MycoData

OncologyImmune supportMetabolic healthSkin & hydration

Nameko · 2020 · Research Article · Antioxidants (Basel, Switzerland)

Pholiota nameko Polysaccharides Promotes Cell Proliferation and Migration and Reduces ROS Content in H2O2-Induced L929 Cells.

Pholiota nameko, a type of edible and medicinal fungus, is currently grown extensively for food and traditional medicine in China and Japan. It possesses various biological activities, such as anti-inflammatory, anti-hyperlipidemia and antitumor activities.

Immune supportMetabolic healthSkin & hydration

Nameko · 2019 · Journal Article · International journal of biological macromolecules

Chemical analysis, moisture-preserving, and antioxidant activities of polysaccharides from Pholiota nameko by fractional precipitation.

This study explored Pholiota nameko (P. nameko) polysaccharide fractions, PNP-40, PNP-60, and PNP-80, purified by gradient concentrations of ethanol (40%, 60%, and 80% (v/v)).

Nameko · 2019 · Journal Article · International journal of biological macromolecules

Gelling functional property, anti-inflammatory and antinociceptive bioactivities of β-D-glucan from the edible mushroom Pholiota nameko.

A β-D-glucan was obtained from the edible mushroom Pholiota nameko by hot aqueous extraction and purification. NMR and methylation analyses of the purified fraction (GHW-PN, 1.46% yield) indicated the presence of a (1 → 3)-linked β-D-glucan, highly substituted (~27%) at O-6 by single units of β-D-Glcp or by (1 →….

Immune supportMetabolic healthGut & microbiomeLiver support

Chaga · 2019 · Journal Article · Journal of microbiology and biotechnology

Secondary Fermented Extract of Chaga-Cheonggukjang Attenuates the Effects of Obesity and Suppresses Inflammatory Response in the Liver and Spleen of High-Fat Diet-Induced Obese Mice.

Cheonggukjang and chaga mushrooms have numerous health benefits, and have been used in alternative medicine. Therefore, a powder mixture of 98: Cheonggukjang and 2: Chaga extracts was fermented with Lactobacillus acidophilus KCTC3925 (FCC) and its anti-obesity effects in high-fat diet (HFD)-induced obese mice were….

Shiitake · 2018 · Journal Article · International journal of medicinal mushrooms

Antimicrobial, Cytotoxic, Anti-Inflammatory, and Antioxidant Activity of Culinary Processed Shiitake Medicinal Mushroom (Lentinus edodes, Agaricomycetes) and Its Major Sulfur Sensory-Active Compound-Lenthionine.

The antimicrobial, cytotoxic, anti-inflammatory, and antioxidant properties of aqueous extracts of raw and culinary processed shiitake mushrooms were evaluated and compared with those of lenthionine (1,2,3,5,6-penta-thiepane), the principal aroma-bearing substance of the shiitake medicinal mushroom (Lentinus edodes)..

OncologyImmune supportRespiratory

Shiitake · 2018 · Journal Article · International journal of medicinal mushrooms

Cross-Flow Ultrafiltration Fractions of a Cold Aqueous Extract of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Exhibit Apoptosis in Tumor Cells.

Lentinus edodes (shiitake) ranks among the most well-known medicinal mushrooms worldwide. Immune-modulating effects of shiitake extracts have been widely demonstrated in animals and humans.

Immune supportGut & microbiome

Shiitake · 2016 · Journal Article · Biotechnology letters

Application of residual polysaccharide-degrading enzymes in dried shiitake mushrooms as an enzyme preparation in food processing.

OBJECTIVE: To examine the activities of residual enzymes in dried shiitake mushrooms, which are a traditional foodstuff in Japanese cuisine, for possible applications in food processing..

Niu-Chang-Chih · 2005 · Patent · journal metadata

A method for producing biological active material with antrodia camphorata and composition thereof

The invention relates to producing biologically active material by cultivating Antrodia camphorata with liquid fermentation culture. This material can enhance immune activity, anti-tumor and anti-parasite.

