway.
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum), a traditional Chinese medicinal herb, is commonly recommended for its potential to promote mental relaxation and alleviate memory impairment..
Reishi · 2025 · Research Article · Biochemistry and biophysics reports
Ganoderma lucidum polysaccharide attenuates retinal ischemia-reperfusion injury by regulating microglial M1/M2 polarization, suppressing neuroinflammation and inhibiting JAK2/STAT3 pathway.
Retinal ischemia-reperfusion (RIR) injury is implicated in the pathogenesis of numerous retinal degenerative disorders, resulting in visual impairment or even blindness in millions of individuals worldwide..
Reishi · 2025 · Journal Article · Food Bioscience
Ganoderma lucidum polysaccharides: A comprehensive overview of pharmacological effects and future perspectives
Ganoderma lucidum polysaccharides (GLPs), derived from the medicinal mushroom Ganoderma lucidum, are recognized for their diverse pharmacological properties. This systematic review offers a detailed analysis of how the structure of GLPs influences their biological functions..
Reishi · 2025 · Journal Article · Journal of pharmaceutical and biomedical analysis
Ganoderma lucidum spore oil attenuates acute liver injury by modulating lipid metabolism and gut microbiota.
The incidence of acute liver injury is increasing and poses a significant threat to human health. Ganoderma lucidum spore oil (GLSO), a lipid substance extracted from Ganoderma lucidum spore powder using supercritical CO2 technology, has been investigated for its potential to prevent acute liver injury..
Reishi · 2025 · Journal Article · Journal of ethnopharmacology
Ganoderma lucidum spore oil modulates immunity in hepatoma H22-bearing mice and restricts tumor growth by inhibiting eicosanoid metabolism pathway.
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum spore oil (GLSO) is a well-known health product that is beneficial for immuno-enhancement, which stems from a medicine fungus: Ganoderma lucidum (Curtis) P. Karst.
Reishi · 2025 · Journal Article · Journal of advanced research
Ganoderma lucidum spore powder enhances IFN-α-mediated antiviral capacity of COVID-19 vaccine boosters revealed by single-cell multi-omics sequencing.
INTRODUCTION: Reduced vaccine efficacy may hinder stable herd immunity. Traditional natural medicinal ingredients, such as Ganoderma lucidum products, have shown potential as safe and effective adjuvants to improve vaccine efficacy..
Reishi · 2025 · Journal Article · Journal of ethnopharmacology
Ganoderma lucidum sporoderm-broken spore powder alleviates kidney aging by modulating gut microbiota.
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum), a revered medicinal mushroom in traditional Chinese medicine (TCM), has been historically documented for its anti-aging properties and nephroprotective effects..
Reishi · 2025 · Review · Antioxidants (Basel, Switzerland)
Ganoderma lucidum-From Ancient Remedies to Modern Applications: Chemistry, Benefits, and Safety.
Ganoderma lucidum (G. lucidum), commonly known as Reishi or Lingzhi, is a medicinal mushroom with a rich history in traditional Asian medicine.
Cordyceps · 2025 · Journal Article · Cellular and molecular biology (Noisy-le-Grand, France)
GC-MS analysis of volatile components in different populations of Ophiocordyceps sinensis.
Cordyceps, a genus of ascomycete fungi, are renowned for their medicinal and functional food applications, and are attributed to bioactive compounds such as nucleosides, lipids, saccharides, and amino acids..
Cordyceps · 2025 · Journal Article · Biotechnology journal
Gene purA, a Key Upstream Target for Cordycepin Overproduction in Cordyceps militaris.
BACKGROUND: Cordycepin, a bioactive compound derived from Cordyceps militaris with diverse pharmacological properties, is predominantly produced using this fungus for industrial applications..
Oyster Mushroom · 2025 · Randomized Controlled Trial · Molecular nutrition & food research
GLP-1 Responses to a Single Meal Fortified With Oyster Mushroom Powder in Adults With Impaired Glucose Tolerance Depend on the Gut Microbiota Composition Before the Meal.
Fortification of a single meal with β-glucan-rich oyster mushroom (Pleurotus ostreatus) powder has been shown to increase the response of glucagon-like peptide 1 (GLP-1) and reduce concentrations of non-esterified fatty acids (NEFAs) in adults with impaired glucose tolerance (IGT)..
Reishi · 2025 · Research Article · mBio
GlSlt2 positively regulates GlMyb-mediated cellulose utilization in Ganoderma lucidum.
UNLABELLED: Fungal degradation of cellulose facilitates the sustainable harnessing of biosphere energy and carbon cycling. Ganoderma lucidum is one of the basidiomycetes with the largest number of hydrolytic enzymes in its genome.
Turkey Tail · 2025 · Journal Article · International journal of medicinal mushrooms
Green Synthesis of Silver Nanoparticles by Aqueous Extract of Turkey Tail Medicinal Mushroom Trametes versicolor (Agaricomycetes).
The turkey tail mushroom (Trametes versicolor) is one of the most important medicinal mushrooms because it contains a variety of effective bioactive compounds. This study aimed to produce a novel biomaterial to combat microbial infections without any harmful effects..
Oyster Mushroom · 2025 · Review · Molecules (Basel, Switzerland)
Green Valorization Strategies of Pleurotus ostreatus and Its By-Products: A Critical Review of Emerging Technologies and Sustainable Applications.
Pleurotus ostreatus, commonly known as the oyster mushroom, is a widely cultivated edible mushroom characterized by its nutritional value and health benefits. However, its large-scale production generates significant amounts of agro-industrial by-products, such as stipes, residual mycelium, and spent mushroom….
Maitake · 2025 · Journal Article · Food Chemistry: X
Grifola frondosa (Maitake) extract as natural antioxidant on emulsion-type pork sausages
This study examined the potential of Grifola frondosa extract (GF) as a natural antioxidant and functional ingredient in emulsion-type pork sausages. GF demonstrated dose-dependent radical scavenging activity in DPPH and ABTS assays, with a concentration of 5 mg/mL achieving effects similar to those of l-ascorbic….
Maitake · 2025 · Research Article · Food chemistry: X
Grifola frondosa (Maitake) extract as natural antioxidant on emulsion-type pork sausages.
This study examined the potential of Grifola frondosa extract (GF) as a natural antioxidant and functional ingredient in emulsion-type pork sausages. GF demonstrated dose-dependent radical scavenging activity in DPPH and ABTS assays, with a concentration of 5 mg/mL achieving effects similar to those of l-ascorbic….
Maitake · 2025 · Research Article · Foods (Basel, Switzerland)
Grifola frondosa Polysaccharide F2 Ameliorates Disordered Glucose and Lipid Metabolism in Prediabetic Mice by Modulating Bile Acids.
Prediabetes (pre-DM) is the buffer period before developing overt type 2 diabetes (T2DM), and the search for novel food agents to protect against pre-DM is in high demand..