MycoData

This experiment was to evaluate the effect of fermented spent mushroom substrate from Pleurotus eryngii (FSMPE) instead of brewers spent grain (BSG) on growth performance, apparent digestibility, serum indices, and fecal bacterial community of Yanbian cattle..

Energy & fatigueGut & microbiome

High relevance

King Oyster · 2025 · Journal Article · Animal science journal = Nihon chikusan Gakkaiho

Growth Performance, Apparent Digestibility, Serum Indices, and Fecal Bacterial Community Diversity in Yanbian Cattle Fed Diets With Fermented Spent Mushroom Substrate From Pleurotus Eryngii Instead of Brewers Spent Grain.

Energy & fatigueGut & microbiome

High relevance

Reishi · 2025 · Review · International journal of biological macromolecules

Health benefits of Ganoderma lucidum polysaccharides: A review of potential cardiovascular protective effects.

Ganoderma lucidum polysaccharides (GLPs) are a diverse class of bioactive compounds abundantly present in the mycelia, fruiting bodies, and spores of Ganoderma lucidum (G. lucidum).

Immune supportMetabolic health

High relevance

Cordyceps · 2025 · Journal Article · International journal of medicinal mushrooms

Heat Treatment Abolishes Cytotoxicity of the Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycota) Cold-Phosphate-Buffered Saline Extract.

Cordyceps militaris is an entomopathogenic fungus that is traditionally used in East Asian medicine. The fungus contains various bioactive compounds that have potential therapeutic applications.

OncologyImmune support

High relevance

Lion's Mane · 2025 · Journal Article · Food Research International

Hericium erinaceus ethanol extract exhibits potent DNA-protective and antioxidant action: Evidence from in vitro and Drosophila melanogaster studies

Lion's mane (Hericium erinaceus (Bull.: Fr.) Pers.) is a highly valued edible fungus recognized for its diverse health benefits. This study investigated the in vitro DNA-protective effects and in vivo genotoxicity and antioxidant activity of an ethanol extract from the fruiting bodies of cultivated H..

Cognition & nerves

High relevance

Lion's Mane · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Hericium erinaceus ethanol extract exhibits potent DNA-protective and antioxidant action: Evidence from in vitro and Drosophila melanogaster studies.

Cognition & nerves

High relevance

Lion's Mane · 2025 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Hericium erinaceus extracts promote neuronal differentiation and excitability through nootropic metabolite activity.

This study investigates the effects of a blend of Hericium erinaceus (lion's mane mushroom) extract on the differentiation of SH-SY5Y cells, a human neuroblastoma cell line, revealing potential therapeutic implications for neuroblastoma management..

Cognition & nerves

High relevance

King Oyster · 2025 · Journal Article · International journal of biological macromolecules

High internal phase Pickering emulsions stabilized by Pleurotus eryngii protein-polysaccharide conjugates.

In this work, Pleurotus eryngii protein-polysaccharide conjugates (PE-PPCs) were used as the only stabilizer for the preparation of high internal phase emulsions (HIPEs)..

Immune supportEnergy & fatigueSkin & hydration

High relevance

Shiitake · 2025 · Review · Chemistry & biodiversity

Holistic Evaluation of Shiitake mushrooms (Lentinula edodes): Unraveling Its Medicinal and Therapeutic Potentials.

Lentinula edodes (Shiitake mushroom [SM]), a Basidiomycete with extensive ethnomedicinal use, exhibits significant nutraceutical and pharmaceutical potential. This review critically discusses findings from multidisciplinary sources, including ScienceDirect, PubMed, Scopus, Web of Science, Google Scholar, and classical….

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Maitake · 2025 · Journal Article · Journal of functional foods

Identification and characterization of antihypertensive peptides from edible Grifola frondosa (maitake) mushroom hydrolysates: Suppression of vascular remodeling in angiotensin II-induced zebrafish model

Grifola frondosa (maitake), a widely consumed edible fungus with documented cardiovascular benefits, is rich in protein and serves as a valuable natural source for bioactive peptide production. Despite its potential, studies on blood pressure-lowering peptides derived from G.

Metabolic health

High relevance

Cordyceps · 2025 · Research Article · Scientific reports

Identification and functional analysis of the SET domain-containing gene family in Cordyceps militaris.