OncologyImmune supportEnergy & fatigue

Niu-Chang-Chih · 2005 · Research Support, Non U.S. Gov'T · International immunopharmacology

Anti-inflammatory potential of Antrodia Camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-kappaB pathway.

Antrodia camphorata (A. camphorata), well known in Taiwan as a traditional Chinese medicine, has been shown to exhibit antioxidant and anticancer effects.

OncologyImmune supportCognition & nervesLiver support

Niu-Chang-Chih · 2005 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Antrodia camphorata prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis.

Antrodia camphorata (A. camphorata) is a rare medicinal fungus with antioxidative, vasorelaxtative, anti-inflammatory and anti-hepatitive effects.

OncologyImmune supportEnergy & fatigueLiver support

Niu-Chang-Chih · 2005 · Research Support, Non U.S. Gov'T · Cancer letters

Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines.

The fruiting body of Antrodia camphorata is well known in Taiwan as a traditional medicine for treating cancer and inflammation. The purpose of this study was to evaluate the apoptotic effects of ethylacetate extract from A.

Niu-Chang-Chih · 2005 · Comparative Study · Journal of agricultural and food chemistry

Characterization and functional study of Antrodia camphorata lipopolysaccharide.

Lipopolysaccharide (LPS) is a highly proinflammatory molecule isolated from bacteria. This study demonstrated the existence of LPS in a medicinal fungus, Antrodia camphorata.

Chaga · 2005 · Research Support, Non U.S. Gov'T · Life sciences

Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus.

Inonotus obliquus BELYU1102 was selected from 12 different strains of Inonotus as a producer of immuno-stimulating polysaccharide. After a batch fermentation of I.

Mesima · 2005 · Research Support, Non U.S. Gov'T · Biotechnology letters

Phellinus linteus grown on germinated brown rice suppresses IgE production by the modulation of Th1/Th2 balance in murine mesenteric lymph node lymphocytes.

We compared the immunomodulating effects of Phellinus linteus (PL), germinated brown rice (BR) and P. linteus grown on germinated brown rice (PB) on IgE production in murine mesenteric lymph node (MLN) lymphocytes..

Niu-Chang-Chih · 2005 · Patent · journal metadata

Protein ACA1 of antrodia camphorata

A new protein, named ACA1, has been isolated and purified from the medical fungi Antrodia camphorata using the technique of anion-exchange chromatography. ACA1, a glycoprotein with a molecular mass of 29 kDa, has a pI value of pH 5.3 and contains 118 amino acids in its peptide moiety..

Zhu Ling · 2004 · English Abstract · Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

[The effect of polyporus umbellatus polysaccharide on the immunosuppression property of culture supernatant of S180 cells].

AIM: To investigate the effect of polyporus umbellatus polysaccharide (PUPS) on the immunosuppression property of tumor cell line S180 culture supernatant. METHODS: The inhibitory effects of the culture supernatant of S180 cells in the presence or absence of PUPS on the ConA-induced mouse splenocyte proliferation,….

OncologyImmune supportEnergy & fatigueLiver support

Niu-Chang-Chih · 2004 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fractions from five different Cinnamomum species.

We have previously reported that polysaccharides extracted from fruiting bodies or cultured mycelia of Antrodia camphorata exhibit an anti-hepatitis B virus effect..

Niu-Chang-Chih · 2004 · Research Support, Non U.S. Gov'T · Toxicology and applied pharmacology

Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action.

Antrodia camphorata is a popular folk medicine that has attracted great attention due to its fame for antitumor activity against cancer. However, there is little information available about its action.

Immune supportMetabolic health

Mesima · 2004 · Patent · journal metadata

Compositions containing polysaccharides from phellinus linteus and methods for treating diabetes mellitus using same

The present invention relates to a novel use of polysaccharides (PL) from Phellinus linteus for treating diabetes mellitus, which provides medicine or food comprising polysaccharide as active components..

