MycoData

OBJECTIVE: To clone the NADPH gene (PuNOX) and Glyoxal oxidase gene (PuGLOX) from a medicinal fungus Polyporus umbellatus, and to carry out the bioinformatic analysis. METHODS: We used the Rapid Amplification of cDNA ends (RACE) technique to obtain the full length cDNA of these two genes..

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Daru: journal of Faculty of Pharmacy, Tehran University of Medical Sciences

Anti-cancer effect of Cordyceps militaris in human colorectal carcinoma RKO cells via cell cycle arrest and mitochondrial apoptosis.

BACKGROUND: Cordyceps militaris has been used as a traditional medicine in Asian countries for a long time. Different types of Cordyceps extract were reported to have various pharmacological activities including an anti-cancer effect..

OncologyEnergy & fatigue

High relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Anti-Gastric Ulcer Activity of Polysaccharide Fraction Isolated from Mycelium Culture of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes).

Hericium erinaceus is a culinary-medicinal mushroom that is used in traditional medicine, in folk medicine, and as medicinal cuisine in Asian countries such as China, Japan, and Korea. H..

OncologyImmune supportCognition & nerves

High relevance

Niu-Chang-Chih · 2015 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Anti-inflammatory effects of Antrodia camphorata, a herbal medicine, in a mouse skin ischemia model.

ETHNOPHARMACOLOGICAL EVIDENCE: Antrodia camphorata, a highly valued polypore mushroom native only to Taiwan, has been traditionally used as a medicine for anti-inflammation..

Immune supportSkin & hydration

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Journal of microbiology (Seoul, Korea)

Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells.

Cordyceps extract has been reported to have various pharmacological activities including an anti-cancer effect. We investigated the inhibitory effect of Cordyceps militaris on hepatitis C virus-infected human hepatocarcinoma 7.5 cells (J6/JFH1-huh 7.5 cells)..

OncologyLiver supportRespiratory

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Antihyperlipidemic and hepatoprotective activities of residue polysaccharide from Cordyceps militaris SU-12.

Cordyceps militaris has been artificially cultivated in China, and the great amounts of produced medium residue were discarded after the harvest. The aims of this work were to analyze the structure of the residue polysaccharide (RPS) of C..

Immune supportMetabolic healthLiver support

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Phytotherapy research: PTR

Apoptotic Effects of the Extracts of Cordyceps militaris via Erk Phosphorylation in a Renal Cell Carcinoma Cell Line.

Cordyceps militaris (CM) is gaining attention as a traditional medicinal food, but its molecular biological mechanisms for anti-cancer activity are not identified or clarified..

Oncology

High relevance

King Oyster · 2015 · Research Support, Non U.S. Gov'T · Water science and technology: a journal of the International Association on Water Pollution Research

Biosorption of aquatic copper (II) by mushroom biomass Pleurotus eryngii: kinetic and isotherm studies.

Biosorption is an effective method for removing heavy metals from effluent. This work mainly aimed to evaluate the adsorption performance of the widely cultivated novel mushroom, Pleurotus eryngii, for the removal of Cu(II) from single aqueous solutions.

Energy & fatigue

High relevance

Oyster Mushroom · 2015 · Research Support, Non U.S. Gov'T · Fungal biology

Characterisation of the large-scale production process of oyster mushroom (Pleurotus ostreatus) with the analysis of succession and spatial heterogeneity of lignocellulolytic enzyme activities.

Oyster mushroom (Pleurotus ostreatus) lignocellulolytic enzyme activity pattern and variation was investigated in a large-scale facility from spawning until the end of the second flush..

High relevance

King Oyster · 2015 · Research Support, Non U.S. Gov'T · Microbiological research

Characterization of the wzc gene from Pantoea sp. strain PPE7 and its influence on extracellular polysaccharide production and virulence on Pleurotus eryngii.

To characterize of the pathogenicity gene from the soft rot pathogen Pantoea sp. PPE7 in Pleurotus eryngii, we constructed over 10,000 kanamycin-resistant transposon mutants of Pantoea sp.

Immune support

High relevance

Chaga · 2015 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Characterization of two water-soluble lignin metabolites with antiproliferative activities from Inonotus obliquus.

The chaga mushroom, Inonotus obliquus has long been recognized as a remedy for cancer, gastritis, ulcers, and tuberculosis of the bones since the 16th century. Herein we reported the identification of two homogenous biological macromolecules, designated as IOW-S-1 and IOW-S-2 with anti-tumor activities from the….

OncologyEnergy & fatigue

High relevance

Chaga · 2015 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal "mushroom".

ETHNOPHARMACOLOGICAL RELEVANCE: In Russian traditional medicine, an extract from the mushroom Inonotus obliquus (Fr.) Pil´at is used as an anti-tumor medicine and diuretic. It has been reported that Inonotus obliquus has therapeutic effects, such as anti-inflammatory, immuno-modulatory and hepatoprotective effects..