The SET domain is the core domain catalyzing histone lysine methyltransferases. The SET domain-containing genes family plays an important role in various developmental and physiological processes of fungi, such as regulating fungal pathogenicity, affecting the synthesis of secondary metabolites, and responding to….

Cognition & nerves

High relevance

Maitake · 2025 · Journal Article · Food Research International

Identification and in silico analysis of novel antioxidant peptides from Grifola frondosa hydrolysates: Cytoprotective effects in H2O2-induced Caco-2 cells

This study sought to extract and characterize novel antioxidant peptides from Grifola frondosa, assessing their protective effects on Caco-2 cells exposed to H₂O₂-induced oxidative stress..

High relevance

Maitake · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Identification and in silico analysis of novel antioxidant peptides from Grifola frondosa hydrolysates: Cytoprotective effects in H2O2-induced Caco-2 cells.

This study sought to extract and characterize novel antioxidant peptides from Grifola frondosa, assessing their protective effects on Caco-2 cells exposed to H2O2-induced oxidative stress..

High relevance

Almond Mushroom · 2025 · Research Article · Foods (Basel, Switzerland)

Identification of a Novel Peptide from Agaricus blazei Murrill and Its Immune-Enhancing Activity by Regulation of PI3K/AKT/mTOR Signaling Pathways in RAW 264.7 Cells.

This study aimed to screen and identify a novel immune-enhancing peptide and explore the molecular mechanism. Five novel peptides were identified from Agaricus blazei Murrill (ABM), and their secondary structure components consisted of random coil (50.5%), α-helix (28.9%), β-turn (15.6%), and β-sheet (5.0%)..

Immune support

High relevance

Oyster Mushroom · 2025 · Journal Article · Food Chemistry

Identification of novel umami peptides from Pleurotus ostreatus and their umami-enhancing effects through virtual screening, sensory evaluation, and molecular simulation

This investigation identified umami-enhancing peptides derived from Pleurotus ostreatus and elucidated their interaction mechanisms via molecular simulations. We identified six peptide candidates with potential umami-enhancing properties through a comprehensive virtual screening process..

High relevance

Oyster Mushroom · 2025 · Journal Article · Food chemistry

Identification of novel umami peptides from Pleurotus ostreatus and their umami-enhancing effects through virtual screening, sensory evaluation, and molecular simulation.

High relevance

Cordyceps · 2025 · Journal Article · Journal of biomolecular structure & dynamics

Identification of potential anti-hyperglycemic compounds in Cordyceps militaris ethyl acetate extract: in vitro and in silico studies.

Cordyceps militaris has been long known for valuable health benefits by folk experience and was recently reported with diabetes-tackling evidences, thus deserving extending efforts on screening for component-activity relationship..

Metabolic health

High relevance

King Oyster · 2025 · Research Article · Journal of xenobiotics

Immobilization of Pleurotus eryngii Laccase via a Protein-Inorganic Hybrid for Efficient Degradation of Bisphenol A as a Potent Xenobiotic.

In the present investigation, an eco-friendly biocatalyst was developed using Pleurotus eryngii laccase (PeLac) through a copper (Cu)-based protein-inorganic hybrid system for the degradation of bisphenol A, a representative xenobiotic..

High relevance

Reishi · 2025 · Review · Current issues in molecular biology

Immunomodulatory Effects of Ganoderma lucidum Bioactive Compounds on Gut-Brain and Gut-Liver Axis Disorders.

Ganoderma lucidum (Lingzhi), a traditional medicinal mushroom, is renowned for its immunomodulatory, anti-inflammatory, and antioxidant properties, primarily attributed to its bioactive components such as polysaccharides and triterpenoids..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Almond Mushroom · 2025 · Research Article · Biomedicines

Immunomodulatory Effects of Multivitamin Complexes Containing Agaricus blazei in Patients Undergoing Curative Resection for Non-Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Multicenter Pilot Trial.

Background/Objectives: Surgical resection of non-small-cell lung cancer (NSCLC) often results in temporary suppression of natural killer cell activity (NKA), potentially increasing the risk of recurrence..

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Shiitake · 2025 · Journal Article · Biocatalysis and Agricultural Biotechnology

Immunomodulatory properties of a β-glucan-rich bioflour of Bactris gasipaes shells colonized by Lentinula edodes

Lentinula edodes β-glucans have shown potential in reducing lung injury caused by inflammation associated with severe acute respiratory syndrome (SARS). This study aimed to investigate the immunomodulatory properties related to lung inflammation, both in vitro and in vivo, of a high-β-glucan content bioflour derived….

