MycoData

We developed a Cordyceps militaris-mediated solid-state fermentation (SSF) strategy to enhance phenolic antioxidants in Astragalus membranaceus residue (AR) and confer neuroprotective effects against oxidative stress..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Cordyceps · 2025 · Research Article · BMC complementary medicine and therapies

Laboratory cultivated Cordyceps militaris modulates cockroach allergen-induced inflammation in keratinocytes and macrophages dual cell platforms.

BACKGROUND: Cordyceps militaris (CM) is noted for its anti-inflammatory properties and potential efficacy in treating allergic diseases. This research aimed to investigate the anti-inflammatory effect of ethanolic and aqueous extracts from laboratory-cultivated specific Cordyceps militaris on Per a 2-induced….

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Cordyceps · 2025 · Research Article · Microbiology spectrum

Light-responsive transcription factor CmOzf integrates conidiation, fruiting body development, and secondary metabolism in Cordyceps militaris.

Cordyceps militaris, an entomopathogenic fungus, produces diverse bioactive compounds. Conidial fitness and secondary metabolite levels critically influence its morphogenesis and entomopathogenicity, yet the regulatory mechanisms remain unclear..

Immune support

High relevance

Snow Fungus · 2025 · Research Article · Frontiers in fungal biology

Lignocellulose adaptation drives polysaccharide biosynthesis in Tremella fuciformis: metabolomic and proteomic insights into CAZyme regulation.

BACKGROUND/OBJECTIVES: Tremella fuciformis is an edible fungus prized for its culinary value. The polysaccharide content of T.

Immune supportMetabolic health

High relevance

Reishi · 2025 · Journal Article · International journal of medicinal mushrooms

Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Aqueous Extract Reverses Hypoxia Induced Redox Imbalance and Inflammatory Response in Rat Thymocytes.

Inflammatory diseases are associated with immune imbalances and the linkage between immune system and inflammatory mechanisms, particularly under hypoxia, is still incomprehensive..

Immune supportEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · International journal of medicinal mushrooms

Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Restores Redox Homeostasis and Modulates Myogenesis, Myostatin, and Muscle Atrophy Markers in Hypobaric Hypoxia Induced Muscle Loss in Rats.

The present study aimed to see the pharmacological effects of the aqueous extract of Ganoderma lucidum in amelioration of hypobaric hypoxia (HH) mediated muscle wastage..

Energy & fatigue

High relevance

Lion's Mane · 2025 · Review · Nutrients

Lion's Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential-A Narrative Review.

Hericium erinaceus, commonly known as lion's mane mushroom, has gained increasing scientific interest due to its rich composition of bioactive compounds and diverse health-promoting properties. This narrative review provides a comprehensive overview of the nutritional and therapeutic potential of H..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Cordyceps · 2025 · Research Article · Food chemistry: X

Low-glycemic index cookies supplemented with Cordyceps militaris substrate: Nutritional values, physicochemical properties, antioxidant activity, bioactive constituents, and bioaccessibility.

Cordyceps militaris substrate (CMS) is a novel ingredient rich in dietary fibers and bioactive compounds; however, its application in food products remains largely unexplored..

Metabolic healthGut & microbiome

High relevance

Mesima · 2025 · Journal Article · Microscopy research and technique

Mechanical Analysis of Phellinus Linteus-Induced Apoptosis of Hepatoma Cells.

Liver cancer is prevalent with the third highest mortality rate globally. The biomechanical properties of cancer cells play a crucial role in their proliferation and differentiation.

OncologyLiver support

High relevance

Turkey Tail · 2025 · Journal Article · International journal of medicinal mushrooms

Mechanism of Antihyperglycemic Activity of Extracellular Polysaccharopeptides from Fermented Turkey Tail Medicinal Mushroom Trametes versicolor (Agaricomycetes) in Type 2 Diabetic Rats.

The antihyperglycemic activity of extracellular polysaccharopeptides (ePSP) obtained from Trametes versicolor (TV) strain LH-1 has been demonstrated in hepatic cells and diabetic animals. This study further investigated the mechanisms of T..

