MycoData

Chaga · 2016 · Review · Biomeditsinskaia khimiia

[Composition and biological activity of triterpenes and steroids from Inonotus obliquus (chaga)].

Data on the chemical composition of triterpenic and steroid compounds, isolated from the chaga mushroom grown in natural environment or in a synthetic culture have been summarized..

Mesima · 2016 · Review · Fitoterapia

Traditional uses, fermentation, phytochemistry and pharmacology of Phellinus linteus: A review.

Medicinal mushroom Phellinus linteus ("Sanghuang" in Chinese, ) is a famous fungus which is widely used in China, Korea, and other Asian countries. As a traditional Chinese medicine with a 2000-year long history, medicinal applications of Phellinus linteus mainly include treating hemorrhage, hemostasis and diseases….

OncologyEnergy & fatigueSkin & hydration

Reishi · 2026 · Research Article · Clinical, cosmetic and investigational dermatology

A Ganoderma lucidum Extract Improves Mitochondrial Function in Aging Skin and Promotes Wound Healing.

PURPOSE: This study investigates whether Ganoderma lucidum extract (GLE) can enhance mitochondrial function to promote wound healing in aging skin. METHODS: Natural senescent human foreskin fibroblasts (BJ) were treated with varying concentrations of GLE, and safe concentrations were determined using the cell counting….

Reishi · 2026 · Journal Article · Journal of food composition and analysis

A review of Ganoderma lucidum: Cultivation, active ingredients and its application as functional ingredients

Ganoderma lucidum, a medicinal and edible fungus with active components possessing antioxidant, anti-inflammatory, and anti-cancer properties, has attracted global attention and been extensively cultivated since the 1970s..

OncologyImmune supportGut & microbiomeLiver support

Snow Fungus · 2026 · Research Article · Foods (Basel, Switzerland)

Absorption, Stability, and Bioactivity of Fungal-Derived Hyaluronic Acid from Tremella fuciformis in a Sequential In Vitro Multi-Barrier Model.

Hyaluronic acid (HA) is widely used in medical, cosmetic, and nutraceutical applications, yet the systemic fate of orally administered HA, particularly non-animal forms, remains poorly characterised..

OncologyImmune supportEnergy & fatigueRespiratory

Reishi · 2026 · Research Article · Discover oncology

Additive anti-tumor and immunomodulatory effects of Sporoderm-removed Ganoderma lucidum spore powder and anti-PD-L1 antibody in lung cancer mice.

BACKGROUND: The therapeutic efficacy of programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) inhibitors in lung cancer management remains suboptimal..

Reishi · 2026 · Journal Article · BMC complementary medicine and therapies

An integrated strategy for screening Q-markers and elucidating anti-fibrotic mechanisms of Ganoderma lucidum.

BACKGROUND: Ganoderma lucidum (G. lucidum) is a medicinal mushroom known for its hepatoprotective effects against various liver diseases.

Reishi · 2026 · Journal Article · Veterinary research communications

Antifibrotic action of medicinal mushrooms Ganoderma lucidum and Polyporus umbellatus in MDCK and CRFK cells.

Chronic kidney disease (CKD) is a significant cause of morbidity and mortality in dogs and cats, characterized by progressive renal dysfunction and interstitial fibrosis. Renal fibrosis is primarily driven by epithelial-mesenchymal transition (EMT) mediated by transforming growth factor-β1 (TGF-β1)..

Shiitake · 2026 · Research Article · Scientific reports

Artificial intelligence-assisted optimization of Lentinula edodes extracts for enhanced bioactive profile and therapeutic potential.

In this study, extraction parameters to increase the biological activities of Lentinula edodes extracts were optimized using both Response Surface Methodology (RSM) and Artificial Neural Network-Genetic Algorithm (ANN-GA) hybrid models..

OncologyImmune supportSkin & hydration

Reishi · 2026 · Research Article · Pharmaceuticals (Basel, Switzerland)

Characterization of a New Biocomposite Based on Bioactive Compounds from Ganoderma lucidum and Jellyfish Collagen Destined for In Vitro Evaluation of Antitumor Effects in the Oral Cavity.

Background/Objectives: Oral squamous cell carcinoma (OSCC) remains a major therapeutic challenge due to treatment-related toxicity and impaired oral tissue regeneration..

