MycoData

Total phenolics, flavonoids, and polysaccharides, and individual ganoderic acid (GA) contents, antioxidant capacity, and transcription levels of key enzyme genes involved in GA biosynthesis in pileus and stipes of Ganoderma lucidum fruiting body at different growth stages were investigated in this study..

Immune support

High relevance

Reishi · 2020 · Comparative Study · International journal of medicinal mushrooms

Comparative Study on Bioactivities from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Gives an Insight into the Fermentation Broth Showing Greater Antioxidative Activities.

Ganoderma lucidum is one of the most famous mushrooms in traditional Chinese medicine. At present, the fully utilized parts of G.

OncologySkin & hydration

High relevance

King Oyster · 2020 · Research Support, Non U.S. Gov'T · Genomics

Comparative transcriptomic analysis reveals molecular processes involved in pileus morphogenesis in Pleurotus eryngii under different light conditions.

Light plays an important role in pileus differentiation in Pleurotus eryngii cultivation, and pileus morphology is influenced by light quality. To understand the effects of light quality on pileus morphology at the transcriptional level, we performed a comparative transcriptomic analysis of pilei grown under blue and….

Respiratory

High relevance

King Oyster · 2020 · Comparative Study · Applied microbiology and biotechnology

Comparative transcriptomics and transcriptional regulation analysis of enhanced laccase production induced by co-culture of Pleurotus eryngii var. ferulae with Rhodotorula mucilaginosa.

The co-culturing of Pleurotus eryngii var. ferulae and Rhodotorula mucilaginosa was confirmed in our previous studies to be an efficient strategy to improve laccase production by submerged fermentation..

Energy & fatigue

High relevance

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Journal of invertebrate pathology

Cordycepin, a metabolite of Cordyceps militaris, reduces immune-related gene expression in insects.

Hypocrealean entomopathogenic fungi (EPF) (Sordariomycetes, Ascomycota) are natural regulators of insect populations in terrestrial environments. Their obligately-killing life-cycle means that there is likely to be strong selection pressure for traits that allow them to evade the effects of the host immune system..

Immune supportSkin & hydration

High relevance

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Cordyceps militaris Exerts Anticancer Effect on Non-Small Cell Lung Cancer by Inhibiting Hedgehog Signaling via Suppression of TCTN3.

This study aimed to investigate the effect of Cordyceps militaris extract on the proliferation and apoptosis of non-small cell lung cancer (NSCLC) cells and determine the underlying mechanisms..

OncologyImmune supportRespiratory

High relevance

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Fungal genetics and biology: FG & B

Diverse function and regulation of CmSnf1 in entomopathogenic fungus Cordyceps militaris.

SNF1/AMPK protein kinases play important roles in fungal development and activation of catabolite-repressed genes. In this study, we characterized the role of SNF1 ortholog in Cordyceps militaris (CmSnf1)..

High relevance

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Efficacy of Ethyl Acetate Fraction of Cordyceps militaris for Cancer-Related Fatigue in Blood Biochemical and 1H-Nuclear Magnetic Resonance Metabolomic Analyses.

This study investigated the adjuvant effects for anticancer and antifatigue of the combination of Cordyceps militaris extract with sorafenib. The 5 extracts of C militaris were obtained through hexane, chloroform, ethyl acetate, butanol, and water and were evaluated for anticancer growth activity..

OncologyEnergy & fatigueMetabolic healthLiver support

High relevance

Shiitake · 2020 · Research Support, Non U.S. Gov'T · PloS one

Mycelial biomass estimation and metabolic quotient of Lentinula edodes using species-specific qPCR.

Lentinula edodes, commonly known as shiitake, is an edible mushroom that is cultivated and consumed around the globe, especially in Asia. Monitoring mycelial growth inside a woody substrate is difficult, but it is essential for effective management of mushroom cultivation..

Metabolic health

High relevance

Oyster Mushroom · 2020 · Research Support, Non U.S. Gov'T · Biomolecules

Nephroprotective Effect of Pleurotus ostreatus and Agaricus bisporus Extracts and Carvedilol on Ethylene Glycol-Induced Urolithiasis: Roles of NF-κB, p53, Bcl-2, Bax and Bak.

This study was designed to assess the nephroprotective effects of Pleurotus ostreatus and Agaricus bisporus aqueous extracts and carvedilol on hyperoxaluria-induced urolithiasis and to scrutinize the possible roles of NF-κB, p53, Bcl-2, Bax and Bak..