Metabolic healthLiver support

High relevance

Shiitake · 2025 · Journal Article · Food Research International

Mechanisms of formation and consumption of VSCs in thermal dehydration of Lentinula edodes: A transcriptomic analysis utilizing WGCNA

The aroma of Lentinula edodes, primarily attributed to volatile sulfur compounds (VSCs), is a crucial factor influencing its commercial and culinary quality. This study investigated cellular activity and transcriptomic changes during gradient hot-air drying (40–60 °C) at various stages..

Skin & hydration

High relevance

Shiitake · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Mechanisms of formation and consumption of VSCs in thermal dehydration of Lentinula edodes: A transcriptomic analysis utilizing WGCNA.

Skin & hydration

High relevance

Chaga · 2025 · Journal Article · Journal of ethnopharmacology

Mechanisms of Inonotus obliquus (Fr.) Pilát polysaccharides in ameliorating lipid-induced skeletal muscle insulin resistance via PI3K/AKT and AMPK/ACC1/CPT1 signaling pathways.

ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus (Fr.) Pilát, a traditional medicinal fungi, has been used to treat diabetes in China and Russia since the 16th century..

Immune supportEnergy & fatigueMetabolic healthLiver support

High relevance

Reishi · 2025 · Research Article · Diabetes, metabolic syndrome and obesity: targets and therapy

Mechanistic Insights Into Ganoderma Lucidum for Diabetes Treatment via Network Pharmacology and Validation.

PURPOSE: There is an urgent need to develop antidiabetic medications with minimal side effects and low toxicity. Ganoderma lucidum, a food-medicine homologous in China, has been used to treat diabetes.

OncologyMetabolic health

High relevance

Chaga · 2025 · Journal Article · International journal of medicinal mushrooms

Mechanistic Study of Chaga Medicinal Mushroom Inonotus obliquus (Agaricomycetes) Phenolic Compounds in the Treatment of Liver Cancer: A Database and Simulation Approach.

Inonotus obliquus is a large fungus with high phenolic content that has demonstrated promising potential for the treatment of liver cancer. However, studies investigating its mechanism of action in the treatment of liver cancer are scarce..

OncologyEnergy & fatigueLiver support

High relevance

Yellow Morel · 2025 · Research Article · Scientific reports

Medicinal potential of Morchella esculenta oil inhibits cancer cell proliferation, metabolite characterization through GCMS, GC×GC-TOF-MS and UHPLC-QTOF-MS.

The current study investigated comprehensive phytochemical profile through high resolution techniques like GCMS, GC×GC-TOF-MS, UHPLC-QTOF-MS, total phenolic content, total flavonoid content, antioxidant, and anticancer activities of Morchella esculenta oil using in vitro approaches..

OncologyGut & microbiome

High relevance

Zhu Ling · 2025 · Journal Article · Natural product research

Metabolic profiling of Polyporus umbellatus (Pers.) Fr.

Polyporus umbellatus (Pers.) Fr. (Sin.

Metabolic health

High relevance

Cordyceps · 2025 · Journal Article · Data in Brief

Metabolomic data on molecular weight fractions of the cultivated fruiting body of Ophiocordyceps sinensis and their pharmacological effects on airway tissues

Ophiocordyceps sinensis is a medicinal mushroom that has been traditionally used for promoting respiratory health and addressing diverse therapeutic needs. The data in this article provides insights into the metabolic profile of the cultivated fruiting body of Ophiocordyceps sinensis (xOs™) across different molecular….

Energy & fatigueMetabolic healthRespiratory

High relevance

Cordyceps · 2025 · Journal Article · Fungal biology

Metabolomic profiles of the infection pathways of Calcarisporium cordycipiticola on the cultivated and medicinal mushroom, Cordyceps militaris.

Cordyceps militaris is a widely cultivated mushroom with multiple medicinal properties. However, the emergence of white mildew disease caused by Calcarisporium cordycipiticola has become a serious dilemma, leading to economic losses in its industrial production.

Metabolic health

High relevance

Cordyceps · 2025 · Journal Article · Food chemistry

Metabolomics analysis reveals the changes of metabolites in Cordyceps militaris during subculture.

Cordyceps militaris (C. militaris) strain is highly prone to degeneration during subculture.

Metabolic healthGut & microbiome

High relevance

Cordyceps · 2025 · Journal Article · Food chemistry

Metabolomics analysis reveals the formation mechanism of Cordyceps militaris fruiting bodies in liquid culture.

