MycoData

OncologyImmune supportMetabolic health

Cordyceps · 2024 · Review · Journal of integrative medicine

Cordyceps as potential therapeutic agents for atherosclerosis.

Atherosclerosis is a leading cause of mortality and morbidity worldwide. Despite the challenges in managing atherosclerosis, researchers continue to investigate new treatments and complementary therapies..

OncologyImmune supportMetabolic healthGut & microbiome

Cordyceps · 2024 · Review · Molecules (Basel, Switzerland)

Cordyceps Polysaccharides: A Review of Their Immunomodulatory Effects.

Cordyceps primarily consists of ascomycetes, a parasitic fungus that infects insects and arthropods. Recently, Cordyceps has been shown to manifest a diverse range of pharmacological activities, rendering it applicable for the treatment and mitigation of various diseases, such as diabetes, acute liver injury, and….

Immune supportEnergy & fatigue

Cordyceps · 2024 · Randomized Controlled Trial · Food & function

Cordyceps sinensis accelerates stem cell recruitment to human skeletal muscle after exercise.

Cordyceps sinensis is a parasitic fungus known to induce immune responses. The impact of Cordyceps supplementation on stem cell homing and expansion to human skeletal muscle after exercise remains unexplored..

Oyster Mushroom · 2024 · Research Article · Life (Basel, Switzerland)

Microbial Inoculation during the Short-Term Composting Process Enhances the Nutritional and Functional Properties of Oyster Mushrooms (Pleurotus ostreatus).

In recent years, short-term composting techniques have been widely applied in oyster mushroom cultivation, but there is still a lack of systematic research on their impact on the nutritional and functional properties of fruiting bodies..

OncologyImmune supportLiver support

Reishi · 2023 · Preprint · journal metadata

A Review of the Application of Ganoderma lucidum (Curtis) P. Karst. In Nanotechnology for the Treatment of Cancer

Ganoderma lucidum, commonly known as the "Lingzhi" or "Reishi" mushroom, has long been recognized for its potential health benefits, and medicinal properties in traditional Chinese medicine..

OncologyImmune supportEnergy & fatigueMetabolic health

Oyster Mushroom · 2023 · Preprint · journal metadata

Active compound test: ethanolic extract of White Oyster Mushroom (Pleurotus ostreatus) Using HPLC and LC-MS

Background: The use of herbs as traditional medicine in Indonesia is increasing, with more than 40% of Indonesia's population utilizing them. White oyster mushroom ( Pleurotus Ostreatus ) is a fungus that has various therapeutic effects including antioxidant, anti-inflammatory, anti-bacterial, anti-cholesterol, and….

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2023 · Preprint · journal metadata

Inonotus obliquus upregulates muscle regeneration and augments function through muscle oxidative metabolism

Abstract Background Skeletal muscle wasting related to aging or pathological conditions is critically associated with the increased incidence and prevalence of secondary diseases including cardiovascular diseases, metabolic syndromes, and chronic inflammations..

Cordyceps · 2023 · Preprint · journal metadata

Overexpression of glycosyltransferase genes enhance the production of extracellular polysaccharides in Cordyceps militaris

This study aimed to increase the production of extracellular polysaccharides in Cordyceps militaris by overexpressing polysaccharide transferase genes, including alpha-1,2-mannosyltransferase ( Kre5 ), alpha-1,3-mannosyltransferase ( CMT1 ), alpha-1,6-mannosyltransferase subunit ( A16 ), and….

OncologyImmune supportCognition & nerves

King Oyster · 2023 · Preprint · journal metadata

The discovery of ergothioneine biosynthesis genes from Pleurotus eryngii and its combinatorial expression in yeast

Ergothioneine (EGT) is a natural amino acid derived from histidine, which has many active functions such as anti-oxidation, anti-inflammation, anti-cancer and prevention of neurodegenerative diseases. Pleurotus eryngii is a delicious edible fungus with high EGT content..

OncologyImmune supportRespiratory

Cordyceps · 2023 · Preprint · journal metadata

Therapeutic potential of Cordyceps militaris mushroom against SARS-CoV-2: Virtual screening against Mpro and in vitro validation

Pathogenic coronavirus, including COVID-19, threatens human health, and there are strong demands for efficient therapeutics. Cordyceps militaris is a medicinal mushroom that has long been used for immune enhancement, anticancer, and antiviral effects.

