MycoData

Cordyceps militaris is a parasitic fungus in a variety of lepidopteran pupae and larvae. It was reported that Cordyceps militaris has strong activity on the immuregulation, tumor, virus, infecction.

OncologyRespiratory

High relevance

Cordyceps · 2013 · Review Article · Journal of traditional and complementary medicine

A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in Dong-ChongXiaCao ( Dōng Chóng Xià Cǎo) and Related Bioactive Ingredients.

The caterpillar fungus Ophiocordyceps sinensis (syn.Cordyceps sinensis), which was originally used in traditional Tibetan and Chinese medicine, is called either "yartsa gunbu" or "DongChongXiaCao ( Dōng Chóng Xià Cǎo)" ("winter worm-summer grass"), respectively..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Lion's Mane · 2013 · Review · Journal of complementary & integrative medicine

Hericium erinaceus: an edible mushroom with medicinal values.

Mushrooms are considered as nutritionally functional foods and source of physiologically beneficial medicines. Hericium erinaceus, also known as Lion's Mane Mushroom or Hedgehog Mushroom, is an edible fungus, which has a long history of usage in traditional Chinese medicine..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2013 · Review · International journal of medicinal mushrooms

The artificial cultivation of medicinal Caterpillar Fungus, Ophiocordyceps sinensis (Ascomycetes): a review.

Caterpillar fungus, Ophiocordyceps sinensis (syn. Cordyceps sinensis), is highly valued in China as a dietary supplement or tonic food and natural remedy.

Immune support

High relevance

Zhu Ling · 2013 · Review · Journal of ethnopharmacology

Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control of Polyporus umbellatus (Pers.) Fries: a review.

ETHNOPHARMACOLOGICAL RELEVANCE: Polyporus umbellatus (Pers.) Fries (Polyporaceae, Zhuling ) has been commonly used in medicine for a wide range of ailments related to the edema, scanty urine, vaginal discharge, urinary dysfunction, as well as jaundice and diarrhea..

OncologyImmune supportLiver support

High relevance

Lion's Mane · 2012 · Review · International journal of medicinal mushrooms

Neuroregenerative potential of lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review).

We present a model case study of the activity of aqueous extract of Hericium erinaceus fresh fruit bodies in promoting functional recovery following crush injury to the peroneal nerve in adult female Sprague-Dawley rats. The aim was to explore the possible use of this mushroom in nerve repair..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Chaga · 2010 · Review · Applied microbiology and biotechnology

Chemical diversity of biologically active metabolites in the sclerotia of Inonotus obliquus and submerged culture strategies for up-regulating their production.

Inonotus obliquus (Fr.) Pilat is a white rot fungus belonging to the family Hymenochaetaceae in the Basidiomycota. In nature, this fungus rarely forms a fruiting body but usually an irregular shape of sclerotial conk called 'Chaga'.

OncologyImmune supportSkin & hydrationRespiratory

High relevance

King Oyster · 2009 · Review · Critical reviews in biotechnology

Biology of Pleurotus eryngii and role in biotechnological processes: a review.

Pleurotus eryngii is considered a complex species owing to a perplexed structure within species and a wide geographical distribution. Due to its remarkable flavor, high nutritional value, and numerous medicinal features, P.

High relevance

Chaga · 2009 · Review · Chinese journal of integrative medicine

Progress of research on Inonotus obliquus.

Inonotus obliquus has high nutritional and medicinal value, especially in treating malignant tumors, diabetes, cardiovascular disease and AIDS, attracting significant attention from scholars in recent years..

OncologyMetabolic health

High relevance

Maitake · 2008 · Review · Revista iberoamericana de micologia

[The fungus maitake (Grifola frondosa) and its therapeutic potential].

Grifola frondosa (Dicks.) Gray is a polyporaceous fungus and, due to its medical properties, has been used in Eastern cultures for thousands of years. A review of previously published literature on this fungus, its ethnomycological, nutritional, pharmacological and medical aspects were investigated..

High relevance

Almond Mushroom · 2008 · Review · Scandinavian journal of immunology

Effects of the medicinal mushroom Agaricus blazei Murill on immunity, infection and cancer.

Agaricus blazei Murill (AbM) is an edible, medicinal mushroom of Brazilian origin. It is used traditionally against a range of diseases, including cancer and chronic hepatitis, and has been cultivated commercially for the health food market..

OncologyImmune supportLiver support

High relevance

Chaga · 2008 · Review Article · Mycobiology

Introduction to Distribution and Ecology of Sterile Conks of Inonotus obliquus.