Snow Fungus · 2026 · Journal Article · Journal of the science of food and agriculture

Deep eutectic solvent extraction of Tremella fuciformis polysaccharide and the extract's antioxidant activity

BACKGROUND: No study has, until now, examined the deep eutectic solvent (DES) extraction of Tremella fuciformis polysaccharide (TFP). In this study, a DES composed of choline chloride and citric acid (1:1 molar ratio) was prepared for TFP extraction..

Snow Fungus · 2026 · Journal Article · Journal of the science of food and agriculture

Deep eutectic solvent extraction of Tremella fuciformis polysaccharide and the extract's antioxidant activity.

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2026 · Journal Article · Cancer letters

Ganoderma lucidum polysaccharide ameliorates cancer cachexia with enhanced efficacy in aged group by reprogramming arginine metabolism to modulate Treg formation.

Cancer cachexia is a syndrome characterized by profound weight loss, muscle wasting, and metabolic disturbance in cancer patients. Cancer-associated cachexia represents significant biological and clinical challenges that profoundly affect human health..

Reishi · 2026 · Research Article · Pharmaceutics

Ganoderma lucidum Polysaccharide Potentiates mRNA-LNP Efficacy: Synergizing Oxidative Stress Mitigation with Innate Immune Modulation.

Background/Objectives: As a primary mRNA delivery platform, lipid nanoparticles (LNPs) often induce oxidative stress that compromises mRNA translation efficiency. Natural polysaccharides are known for their antioxidant properties..

OncologyImmune supportLiver supportRespiratory

Reishi · 2026 · Research Article · Materials today. Bio

Ganoderma lucidum polysaccharide-decorated extracellular vesicle enables synergistical antitumor immunotherapy.

Ganoderma lucidum polysaccharide (GLP) holds considerable promise for tumor therapy, but its clinical application is limited by its poor tumor-targeting capability..

Maitake · 2026 · Journal Article · Journal of the science of food and agriculture

Grifola frondosa polysaccharide ameliorates adenine-induced CKD by inhibiting TGF-β1/Smad signaling pathway in mice.

BACKGROUND: Chronic kidney disease (CKD) is pathologically characterized by oxidative stress, inflammation, and renal fibrosis, yet effective therapeutic interventions for this condition remains limited. Grifola frondosa polysaccharide (GFP), an active component derived from the edible and medicinal mushroom G..

Reishi · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Heat-Stress Induced Apoptosis: A New Biotechnological Strategy to Enhance Ganoderic Acids Production in Ganoderma lucidum.

Ganoderma lucidum is a medicinal fungus widely utilized in traditional medicine and functional foods. Its primary bioactive constituents are ganoderic acids (GAs), a group of triterpenoid compounds..

OncologyImmune supportMetabolic healthSkin & hydration

Reishi · 2026 · Research Article · Molecules (Basel, Switzerland)

In Vitro and In Vivo Evaluation of the Skincare Bioactivity of β-1,3;1,6-Glucans-Rich Ganoderma lucidum Polysaccharides.

Extracted from Ganoderma lucidum mycelium, the developed β-1,3;1,6-glucan rich polysaccharides have the potential to be used during the industrial production of health food products due to their inhibition of metabolic syndrome, immunomodulatory and antitumor activities and other health benefits..

OncologyMetabolic healthGut & microbiome

Reishi · 2026 · Journal Article · International journal of biological macromolecules

Intestinal epithelial protection and gut microbiota modulation by Ganoderma lucidum proteoglycan are associated with its hypoglycemic potential in type 2 diabetes.

The interplay between gut microbiota, oxidative stress, and intestinal barrier integrity is increasingly recognized as a driving force in the progression of type 2 diabetes mellitus..

OncologyImmune supportEnergy & fatigue

Maitake · 2026 · Research Article · Food chemistry: X

Mechanistic insights into Grifola frondosa-driven fermentation of Rice-wheat bran: Metabolomic profiling, molecular dynamics, and enhanced antioxidant efficacy.

Rice bran (RB) and wheat bran (WB) are rich in bioactives but poorly utilized due to limited bioaccessibility. Here, a fungal fermentation strategy was developed to valorize RB-WB blends.

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2026 · Journal Article · Journal of biotechnology

Morphological and molecular characterization of Mexican Hericium erinaceus strains.

Hericium erinaceus is an edible and medicinal fungus recognized for its antimicrobial, antioxidant, anticancer, neuroprotective, and immunomodulatory properties. Despite its biological and biotechnological relevance, reports of this species in Mexico remain limited, with only one previous molecularly confirmed record….

