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OncologyImmune supportEnergy & fatigueSkin & hydration

Maitake · 2022 · Research Article · Nutrients

Grifola frondosa Extract Containing Bioactive Components Blocks Skin Fibroblastic Inflammation and Cytotoxicity Caused by Endocrine Disrupting Chemical, Bisphenol A.

Grifola frondosa (GF), a species of Basidiomycotina, is widely distributed across Asia and has been used as an immunomodulatory, anti-bacterial, and anti-cancer agent..

Reishi · 2022 · Journal Article · Fitoterapia

Meroterpenoids with a large conjugated system from Ganoderma lucidum and their inhibitory activities against renal fibrosis.

Baoslingzhines A-E (1-5), five new meroterpenoids were isolated from the fruiting bodies of Ganoderma lucidum. The structures including their absolute configurations were characterized by using spectroscopic and computational methods..

Reishi · 2022 · Research Article · Polymers

Mushroom β-Glucan Recovered from Antler-Type Fruiting Body of Ganoderma lucidum by Enzymatic Process and Its Potential Biological Activities for Cosmeceutical Applications.

Mushrooms are incredibly valuable macro fungi that are an important and integral part of the ecosystem. In addition to being used as cuisine, mushrooms have been used for medicinal purposes for many centuries..

OncologyImmune supportSkin & hydration

Zhu Ling · 2022 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Phytochemistry and bioactivities of the main constituents of Polyporus umbellatus (Pers.) Fries.

BACKGROUND: Edible fungi resources have good application prospects in the research and development of food, medicine, and health products. Polyporus umbellatus (Pers.) Fries, as a precious edible and medicinal fungus, has long been used by Chinese medicine to treat urinary systems and related kidney diseases..

Shiitake · 2022 · Journal Article · Food chemistry

Quality characteristics and non-volatile taste formation mechanism of Lentinula edodes during hot air drying.

In this paper, the changes of non-volatile taste substances and the formation mechanism of taste quality of Lentinula edodes during hot air drying at 50 °C were studied..

Immune supportCognition & nervesEnergy & fatigueSkin & hydration

Lion's Mane · 2022 · Research Article · Nutrients

Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The "Longevity Vitamin" Improves Locomotor Performances during Aging.

Phenotypic frailty is characterized by a progressive decline in physical functioning. During ageing, morphological and functional alterations involve the brain, and chief theories involve oxidative stress, free radical accumulation, and reduced antioxidant defenses as the most implicated mechanisms..

Snow Fungus · 2022 · Journal Article · Food chemistry

Study on effects of preparation method on the structure and antioxidant activity of protein-Tremella fuciformis polysaccharide complexes by asymmetrical flow field-flow fractionation.

Oxidation is an essential biological process for human life. In this study, low density lipoprotein-Tremella fuciformis polysaccharide (LDL-TFP) complexes were prepared by electrostatic and covalent methods..

OncologyImmune supportGut & microbiomeSkin & hydration

Reishi · 2022 · Journal Article · PloS one

The medicinal mushroom Ganoderma lucidum attenuates UV-induced skin carcinogenesis and immunosuppression.

The medicinal mushroom Ganoderma lucidum is traditionally used for treating multiple diseases, including cancer. This study examined skin cancer preventive activity of a commercial product containing spore and fruiting body in 30:8 ratio (GLSF)..

Snow Fungus · 2022 · Research Article · In vivo (Athens, Greece)

Tremella fuciformis Inhibits Melanogenesis in B16F10 Cells and Promotes Migration of Human Fibroblasts and Keratinocytes.

BACKGROUND/AIM: Natural skin whiteners have been investigated for centuries. The development of preparations that safely achieve whitening of hyper-pigmented skin lesions is a challenge for the cosmetics industry..

OncologyImmune supportEnergy & fatigueSkin & hydration

Reishi · 2022 · Research Article · Nutrients

Triterpenoids and Polysaccharides from Ganoderma lucidum Improve the Histomorphology and Function of Testes in Middle-Aged Male Mice by Alleviating Oxidative Stress and Cellular Apoptosis.

Aging is an inevitable physiological process accompanied by a decline in body physiology, including male fertility. A preparation from Ganoderma lucidum (GL) containing triterpenes and polysaccharides has been shown to have anti-aging properties..