Inonotus obliquus is a fungus that causes white heart rot on several broad-leaved species. This fungus forms typical charcoal-black, sterile conks (chaga) or cinder conks on infected stems of the birche (Betula spp).

High relevance

Almond Mushroom · 2008 · Review Article · Evidence-based complementary and alternative medicine: eCAM

The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems.

Agaricus blazei Murrill (ABM) popularly known as 'Cogumelo do Sol' in Brazil, or 'Himematsutake' in Japan, is a mushroom native to Brazil, and widely cultivated in Japan for its medicinal uses, so it is now considered as one of the most important edible and culinary-medicinal biotechnological species..

OncologyImmune supportMetabolic healthLiver support

High relevance

Yellow Morel · 2026 · Comparative Study · International journal of biological macromolecules

A comparative study of protein extraction methods from Morchella esculenta stipes: Comprehensive analysis of physicochemical, nutritional, digestive, and functional properties.

This study systematically compared four extraction methods-alkaline extraction (AE), ultrasound-assisted alkaline extraction (UAE), subcritical water extraction (SWE), and deep eutectic solvent extraction (DES)-for their effects on the extraction efficiency, structural characteristics, functional properties and….

Gut & microbiome

High relevance

Shiitake · 2026 · Research Support, Non U.S. Gov'T · Journal of translational medicine

A novel combination for in vivo breast cancer treatment: TAK1 inhibition combined with metformin and Lentinula edodes compounds synergistically reinvigorates CD8+ T Cells.

BACKGROUND: Breast cancer (BC) is the most prevalent cancer among women, and retrieving the anti-tumor function of the immune system seems a promising treatment approach for its crucial role in combating cancer cells..

OncologyImmune supportMetabolic health

High relevance

Reishi · 2026 · Comparative Study · Australian endodontic journal: the journal of the Australian Society of Endodontology Inc

Comparative In Vitro Evaluation of Antibacterial Activity of Ganoderma lucidum- and Psidium guajava-Loaded Drug Delivery Scaffolds Against Enterococcus faecalis Biofilms.

This in vitro study evaluated the antibacterial efficacy of novel herbal intracanal medicaments, specifically Ganoderma lucidum (GL) and Psidium guajava (PG) extracts, incorporated into Pluronic F127 drug delivery scaffolds, against Enterococcus faecalis biofilms..

Energy & fatigueGut & microbiomeLiver support

High relevance

Lion's Mane · 2026 · Comparative Study · Food chemistry

Comparative Iron biofortification in Hericium erinaceus: A study of different ionic forms and their uptake efficiency.

Iron biofortification of Hericium erinaceus is a promising strategy for enhancing its nutritional profile. This study examined the effects of supplementing growth substrates with various iron forms (FeCl3·6H2O, FeSO4·7H2O, and FeHBED) on iron uptake, accumulation, and metabolic profiles in H..

Energy & fatigueMetabolic health

High relevance

Shiitake · 2026 · Research Support, Non U.S. Gov'T · Applied and environmental microbiology

Genome-wide identification of small GTPase gene family members in Lentinula edodes and the roles of LeRho1 in biotic and abiotic stress responses.

Lentinula edodes (L. edodes) is the largest proportion of edible mushrooms in China.

High relevance

Shiitake · 2026 · Evaluation Study · Food chemistry

Intense pulsed light-assisted water extraction of polysaccharides from Lentinula edodes: In vitro structural characterization and verification of antioxidant activities.

Polysaccharides from Lentinula edodes (L. edodes) exhibit antioxidant and immunomodulatory activities, but conventional extraction is limited by low efficiency and potential loss of bioactivity..

Immune supportGut & microbiomeSkin & hydration

High relevance

Shiitake · 2026 · Research Support, Non U.S. Gov'T · The breast journal

Lentinula edodes Cultured Extract Intake at Puberty Mitigates Inflammatory Signals at the Mammary Glands by the Involvement of Epigenetic Mechanisms in BALB/c Mice.

Exposure to immune stress or lipopolysaccharide (LPS) during critical developmental stages like puberty may lead to gut microbiome dysbiosis and epigenetic dysregulation in mammary glands, affecting gene expression and potentially elevating breast cancer susceptibility in adulthood..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Oyster Mushroom · 2026 · Evaluation Study · Food chemistry

Low-temperature ultrasonic-deep eutectic solvent extraction of ergothioneine from Pleurotus ostreatus: A sustainable new strategy.