OncologyImmune support

High relevance

Reishi · 2020 · Research Support, Non U.S. Gov'T · PloS one

Optimization of ultrasonic-assisted extraction of polysaccharides and triterpenoids from the medicinal mushroom Ganoderma lucidum and evaluation of their in vitro antioxidant capacities.

Ganoderma lucidum (Fr.) Krast, commonly known as "Lingzhi" in Chinese, is a medicinal mushroom that is rich in biologically active substances. Polysaccharides and triterpenoids are the two major components responsible for the bioactivity of this fungus..

Immune support

High relevance

King Oyster · 2020 · Research Support, Non U.S. Gov'T · Scientific reports

Physicochemical properties, microstructures, nutritional components, and free amino acids of Pleurotus eryngii as affected by different drying methods.

In this study, we determined the influences of different drying techniques such as natural air (ND), hot-air (HD), vacuum (VD), infrared (ID), microwave (MD), and freeze drying (FD) methods on the color, shrinkage ratio (SR), rehydration ratio (RR), firmness, crispness, microstructures, nutritional components, and….

Skin & hydration

High relevance

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Cells

Probing Carbon Utilization of Cordyceps militaris by Sugar Transportome and Protein Structural Analysis.

Beyond comparative genomics, we identified 85 sugar transporter genes in Cordyceps militaris, clustering into nine subfamilies as sequence- and phylogenetic-based functional classification, presuming the versatile capability of the fungal growths on a range of sugars..

Energy & fatigueMetabolic health

High relevance

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Journal of economic entomology

Report on the Emergence Time of a Species of Thitarodes Ghost Moth (Lepidoptera: Hepialidae), Host of the Caterpillar Fungus Ophiocordyceps sinensis (Ascomycota: Ophiocordycipitaceae) in Uttarakhand, India.

Ghost moths in the genus Thitarodes Viette, 1968, are hosts of the economically important caterpillar fungus, which is harvested in high mountain meadows across the Hengduan mountains and the Himalayas..

High relevance

Lion's Mane · 2020 · Comparative Study · Food chemistry

Selenium biofortification in Hericium erinaceus (Lion's Mane mushroom) and its in vitro bioaccessibility.

Hericium erinaceus is a traditional edible mushroom. Selenium (Se) is an essential trace element for humans and other mammals.

Gut & microbiome

High relevance

Oyster Mushroom · 2020 · Research Support, Non U.S. Gov'T · Glycobiology

Structure and properties of the oyster mushroom (Pleurotus ostreatus) lectin.

Pleurotus ostreatus Lectin (POL) is a 353 amino acid chain lectin that can be purified from the fruiting bodies of the very well-known and widely diffused edible oyster mushrooms (P. ostreatus)..

Oncology

High relevance

Cordyceps · 2020 · Abstract · Current developments in nutrition

The Antidepressive and Anxiolytic Effects of Formula Consisted of Poria cocos and Cordyceps militaris Waster Medium Extract in Unpredictable Chronic Mild Stress Animal Model

Abstract Objectives According to the WHO report, depression will be the first of the global burden of diseases in 2030. There is more than fifty % of people suffered from depression and anxiety..

Immune supportCognition & nervesMetabolic health

High relevance

Almond Mushroom · 2020 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

The beneficial effects of Agaricus blazei Murrill on hepatic antioxidant enzymes and the pancreatic tissue recovery in streptozotocin-induced diabetic rats.

Agaricus blazei Murrill (ABM), is a medicinal mushroom, has beneficial effects on diabetes mellitus. In this study, ABM extracts (ethanol extract, EE and ethyl acetate extract, EA) were evaluated to explore the beneficial effect on hepatic antioxidant activity and recovery of the pancreatic tissue in….

Metabolic healthLiver support

High relevance

Reishi · 2020 · Research Support, Non U.S. Gov'T · PloS one

The ITS region provides a reliable DNA barcode for identifying reishi/lingzhi (Ganoderma) from herbal supplements.

The dietary supplement industry is rapidly growing yet, a recent study revealed that up to 60% of supplements may have substituted ingredients, some of which can be harmful contaminants or additives..

High relevance

Oyster Mushroom · 2020 · Research Support, Non U.S. Gov'T · Scientific reports

The PoV mycovirus affects extracellular enzyme expression and fruiting body yield in the oyster mushroom, Pleurotus ostreatus.

Isogenic virus-cured and virus-infected fungal strains were previously obtained and compared to investigate mycoviral diseases and, specifically, the influence of viral infection on the vegetative growth of Pleurotus ostreatus..