OncologyImmune supportGut & microbiome

Enoki · 2004 · Research Support, Non U.S. Gov'T · Bioscience, biotechnology, and biochemistry

Effect of a Pore-Forming Protein Derived from Flammulina velutipes on the Caco-2 Intestinal Epithelial Cell Monolayer

We have previously found a transepithelial electrical resistance (TEER)-decreasing protein derived from Flammulina velutipes, which was revealed to be identical to flammutoxin (FTX) that is known as a hemolytic pore-forming protein..

OncologyImmune supportEnergy & fatigue

Niu-Chang-Chih · 2004 · Research Support, Non U.S. Gov'T · Planta medica

Evaluation of the anti-inflammatory activity of zhankuic acids isolated from the fruiting bodies of Antrodia camphorata.

We have previously shown that a concentrated ethanol extract of the fruiting bodies of Antrodia camphorata exhibited immunomodulating effects in human leukocytes and fourteen compounds including zhankuic acids A, B, C, and antcin K were identified in the extract..

Enoki · 2004 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Fungal immunomodulatory protein from Flammulina velutipes induces interferon-gamma production through p38 mitogen-activated protein kinase signaling pathway.

FIP-fve is a fungal immunomodulatory protein purified from Flammulina velutipes, an edible golden needle mushroom thought to possess potent immunomodulatory properties..

OncologyImmune supportCognition & nerves

Mesima · 2004 · Research Support, Non U.S. Gov'T · International journal of molecular medicine

Induction of apoptotic cell death by mycelium extracts of Phellinus linteus in human neuroblastoma cells.

Phellinus linteus is a well-known Oriental medicinal fungus that has various biological activities, including immunomodulatory and anti-tumor activities, the mechanisms of which are poorly understood. In the present study, we investigated the effects of mycelium extracts of P..

Mesima · 2004 · Research Support, Non U.S. Gov'T · Biological & pharmaceutical bulletin

Proteoglycan Isolated from Phellinus linteus Induces Toll-Like Receptors 2- and 4-Mediated Maturation of Murine Dendritic Cells via Activation of ERK, p38, and NF-κB

Mushroom polysaccharides are increasingly being utilized to treat a wide variety of diseases. Phellinus linteus proteoglycan (PL) has been reported to have anti-tumor and immunomodulatory properties.

Mesima · 2004 · Research Support, Non U.S. Gov'T · FEBS letters

Proteoglycan isolated from Phellinus linteus inhibits tumor growth through mechanisms leading to an activation of CD11c+CD8+ DC and type I helper T cell-dominant immune state.

Dendritic cells (DC) are known to not only induce the activation of T cells, but are also associated with the polarization of T cells. This study investigated whether or not proteoglycan (PG) isolated from Phellinus linteus induces the phenotypic and functional maturation of CD11c+ DC in vitro and in vivo..

Maitake · 2003 · English Abstract · Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

[Anti-tumor effect of polysaccharide from Grifola frondosa and its influence on immunological function].

When the polysaccharide from Grifola frondosa (PGF) was taken orally by S180 bearing mice at the dosage of 50-150 mg/kg.d for 9 d, the inhibitory rate to S180 was 27.97%-38.46%..

Mesima · 2003 · Research Support, Non U.S. Gov'T · Biochemical and biophysical research communications

Acidic polysaccharide isolated from Phellinus linteus induces nitric oxide-mediated tumoricidal activity of macrophages through protein tyrosine kinase and protein kinase C.

Mushroom polysaccharides are increasingly being utilized to treat a wide variety of diseases. Aqueous extracts from the Phellinus linteus have been reported to have anti-tumor and immunomodulatory properties.

Mesima · 2003 · Research Support, Non U.S. Gov'T · Biochemical and biophysical research communications

Acidic polysaccharides isolated from Phellinus linteus induce phenotypic and functional maturation of murine dendritic cells.

Acidic polysaccharides (PL) isolated from Phellinus linteus are known to stimulate the proliferation of T lymphocytes and humoral immune functions to act as a polyclonal activator of B cells, and to inhibit tumor growth and metastasis..

Mesima · 2003 · Research Support, Non U.S. Gov'T · Biological & pharmaceutical bulletin

Alleviation of Experimental Septic Shock in Mice by Acidic Polysaccharide Isolated from the Medicinal Mushroom Phellinus linteus

This study reports that acidic polysaccharide (PL) isolated from Phellinus linteus alleviated the septic shock induced by high dose lipopolysaccharide (LPS) injection in mice..