Ergothioneine (EGT) is a potent antioxidant. This study employed a low-temperature ultrasonic-assisted deep eutectic solvent (UA-DES) method for the efficient and sustainable extraction of EGT from Pleurotus ostreatus mushrooms..

Energy & fatigue

High relevance

Lion's Mane · 2026 · Evaluation Study · Food chemistry

Static magnetic field-assisted fermentation of corn dietary fiber by Hericium erinaceus: Insight into fermentation mechanisms and related characteristics.

This study aimed to increase the product's soluble dietary fiber (SDF) yield through static magnetic field (SSF)-assisted Hericium erinaceus solid-state fermentation (MSSF) of corn husks..

High relevance

Reishi · 2026 · Research Support, Non U.S. Gov'T · Biomolecules

Study on the Mechanism of Ganoderma lucidum Polysaccharides for Ameliorating Dyslipidemia via Regulating Gut Microbiota and Fecal Metabolites.

In today's world, unhealthy living habits have contributed to the rise in metabolic disorders like hyperlipidemia. Recognized as a popular edible and medicinal mushroom in China and various eastern nations, Ganoderma lucidum is a promising high-value functional and medicinal food with multiple biological activities..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Cordyceps · 2026 · Journal Article · Analytical methods: advancing methods and applications

Unraveling the alteration of chemical compositions in Cordyceps and its host larvae using mass spectrometry imaging.

Cordyceps (Chinese caterpillar fungus) is a precious medicinal and edible fungus-larva complex that is naturally formed in a specific environment. However, limited data have been reported on spatial alterations in the lipidome and metabolome of larvae before and after entomopathogenic fungal infection..

Metabolic health

High relevance

Lion's Mane · 2025 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Anti-radiation metabolomics of Hericium erinaceus polysaccharides based on gas chromatography-mass spectrometry].

A serum metabolomics analysis method based on gas chromatography-mass spectrometry(GC-MS) was used to investigate the metabolic regulation mechanism of Hericium erinaceus(H. erinaceus) polysaccharides on radiation injury.

Immune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2025 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Efficacy of Ganoderma lucidum spores in invigorating spleen via spleen meridian].

Based on the model of spleen deficiency, this study investigated the medicinal properties of spleen meridian tropism of Ganoderma lucidum spores and their efficacy of strengthening the spleen..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Reishi · 2025 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Ganoderma lucidum spore polysaccharides regulate JAK2/STAT3 pathway to alleviate cancer-related fatigue in mouse model of spleen deficiency syndrome].

Ganoderma lucidum spore polysaccharides(GLSP) are the main active ingredients of G. lucidum spores and have pharmacological effects of regulating immunity and inhibiting tumor growth.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2025 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Regulation of apoptosis and autophagy in hepatoblastoma cells by Ganoderma lucidum polysaccharides through Akt/mTOR pathway].

This research investigated the impact of Ganoderma lucidum polysaccharides(GLP) on hepatoblastoma HepG2 and Huh6 cell models, as well as KM mouse model with in situ transplanted tumors, so as to provide a theoretical basis for the clinical application of GLP..

OncologyImmune supportLiver supportRespiratory

High relevance

Snow Fungus · 2025 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

A Novel Polysaccharide From Tremella fuciformis Alleviated High-Fat Diet-Induced Obesity by Promoting AMPK/PINK1/PRKN-Mediated Mitophagy in Mice.

SCOPE: Polysaccharides from Tremella fuciformis have gained significant interest due to their diverse biological activities. This study focuses on characterizing a purified polysaccharide, TPSP2, extracted from T.

Immune supportEnergy & fatigueMetabolic healthLiver support

High relevance

Shiitake · 2025 · Evaluation Study · Food chemistry

Blue light attenuated the umami loss of postharvest Lentinula edodes during spore discharge: Crucial roles of energy status.

Postharvest Lentinula edodes face significant umami quality decline during spore release. Light is a novel strategy for enhancing the flavor of edible mushrooms.

Energy & fatigue

High relevance

Shiitake · 2025 · Comparative Study · Food research international (Ottawa, Ont.)

Comparative analysis of the quality of pan-fried Lentinula edodes with different edible oils: physical, chemical and flavor profiles combined with multivariate statistical analysis.

The effects of pan-frying with different edible oils on the physical, chemical and flavor profile of Lentinula edodes were systematically evaluated. After pan-frying, hardness, a* and b* values increased, whereas L* decreased..