Immune supportMetabolic health

Shiitake · 2022 · Preprint · journal metadata

Combining UV-irradiation and alkaline deacetylation to obtain vitamin D- and chitosan-enriched fractions from shiitake mushrooms (Lentinula edodes)

Shiitake mushrooms ( Lentinula edodes ) contain compounds with hypocholesterolemic and immune-modulatory activities such as ergosterol and chitin that can be partially transformed into vitamin D and chitosan to yield extracts with enhanced bioactivities..

Lion's Mane · 2022 · Preprint · journal metadata

Effects of Polysaccharide from Hericium Erinaceus on Diarrhea Rats Induced by Lincomycin Hydrochloride: A Potential Treatment for Gut Microbiota Dysbiosis

Abstract In China, the fungus Hericium erinaceus is known as a healthy food crop which possesses digestive tract protection functionality. This research was focus on the effects of polysaccharides extracted from Hericium erinaceus (WHP) on rats with diarrhea induced by antibiotic, specifically on the shifts of gut….

King Oyster · 2022 · Preprint · journal metadata

Enhancement of hyphae growth and medium optimization by Pleurotus eryngii-3 under submerged fermentation

Abstract There were a variety of amino acids and polysaccharides in Pleurotus eryngii contained that could improve human immunity and prevent cancer. In this paper, the medium was screened and carton and nitrogen sources were screened and optimized as 40 g/L corn flour and soybean meal by P.

OncologyImmune support

King Oyster · 2022 · Preprint · journal metadata

Influence of different drying methods on drying characteristics, three- dimensional appearance, physicochemical property and microstructure of Pleurotus eryngii

This study investigated the effects of different drying methods, including hot air drying (HAD ), infrared drying (ID), and microwave drying (MD), on the drying characteristics, three-dimensional (3D) appearance, color, total polysaccharide content (TPC), antioxidant activity and microstructure of Pleurotus eryngii….

OncologyImmune supportLiver support

Chaga · 2021 · Preprint · journal metadata

Characterization and Anticancer Effects of Folate Targeted Inotodiol Liposome From Inonotus Obliquus (Chaga Mushroom)

Abstract Inotodiol, one tetracyclic triterpenoid isolated from inonotus obliquus (Chaga mushroom) possess excellent anticancer, antioxidant and anti-inflammatory activities, however it has not been applied to medical use due to its low solubility and low bioavailability..

OncologyImmune supportEnergy & fatigue

Cordyceps · 2021 · Preprint · journal metadata

Cordyceps Militaris Carotenoids Protect ARPE-19 Cells From Oxidative Stress Damage Induced By Hydrogen Peroxide

A retinal disorder known as age-related macular degeneration (AMD) can be very damaging, which may result in vision loss. Cordyceps militaris has antioxidant, anti-inflammatory, anticancer activity and immunomodulatory functions..

OncologyImmune supportEnergy & fatigueMetabolic health

Oyster Mushroom · 2021 · Preprint · journal metadata

In-silico Study Of Oyster Mushroom (Pleurotus Ostreatus ) Targeting PARP Protein (4UND)

Oyster mushroom( Pleurotus ostreatus) is belong to the group of healthy foods, as they contain high levels of proteins, vitamins and different classes of compounds, it is discovered that oyster mushrooms could play a key role in maintaining good health..

OncologyImmune supportRespiratory

Almond Mushroom · 2021 · Preprint · journal metadata

Subcritical Water Extracts from Agaricus blazei Murrill's Mycelium Inhibits the Expression of Immune Checkpoint Molecules and Axl receptor

Agaricus blazei Murrill or Himematsutake is an edible and medicinal mushroom. Agaricus blazei Murrill's fruiting body extracts have anticancer properties, although the mechanism is unknown..

Lion's Mane · 2026 · Comparative Study · International journal of medicinal mushrooms

Comparative Analysis of Extraction Techniques for Phenolics and Polysaccharides from Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes): Optimization and Yield Evaluation.

Hericium erinaceus is widely recognized for its culinary and medicinal properties. This study evaluates various extraction techniques to optimize total phenolic and polysaccharide fractions in H.

Immune supportGut & microbiome

Maitake · 2025 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

Attenuative Effect of Grifola frondosa (Maitake Mushroom) on Severe DSS-Induced Colitis in Vitamin D-Deficient Mice.