Immune supportGut & microbiomeRespiratory

High relevance

Cordyceps · 2025 · Journal Article · International Journal of Biological Macromolecules

Impact of cell disruption technologies on the structure, functionality, and digestibility of Cordyceps militaris protein isolates

Cell disruption is essential for extracting intracellular proteins from fungal biomass. However, its effects on the structural and functional properties of proteins remain insufficiently understood..

Gut & microbiome

High relevance

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Impact of cell disruption technologies on the structure, functionality, and digestibility of Cordyceps militaris protein isolates.

Cell disruption is essential for extracting intracellular proteins from fungal biomass. However, its effects on the structural and functional properties of proteins remain insufficiently understood..

Gut & microbiome

High relevance

Oyster Mushroom · 2025 · Research Article · Molecules (Basel, Switzerland)

Impact of Drying Methods on β-Glucan Retention and Lipid Stability in Oyster Mushroom (Pleurotus ostreatus) Enriched Carp (Cyprinus carpio, L.) Fish Burgers.

BACKGROUND: The incorporation of edible mushrooms into fish-based products offers a promising approach to enhance nutritional quality and oxidative stability. Oyster mushrooms (Pleurotus ostreatus) are valued for their β-glucans and bioactive compounds..

Skin & hydration

High relevance

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Impact of the sterol O-acyltransferase gene (Cmare2) on morphology and stability of the mushroom Cordyceps militaris.

Strain degeneration in mushroom cultivation can lead to significant commercial losses, yet the genetic factors remain elusive. This study identified the sterol O-acyltransferase gene, Cmare2, which is associated with colony sectorization in Cordyceps militaris, using a T-DNA insertion-mutant library..

Energy & fatigueGut & microbiome

High relevance

Oyster Mushroom · 2025 · Research Article · Current research in food science

Implications of Pleurotus ostreatus solid-state bioprocessing on the nutritional composition, protein structure, and anti-hypertensive and anti-inflammatory potential of local beans (Phaseolus vulgaris L.).

Improving snacks formulation to make them more nutritionally balanced can support healthy growth and development in children. Specifically, this approach can be beneficial for preventing obesity and promoting overall metabolic health..

Immune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2025 · Journal Article · Journal of food science

Improved Functional Components and Anti-Inflammatory and Anti-Oxidant Activity of Coconut Water by Bidirectional Fermentation Using Ganoderma lucidum.

This study addresses the limited variety of coconut-based products by exploring bidirectional fermentation of coconut water with Ganoderma lucidum to enhance its value..

Immune support

High relevance

Cordyceps · 2025 · Journal Article · Sugar tech

Improvement of Cordyceps militaris Polysaccharides Production by a Sole Corn Steep Liquor Medium, and its Antioxidant Activity

The production of polysaccharides through submerged fermentation using a sole corn steep liquor (CSL) medium with Cordyceps militaris (C. militaris GDMCC 5270) has been successfully demonstrated.

Immune supportSkin & hydration

High relevance

Cordyceps · 2025 · Journal Article · Food chemistry

In silico mining of sn-1,3 regioselective Rhizomucor miehei lipase homolog with strict pH sensitivity from Cordyceps militaris.

Regioselectivity is crucial for lipase-catalyzed lipid modification. Rhizomucor miehei lipase (RML) is a representative sn-1(3) regioselective lipase utilized in food industry, but it exhibits sn-1 stereo-preference..

High relevance

Reishi · 2025 · Journal Article · Heliyon

In vitro evaluation of antioxidant, probiotic, and antiproliferative activity of Ganoderma lucidum-extracted polysaccharides for the prevention of complication associated with gastrointestinal inflammatory diseases

Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, are associated with increased oxidative stress, chronic inflammation, and in some cases, abnormal cell proliferation, which can lead to serious complications such as cancer..

OncologyImmune supportGut & microbiome

High relevance

Maitake · 2025 · Research Article · Nutrients

In Vitro Gastrointestinal Digestion of Grifola frondosa Polysaccharides and Their Enhancement of GABA Production via Gut Microbiota Modulation.