Reishi · 2026 · Research Article · Applied microbiology and biotechnology

N-Glycosylation of Band 3 is essential for the binding of Ganoderma lucidum immunomodulatory protein rLZ-8.

Fungal immunomodulatory proteins (FIPs) are considered potential therapeutic candidates due to their immunomodulatory and anti-cancer activities. Meanwhile, they are capable of agglutinating mammalian red blood cells in a manner similar to lectins..

OncologyImmune supportCognition & nervesGut & microbiome

Shiitake · 2026 · Research Article · Scientific reports

Oral Lentinula edodes mycelia extract enhances the antitumor effect of radiotherapy via gut-associated activation of dendritic and cytotoxic T cells.

Oral administration of Lentinula edodes mycelia extract (L.E.M.) has been shown to stimulate systemic T cell-mediated antitumor immunity and inhibit tumor growth in mice, suggesting its potential to modulate host immune responses. However, the route of this systemic antitumor effect remains unclear..

OncologyImmune supportEnergy & fatigueLiver support

Mesima · 2026 · Research Article · American journal of cancer research

Phellinus linteus polysaccharides inhibit castration-resistant prostate cancer progression possibly via dual modulation of PIK3R1 and PGC-1α: a preclinical evaluation.

Castration-resistant prostate cancer (CRPC) remains a major challenge due to limited treatment options and frequent therapeutic resistance. This study demonstrates that Phellinus linteus polysaccharides (PLP), both in the form of drug-loaded serum and as a purified extract, exhibit potent anti-CRPC activity through a….

Lion's Mane · 2026 · Journal Article · Colloids and surfaces. B, Biointerfaces

Physicochemical properties and immunological effects of macrophage membrane-coated PLGA nanoparticles loaded with Hericium erinaceus polysaccharides.

In this study, we developed biomimetic Hericium erinaceus polysaccharides PLGA nanoparticles (NPs) coated with macrophage membrane (MM-PLGA-HEP) and examined their immune activity in vitro and in vivo..

Oyster Mushroom · 2026 · Research Article · Frontiers in pharmacology

Pleurotus ostreatus ethanolic extract exerts anti-cancer effects via PI3K/Akt/mTOR pathway modulation in DMBA-NMU induced breast cancer in female Sprague Dawley rats.

Hormone receptor-positive Breast Cancer (BC) driven by PI3K/Akt/mTOR signaling remains a major therapeutic challenge, particularly in settings where conventional chemotherapy causes severe systemic and reproductive toxicity..

OncologyImmune supportGut & microbiome

Oyster Mushroom · 2026 · Journal Article · Harmful algae

Pleurotus ostreatus polysaccharides improve microcystin-LR-induced intestinal damage in tadpoles by regulating the interaction between microbiota and intestine.

Exposure to microcystins (MCs) can cause severe intestinal damage. This study aimed to assess the efficacy of Pleurotus ostreatus polysaccharide in alleviating intestinal damage induced by microcystin-leucine-arginine (MC-LR) in tadpoles..

Lion's Mane · 2026 · Journal Article · Journal of the science of food and agriculture

Preparation, characterization and immune enhancement study of Hericium erinaceus polysaccharide-loaded polyethyleneimine-modified poly(lactic-co-glycolic acid) nanoparticles.

BACKGROUND: Hericium erinaceus polysaccharides (HEPs) exhibit remarkable immunomodulatory properties but are hampered by poor oral bioavailability. To overcome these limitations, this study developed and optimized HEP-loaded polyethyleneimine (PEI)-modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles….

OncologyImmune supportEnergy & fatigueLiver support

Reishi · 2026 · Journal Article · Journal of ethnopharmacology

Protective effects of Ganoderma lucidum polysaccharide peptides against cisplatin-induced toxicity.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum) has been used in traditional Chinese medicine for centuries to enhance vitality and support organ function.

Reishi · 2026 · Journal Article · Phytochemistry

Seven undescribed metabolites from Ganoderma lucidum-derived endophytic Talaromyces sp. GLQ04 and their anti-DLBCL (diffuse large B-cell lymphoma) activities.

Seven undescribed metabolites and four known compounds were isolated from a Ganoderma lucidum-derived endophytic fungus Talaromyces sp. GLQ04.

Maitake · 2026 · Journal Article · Carbohydrate polymers

Structural characterization and antitumor activity via immune modulation of an α-glucan from Grifola frondosa.