Cordyceps militaris is a functional fungus renowned for its significant nutritional and therapeutic value. However, the mechanisms governing its growth and fruiting body formation in liquid culture remain poorly understood..

Metabolic health

High relevance

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Metabolomics and Transcriptomics Reveal the Effects of Different Fermentation Times on Antioxidant Activities of Ophiocordyceps sinensis.

Ophiocordyceps sinensis is a fungus that is cultured through fermentation from wild Chinese cordyceps. While studies have examined its metabolites, the evaluation of its antioxidant capacity remains to be conducted.

Metabolic health

High relevance

Snow Fungus · 2025 · Research Article · Microorganisms

Microbiota Involved in the Degradation of Tremella fuciformis Polysaccharide and Microbial Enzymatic Potential Revealed by Microbiome and Metagenome.

Tremella fuciformis, as a traditional edible fungus in Asian countries, is rich in polysaccharides with a variety of bioactivities. Nevertheless, its high molecular weight and complex structure have caused limitations in its application and structural analysis..

Immune supportGut & microbiome

High relevance

Reishi · 2025 · Research Article · Veterinary world

Microencapsulated Ganoderma lucidum extract improves antioxidant capacity, intestinal morphology, and nutrient digestibility in free-range laying hens under tropical conditions.

BACKGROUND AND AIM: Free-range laying hens raised under tropical climates are susceptible to heat stress (HS), which compromises intestinal integrity, nutrient absorption, and egg quality..

Energy & fatigueMetabolic healthGut & microbiome

High relevance

Chaga · 2025 · Journal Article · Environmental toxicology and pharmacology

Mitigation of experimental hepatocellular Carcinoma by Inonotus obliquus Mushroom extract in association with oxidative stress and inflammation signaling.

Chaga mushroom (Inonotus obliquus) has been a component of folk medicine treating several disorders mainly through its anti-inflammatory and antioxidant properties, yet its effects on liver carcinoma needed elucidation..

OncologyImmune supportMetabolic healthLiver support

High relevance

Turkey Tail · 2025 · Journal Article · International journal of biological macromolecules

Molecular and functional modulation of mycoprotein extract from edible Trametes versicolor via pH cycling and ultrasound-enhanced transglutaminase treatment.

This study investigates the structural and functional modification of mycoprotein extract from Trametes versicolor through ultrasound (US) processing combined with either pH cycling treatment or transglutaminase (TGase) cross-linking..

Gut & microbiome

High relevance

Cordyceps · 2025 · Review · International journal of medicinal mushrooms

Molecular Identification Technologies in Authentication of Chinese Caterpillar Mushroom Ophiocordyceps sinensis (Ascomycota) and Related Species: A Review.

Ophiocordyceps sinensis fruit bodies, an insect-fungi complex, is a renowned ingredient in traditional Chinese medicine. Although numerous previous reviews have concentrated on the bioactive components and pharmacological properties of O..

High relevance

Chaga · 2025 · Research Article · International journal of molecular sciences

Molecular Mechanisms of Phytochemicals from Chaga Mushroom (Inonotus obliquus) Against Colorectal Cancer: Insights from Network Pharmacology, Molecular Docking, and Bioinformatics.

This study aimed to explore the molecular mechanisms of phytochemicals from Chaga mushroom (Inonotus obliquus) against colorectal cancer (CRC) using a combination of network pharmacology, molecular docking, and bioinformatics. Active components and targets of Chaga mushroom and CRC were collected from databases..

OncologyImmune support

High relevance

Lion's Mane · 2025 · Review · Brazilian journal of biology = Revista brasleira de biologia

Morphology, anticancer and neurological activities of Hericium erinaceus.

Hericium erinaceus, commonly known as Lion's Mane, is a species of medicinal mushroom that possesses remarkable therapeutic properties and has been extensively employed in the practice of traditional Chinese medicine. H..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2025 · Journal Article · Microbiological research

MR-10 peptide from Cordyceps militaris enhances thermotolerance in Lacticaseibacillus paracasei R21 by preserving membrane integrity and promoting biofilm formation.

Protein hydrolysates derived from the mycelium of Cordyceps militaris (C. militaris) have shown potential as thermoprotective agents for lactobacilli.

High relevance

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Multilayered regulation of autophagy-related protein kinase in Cordyceps militaris.