Respiratory

High relevance

Shiitake · 2020 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Umami Ingredient: Flavor enhancer from shiitake (Lentinula edodes) byproducts.

An alternative use of shiitake stipes, usually treated as waste, was proposed for the production of a powder ingredient, rich in umami compounds, aiming its application in food..

Skin & hydration

High relevance

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Journal of invertebrate pathology

Vegetative development and host immune interaction of Ophiocordyceps sinensis within the hemocoel of the ghost moth larva, Thitarodes xiaojinensis.

Ophiocordyceps sinensis is an entomopathogenic fungus that infects ghost moth larva, forming the most valuable and rare traditional Chinese medicine, Chinese cordyceps. Our knowledge of the basic morphology and developmental biology of Chinese cordyceps is limited..

Immune support

High relevance

Enoki · 2019 · Research Support, Non U.S. Gov'T · Applied and environmental microbiology

A Single Transcription Factor (PDD1) Determines Development and Yield of Winter Mushroom (Flammulina velutipes).

Most of the edible mushrooms cannot be cultivated or have low yield under industrial conditions, partially due to the lack of knowledge on how basidioma (fruiting body) development is regulated..

High relevance

King Oyster · 2019 · Research Support, Non U.S. Gov'T · International journal of environmental research and public health

Adsorption Thermodynamics and Dynamics of Three Typical Dyes onto Bio-adsorbent Spent Substrate of Pleurotus eryngii.

Dyeing wastewater is very hard to treat, and adsorption could be a good choice. Spent substrate of Pleurotus eryngii (SSPE) was first used to adsorb malachite green, safranine T and methylene blue from aqueous solutions, and the corresponding adsorption isotherm, thermodynamics and dynamics models were simulated..

High relevance

Cordyceps · 2019 · Abstract · Current developments in nutrition

Anticancer Effects of Cordyceps Militaris Extract in Human Ovarian Cancer Cells via ADORA2B (P05-012-19)

Abstract Objectives The study was aimed to determine anticancer effects of Cordyceps militaris extract (CME) and its major bioactive compound, cordycepin, in human ovarian cancer cells, and to identify their putative molecular mechanism mediated by adenosine receptors (ADORAs)..

Oncology

High relevance

Cordyceps · 2019 · Research Support, Non U.S. Gov'T · Biotechnology progress

Catalytic characteristics of a sn-1(3) regioselective lipase from Cordyceps militaris.

A total of 39 agricultural products were screened for natural sources of lipases with distinctive positional specificity. Based on this, Cordyceps militaris lipase (CML) was selected and subsequently purified by sequential chromatography involving anion-exchange, hydrophobic-interaction, and gel-permeation columns..

High relevance

Oyster Mushroom · 2019 · Comparative Study · International journal of molecular sciences

Comparative Proteomic Analysis of Pleurotus ostreatus Reveals Great Metabolic Differences in the Cap and Stipe Development and the Potential Role of Ca2+ in the Primordium Differentiation.

Pleurotus ostreatus is a widely cultivated edible fungus around the world. At present, studies on the developmental process of the fruiting body are limited.

Metabolic health

High relevance

Cordyceps · 2019 · Comparative Study · International journal of biological macromolecules

Comparisons of the anti-tumor activity of polysaccharides from fermented mycelia and cultivated fruiting bodies of Cordyceps militaris in vitro.

A comparison of the anti-tumor activity of CMPS-II and CBPS-II polysaccharides, respectively is obtained from the fermented mycelium and cultivated fruiting bodies of Cordyceps militaris..

OncologyImmune supportRespiratory

High relevance

King Oyster · 2019 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

Dietary Intake of Pleurotus eryngii Ameliorated Dextran-Sodium-Sulfate-Induced Colitis in Mice.

SCOPE: Pleurotus eryngii, an edible mushroom, is widely consumed as a functional food for various health benefits due to its multiple bioactive components. There are growing interests in using whole-food-based strategies to prevent colonic inflammation via potential synergistic interactions among different components….

Immune supportGut & microbiome

High relevance

Cordyceps · 2019 · Evaluation Study · Journal of the science of food and agriculture

Effect of radio-frequency heating on microbial load, flavor, color, and texture profiles of Cordyceps militaris.

BACKGROUND: Cordyceps militaris is a medicine and food dual-purpose mushroom extensively cultivated and consumed in East and Southeast Asia for centuries. However, it has an extremely short shelf life of 3-4 days at room temperature.

