MycoData

Turkey Tail · 2019 · Journal Article · ACS applied materials & interfaces

Enhanced Thermostability and Anticancer Activity in Breast Cancer Cells of Laccase Immobilized on Pluronic-Stabilized Nanoparticles.

Laccases are multi-copper oxidase enzymes having widespread applications in various biotechnological fields. However, low stability of free enzymes restricts their industrial use..

Turkey Tail · 2019 · Research Article · RSC advances

Functionalization of hydrophobic surfaces with antimicrobial peptides immobilized on a bio-interfactant layer.

The design of functionalized polymer surfaces using bioactive compounds has grown rapidly over the past decade within many industries including biomedical, textile, microelectronics, bioprocessing and food packaging sectors..

OncologyImmune supportEnergy & fatigue

Mesima · 2019 · Journal Article · Pakistan journal of pharmaceutical sciences

Hispolon induces apoptosis against prostate DU145 cancer cells via modulation of mitochondrial and STAT3 pathways.

Hispolon, a bioactive polyphenolic entity extracted from Phellinus linteus, possesses anticancer, antiinflammatory and anti-oxidant properties. Despite the reported therapeutic effects of this natural chemical entity, inhibitory potential of hispolon towards prostate carcinoma DU145 cells and mechanism of its action….

OncologyImmune supportRespiratory

Mesima · 2019 · Journal Article · Life sciences

Protective effect of a polyphenols-rich extract from Inonotus Sanghuang on bleomycin-induced acute lung injury in mice.

Mushroom Phellinus linteus ("Sanghuang" in Chinese) is a popular medicinal polypore used to treat several disorders through its various biological functions. Inonotus sanghuang is claimed to produce general immune-potentiating and strengthening, anti-inflammatory, anti-tumor and anti-microbial properties, but its….

OncologyLiver supportRespiratory

Turkey Tail · 2018 · Journal Article · International journal of biological macromolecules

Anti-proliferative applications of laccase immobilized on super-magnetic chitosan-functionalized halloysite nanotubes.

Owing to the ubiquitous availability and simple biocatalysis, the anti-proliferative laccase holds enormous opportunities for anti-cancer applications. However, accessing efficient and specific (super-magnetically targetable) new delivery system for anti-proliferative laccase is vital step towards laccase based….

OncologyGut & microbiomeRespiratory

Lion's Mane · 2018 · Research Article · Food science & nutrition

Anticancer, antithrombotic, antityrosinase, and anti-α-glucosidase activities of selected wild and commercial mushrooms from Pakistan.

Mushrooms have been accepted as nutraceutical foods because of their high nutritional and functional values. They have also gained interest due to their medicinal properties, economic importance, and organoleptic merit..

OncologyGut & microbiomeRespiratory

Turkey Tail · 2018 · Journal Article · International journal of medicinal mushrooms

Antiproliferative Activity and Cytotoxicity of Some Medicinal Wood-Destroying Mushrooms from Russia.

We analyzed the antiproliferative activity of 6 medicinal wood-destroying mushrooms (Fomes fomentarius, Fomitopsis pinicola, Trametes versicolor, Trichaptum biforme, Inonotus obliquus, and Coniophora puteana) that are common in deciduous and mixed coniferous forests in Central Russia..

OncologyImmune supportGut & microbiome

Mesima · 2018 · Journal Article · Anticancer research

Combination Effects of Hispidin and Gemcitabine via Inhibition of Stemness in Pancreatic Cancer Stem Cells.

BACKGROUND/AIM: Natural products extracted from plants can be potent for developing pharmaceutical products. Hispidin, a polyphenolic compound mainly derived from the medicinal mushroom Phellinus linteus, has been shown to have a therapeutic potential against cancer cells..

Turkey Tail · 2018 · Journal Article · The Science of the total environment

Elimination of Isoxazolyl-Penicillins antibiotics in waters by the ligninolytic native Colombian strain Leptosphaerulina sp. considerations on biodegradation process and antimicrobial activity removal.

In this work, Leptosphaerulina sp. (a Colombian native fungus) significantly removed three Isoxazolyl-Penicillin antibiotics (IP): oxacillin (OXA, 16000 μg L-1), cloxacillin (CLX, 17500 μg L-1) and dicloxacillin (DCX, 19000 μg L-1) from water..