Energy & fatigue

High relevance

Zhu Ling · 2025 · Comparative Study · International journal of biological macromolecules

Comparative study of physicochemical properties, antioxidant activity, antitumor activity and in vitro fermentation prebiotic properties of Polyporus umbellatus (Pers.) Fries polysaccharides at different solvent extractions.

Polyporus umbellatus (Pers.) Fries (PU), a medicinal fungus, contains polysaccharides (PUPs) as its primary bioactive components. In this paper, physicochemical properties, biological activities and in vitro fermentation prebiotic properties of PUPs, extracted by 90 °C hot water (PUP-W), 0.9 % NaCl (PUP-N), citric….

OncologyImmune supportGut & microbiome

High relevance

Lion's Mane · 2025 · Research Support, Non U.S. Gov'T · Bioorganic chemistry

Discovery and biochemical characterization of prenyltransferases in the biosynthetic pathway of hericenones from Hericium erinaceus.

Hericenones, neurotrophic meroterpenoids from the medicinal mushroom Hericium erinaceus, exhibit remarkable nerve growth factor-enhancing properties with therapeutic potential for neurodegenerative disorders..

Cognition & nerves

High relevance

Reishi · 2025 · Evaluation Study · Food chemistry

Entrainer-assisted supercritical fluid extraction removing the phthalate plasticizers from Ganoderma Lucidum spores oil.

Ganoderma lucidum (G. lucidum) spore oil, an important health supplement, has been found to frequently contain the excessive levels of phthalate plasticizers (PAEs), which may cause the safety and quality risks..

High relevance

Cordyceps · 2025 · Evaluation Study · Food chemistry

Food traceability analysis and quality marker monitoring in Ophiocordyceps sinensis with multimodal ensemble learning.

Ophiocordyceps sinensis (OS) faces serious risks of food fraud, including quality misrepresentation, adulteration and illegal additives. To preserve the economic interests of consumers and the transparent management of food trade, so this study proposed a rapid and non-destructive detection tool to identify….

Immune supportCognition & nerves

High relevance

Zhu Ling · 2025 · Brief Report · BMC genomic data

Genome sequencing highlights the fungal sclerotium formation of medicinal fungi Polyporus umbellatus.

OBJECTIVES: Polyporus umbellatus is a well-known medicinal fungus in Asia. Due to its long growth cycle, wild resources of P.

High relevance

Reishi · 2025 · Evaluation Study · Food chemistry

Highly sensitive aggregation-induced electrochemiluminescence sensor for cadmium detection in Ganoderma lucidum.

Cadmium (Cd) pollution poses a major threat to food safety. Sensitive detection of Cd2+ is of great significance for the life health.

High relevance

Niu-Chang-Chih · 2025 · English Abstract · Angewandte Chemie (International ed. in English)

Identification of Key Post‐modification Enzymes Involved in the Biosynthesis of Lanostane‐type Triterpenoids in the Medicinal Mushroom Antrodia camphorata.

Through different gene mining strategies, three key enzymes (AcCYP4, AcSDR6, AcSMT1) involved in the downstream biosynthesis of major lanostane-type triterpenoids were discovered and identified from Antrodia camphorata. The catalytic mechanisms of AcSDR6 were elucidated by crystal structure analysis..

High relevance

Cordyceps · 2025 · Comparative Study · Journal of pharmaceutical and biomedical analysis

Integrating 2D NMR-based metabolomics and in vitro assays to explore the potential viability of cultivated Ophiocordyceps sinensis as an alternative to the wild counterpart.

Ophiocordyceps sinensis is widely used to treat various diseases and as a health supplement. The present study comprehensively compared the metabolic differences between wild and cultivated O.

OncologyMetabolic healthRespiratory

High relevance

Snow Fungus · 2025 · Evaluation Study · Food chemistry

Monitoring Tremella fuciformis submerged fermentation using ATR-MIR combined with chemometrics.

This study employed mid-infrared attenuated total reflection (ATR-MIR) spectroscopy and chemometrics to monitor the submerged fermentation process of Tremella fuciformis (T. fuciformis)..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Mesima · 2025 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Perioperative Clinical Usage of Phellinus Linteus as a Nutraceutical for Non-FOLFIRINOX-Based Postoperative Adjuvant Chemotherapy for Resected Pancreatic Cancer: A Retrospective Cohort Study.