Snow Fungus · 2021 · Journal Article · International journal of food science & technology

A comparative study on the physio‐chemical properties, antioxidant and immuno‐stimulating activities of two national geographical indication products of Tremella fuciformis in China

Tremella fuciformis from Gutian in Fujian Province (TF‐GT) and Tongjiang in Sichuan Province (TF‐TJ) in China are two geographical indication (GI) products that are mainly differentiated and characterised by their cultivation methods. To better understand the qualities of the GI products of T..

Shiitake · 2021 · Research Article · Oncology letters

A standardized extract of cultured Lentinula edodes mycelia downregulates cortactin in gemcitabine-resistant pancreatic cancer cells.

AHCC®, a standardized extract of cultured Lentinula edodes mycelia, enhances the therapeutic effects and reduces the adverse effects of chemotherapy. Our previous study reported that treatment with AHCC® downregulated the expression levels of tumor-associated proteins in the gemcitabine-resistant pancreatic cancer….

Turkey Tail · 2021 · Research Article · 3 Biotech

Bioremediation of phenolic pollutant bisphenol A using optimized reverse micelles system of Trametes versicolor laccase in non-aqueous environment.

UNLABELLED: In recent times, there is increased public interest and indeed strong movement against the use of Bisphenol A (4,4'-(propane-2,2,-diphenol)) due to its endocrine disrupting properties. In the present study, biotransformation of Bisphenol A (BPA) was accomplished using Trametes versicolor laccase (E.C..

Immune supportGut & microbiomeSkin & hydration

Wood Ear · 2021 · Journal Article · International journal of biological macromolecules

Effects of Auricularia auricula-judae polysaccharide on pasting, gelatinization, rheology, structural properties and in vitro digestibility of kidney bean starch.

Auricularia auricula-judae polysaccharide (AP) has unique molecular structures and multiple bioactivities with excellent gel-forming property and thermal tolerance. However, few researches focus on the interactions between AP and legume starches..

Energy & fatigueSkin & hydration

Shiitake · 2021 · Journal Article · Journal of the science of food and agriculture

Effects of pre‐cutting treatments and combination drying with different orders on drying characteristics and physicochemical properties of Lentinula edodes

BACKGROUND: Combination drying is recognized as an energy‐efficient method utilized for dry product processing, and proper order of combination is a critical factor determining the effectiveness of the technique..

OncologyGut & microbiomeSkin & hydration

Shiitake · 2021 · Journal Article · European journal of pharmacology

Latcripin-7A from Lentinula edodes C91-3 induces apoptosis, autophagy, and cell cycle arrest at G1 phase in human gastric cancer cells via inhibiting PI3K/Akt/mTOR signaling.

Gastric cancer (G.C) is one of the most lethal cancer types worldwide. Current treatment requires surgery along with chemotherapy, which causes obstacles for speedy recovery.

Energy & fatigueMetabolic healthSkin & hydration

Chaga · 2021 · Journal Article · Journal of natural medicines

Phelligridin D from Inonotus obliquus attenuates oxidative stress and accumulation of ECM in mesangial cells under high glucose via activating Nrf2.

Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus and becomes the financial burden and health problem. Pathogenesis of DN has revealed that high glucose has resulted in the oxidative stress and accumulation of extracellular matrix (ECM)..

Immune supportMetabolic healthSkin & hydration

Wood Ear · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

Skin Wound-Healing Potential of Polysaccharides from Medicinal Mushroom Auricularia auricula-judae (Bull.).

Auricularia auricula-judae, a nutrient-rich mushroom used in traditional medicine, is a macrofungi that exhibits various biological properties. In this study, we have reported on the mechanisms that promote the wound-healing effects of a water-soluble polysaccharide-rich extract obtained from A.

Energy & fatigueSkin & hydration

Cordyceps · 2023 · Journal Article · Journal of microencapsulation

Nanoencapsulated cordyceps extract enhances collagen synthesis and skin cell regeneration through antioxidation and autophagy.

Oxidative stress from reactive oxygen species is the main cause of skin ageing. Cordycepin, a bioactive compound of Cordyceps militaris, contains antioxidant activity..

Reishi · 2022 · Research Article · Pharmaceuticals (Basel, Switzerland)

Discovery of a Multifunctional Octapeptide from Lingzhi with Antioxidant and Tyrosinase Inhibitory Activity.

Ganoderma lucidum or Lingzhi is a fungus species widely known as a traditional medicine. Exploring the beneficial peptides by hydrolysis using pepsin and trypsin has been extensively performed to identify new bioactive natural products..