Vitamin D deficiency, which has been a global health issue for decades, is involved in gut health and diseases. We examined the health benefits of Grifola frondosa (maitake mushroom), a potent dietary source of fungal vitamin D (D2), on DSS-induced colitis in vitamin D-deficient mice..

Immune supportEnergy & fatigueSkin & hydration

Chaga · 2025 · Comparative Study · International journal of molecular sciences

Comparative Study of Chaga (Inonotus obliquus) Dietary Supplements Using Complementary Analytical Techniques.

Chaga (Inonotus obliquus) is an increasingly used natural product in botanical dietary supplements, valued for its bioactive compounds. However, inconsistent standardized analytical methods raise concerns over product authenticity, mislabeling, and quality control..

Cordyceps · 2025 · Comparative Study · Chemistry & biodiversity

Enhanced Antioxidant and Anti-inflammatory Properties of Albino Cordyceps militaris: A Comparative Study With Wild-type Strain.

Cordyceps militaris is a medicinal fungus known for its immunomodulatory effects. This study compared the antioxidant and anti-inflammatory activities of an albino strain (C.

King Oyster · 2025 · Comparative Study · Journal of the science of food and agriculture

Systematic comparison of the effects of exogenous inorganic selenium and organic selenium on the quality and antioxidant capacity of Pleurotus eryngii.

BACKGROUND: Pleurotus eryngii is an ideal food to improve the nutritional status of selenium (Se) in the human body. Besides Se accumulation and speciation, quality parameters and antioxidant capacity are key factors in determining the nutritional value of P.

Immune supportMetabolic healthGut & microbiomeRespiratory

Cordyceps · 2024 · Research Support, Non U.S. Gov'T · Frontiers in immunology

Cordyceps militaris solid medium extract alleviates lipopolysaccharide-induced acute lung injury via regulating gut microbiota and metabolism.

Acute lung injury (ALI) is a common respiratory disease, Cordycepin has been reported to reduce ALI, which is an effective component in Cordyceps militaris solid medium extract (CMME). Therefore, we aimed to explore the alleviating effect and mechanism of CMME on ALI..

Immune supportEnergy & fatigue

Cordyceps · 2024 · Research Support, Non U.S. Gov'T · Developmental and comparative immunology

Histopathological observations and comparative transcriptome analysis of Ophiocordyceps sinensis infection of Hepialus xiaojinensis in the early stage.

Hepialus xiaojinensis is a Lepidopteran insect and one of the hosts for the artificial cultivation of Cordyceps. Ophiocordyceps sinensis can infect and coexist with H.

Maitake · 2024 · Research Support, Non U.S. Gov'T · International journal of biological sciences

Polysaccharide isolated from Grifola frondosa eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T cells responses.

Myeloid derived suppressor cells (MDSCs) are known to accumulate in cancer patients and tumor-bearing mice, playing a significant role in promoting tumor growth. Depleting MDSCs has emerged as a potential therapeutic strategy for cancer..

OncologyImmune support

OncologyImmune supportMetabolic healthGut & microbiome

Shiitake · 2024 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Simulated human digestion and fermentation of a high-molecular weight polysaccharide from Lentinula edodes mushroom and protective effects on intestinal barrier.

Lentinula edodes (Shiitake) is an important edible mushroom and polysaccharides are its major constituents with proven health benefits. The study was to investigate the gut bacterial fermentation and subsequent effects on gut barrier function of a glucan-rich polysaccharide, LePS40 precipitated from the mushroom water….

Immune supportMetabolic health

Reishi · 2023 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

A 26-week repeated dose toxicity evaluation of sporoderm-removed Ganoderma lucidum spores in rats.

Ganoderma lucidum spore powder is a traditional Chinese medicine with a variety of health benefits. Sporoderm-removed Ganoderma lucidum spores (RGLS) can be more effectively absorbed and utilized by the body..

Cordyceps · 2023 · Research Article · Antioxidants (Basel, Switzerland)

Adenosine Deaminase Inhibitory Activity of Medicinal Plants: Boost the Production of Cordycepin in Cordyceps militaris.

Cordycepin, also known as 3'-deoxyadenosine, is a major active ingredient of Cordyceps militaris with diverse pharmacological effects. Due to its limited supply, many attempts have been conducted to enhance the cordycepin content..