INTRODUCTION: Most patients with pancreatic cancer experience systemic recurrence within 1 to 2 years after radical pancreatectomy. Phellinus linteus (PL) has demonstrated anti-inflammatory, antioxidant, and anti-cancer properties, suggesting potential as an adjunct to cancer therapy..

OncologyImmune support

High relevance

Chaga · 2025 · Research Support, Non U.S. Gov'T · Bioengineered

Photoregulation of the biosynthetic activity of fungus Inonotus obliquus using colloidal solutions of biogenic metal nanoparticles and low-intensity laser radiation.

This article presents new data on the integrated use of colloidal solutions of nanoparticles and low-intensity laser radiation on the biosynthetic activity of the medicinal mushroom Inonotus obliquus in vitro..

Immune supportSkin & hydration

High relevance

Oyster Mushroom · 2025 · Research Support, Non U.S. Gov'T · Fungal genetics and biology: FG & B

Physiological function of hydrophobin Hydph16 in cell wall formation in agaricomycete Pleurotus ostreatus.

Hydrophobins are small-secreted proteins with both hydrophobic and hydrophilic regions, enabling the mycelium to break through the air-medium interface by reducing the medium surface tension. Over 20 putative hydrophobin-encoding genes have been predicted in the agaricomycete Pleurotus ostreatus..

Immune support

High relevance

Lion's Mane · 2025 · Letter · World journal of gastroenterology

Potential of traditional Chinese medicine in gastrointestinal disorders: Hericium erinaceus in chronic atrophic gastritis.

Traditional Chinese medicine (TCM) has been extensively explored with various naturally derived compounds as a potential therapeutic agent for chronic atrophic gastritis (CAG)..

OncologyCognition & nervesGut & microbiome

High relevance

Reishi · 2025 · Research Support, Non U.S. Gov'T · Applied and environmental microbiology

Spermidine enhances the heat tolerance of Ganoderma lucidum by promoting mitochondrial respiration driven by fatty acid β-oxidation.

UNLABELLED: High temperature is an unavoidable environmental stress that generally exerts detrimental effects on organisms and has widespread effects on metabolism. Spermidine is an important member of the polyamines family and is involved in a range of abiotic stress responses in plants..

Energy & fatigueRespiratory

High relevance

Reishi · 2025 · Research Support, Non U.S. Gov'T · Bioengineered

Targeted insertion of heterogenous DNA using Cas9-gRNA ribonucleoprotein-mediated gene editing in Ganoderma lucidum.

Gene editing is emerging as a powerful tool for introducing novel functionalities in mushrooms. While CRISPR/Cas9-induced double-strand breaks (DSBs) typically rely on non-homologous end joining (NHEJ) for gene disruption, precise insertion of heterologous DNA in mushrooms is less explored..

High relevance

Almond Mushroom · 2025 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

The Age-Dependent Anticancer Efficacy of Agaricus blazei Murill Polysaccharide in Colon Cancer.

Agaricus blazei Murill polysaccharide (ABMP) has been found to exhibit significant immune regulatory effects, making them a promising candidate for complementary to the pharmacological treatment of colorectal cancer immune-related diseases..

OncologyImmune supportGut & microbiome

High relevance

Reishi · 2025 · Research Support, Non U.S. Gov'T · Applied and environmental microbiology

The GCN4-Swi6B module mediates low nitrogen-induced cell wall remodeling in Ganoderma lucidum.

UNLABELLED: In natural habitats, microorganisms encounter various unfavorable environmental stresses, including nitrogen deficiency. As the outermost barrier, the cell wall plays a crucial role in the interaction between the cell and the external environment..

Immune support

High relevance

Oyster Mushroom · 2025 · Evaluation Study · Journal of the science of food and agriculture

Three-dimensional printing of dysphagia-friendly foods using Pleurotus ostreatus mycelium, xanthan gum, and egg white protein: influence of mycelium concentration.

BACKGROUD: Dysphagia represents a significant public health concern, and there is an increasing demand for the development of food products tailored to the needs of dysphagia patients..

Energy & fatigue

High relevance

Reishi · 2024 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Chemical composition analysis of Ganoderma lucidum based on UPLC-Orbitrap-HRMS and virtual screening of FXR activators for treatment of liver fibrosis].

The chemical composition of Ganoderma lucidum ethanol extracts was systematically analyzed and identified by ultra-high performance liquid chromatography-quadrupole electrostatic field orbitrap high-resolution mass spectrometry(UPLC-Orbitrap-HRMS)..

Energy & fatigueLiver support