Background: The water-soluble Grifola frondosa polysaccharides (GFPs) are the primary bioactive component of the edible and medicinal fungus Grifola frondosa. However, the digestive behavior of GFPs in the human gastrointestinal (GI) tract and their subsequent interaction with gut microbiota (GM) to exert health….

Immune supportGut & microbiome

High relevance

King Oyster · 2025 · Research Article · Antioxidants (Basel, Switzerland)

Incorporating Fresh Durum Wheat Semolina Pasta Fortified with Cardoncello (Pleurotus eryngii) Mushroom Powder as a Mediterranean Diet Staple.

Pasta made from durum wheat semolina has a medium-high glycemic index score, high starch digestibility, and limited nutritional value due to its low fiber, vitamin, and bioactive compound content..

Metabolic healthGut & microbiome

High relevance

Reishi · 2025 · Research Article · Journal of food science and technology

Incorporating Ganoderma lucidum extract and powder with probiotic cultures (Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis) enhanced the functional, textural, and sensory qualities of yogurt.

In this study, the extract and powder obtained from the Reishi mushroom (Ganoderma lucidum) were used in the production of yogurt, and also Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis bacteria were also inoculated..

Gut & microbiome

High relevance

Chaga · 2025 · Research Article · Scientific reports

Independent evolution of betulin biosynthesis in Inonotus obliquus.

Chaga mushroom (Inonotus obliquus) is a fungal species in the family Hymenochaetaceae (Basidiomycota) and the causative agent of white rot decay in Betula species..

Metabolic health

High relevance

Almond Mushroom · 2025 · Journal Article · Biometals: an international journal on the role of metal ions in biology, biochemistry, and medicine

Influence of Agaricus blazei Murill polysaccharides on synthesis, stabilization, acute toxicity and antifungal activity of copper (II) oxide nanoparticles.

In general, nanomaterials tend to have better physical, chemical and biological properties than conventional materials. Furthermore, the polysaccharides from Agaricus blazei Murill mushroom have several pharmacological properties, in addition to low cytotoxicity and high biocompatibility..

OncologyImmune support

High relevance

Cordyceps · 2025 · Review · Foods (Basel, Switzerland)

Influence of Culture Conditions on Bioactive Compounds in Cordyceps militaris: A Comprehensive Review.

Cordyceps militaris (C. militaris) is a medicinal fungus renowned for its diverse therapeutic properties, largely attributed to bioactive compounds such as cordycepin, polysaccharides, adenosine, D-mannitol, carotenoids, and ergosterol..

Immune supportEnergy & fatigue

High relevance

King Oyster · 2025 · Research Article · BMC biotechnology

Influence of low-intensity artificial light on the fatty acid profile of the biotechnologically important culinary mushroom Pleurotus eryngii in vitro.

BACKGROUND: The problem of searching for environmentally friendly regulators of the biosynthetic activity of edible and medicinal mushrooms is crucial for creating highly effective biotechnologies. One such regulator is light..

Energy & fatigue

High relevance

King Oyster · 2025 · Research Article · Foods (Basel, Switzerland)

Influence of Pleurotus eryngii Protein on Myofibrillar Protein Gelation and Application in Chicken Mince Products.

Pleurotus eryngii is rich in essential proteins, and is recognized for its medicinal and nutritional attributes. This study investigated the effects of P.

High relevance

Lion's Mane · 2025 · Research Article · Fungal biology and biotechnology

Influences of substrate and tissue type on erinacine production and biosynthetic gene expression in Hericium erinaceus.

BACKGROUND: Lion's mane (Hericium erinaceus) mycelium produces erinacines, a suite of cyathane diterpenoids with established neuroactivities. While H.

Cognition & nervesEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · Phytotherapy research: PTR

Inhibition of Hepatoblastoma by Ganoderma Lucidum Polysaccharide via the Induction of HDAC4-p16-RB Axis-Mediated Cellular Senescence.

Hepatoblastoma (HB), the most common primary malignant liver tumor in children, is characterized by high metastatic potential and poor prognosis. Ganoderma lucidum polysaccharide (GLP), the main bioactive compound of Ganoderma lucidum, has not been fully investigated for its therapeutic effects on HB..