Immune supportSkin & hydration

Mesima · 2003 · Research Support, Non U.S. Gov'T · Biological & pharmaceutical bulletin

Oral Administration of Proteoglycan Isolated from Phellinus linteus in the Prevention and Treatment of Collagen-Induced Arthritis in Mice

To examine whether oral administration of proteoglycan derived from Phellinus linteus, which is known as the medicinal mushroom, can prevent or treat collagen-induced arthritis (CIA) in mice as experimental model of autoimmune disease..

Niu-Chang-Chih · 2003 · Patent · journal metadata

Preparation and compositions for antrodia camphorata mycelium biologically active material

The present invention relates to biologically active material, containing mainly polysaccharides, from the solution culturing for mycelium of Antrodia camphorata, a kind of mushroom that only grows inside a unique Taiwanese plant called Cinnamomum kanehirae tree, being able to improve immunity and resist tumors and….

OncologyImmune supportEnergy & fatigue

Mesima · 2003 · Research Support, Non U.S. Gov'T · International immunopharmacology

Proteoglycan isolated from Phellinus linteus activates murine B lymphocytes via protein kinase C and protein tyrosine kinase.

Medicinal mushrooms are increasingly used to treat a wide variety of disease processes. Aqueous extract from the fruiting body or mycelia of Phellinus linteus has been reported to produce antitumor and immunomodulatory activities in vivo and in vitro.

Mesima · 2003 · Research Support, Non U.S. Gov'T · Bioresource technology

Purification and characterization of acidic proteo-heteroglycan from the fruiting body of Phellinus linteus (Berk. & M.A. Curtis) Teng.

Phellinus linteus is a well-known oriental medicinal fungus that has various biological activities such as stimulation of humoral and cell mediated immunity, anti-mutagenicity activity, and anti-cancer activity. The process of isolating and purifying a water-soluble glycan from P..

Niu-Chang-Chih · 2002 · Comparative Study · Journal of agricultural and food chemistry

Antioxidant properties of Antrodia camphorata in submerged culture.

The biologically active compounds, antioxidant activities, and free radical scavenging effects of dry matter of cultural medium (DMCM), filtrate (DMF), and different solvent extracts of mycelia from Antrodia camphorata in submerged culture (ACSC) were investigated..

OncologyImmune supportEnergy & fatigueMetabolic health

Niu-Chang-Chih · 2002 · Comparative Study · FEMS microbiology letters

Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects.

Polysaccharides were extracted from fruiting bodies and cultured mycelia from five Antrodia camphorata strains. Polysaccharide profiles of the five strains, as determined by high-performance anion-exchange chromatography, showed varying yields and composition of neutral sugars.

Yellow Morel · 2002 · Research Support, U.S. Gov'T, Non P.H.S. · Journal of agricultural and food chemistry

Isolation of a galactomannan that enhances macrophage activation from the edible fungus Morchella esculenta.

The edible mushroom Morchella esculenta is among the most highly prized and morphologically recognizable fungi in the world. We describe the isolation from a polar extract of M.

Immune supportMetabolic health

Mesima · 2001 · Patent · journal metadata

NOVEL USE OF POLYSACCHARIDE FROM PHELLINUS LINTEUS FOR TREATING DIABETES MELLITUS

Enoki · 1998 · Research Support, Non U.S. Gov'T · The Biochemical journal

Assembly of flammutoxin, a cytolytic protein from the edible mushroom Flammulina velutipes, into a pore-forming ring-shaped oligomer on the target cell.

Flammutoxin has been previously isolated as a cardiotoxic and cytolytic polypeptide of 22 or 32 kDa from the fruiting bodies of the edible mushroom Flammulina velutipes. In the present study, we purified flammutoxin as a single haemolytic protein of 31 kDa and studied the mode of its cytolytic action..

Snow Fungus · 1997 · Research Support, Non U.S. Gov'T · Planta medica

Characterization and cytokine-stimulating activities of acidic heteroglycans from Tremella fuciformis.