Maitake · 2018 · Research Article · PeerJ

Green synthesis of nanoparticles with extracellular and intracellular extracts of basidiomycetes.

Au, Ag, Se, and Si nanoparticles were synthesized from aqueous solutions of HAuCl4, AgNO3, Na2SeO3, and Na2SiO3 with extra- and intracellular extracts from the xylotrophic basidiomycetes Pleurotus ostreatus, Lentinus edodes, Ganoderma lucidum, and Grifola frondosa..

OncologyImmune supportRespiratory

Shiitake · 2018 · Journal Article · Frontiers in microbiology

Inhibition of Influenza Virus Infection by Lentinus edodes Mycelia Extract Through Its Direct Action and Immunopotentiating Activity.

Lentinula edodes mycelia (LEM) solid culture extracts contain many bioactive compounds with diverse pharmacological activities such as antitumor, antiviral, and immunopotentiating effects. In this study, we examined the anti-influenza virus activity of LEM in vitro and in vivo..

OncologyImmune supportMetabolic health

Chaga · 2018 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Inotodiol suppresses proliferation of breast cancer in rat model of type 2 diabetes mellitus via downregulation of β-catenin signaling.

Breast cancer is amongst the most common cancers causing death of women worldwide. Breast cancer occurrence is more prominent in people with diabetes.

OncologyImmune supportGut & microbiomeLiver support

Shiitake · 2018 · Journal Article · Journal of natural medicines

Lignosulfonic acid attenuates NF-κB activation and intestinal epithelial barrier dysfunction induced by TNF-α/IFN-γ in Caco-2 cells.

Lentinula edodes mycelia solid culture extract (MSCE) is used as a medical food ingredient and provides beneficial effects to patients with cancer and chronic type C hepatitis..

OncologyImmune supportEnergy & fatigueRespiratory

Mesima · 2017 · Journal Article · International immunopharmacology

3, 4-dihydroxybenzalacetone attenuates lipopolysaccharide-induced inflammation in acute lung injury via down-regulation of MMP-2 and MMP-9 activities through suppressing ROS-mediated MAPK and PI3K/AKT signaling pathways.

3, 4-Dihydroxybenzalacetone (DBL) is a constituent of Phellinus linteus. This study demonstrated the protective effect of DBL on lipopolysaccharide (LPS)-induced acute lung injuries in mice.

OncologyEnergy & fatigueRespiratory

Mesima · 2017 · Research Article · Molecules (Basel, Switzerland)

3,4-Dihydroxybenzalactone Suppresses Human Non-Small Cell Lung Carcinoma Cells Metastasis via Suppression of Epithelial to Mesenchymal Transition, ROS-Mediated PI3K/AKT/MAPK/MMP and NFκB Signaling Pathways.

3,4-Dihydroxybenzalactone (DBL) was isolated from Phellinus linteus (PL), which is a folk medicine possessing various physiological effects. In this study, we used highly metastatic A549 cells to investigate efficacy of DBL inhibition of cancer metastasis and possible mechanisms..

OncologyCognition & nervesEnergy & fatigue

Lion's Mane · 2017 · Journal Article · Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology

A Comparative Proteomic Analysis of Erinacine A's Inhibition of Gastric Cancer Cell Viability and Invasiveness.

UNLABELLED: Background / Aims: Erinacine A, isolated from the ethanol extract of the Hericium erinaceus mycelium, has been demonstrated as a new alternative anticancer medicine..

OncologyCognition & nervesEnergy & fatigue

Lion's Mane · 2017 · Research Article · Journal of cellular and molecular medicine

A proteomics approach to identifying novel protein targets involved in erinacine A-mediated inhibition of colorectal cancer cells' aggressiveness.

Erinacine A, a major active component of a diterpenoid derivative isolated from Hericium erinaceus mycelium, has been demonstrated to exert anticancer effects. Herein, we present an investigation of the molecular mechanism of erinacine A induction associated with cancer cells' aggressive status and death..

Wood Ear · 2017 · Journal Article · Journal of materials chemistry. B

Dendritic nanotubes self-assembled from stiff polysaccharides as drug and probe carriers.

Dendritic nanotubes (DNTs) with hydrophobic cavities were constructed directly from rigid branched β-1,3-d-glucan (AF1) in aqueous solution, and the AF1 sample was isolated from the fruiting bodies of Auricularia auricula-judae, a household nutritional food..