OncologyImmune supportMetabolic healthGut & microbiome

Almond Mushroom · 2023 · Research Article · Nutrients

Agaricus blazei Polysaccharide Alleviates DSS-Induced Colitis in Mice by Modulating Intestinal Barrier and Remodeling Metabolism.

Ulcerative colitis (UC) is a chronic noninfectious intestinal disease that severely affects patients' quality of life. Agaricus blazei Murrill polysaccharide (ABP) is an effective active ingredient extracted from Agaricus blazei Murrill (ABM)..

Immune supportGut & microbiomeLiver support

Lion's Mane · 2023 · Journal Article · Food & function

Ameliorating effects of Hericium erinaceus polysaccharides on intestinal barrier injury in immunocompromised mice induced by cyclophosphamide.

Hericium erinaceus is a kind of large fungus with rich nutrition and its polysaccharides exhibit various biological activities. In recent years, widespread interest has been focused on maintaining or improving intestinal health through the consumption of edible fungi..

OncologyImmune supportSkin & hydrationRespiratory

Cordyceps · 2023 · Research Article · PloS one

Antimicrobial, antioxidant, anti-inflammatory, and cytotoxic activities of Cordyceps militaris spent substrate.

Cordyceps militaris is a medicinal mushroom and has been extensively used as a traditional medicine in East Asia. After the chrysalis seeds are matured and harvested, the spent substrate of C.

Immune supportCognition & nervesEnergy & fatigue

King Oyster · 2023 · Research Article · Molecules (Basel, Switzerland)

Antioxidant Activity of Polysaccharides from the Edible Mushroom Pleurotus eryngii.

In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii was evaluated.

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2023 · Research Article · Molecules (Basel, Switzerland)

Antioxidative Activities of Micronized Solid-State Cultivated Hericium erinaceus Rich in Erinacine A against MPTP-Induced Damages.

The Lion's mane mushroom (Hericium erinaceus, HE) is a traditional medical mushroom with high nutritional and economic value. HE possesses anticancer, antimicrobial, antioxidant, immunomodulating, neurotrophic, and neuroprotective activities..

Immune supportEnergy & fatigue

Enoki · 2023 · Research Article · IET nanobiotechnology

Biosynthesis of gold nanoparticles in the fruiting body of enoki mushrooms (Flammulina velutipes) under Pb2+ induction.

Fungi can produce many compounds, such as proteins, enzymes, amino acids, and polysaccharides, which are internalised and enriched for metals, and are widely used as reducing and stabilising agents for the biosynthesis of gold nanoparticles (Au NPs)..

Reishi · 2023 · Research Article · Evidence-based complementary and alternative medicine: eCAM

CD8+ T Cell-Mediated Therapeutic Antitumor Effect of an Herbal Mixture Containing Ganoderma lucidum.

Although Kampo-a traditional Japanese herbal medicine-contributes in the control of tumor growth in vivo in experimental animals, most of the antitumor effects are prophylactic and not therapeutic..

OncologyImmune support

OncologyImmune supportSkin & hydration

Chaga · 2023 · Journal Article · International journal of medicinal mushrooms

Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), Polysaccharides Alleviate Photoaging by Regulating Nrf2 Pathway and Autophagy.

Inonotus obliquus is a medicinal mushroom that contains the valuable I. obliquus polysaccharides (IOP), which is known for its bioactive properties.

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2023 · Journal Article · International journal of biological macromolecules

CM3-SII polysaccharide obtained from Cordyceps militaris ameliorates hyperlipidemia in heterozygous LDLR-deficient hamsters by modulating gut microbiota and NPC1L1 and PPARα levels.

Accumulating evidence has demonstrated that polysaccharides derived from edible fungi have lipid-lowering effects in mice. However, the lipid metabolism mechanisms in mice and humans are different..

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2023 · Research Article · Chinese medicine

Cordycepin from Cordyceps militaris ameliorates diabetic nephropathy via the miR-193b-5p/MCL-1 axis.

BACKGROUND: Diabetic nephropathy (DN) is a chronic kidney disease that develops in patients with diabetes mellitus. Cordycepin (CRD), a secondary metabolite produced by Cordyceps militaris, has a variety of bioactive properties..