Grifola frondosa is a valued edible and medicinal fungus whose polysaccharides are key bioactive components, yet the identification of specific homogeneous effectors and their detailed immunomodulatory mechanisms remains a critical focus of research. In this study, polysaccharide fractions were isolated from G..

OncologyImmune supportMetabolic healthGut & microbiome

Enoki · 2026 · Research Article · International journal of molecular sciences

The Brown Strain of Flammulina velutipes Singer Attenuates 5-Fluorouracil-Induced Intestinal Injury by Suppressing Inflammation, Oxidative Stress, and Barrier Disruption via Modulation of Epithelial-Mesenchymal Transition and Tight Junction Integrity.

5-Fluorouracil (5-FU) remains a cornerstone chemotherapeutic for colorectal cancer, exerting its antitumor effects primarily through disruption of DNA and RNA synthesis and subsequent induction of apoptosis. Nonetheless, its clinical efficacy is often compromised by prominent adverse effects, particularly mucositis..

OncologyImmune supportEnergy & fatigue

Chaga · 2026 · Research Article · Frontiers in veterinary science

The effects of polysaccharides from Inonotus obliquus, artemisinin, and dihydroartemisinin on the reproductive system of male mice infected with Neospora caninum.

The present study investigated the protective effects of Inonotus obliquus polysaccharides (IOPs), artemisinin, and dihydroartemisinin (DHA) on Neospora caninum-induced damage of the reproductive system in male BALB/c mice..

OncologyImmune supportGut & microbiome

Reishi · 2026 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

The paradox of potency: Insights into emergent mechanisms of Ganoderma lucidum's antitumor effects.

BACKGROUND: An arms race between cancer cells and therapeutic pressure fuels drug resistance, immune evasion, and tumor heterogeneity, hindering therapy. Ganoderma lucidum (G.

OncologyImmune supportEnergy & fatigueGut & microbiome

Reishi · 2026 · Journal Article · Molecular and cellular biochemistry

The role of mitochondrial regulation in macrophage polarization by Ganoderma lucidum polysaccharide for the treatment of colitis-associated colorectal cancer.

Colorectal cancer (CRC) is a common malignant tumor of the digestive tract. Ganoderma lucidum polysaccharide (GLP) has shown significant potential in regulating macrophage polarization and treating CRC..

Shiitake · 2026 · Research Article · Current issues in molecular biology

Treatment of Mesenchymal Stem Cell-Derived Extracellular Vesicles with Extract of Cultured Lentinula edodes Modulates Breast Cancer Stem Cells and MicroRNA Reprogramming.

Breast carcinoma represents the most frequent malignancy in women in Canada, and intrinsic or acquired drug resistance significantly increases the risk of recurrence and metastasis..

Snow Fungus · 2026 · Research Article · European journal of translational myology

Tremella fuciformis polysaccharide: enhancing ischemic hypoxic adaptation of mesenchymal stem cells.

Human Placenta-Derived Mesenchymal Stem Cells (HP-MSCs) are recognized for their potential in treating various diseases due to their multidirectional differentiation and immunomodulatory abilities. However, the therapeutic efficacy is often compromised in ischemic and hypoxic environments..

OncologyImmune supportEnergy & fatigueGut & microbiome

Lion's Mane · 2026 · Journal Article · International journal of biological macromolecules

β-Glucan-rich Hericium erinaceus hot-water extract ameliorates acute colitis by suppressing inflammation, preserving the epithelial barrier, and modulating gut microbiota ecosystem.

Inflammatory bowel disease (IBD) is a chronic disorder marked by mucosal barrier disruption, immune imbalance, and gut dysbiosis. Polysaccharide-enriched extracts of Hericium erinaceus (HE) have shown anti-colitic effects, but the role of its β-glucan-rich water extract (HE-HW) remains unclear..

Reishi · 2025 · Journal Article · International journal of biological macromolecules

A glucomannan from defatted Ganoderma lucidum spores: structural characterization and immunomodulatory activity via activating TLR4/MyD88/NF-κB signaling pathway.

Ganoderma lucidum spores are tiny mature germ cells ejected from the abaxial side of the pileus and were responsible for multiple pharmacological properties. The defatted G.

OncologyImmune supportCognition & nerves

Lion's Mane · 2025 · Research Article · International journal of medical sciences

A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation.

Hericium erinaceus, renowned for its pharmaceutical potential, is particularly notable for its isolated diterpenoid derivative, erinacine S. Colorectal cancer (CRC) is one of the most prevalent cancers, characterized by CSC that contribute to chemoresistance and sustained tumor growth..