Mesima · 2017 · Journal Article · Environmental toxicology

Effects of hispolon on glioblastoma cell growth.

Hispolon is a polyphenolic compound isolated from Phellinus linteus which exhibits antitumor activity. Here, we explored the effects of hispolon on human glioblastoma cells U87MG.

Chaga · 2017 · Journal Article · International journal of medicinal mushrooms

Growth-Inhibitory and Immunomodulatory Activities of Wild Mushrooms from North-Central British Columbia (Canada).

Wild mushrooms, especially from North America, have not been systematically explored for their medicinal properties. Here we report screening for the growth-inhibitory and immunomodulatory activities of 12 species collected from multiple locations in north-central British Columbia, Canada..

Mesima · 2017 · Research Article · Oncology letters

Hispolon as an inhibitor of TGF-β-induced epithelial-mesenchymal transition in human epithelial cancer cells by co-regulation of TGF-β-Snail/Twist axis.

Hispolon (HPL), isolated from Phellinus linteus, has been used to treat various types of pathology, including inflammation, gastroenteric disorders, lymphatic diseases and numerous cancer subtypes..

OncologyImmune supportCognition & nervesEnergy & fatigue

Mesima · 2017 · Journal Article · The American journal of Chinese medicine

Hispolon Suppresses LPS- or LTA-Induced iNOS/NO Production and Apoptosis in BV-2 Microglial Cells.

Hispolon (HIS) is an active polyphenol compound derived from Phellinus linteus (Berkeley & Curtis), and our previous study showed that HIS effectively inhibited inflammatory responses in macrophages [Yang, L.Y., S.C. Shen, K.T.

Turkey Tail · 2017 · Research Article · Oxidative medicine and cellular longevity

Preclinical Antileukemia Activity of Tramesan: A Newly Identified Bioactive Fungal Metabolite.

Despite improvements that occurred in the last decades in the acute myeloid leukemia (AML) treatment, clinical results are still unsatisfactory. More effective therapies are required, and innovative approaches are ongoing, including the discovery of novel antileukemia natural compounds..

Wood Ear · 2016 · Journal Article · Journal of materials chemistry. B

Anti-hepatoma activity of the stiff branched β-d-glucan and effects of molecular weight.

The water soluble β-(1 → 3)-d-glucan with short branches (AF1) isolated from Auricularia auricula-judae was successfully fractionated by ultrasonication into three fractions with different weight-average molecular weights (Mws)..

OncologyImmune supportEnergy & fatigue

Wood Ear · 2016 · Journal Article · Genetics and molecular research: GMR

Antioxidant activity, anti-proliferative activity, and amino acid profiles of ethanolic extracts of edible mushrooms.

Biological activities of various mushrooms have recently been discovered, particularly, immunomodulatory and antitumor activities. Herein, three edible mushrooms, Auricularia auricula-judae (AA), Pleurotus abalonus (PA) and Pleurotus sajor-caju (PS) extracted using Soxhlet ethanol extraction were evaluated for their….

OncologyImmune supportSkin & hydrationRespiratory

Maitake · 2016 · Journal Article · International journal of medicinal mushrooms

Antitumor Activity of Extracts from Medicinal Basidiomycetes Mushrooms.

Aqueous extracts from the vegetative submerged mycelia of cultivated Basidiomycetes Ganoderma lucidum, Lentinus edodes, and Grifola frondosa, as well as from the fruiting bodies of G. lucidum, were found to have antitumor activity..

Enoki · 2016 · Research Article · PloS one

Identification and Characterisation of a Novel Protein FIP-sch3 from Stachybotrys chartarum.

In this study, a novel FIP named FIP-sch3 has been identified and characterised. FIP-sch3 was identified in the ascomycete Stachybotrys chartarum, making it the second FIP to be identified outside the order of Basidiomycota..

OncologyRespiratory

OncologyEnergy & fatigueRespiratory

Shiitake · 2016 · Journal Article · Oncology reports

Latcripin-13 domain induces apoptosis and cell cycle arrest at the G1 phase in human lung carcinoma A549 cells.

Latcripin-13 domain, isolated from the transcriptome of Lentinula edodes C91-3, contains a regulator of chromosome condensation (RCC1) domain/β-lactamase-inhibitor protein II (BLIP-II) and a plant homeodomain (PHD). Latcripin-13 domain has been shown to have antitumor effects..