Four acidic heteroglycans, T2a-T2d, were isolated from the body of Tremella fuciformis Berk. They contained 1.9%-2.9% of acetyl groups and were composed of mannose (Man), glucuronic acid (GlcA), and small amounts of xylose (Xyl), glucose (Glc), and fucose (Fuc)..

Enoki · 1997 · Research Support, Non U.S. Gov'T · Journal of the Formosan Medical Association = Taiwan yi zhi

Molecular cloning and expression of a fungal immunomodulatory protein, FIP-fve, from Flammulina velutipes.

FIP-fve, a fungal immunomodulatory protein, was isolated from the fruiting bodies of the edible mushroom, Flammulina velutipes. FIP-fve was shown to stimulate blast-forming activity of human peripheral blood lymphocytes and gene expression of interleukin-2, interferon-gamma and tumor necrosis factor-alpha..

Enoki · 1997 · Research Support, Non U.S. Gov'T · Immunopharmacology

The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from Flammulina velutipes.

Alkaline-soluble antitumor polysaccharide was prepared from the cell wall of the mushroom Flammulina velutipes. The backbones) of the polysaccharide is mainly composed of beta-(1-->3)-D-linked glucose and its molecular weight was estimated to be about 200 kD..

Snow Fungus · 1996 · Research Support, Non U.S. Gov'T · Carbohydrate research

Characterisation of acidic heteroglycans from Tremella fuciformis Berk with cytokine stimulating activity.

Four kinds of acidic heteroglycan, T3a-T3d, were isolated from the body of the fungus Tremella fuciformis Berk. The molecular weights of T3a-T3d were 550, 420, 55, and 48 kDa, respectively..

Snow Fungus · 1996 · Research Support, Non U.S. Gov'T · Planta medica

Characterization and cytokine stimulating activities of heteroglycans from Tremella fuciformis.

Three heteroglycans, T1a, T1b, and T1c, have been isolated from the body of Tremella fuciformis Berk. They are composed of mannose (Man), xylose (Xyl), glucose (Glc), fucose (Fuc), and glucuronic acid (GlcA)..

Mesima · 1996 · Research Support, Non U.S. Gov'T · Chemical & pharmaceutical bulletin

Characterization of carbohydrate-peptide linkage of acidic heteroglycopeptide with immuno-stimulating activity from mycelium of Phellinus linteus.

The carbohydrate-peptide linkage in acidic heteroglycopeptide from Phellinus linteus was characterized. Amino acid analysis showed large amounts of serine and threonine.

Mesima · 1996 · Research Support, Non U.S. Gov'T · International journal of immunopharmacology

Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus.

Polysaccharide was purified from mycelial culture of Phellinus linteus (PL) and its effect on immunocompetence of normal splenocytes was observed. Overall in vitro immune function was enhanced by addition of PL into culture of mouse spleen lymphocyte and i.p..

Enoki · 1995 · Research Support, Non U.S. Gov'T · European journal of biochemistry

A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence.

A new fungal immunomodulatory protein (FIP-fve) has been isolated and purified from the edible golden needle mushroom (Flammulina velutipes). The apparent molecular mass of FIP-fve determined by SDS/PAGE agrees well with the value of 12704 Da calculated from its amino acid composition and sequence..

Immune supportCognition & nerves

Enoki · 1995 · Research Support, Non U.S. Gov'T · European journal of cell biology

Actin filaments are involved in cellular graviperception of the basidiomycete Flammulina velutipes.

Inhibitor studies demonstrate a major role of the actin cytoskeleton in cellular graviperception of the basidiomycete Flammulina velutipes. Treatment of explanted fruiting body stipes with 10(-4) M of the actin filament-disrupting agent cytochalasin D causes specific suppression of gravitropic curvature to 21% of the….

Lion's Mane · 1994 · English Abstract · Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

[Immunomodulatory function of polysaccharide of Hericium erinaceus].

Hericium erinaceus is a Chinese herbal medicine. The Apollo oral liquid contains polysaccharide of H.