OncologyImmune supportLiver supportSkin & hydration

High relevance

Chaga · 2025 · Preprint · journal metadata

Inoculation success of Inonotus obliquus in birch and alder sites in Estonia

Abstract Inonotus obliquus (commonly known as Chaga) is a medicinal fungus traditionally harvested from birch trees but increasingly explored for artificial cultivation due to rising commercial demand. This study evaluates the inoculation success of I.

High relevance

Chaga · 2025 · Research Article · Frontiers in pharmacology

Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing.

BACKGROUND: Renal fibrosis, characterized by the abnormal accumulation of extracellular matrix in renal tissue and progressive loss of kidney function, is posing a significant challenge in clinical treatment. While several therapeutic options exist, effective treatments remain limited..

Immune supportSkin & hydration

High relevance

Chaga · 2025 · Research Article · Animal microbiome

Inonotus obliquus fermentation product improves growth performance and meat quality probably through intestine and antioxidant capacity enhanced by gut microbes and metabolites regulation in rabbits.

BACKGROUND: Inonotus obliquus is a medicinal edible fungus that contains a variety of biologically active ingredients and has multiple physiological effects. When supplemented in avian diet, Inonotus obliquus has proved to be beneficial.

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Chaga · 2025 · Journal Article · International Journal of Biological Macromolecules

Inonotus obliquus polysaccharides improve hyperlipidemia with respect to lipid synthesis and intestinal flora modulation

Chronic high-fat diet can lead to fatty liver metabolism, hyperlipidemia disorders, and other diseases. Polysaccharides are natural lipid-lowering agents.

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Chaga · 2025 · Journal Article · International journal of biological macromolecules

Inonotus obliquus polysaccharides improve hyperlipidemia with respect to lipid synthesis and intestinal flora modulation.

Chronic high-fat diet can lead to fatty liver metabolism, hyperlipidemia disorders, and other diseases. Polysaccharides are natural lipid-lowering agents.

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Cordyceps · 2025 · Journal Article · Anticancer research

Integrating Network Pharmacology and Optimization of Preparation Methods to Enhance the Anticancer Effect of Cordyceps militaris on Lung Cancer.

BACKGROUND/AIM: Cordyceps militaris, a medicinal fungus, is renowned for its anticancer properties. To maximize its therapeutic efficacy, this study aimed to optimize the extraction and preparation methods of Cordyceps militaris and evaluate its effects on non-small cell lung cancer (NSCLC)..

OncologyGut & microbiomeRespiratory

High relevance

Cordyceps · 2025 · Journal Article · International journal of medicinal mushrooms

Internet of Things (IoT)-Driven Fermentation System for Enhanced Cordycepin Production in Cordyceps militaris (Ascomycetes) under Hypoxic Conditions.

Cordycepin, known for its tumor-suppressive and antiviral properties, has garnered attention due to its therapeutic and biological potential. Current Cordyceps militaris - based cordycepin production methods involve time-consuming and cost-intensive solid-state fermentation..

OncologyMetabolic healthRespiratory

High relevance

Reishi · 2025 · Journal Article · Biochemical and biophysical research communications

Investigating the therapeutic potential of Ganoderma lucidum in treating optic nerve atrophy through network pharmacology and experimental validation.

OBJECTIVE: The aim of this study is to employ network pharmacology to identify potential therapeutic targets for Ganoderma lucidum in the treatment of optic atrophy, and elucidate the underlying pharmacological mechanism. METHODS: This study is mainly divided into two parts..

OncologyImmune supportCognition & nerves

High relevance

Cordyceps · 2025 · Research Article · PloS one

Investigation of biometabolites and novel antimicrobial peptides derived from promising source Cordyceps militaris and effect of non-small cell lung cancer genes computationally.

Mushrooms are considered one of the safe and effective medications because they have great economic importance due to countless biological properties. Cordyceps militaris contains bioactive compounds with antioxidant, antimicrobial and anti-cancerous properties..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2025 · Journal Article · Food Chemistry

Investigation of the solid-state fermentation of Astragalus membranaceus residue with Cordyceps militaris: effects on phenolic profile and in vitro neuroprotective activity

We developed a Cordyceps militaris-mediated solid-state fermentation (SSF) strategy to enhance phenolic antioxidants in Astragalus membranaceus residue (AR) and confer neuroprotective effects against oxidative stress..

Immune supportCognition & nervesEnergy & fatigue