High relevance

Cordyceps · 2019 · Comparative Study · Journal of bioscience and bioengineering

Enhanced exopolysaccharide production by Cordyceps militaris using repeated batch cultivation.

Cordyceps militaris exo-polysaccharides (EPS) have been reported to possess many benefits, such as anti-tumor, anti-inflammatory and antioxidant activities. In this study, the production of EPS via cultivation in a bioreactor was investigated..

OncologyImmune supportMetabolic health

High relevance

Reishi · 2019 · Research Support, Non U.S. Gov'T · Progress in molecular biology and translational science

Ganoderma lucidum polysaccharide used for treating physical frailty in China.

Ganoderma lucidum is an edible medicinal mushroom known as "Lingzhi" in China and "Reishi or Manetake" in Japan. It is a highly prized vitality-enhancing herb for >2000 years.

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Wood Ear · 2019 · Evaluation Study · International journal of medicinal mushrooms

Hypoglycemic Effect of the Degraded Polysaccharides from the Wood Ear Medicinal Mushroom Auricularia auricula-judae (Agaricomycetes).

Auricularia auricula-judae is an important culinary-medicinal mushroom. The A.

Immune supportMetabolic healthSkin & hydration

High relevance

Cordyceps · 2019 · Research Support, Non U.S. Gov'T · Biomolecules

Improved Cordycepin Production by Cordyceps militaris KYL05 Using Casein Hydrolysate in Submerged Conditions.

Cordycepin, a beneficial bioactive product specifically found in Cordyceps, has received attention in various bioindustrial applications such as in pharmaceuticals, functional foods, and cosmetics, due to its significant functions. However, low productivity of cordycepin is a barrier to commercialization..

Metabolic healthSkin & hydration

High relevance

Chaga · 2019 · Research Support, Non U.S. Gov'T · PloS one

Inonotus obliquus attenuates histamine-induced microvascular inflammation.

Cell-to-cell communication is a key element of microvascular blood flow control, including rapidly carrying signals through the vascular endothelium in response to local stimuli. This cell-to-cell communication is negatively impacted during inflammation through the disruption of junctional integrity..

Immune supportEnergy & fatigue

High relevance

Cordyceps · 2019 · Comparative Study · MicrobiologyOpen

Metabolic comparison of aerial and submerged mycelia formed in the liquid surface culture of Cordyceps militaris.

An entomopathogenic fungus, Cordyceps sp. has been known to produce cordycepin which is a purine nucleoside antimetabolite and antibiotic with potential anticancer, antioxidant and anti-inflammatory activities..

OncologyImmune supportMetabolic health

High relevance

Lion's Mane · 2019 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

Molecular properties, structure, and antioxidant activities of the oligosaccharide Hep-2 isolated from cultured mycelium of Hericium erinaceus.

The oligosaccharide Hep-2 from cultured mycelium of Hericium erinaceus was obtained with a hollow-fiber ultrafiltration cartridge and purified with a DEAE Sephadex A-50 column followed by a Bio-Gel P-30 column. The properties, structure, and antioxidant activities of Hep-2 were studied..

OncologyEnergy & fatigueGut & microbiome

High relevance

Oyster Mushroom · 2019 · Research Support, Non U.S. Gov'T · PloS one

Optimization of extraction of antioxidant polysaccharide from Pleurotus ostreatus (Jacq.) P. Kumm and its cytotoxic activity against murine lymphoid cancer cell line.

The purpose of this study was to optimize the extraction method for polysaccharide from the fruiting bodies of Pleurotus ostreatus (Jacq.) P. Kumm and to assess the antioxidant and cytotoxic potentials of polysaccharide.

OncologyImmune supportEnergy & fatigue

High relevance

Yellow Morel · 2019 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

Polysaccharides production from soybean curd residue via Morchella esculenta.

To minimize the serious environmental pollution caused by food byproducts, soybean curd residue was used as the substrate to ferment polysaccharides by Morchella esculenta..

Immune supportMetabolic health

High relevance

Cordyceps · 2019 · Research Support, Non U.S. Gov'T · The Journal of biological chemistry

Structural basis for the specific cleavage of core-fucosylated N-glycans by endo-β-N-acetylglucosaminidase from the fungus Cordyceps militaris.

N-Linked glycans play important roles in various cellular and immunological events. Endo-β-N-acetylglucosaminidase (ENGase) can release or transglycosylate N-glycans and is a promising tool for the chemoenzymatic synthesis of glycoproteins with homogeneously modified glycans..