Metabolic healthSkin & hydration

Shiitake · 2022 · Journal Article · International journal of food science & technology

Utilisation of dried shiitake, black ear and silver ear mushrooms into sorghum biscuits manipulates the predictive glycaemic response in relation to variations in biscuit physical characteristics

The nutritional quality of gluten‐free products is important to the health of individuals with coeliac disease. Mushrooms are good sources of vitamins, dietary fibres and proteins, and are a low‐calorie option that can be used in gluten‐free diets to improve their nutritional value..

Cordyceps · 2021 · Research Article · PeerJ

Arsenic transfer along the soil-sclerotium-stroma chain in Chinese cordyceps and the related health risk assessment.

BACKGROUND: Chinese cordyceps (Lepidoptera: Ophiocordyceps sinensis)is a larval-fungus complex. The concentration and distribution of arsenic (As) may vary during the stroma (ST) germination process and between the sclerotium (SC) and the ST..

Energy & fatigueSkin & hydration

Cordyceps · 2021 · Journal Article · Journal of ethnopharmacology

Discovery of the signal pathways and major bioactive compounds responsible for the anti-hypoxia effect of Chinese cordyceps.

ETHNOPHARMACOLOGICAL RELEVANCE: Hypoxia will cause an increase in the rate of fatigue and aging. Chinese cordyceps, a parasitic Thitarodes insect-Ophiocordyceps sinensis fungus complex in the Qinghai-Tibet Plateau, has long been used to ameliorate human conditions associated with aging and senescence, it is….

OncologyImmune supportMetabolic healthSkin & hydration

Reishi · 2026 · Review · Journal of natural medicines

The emerging role of fatty acids as key bioactive components of Ganoderma lucidum spore oil in alleviating tumor progression.

Ganoderma lucidum, long revered as a divine fungus in traditional medicine, has garnered significant attention for its therapeutic potential. Ganoderma lucidum spore oil (GLSO) is an oil-like substance extracted from cracked Ganoderma lucidum spores using supercritical CO₂ extraction technology..

Immune supportEnergy & fatigueSkin & hydration

Reishi · 2025 · Research Article · Current issues in molecular biology

Ganoderma lucidum Extract Modulates Gene Expression Profiles Associated with Antioxidant Defense, Cytoprotection, and Senescence in Human Dermal Fibroblasts: Investigation of Quantitative Gene Expression by qPCR.

Cellular senescence plays a crucial role in skin aging, with senescent dermal fibroblasts contributing to reduced skin elasticity and increased inflammation. This study investigated the potential of Ganoderma lucidum (Reishi) ethanol extract to modulate the senescent phenotype of human dermal fibroblasts..

OncologyImmune supportSkin & hydration

Maitake · 2020 · Review · Carbohydrate polymers

Preparation and activities of selenium polysaccharide from plant such as Grifola frondosa.

Selenium polysaccharide is an organic selenium compound formed by the combination of polysaccharide and selenium. The biological activity of selenium polysaccharide from plant such as Grifola frondosa is generally higher than that of selenium and polysaccharide, and it is more easily absorbed and utilized by human….

Immune supportSkin & hydrationRespiratory

Cordyceps · 2025 · Review · Life (Basel, Switzerland)

The Genus Cordyceps Sensu Lato: Their Chemical Constituents, Biological Activities, and Therapeutic Effects on Air Pollutants Related to Lung and Vascular Diseases.

Air pollutants are significant environmental factors that contribute to the exacerbation of respiratory, cardiopulmonary, and skin diseases in East Asia, and their impact is based on particle size..

Cordyceps · 2024 · Review · Journal of chromatography. A

Insights into the methods for separation and chromatographic determination of nucleotides/nucleosides in Cordyceps spp.

Cordyceps genus is entomopathogenic mushrooms that have traditionally been used in ethnomedicine in Asian countries. Nucleosides (Ns), nucleotide(Nt), Nucleobases (Nb) and their analogues play a critically physiological role and have a great potential in drug development, such as pentostatin and cordycepin (COR)..

OncologySkin & hydrationRespiratory

Shiitake · 2016 · Review · Pharmacognosy reviews

The Unexplored Anticaries Potential of Shiitake Mushroom.