Turkey Tail · 2016 · Journal Article · International journal of medicinal mushrooms

Mushroom Extracts Decrease Bone Resorption and Improve Bone Formation.

Mushroom extracts have shown promising effects in the treatment of cancer and various chronic diseases. Osteoporosis is considered one of the most widespread chronic diseases, for which currently available therapies show mixed results..

Lion's Mane · 2016 · Journal Article · Fitoterapia

New isoindolinones from the fruiting bodies of Hericium erinaceum.

Hericium erinaceus is a well-known medicinal and edible mushroom, which is considered as a potential source to obtain antitumor candidates. In this work, five new isoindolinones, named erinaceolactams A-E (1-5), along with five known compounds (6-10), were isolated from 70% ethanol extract of the fruiting bodies of H..

OncologyLiver support

Turkey Tail · 2014 · Review · Integrative medicine (Encinitas, Calif.)

Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology.

This review discusses the immunological roles of 5 major mushrooms in oncology: Agaricus blazei, Cordyceps sinensis, Grifola frondosa, Ganoderma lucidum, and Trametes versicolor. These mushrooms were selected based on the body of research performed on mushroom immunology in an oncology model..

Niu-Chang-Chih · 2013 · Review · Current topics in medicinal chemistry

Mycotherapy of cancer: an update on cytotoxic and antitumor activities of mushrooms, bioactive principles and molecular mechanisms of their action.

Mycotherapy is defined as the study of the use of extracts and compounds obtained from mushrooms as medicines or health-promoting agents. The present review updates the recent findings on anticancer/antitumor agents derived from mushroom extracts and their metabolites..

Chaga · 2012 · Review · Journal of natural products

Lanostanoids from fungi: a group of potential anticancer compounds.

Lanostanes are a group of tetracyclic triterpenoids derived from lanosterol. They have relevant biological and pharmacological properties, such as their cytotoxic effects via induction of apoptosis..

Maitake · 2003 · Journal Article · Cancer letters

Relationship between dendritic cells and the D-fraction-induced Th-1 dominant response in BALB/c tumor-bearing mice.

Dendritic cells (DCs) are known to not only induce the activation of T cells, but are also associated with the differentiation of T cells. The D-fraction, a beta-glucan extracted from maitake (Grifola frondosa) which expresses anti-tumor effects by establishing a helper (Th)-1 dominance in BALB/c mice, enhanced….

OncologyImmune supportLiver supportRespiratory

Agarikon · 2011 · Journal Article · International journal of medicinal mushrooms

New dietary supplements from medicinal mushrooms: Dr Myko San--a registration report.

In December 2010 the Ministry of Health and Social Welfare of the Republic of Croatia registered tablet preparations AGARIKON. 1 and MYKOPROTECT.

Mesima · 2005 · Patent · journal metadata

ANTICANCER RICE COATING COMPOSITION AND THE ANTICANCER RICE COATED WITH THE SAME HAVING IMPROVED FUNCTION AS WELL AS TASTE AND NUTRITION

PURPOSE: An anticancer rice coating composition and the anticancer rice coated with the same composition are provided, thereby adding anticancer function into the rice to improve function of the rice as well as taste and nutrition..

OncologyImmune supportMetabolic healthLiver support

Niu-Chang-Chih · 2004 · Patent · journal metadata

New phenyl maleic anhydride and maleimide derivatives used for lowering blood pressure, increasing high-density lipoprotein or as central cholinergic agonists, hepatoprotective, antiinflammatory agents and antitumor agents

Phenyl maleic anhydride and maleimide derivatives (I) are new. Phenyl maleic anhydride and maleimide derivatives of formula (I), are new.

OncologyImmune supportEnergy & fatigueSkin & hydration

Mesima · 2004 · Patent · journal metadata

PRODUCTION OF GINSENG PRODUCT HAVING INCREASED CONTENT OF GINSENOSIDE AND BETA-GLUCAN BY SOAKING GINSENG IN YEAST EXTRACT, INOCULATING WITH MUSHROOM STRAINS AND CULTURING IT

PURPOSE: A method of making a ginseng product by soaking cut pieces of ginseng in the yeast extract, inoculating them with mushroom strains such as Paecilomyces tenuipes, Cordyceps militaris, Cordyceps sinensis and Phellinus Linteus and then culturing them is provided..