Autophagy is a general eukaryotic mechanism for the degradation and recycling of macromolecules and organelles, whereby the ATG1-kinase complex plays a crucial initiator role..

High relevance

Shiitake · 2025 · Journal Article · Biocatalysis and Agricultural Biotechnology

Mycelial vigor, growth, physicochemical and sensory characteristics of Lentinula edodes produced from agroindustrial residues and their anaerobic digestates

In some Latin American countries, agro-industrial wastes (AIW) are put aside in significant quantities, as it is treated as common garbage without a specific management plan. A viable alternative would be to use AIW as substrates for further valorization processes..

Gut & microbiome

High relevance

Chaga · 2025 · Review · Current issues in molecular biology

Natural Products and Health Care Functions of Inonotus obliquus.

With the increasing attention of modern medicine to natural medicinal agents, Inonotus obliquus (chaga), a macrofungus with remarkable medicinal value, has gradually garnered widespread academic interest. This paper reviews the primary bioactive components of I..

OncologyImmune support

High relevance

Reishi · 2025 · Journal Article · Journal of Ethnopharmacology

Network pharmacology combined with transcriptomics reveals that Ganoderma lucidum spore and Sanghuangporus vaninii compound extract exerts anti-colorectal cancer effects via CYP24A1-mediated VDR pathway and TERT-mediated Wnt signaling pathway

As traditional medicinal fungi, Ganoderma lucidum and Sanghuangporus vaninii are widely used in the treatment of tumor related diseases and cancer adjuvant therapy with potent anticancer effects. However, the anticancer effect and mechanism of action of their compound extract remain unclear..

OncologyEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Network pharmacology combined with transcriptomics reveals that Ganoderma lucidum spore and Sanghuangporus vaninii compound extract exerts anti-colorectal cancer effects via CYP24A1-mediated VDR pathway and TERT-mediated Wnt signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: As traditional medicinal fungi, Ganoderma lucidum and Sanghuangporus vaninii are widely used in the treatment of tumor related diseases and cancer adjuvant therapy with potent anticancer effects..

OncologyEnergy & fatigue

High relevance

Maitake · 2025 · Research Article · Nutrients

Network Pharmacology-Based Elucidation of the Hypoglycemic Mechanism of Grifola frondosa GF5000 Polysaccharides via GCK modulation in Diabetic Rats.

BACKGROUND/OBJECTIVES: Our lab has previously reported that Grifola frondosa (maitake mushroom) GF5000 has antidiabetic potential owing to its ability to improve insulin resistance..

Immune supportMetabolic healthLiver support

High relevance

Enoki · 2025 · Research Article · Nutrients

Neuroprotective and Neurotrophic Potential of Flammulina velutipes Extracts in Primary Hippocampal Neuronal Culture.

Flammulina velutipes (enoki mushroom) is a functional edible mushroom rich in antioxidants, polysaccharides, mycosterols, fiber, and minerals. Accumulating evidence highlights its therapeutic potential across diverse pathological contexts, including boosting cognitive function..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Shiitake · 2025 · Research Article · Journal of virology

New insights into temperature-impacted mycovirus-fungus interactions regulated by a microRNA in Lentinula edodes.

The onset of symptoms in virus-infected mushrooms merits investigation. In this study, the influence of heat stress (HS) on the interaction between Lentinula edodes mycovirus HKB (LeV) and its mushroom host, Lentinula edodes, was explored, revealing that HS treatment facilitated LeV replication and compromised the….

Metabolic healthRespiratory

High relevance

King Oyster · 2025 · Journal Article · International journal of biological macromolecules

New insights into the drying technology of Pleurotus eryngii: Effects on protein structure, properties and product flavor analysis.

Drying techniques have been widely used in food macromolecule modification, sterilization, and other fields. However, comparisons about the effects of different heat treatments on the structural and functional properties of proteins have yet to be elucidated..

High relevance

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

New insights of rotenone targeting cordycepin synthetase 1-cordycepin synthetase 2-glyceraldehyde-3-phosphate dehydrogenase (Cns1-Cns2-GAPDH) triple complex to enhance cordycepin synthesis in Cordyceps militaris.

Cordycepin isolated from Cordyceps militaris is an adenosine analogue with various biological activities, and its synthesis is dependent on cordycepin synthetase 1 (Cns1) and cordycepin synthetase 2 (Cns2)..