Keeping an eye the escalating costs of dental services, the treatment cost of the consequences of dental caries can be reduced to manageable proportions by preventive measures aimed at decreasing the prevalence. One such measure is by increasing the consumption of caries preventive foods..

OncologyEnergy & fatigueSkin & hydration

Maitake · 2026 · Journal Article · Journal of complementary & integrative medicine

Evaluating the anticancer potential of black maitake extract in A375 human malignant melanoma cells.

UNLABELLED: Melanoma is one of the deadliest skin cancers, characterized by high metastatic potential and poor prognosis in advanced stages. While chemotherapeutic agent temozolomide (TMZ) is the standard treatment, its clinical utility is hindered by toxicity and limited specificity..

Oyster Mushroom · 2021 · Journal Article · International journal of food science & technology

Effects of ultraviolet‐C irradiation on the physicochemical properties of polysaccharide films prepared from the stalk base of oyster mushrooms (Pleurotus ostreatus)

The effects of ultraviolet (UV)‐C irradiation on the physicochemical properties of oyster mushroom polysaccharide (OMP) films were investigated. The prepared OMP films were subjected to UV‐C treatment (5.4 kJ m⁻²)..

Reishi · 2020 · Comparative Study · International journal of medicinal mushrooms

Comparative Study on Bioactivities from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Gives an Insight into the Fermentation Broth Showing Greater Antioxidative Activities.

Ganoderma lucidum is one of the most famous mushrooms in traditional Chinese medicine. At present, the fully utilized parts of G.

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Journal of invertebrate pathology

Cordycepin, a metabolite of Cordyceps militaris, reduces immune-related gene expression in insects.

Hypocrealean entomopathogenic fungi (EPF) (Sordariomycetes, Ascomycota) are natural regulators of insect populations in terrestrial environments. Their obligately-killing life-cycle means that there is likely to be strong selection pressure for traits that allow them to evade the effects of the host immune system..

King Oyster · 2020 · Research Support, Non U.S. Gov'T · Scientific reports

Physicochemical properties, microstructures, nutritional components, and free amino acids of Pleurotus eryngii as affected by different drying methods.

In this study, we determined the influences of different drying techniques such as natural air (ND), hot-air (HD), vacuum (VD), infrared (ID), microwave (MD), and freeze drying (FD) methods on the color, shrinkage ratio (SR), rehydration ratio (RR), firmness, crispness, microstructures, nutritional components, and….

Shiitake · 2020 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Umami Ingredient: Flavor enhancer from shiitake (Lentinula edodes) byproducts.

An alternative use of shiitake stipes, usually treated as waste, was proposed for the production of a powder ingredient, rich in umami compounds, aiming its application in food..

Immune supportMetabolic healthSkin & hydration

Wood Ear · 2019 · Evaluation Study · International journal of medicinal mushrooms

Hypoglycemic Effect of the Degraded Polysaccharides from the Wood Ear Medicinal Mushroom Auricularia auricula-judae (Agaricomycetes).

Auricularia auricula-judae is an important culinary-medicinal mushroom. The A.

Metabolic healthSkin & hydration

Cordyceps · 2019 · Research Support, Non U.S. Gov'T · Biomolecules

Improved Cordycepin Production by Cordyceps militaris KYL05 Using Casein Hydrolysate in Submerged Conditions.

Cordycepin, a beneficial bioactive product specifically found in Cordyceps, has received attention in various bioindustrial applications such as in pharmaceuticals, functional foods, and cosmetics, due to its significant functions. However, low productivity of cordycepin is a barrier to commercialization..

Immune supportLiver supportSkin & hydration

Shiitake · 2016 · Research Support, Non U.S. Gov'T · Journal of medicinal food

Extracts from Lentinula edodes (Shiitake) Edible Mushrooms Enriched with Vitamin D Exert an Anti-Inflammatory Hepatoprotective Effect.

Vitamin D has been known for its anti-inflammatory properties. Extracts derived from Lentinula edodes (Shiitake) edible mushroom exert an anti-inflammatory effect..

Niu-Chang-Chih · 2015 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Application of Antrodia camphorata Promotes Rat's Wound Healing In Vivo and Facilitates Fibroblast Cell Proliferation In Vitro.

Antrodia camphorata is a parasitic fungus from Taiwan, it has been documented to possess a variety of pharmacological and biological activities. The present study was undertaken to evaluate the potential of Antrodia camphorata ethanol extract to accelerate the rate of wound healing closure and histology of wound area….