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · eLife

Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt.

The maintenance of the functional integrity of the intestinal epithelium requires a tight coordination between cell production, migration, and shedding along the crypt-villus axis. Dysregulation of these processes may result in loss of the intestinal barrier and disease..

OncologyGut & microbiome

OncologyImmune supportEnergy & fatigueRespiratory

Cordyceps · 2023 · Case Reports · World journal of clinical cases

Severe inflammatory disorder in trisomy 8 without myelodysplastic syndrome and response to methylprednisolone: A case report.

BACKGROUND: Patients with trisomy 8 consistently present with myeloid neoplasms and/or auto-inflammatory syndrome. A possible link between myelodysplastic syndromes (MDS) with trisomy 8 (+8-MDS) and inflammatory disorders is well recognized, several cases having been reported..

Shiitake · 2021 · Case Reports · Acta dermatovenerologica Croatica: ADC

Flagellate Dermatitis due to Bleomycin Intake.

Flagellate dermatitis is a rare cutaneous manifestation in which long, striated erythematous lesion appear on the patient's skin. It is most frequently associated with bleomycin treatment or Shiitake mushroom intake, but it may also be attributed to many other possible causes..

OncologySkin & hydration

OncologyImmune supportEnergy & fatigue

King Oyster · 2015 · Comparative Study · International journal of medicinal mushrooms

Comparison of antioxidant and antiproliferation activities of polysaccharides from eight species of medicinal mushrooms.

Polysaccharides from mushrooms including Pleurotus eryngii, P. ostreatus, P.

Enoki · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Depigmenting Effect of Winter Medicinal Mushroom Flammulna velutipes (Higher Basidiomycetes) on Melanoma Cells.

In humans, skin pigmentation results from the biochemichal synthesis and accumulation of melanin. We previously revealed that edible winter mushroom Flammulina velutipes extract inhibited melanosis in commercially available edible crustacea..

OncologySkin & hydration

Mesima · 2015 · Research Support, Non U.S. Gov'T · Biochemical and biophysical research communications

Hispolon inhibits the growth of estrogen receptor positive human breast cancer cells through modulation of estrogen receptor alpha.

Human estrogen receptor α (ERα) is a nuclear transcription factor that is a major therapeutic target in breast cancer. The transcriptional activity of ERα is regulated by certain estrogen-receptor modulators..

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Current microbiology

Heat stress induces apoptotic-like cell death in two Pleurotus species.

High temperature is an important environmental factor that affects the growth and development of most edible fungi, however, the mechanism(s) for resistance to high temperature remains elusive..

King Oyster · 2014 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

In vitro antitumor effects of the cold-water extracts of Mediterranean species of genus Pleurotus (higher Basidiomycetes) on human colon cancer cells.

The aim of this study was to evaluate whether the cold-water extracts of Pleurotus eryngii var. ferulae (CWE-Pef) and Pleurotus nebrodensis (CWE-Pn), 2 of the most prized wild and cultivated edible mushrooms, can affect the tumor phenotype of human colon cancer HCT116 cells..

OncologyGut & microbiome

Maitake · 2010 · Patent · journal metadata

Beta-Glucan Enhances Hematopoietic Progenitor Cells Engraftment and Promotes Recovery from Chemotoxicity

Methods to use beta glucans in the culture of cell populations containing CD34+ cells in order to expand the numbers of CD34+ subsets of progenitor and stem cells are provided..

Maitake · 2010 · Research Support, Non U.S. Gov'T · Experimental biology and medicine (Maywood, N.J.)

Commonly consumed and specialty dietary mushrooms reduce cellular proliferation in MCF-7 human breast cancer cells.

Worldwide, over one million women will be newly diagnosed with breast cancer in the next year. Moreover, breast cancer is the second leading cause of cancer death in the USA.

Maitake · 2009 · Case Reports · International journal of general medicine

Possible disease remission in patient with invasive bladder cancer with D-fraction regimen.

Superficial bladder tumors are the most prevalent form of bladder cancers and transurethral resection is the primary surgical modality for those tumors. However, nearly 65% of patients will have tumor recurrence in five years while about 15% will have progression to muscle invasion..