Immune supportCognition & nerves

High relevance

Shiitake · 2019 · Research Support, Non U.S. Gov'T · Virology

Two novel fungal negative-strand RNA viruses related to mymonaviruses and phenuiviruses in the shiitake mushroom (Lentinula edodes).

There is still limited information on the diversity of (-)ssRNA viruses that infect fungi. Here, we have discovered two novel (-)ssRNA mycoviruses in the shiitake mushroom (Lentinula edodes)..

Respiratory

High relevance

Maitake · 2018 · Research Support, Non U.S. Gov'T · Scientific reports

A polysaccharide-peptide with mercury clearance activity from dried fruiting bodies of maitake mushroom Grifola frondosa.

Mercury is considered to be "a global pollutant" and raises concern worldwide. Once mercury enters the body, it will be distributed all over the body but will accumulate in the brain, kidney and liver.

Immune supportCognition & nervesLiver support

High relevance

Chaga · 2018 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Chaga ( Inonotus obliquus), a Future Potential Medicinal Fungus in Oncology? A Chemical Study and a Comparison of the Cytotoxicity Against Human Lung Adenocarcinoma Cells (A549) and Human Bronchial Epithelial Cells (BEAS-2B).

BACKGROUND: Inonotus obliquus, also known as Chaga, is a parasitic fungus growing on birches and used in traditional medicine (especially by Khanty people) to treat various health problems..

OncologyEnergy & fatigueRespiratory

High relevance

Cordyceps · 2018 · Research Support, Non U.S. Gov'T · Scientific reports

Characterization of novel endo-β-N-acetylglucosaminidases from Sphingobacterium species, Beauveria bassiana and Cordyceps militaris that specifically hydrolyze fucose-containing oligosaccharides and human IgG.

Endo-β-N-acetylglucosaminidase (ENGase) catalyzes hydrolysis of N-linked oligosaccharides. Although many ENGases have been characterized from various organisms, so far no fucose-containing oligosaccharides-specific ENGase has been identified in any organism..

Immune support

High relevance

King Oyster · 2018 · Research Support, Non U.S. Gov'T · Genomics

Comparative transcriptomics of Pleurotus eryngii reveals blue-light regulation of carbohydrate-active enzymes (CAZymes) expression at primordium differentiated into fruiting body stage.

Blue light is an important environmental factor which could induce mushroom primordium differentiation and fruiting body development. However, the mechanisms of Pleurotus eryngii primordium differentiation and development induced by blue light are still unclear..

High relevance

Cordyceps · 2018 · Evaluation Study · Journal of the science of food and agriculture

Effects of microwave-assisted pulse-spouted bed freeze-drying (MPSFD) on volatile compounds and structural aspects of Cordyceps militaris.

BACKGROUND: Microwave-assisted pulse-spouted bed freeze-drying (MPSFD) uses microwave heating to substitute the customary conduction heating during freeze drying (FD), resulting in high-quality dried samples with a short drying time..

Energy & fatigue

High relevance

King Oyster · 2018 · Research Support, Non U.S. Gov'T · Journal of microbiological methods

Efficient transformation of Pleurotus eryngii with a safe selective marker mutated from the Pesdi1 gene.

We introduced a site-directed mutation in the sdi1 gene and used it as a selective marker for the polyethylene glycol-mediated transformation of Pleurotus eryngii monokaryon protoplasts..

High relevance

Cordyceps · 2018 · Dissertation · journal metadata

Elucidating the natural function of cordycepin, a secondary metabolite of the fungus Cordyceps militaris, and its potential as a novel biopesticide in Integrated Pest Management

Metadata-grounded summary: This dissertation indexes research on Cordyceps militaris in 2018. MycoData maps the paper to energy & fatigue based on its title, species context, article metadata, and study classification..

Energy & fatigue

High relevance

Shiitake · 2018 · Research Support, Non U.S. Gov'T · Biotechnology progress

Extraction of bioactive compounds against cardiovascular diseases from Lentinula edodes using a sequential extraction method.

Three extraction methods were sequentially combined to obtain fractions from Lentinula edodes (shiitake mushrooms) containing bioactive compounds against cardiovascular diseases (CVDs)..

Metabolic health

High relevance

Shiitake · 2018 · Research Support, Non U.S. Gov'T · PloS one

Identification and evaluation of reference genes for qRT-PCR studies in Lentinula edodes.

Lentinula edodes (shiitake mushroom) is a common edible mushroom with a number of potential therapeutic and nutritional applications. It contains various medically important molecules, such as polysaccharides, terpenoids, sterols, and lipids, were contained in this mushroom..

Immune support