OncologyCognition & nerves

Shiitake · 2025 · Research Article · Frontiers in oncology

A placebo-controlled study of the doses and efficacy of Lentinula edodes mycelia for oxaliplatin-induced peripheral neuropathy in colorectal cancer.

INTRODUCTION: Preclinical studies have demonstrated the potential of Lentinula edodes mycelium (L.E.M.) extract for managing oxaliplatin-induced peripheral neuropathy (OIPN). The efficacy and optimal dosage of L.E.M.

Almond Mushroom · 2025 · Journal Article · Combinatorial chemistry & high throughput screening

Agaricus blazei Murill Extract (FA-2-b-β) Induces Ferroptosis in Diffuse Large B-Cell Lymphoma via the Nrf2/Ho-1 Pathway.

INTRODUCTION: Ferroptosis is a recently identified iron-dependent programmed cell death closely linked to the progression of diffuse large B-cell lymphoma (DLBCL)..

OncologyEnergy & fatigue

OncologyImmune supportCognition & nervesLiver support

Zhu Ling · 2025 · Research Article · Computational and structural biotechnology journal

Anticancer effects and mechanisms of Pulsatilla chinensis, Bupleurum chinense and Polyporus umbellatus on human lung carcinoma and hepatoma cells.

Herbs are extensively utilized in Traditional Chinese Medicine (TCM) for lung and liver cancer treatment, but the mechanisms behind these herbs remain largely unknown. Here, high-throughput transcriptomic analysis technology was used to uncover molecular mechanisms of herbal treatment..

Turkey Tail · 2025 · Journal Article · Molecular biology reports

Anticancer potential of purified laccase enzyme from Trametes versicolor: specific cytotoxicity against thyroid and endometrial cancer cells.

BACKGROUND: Cancer is one of the leading causes of death worldwide, highlighting the need to develop novel therapeutic strategies that are more effective and have fewer side effects than conventional treatments. Enzymatic cancer therapy is a promising approach due to its high specificity and minimal toxicity..

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · Journal of medicinal food

Antioxidant Properties of Mexican Ganoderma lucidum Extracts in Obese C57BL/6 Mice Fed with a High-Fat and Sugar Diet.

Oxidative stress is a key factor of comorbidities in obesity. A Mexican genotype of the medicinal mushroom Ganoderma lucidum (Gl) contains bioactive compounds showing antioxidant, hypocholesterolemic, anti-inflammatory, anticancer, and prebiotic properties..

OncologyImmune supportEnergy & fatigueSkin & hydration

Reishi · 2025 · Research Article · Microbial cell factories

ATP deficiency triggers ganoderic acids accumulation via fatty acid β-oxidation pathway in Ganoderma lucidum.

BACKGROUND: Ganoderic acids (GAs), recognized as significant triterpenoid bioactive components in Ganoderma lucidum, exhibit a broad spectrum of pharmacological activities, including immunomodulation, anti-cancer, and anti-aging properties..

Reishi · 2025 · Journal Article · Phytochemistry

Baoslingzhines Q-X: Structurally previously undescribed trace phenolic meroterpenoids from Ganoderma lucidum and their biological activities toward renal fibrosis and cytotoxicity.

Eight previously undescribed phenolic meroterpenoids baoslingzhines Q-X (1-8) including three enantiomeric (±)-baoslingzhines Q-S (1-3) harboring a 2-methylbenzofuran moiety, two trinormeroterpenoids baoslingzhines T and U (4 and 5) containing a 5-methylbenzyl motif as a connection point with another ring, an alkaloid….

OncologySkin & hydration

OncologyImmune supportMetabolic healthRespiratory

Oyster Mushroom · 2025 · Research Article · Current research in food science

Bioactive properties of selenium-enriched polysaccharides extracted from Pleurotus ostreatus using ultrasonic-assisted extraction.

Mushrooms are well recognized as functional foods owing to their rich nutritional and medicinal properties, particularly polysaccharides with notable therapeutic potential..

Mesima · 2025 · Research Article · Current issues in molecular biology

Bioconversion of Chamaecyparis obtusa Leaves with Phellinus linteus Mycelium Modulates Antioxidant and Anti-Inflammatory Activities.

Chamaecyparis obtusa (Hinoki cypress) has been extensively studied for its leaves and bark, which are known to contain high levels of polyphenols and flavonoids with potent bioactivities. In this study, the phytochemical transformation and changes in bioactivity of C..