Immune supportCognition & nervesEnergy & fatigue

Cordyceps · 2023 · Journal Article · International journal of biological macromolecules

Cordyceps militaris acidic polysaccharides improve learning and memory impairment in mice with exercise fatigue through the PI3K/NRF2/HO-1 signalling pathway.

Excessive exercise leads to body fatigue and destroys the balance of the oxidation/oxidation resistance system in the body, thus damaging the central nervous system and reducing learning and memory ability. Nrf2 is an important transcription factor that regulates the cell oxidative stress response..

Cordyceps · 2023 · Research Article · Frontiers in pharmacology

Cordyceps militaris extracts and cordycepin ameliorate type 2 diabetes mellitus by modulating the gut microbiota and metabolites.

Introduction: Cordyceps militaris, which has many potential medicinal properties, has rarely been reported to alleviate type 2 diabetes mellitus (T2DM). Methods: The effects of C..

Cordyceps · 2023 · Journal Article · International journal of biological macromolecules

Cordyceps militaris polysaccharide alleviates diabetic symptoms by regulating gut microbiota against TLR4/NF-κB pathway.

The relationship between gut microbiota and type 2 diabetes mellitus (T2DM) has attracted increasing attention. In our work, one purified fraction a (AEPSa) was obtained from Cordyceps militaris polysaccharides, and its hypoglycemic activity and underlying mechanisms were investigated in high-fat diet (HFD)- and….

Immune supportGut & microbiomeRespiratory

Cordyceps · 2023 · Journal Article · International journal of biological macromolecules

Cordyceps militaris polysaccharide alleviates ovalbumin-induced allergic asthma through the Nrf2/HO-1 and NF-κB signaling pathways and regulates the gut microbiota.

Polysaccharides, as one of the main types of bioactive components of Cordyceps militaris, have anti-allergic asthma effects. Herein, an ovalbumin-induced allergic asthma mouse model was established to assess the potential mechanisms of the separated and purified Cordyceps militaris polysaccharide (CMP)..

Cordyceps · 2023 · Journal Article · Journal of the science of food and agriculture

Cordyceps militaris polysaccharides modulate gut microbiota and improve metabolic disorders in mice with diet-induced obesity.

BACKGROUND: Cordyceps militaris is an edible and medicinal fungus, and its polysaccharides are among its main pharmacological components. They can display immunomodulation, anti-oxidation, anti-inflammation, anti-hypolipidemic, and other functions.

Immune supportSkin & hydration

Cordyceps · 2023 · Research Article · Fungal biology and biotechnology

Cordyceps militaris polysaccharides: preparation and topical product application.

BACKGROUND: Topical product derived from the fungus Cordyceps militaris was explored as a feasible method for an industrial practice. RESULTS: The mycelium residue of C..

Immune supportRespiratory

Cordyceps · 2023 · Research Article · International journal of molecular sciences

Cordyceps militaris Solid Medium Extract Alleviates Lipoteichoic Acid-Induced MH-S Inflammation by Inhibiting TLR2/NF-κB/NLRP3 Pathways.

The aim of this study was to investigate the inhibitory effects of Cordyceps militaris solid medium extract (CME) and cordycepin (COR) on LTA-induced inflammation in MH-S cells and their mechanisms of action..

OncologyImmune supportRespiratory

Turkey Tail · 2023 · Journal Article · International journal of medicinal mushrooms

Detection of Mitogenic and Genotoxic Effects of the Turkey Tail Medicinal Mushroom (Trametes versicolor, Agaricomycetes) Extracts from Mexico on Human Lymphocyte Cultures.

Diseases caused by a compromised immune system, characterized by decreased production and diversification of T lymphocytes, such as immunodeficiencies or chronic infections, are becoming increasingly prominent..

Immune supportEnergy & fatigueMetabolic healthLiver support

Mesima · 2023 · Journal Article · Journal of trace elements in medicine and biology: organ of the Society for Minerals and Trace Elements (GMS)

Dietary supplementation with selenium polysaccharide from selenium-enriched Phellinus linteus improves antioxidant capacity, immunity and production performance of laying hens.

BACKGROUND: Selenium (Se) plays a beneficial role in the physiological function of humans and animals. Selenium polysaccharide, improving enzyme activity and regulating immunity, is the extraction from selenium-rich plants or mushrooms..