Metabolic healthGut & microbiomeSkin & hydration

King Oyster · 2014 · Journal Article · Plant disease

First Report of Sporobolomyces symmetricus Induced Red Spot Disease of Pleurotus eryngii in China.

Pleurotus eryngii is cultivated on a large scale in China and other Asian countries due to its exceptional flavor and its popularity in cuisine. In January of 2009, red spot disease on cultivated P.

Chaga · 2014 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Inhibitory and Acceleratory Effects of Inonotus obliquus on Tyrosinase Activity and Melanin Formation in B16 Melanoma Cells.

The aim of the present study is to preliminarily investigate the antimelanogenesis effect of Inonotus obliquus extracts by cell-free mushroom tyrosinase assay. It was found that petroleum ether and n-butanol extracts might contain unknown potential tyrosinase inhibitors, while its ethyl acetate extract might contain….

OncologyImmune supportLiver supportSkin & hydration

Shiitake · 2012 · Journal Article · Biological & pharmaceutical bulletin

Direct Cytotoxicity of Lentinula edodes Mycelia Extract on Human Hepatocellular Carcinoma Cell Line

Lentinula edodes mycelia (L.E.M.) is a dried powder extracted from shiitake mushrooms (Lentinula edodes). We previously demonstrated that it has immunomodulatory effects.

Immune supportMetabolic healthSkin & hydration

Almond Mushroom · 2010 · Journal Article · International journal of biological macromolecules

Chemical analysis of Agaricus blazei polysaccharides and effect of the polysaccharides on IL-1beta mRNA expression in skin of burn wound-treated rats.

Agaricus blazei polysaccharides were analyzed by GC-MS. Results indicated that the polysaccharides contained glucose (93.87%), mannose (3.54%), and arabinose (2.25%).

Shiitake · 2010 · Journal Article · Journal of wood science

The smell and odorous components of dried shiitake mushroom, Lentinula edodes V: changes in lenthionine and lentinic acid contents during the drying process

This study on dried shiitake mushroom [Lentinula edodes (Berk.) Pegler] focuses on the behavior of the aromatic lenthionine compound and its precursor, lentinic acid, during the drying process..

Shiitake · 2009 · Journal Article · Bioscience, biotechnology, and biochemistry

The Tyrosinase-Encoding Gene of Lentinula edodes, Letyr, Is Abundantly Expressed in the Gills of the Fruit-Body during Post-Harvest Preservation

The gill browning of Lentinula edodes fruit-bodies during preservation is thought to be due to melanin biosynthesis catalyzed by tyrosinase. We isolated a genomic DNA sequence and cDNA encoding a putative tyrosinase from the white rot basidiomycete Lentinula edodes (shiitake mushroom)..

Liver supportSkin & hydration

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · Journal of biomedical materials research. Part B, Applied biomaterials

Agaricus blazei Murill extract-loaded in alginate/poly(vinyl alcohol) films prepared by Ca2+ cross-linking for wound healing applications.

This work aimed the development and evaluation of the wound healing activity of films based on sodium alginate, polyvinyl alcohol (PVA) and Ca2+ loaded with Agaricus blazei Murill hydroalcoholic extract (AbE). Firstly, AbE was prepared using a previously standardized methodology..

Immune supportMetabolic healthLiver supportSkin & hydration

Reishi · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Amelioration of CCl4-induced oxidative stress and hepatotoxicity by Ganoderma lucidum in long evans rats.

Liver disease is a serious health problem affecting people worldwide at an alarming rate. The present study aimed to investigate the protective effects of Ganoderma lucidum against CCl4-induced liver toxicity in rats..

Chaga · 2023 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Inonotus obliquus sclerotia epidermis were different from internal tissues in compound composition, antioxidant activity, and associated fungi.

Inonotus obliquus is a medicinal fungus with potential for use in various health applications. To better utilize this fungus, this study focused on epidermis and internal tissues of five sclerotia from different regions in Jilin, Inner Mongolia, and Heilongjiang, examining their polyphenols, polysaccharides,….

Reishi · 2022 · Research Support, Non U.S. Gov'T · Aging

An active ingredient isolated from Ganoderma lucidum promotes burn wound healing via TRPV1/SMAD signaling.

The mushroom Ganoderma lucidum is a traditional Chinese medicine and G. lucidum spore oil (GLSO) is the lipid fraction isolated from Ganoderma spores.