Immune supportEnergy & fatigueMetabolic health

High relevance

Snow Fungus · 2025 · Research Article · Foods (Basel, Switzerland)

Non-Animal Hyaluronic Acid from Tremella fuciformis: A New Source with a Structure and Chemical Profile Comparable to Hyaluronic Acid.

Tremella fuciformis is high in polysaccharides, which have a structure made up of a straight chain of (1→3) α-D-mannan and side chains of glucuronic acid, xylose, and fucose..

Immune supportSkin & hydration

High relevance

Reishi · 2025 · Research Article · Frontiers in chemistry

Non-destructive analysis of Ganoderma lucidum composition using hyperspectral imaging and machine learning.

BACKGROUND: Ganoderma lucidum is a widely used medicinal fungus whose quality is influenced by various factors, making traditional chemical detection methods complex and economically challenging..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Cordyceps · 2025 · Journal Article · Food and Bioproducts Processing

Novel advanced nanoliposomes incorporating adenosine, cordycepin from riched-Cordyceps militaris extract, and curcumin: Formulation, stability, in vitro digestion, and enhanced biological activities

This study details the development and evaluation of novel nanoliposomes for the co-delivery of adenosine and cordycepin from Cordyceps militaris extract, alongside curcumin..

OncologyGut & microbiomeLiver support

High relevance

Oyster Mushroom · 2025 · Journal Article · World J Microbiol Biotechnol

Novel chia (Salvia Hispanica L.) residue-based substrate formulations for oyster mushroom (Pleurotus ostreatus) cultivation

Chia (Salvia hispanica) and mushrooms represent valuable natural resources with numerous beneficial attributes as functional food ingredient with potential health benefits that support human health..

Gut & microbiome

High relevance

Oyster Mushroom · 2025 · Research Article · World journal of microbiology & biotechnology

Novel chia (Salvia Hispanica L.) residue-based substrate formulations for oyster mushroom (Pleurotus ostreatus) cultivation.

Chia (Salvia hispanica) and mushrooms represent valuable natural resources with numerous beneficial attributes as functional food ingredient with potential health benefits that support human health..

Gut & microbiome

High relevance

Cordyceps · 2025 · Journal Article · Food & function

Novel double nanoemulsion loading of Cordyceps militaris extract: formulation, stability, in vitro digestion, and in vivo evaluation for regulation of acute lipid disorders.

This study explores a novel approach for addressing acute lipid disorders using a double nanoemulsion system (NCMs) loading Cordyceps militaris extract. Cordyceps militaris, a medicinal mushroom, is valued for its bioactive compounds, particularly adenosine (ADE) and cordycepin (COR), which possess lipid-regulating….

Metabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2025 · Journal Article · Carbohydrate polymers

Novel galactose-rich polysaccharide from Ganoderma lucidum: structural characterization and immunomodulatory activities

Galactose-rich polysaccharides from Ganoderma lucidum have emerged as promising immunomodulatory agents, yet their structural characteristics and mechanisms of action remain poorly understood. Here, we isolated and characterized a novel galactose-rich polysaccharide (GLP-1b, 16.79 kDa) from Ganoderma lucidum..

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Carbohydrate polymers

Novel galactose-rich polysaccharide from Ganoderma lucidum: structural characterization and immunomodulatory activities.

Immune supportMetabolic healthGut & microbiome

High relevance

Shiitake · 2025 · Research Article · Food science & nutrition

Novel Insights Into Peptide-Calcium Chelates From Lentinula edodes: Preparation and Its Structure, Stability, and Calcium Transport Analysis.

Peptide-Ca chelates are innovative calcium supplements. Lentinula edodes possesses nutritional advantages for preparing calcium-binding peptides (CBPs), although there are limited studies on this subject..

Gut & microbiome

High relevance

Shiitake · 2025 · Journal Article · Journal of agricultural and food chemistry

Novel Umami Peptides from Lentinula edodes: Evaluation of the Umami Enhancing Effect Using Biosensors and Molecular Simulation.

Lentinula edodes are edible fungi with a unique aroma and umami flavor. The current study sought to identify novel umami peptides in Lentinula edodes while investigating their umami-enhancing properties..

Energy & fatigue