OncologyImmune supportLiver support

High relevance

Almond Mushroom · 2015 · Research Support, Non U.S. Gov'T · Molecular medicine reports

Chitosan oligosaccharides in combination with Agaricus blazei Murill extract reduces hepatoma formation in mice with severe combined immunodeficiency.

Chitosan and Agaricus blazei Murill (ABM) extracts possess antitumor activities. The aim of the present study was to investigate whether chitosan, ABM extract or the two in combination were effective against tumors in tumor‑bearing mice..

OncologyImmune supportLiver support

High relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · Molecular medicine reports

Composition and antioxidant activity of water-soluble oligosaccharides from Hericium erinaceus.

Oligosaccharide are carbohydrate molecules, comprising repeating units joined together by glycosidic bonds. In recent years, an increasing number of oligosaccharides have been reported to exhibit various biological activities, including antitumor, immune-stimulation and antioxidation effects..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Almond Mushroom · 2015 · Research Support, Non U.S. Gov'T · Malaria journal

Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria.

BACKGROUND: Cerebral malaria (CM) is debilitating and sometimes fatal. Disease severity has been associated with poor treatment access, therapeutic complexity and drug resistance and, thus, alternative therapies are increasingly necessary..

Immune supportCognition & nervesMetabolic health

High relevance

King Oyster · 2015 · Research Support, Non U.S. Gov'T · Poultry science

Effects of co-fermented Pleurotus eryngii stalk residues and soybean hulls by Aureobasidium pullulans on performance and intestinal morphology in broiler chickens.

Soybean hulls are a by-product of soybean processing for oil and meal production; Pleurotus eryngii stalk residues (PESR) are by-products of the edible portion of the fruiting body enriched in bioactive metabolites..

Energy & fatigueMetabolic healthGut & microbiome

High relevance

King Oyster · 2015 · Research Support, Non U.S. Gov'T · Food chemistry

Effects of drying methods on the tasty compounds of Pleurotus eryngii.

The aim of this research was to study effects of drying methods on the tasty compounds of Pleurotus eryngii, a common commercial edible fungus. In order to maximally maintain the taste of P..

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Natural product communications

Ergosterol of Cordyceps militaris Attenuates LPS Induced Inflammation in BV2 Microglia Cells.

Different solvent extracts of Cordyceps militaris stroma powder were tested for cell viability and inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS) triggered BV2 microglia cells. Chemical investigation of the ethyl acetate fraction resulted in an enriched ergosterol sub-fraction CE3..

OncologyImmune support

High relevance

Chaga · 2015 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer.

AIM OF THE STUDY: In this study, we examined the effect of different fractions and components of Chaga mushroom (Inonotus Obliquus) on viability and apoptosis of colon cancer cells. Among them, one component showed the most effective growth inhibition and was identified as ergosterol peroxide by NMR analysis..

OncologyImmune supportGut & microbiome

High relevance

Chaga · 2015 · Research Article · Nutrition research and practice

Ethanol extract of Innotus obliquus (Chaga mushroom) induces G1 cell cycle arrest in HT-29 human colon cancer cells.

BACKGROUND/OBJECTIVES: Inonotus obliquus (I. obliquus, Chaga mushroom) has long been used as a folk medicine to treat cancer.

OncologyGut & microbiome

High relevance

Shiitake · 2015 · Research Support, Non U.S. Gov'T · Gene

Expression and functional analysis of novel molecule - Latcripin-13 domain from Lentinula edodes C91-3 produced in prokaryotic expression system.

The shiitake mushroom Lentinula edodes has health benefits and is used to treat various diseases due to its immunomodulatory and antineoplastic properties. In the present study, the Latcripin-13 domain, isolated from L.

OncologyImmune supportRespiratory

High relevance

Enoki · 2015 · Research Support, Non U.S. Gov'T · Applied microbiology and biotechnology

Expression of enterovirus 71 virus-like particles in transgenic enoki (Flammulina velutipes).

No commercial vaccines are currently available for enterovirus 71 (EV71) infection. Oral virus-like particle (VLP) vaccines are regarded as a better choice for prevention from food-borne diseases compared with injected whole virus vaccines..

Gut & microbiomeRespiratory

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Fruiting Body Production of the Medicinal Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes), in Artificial Medium.

Ophiocordyceps sinensis (syn. Cordyceps sinensis), regarded as the "Himalayan Viagra", is widely used for medicinal treatment and health foods.

High relevance

Cordyceps · 2015 · Brief Report · Genome announcements

Genome Sequence of a Novel Iflavirus from mRNA Sequencing of the Pupa of Bombyx mori Inoculated with Cordyceps militaris.

We discovered a novel iflavirus from the transcriptome of the Bombyx mori pupa inoculated with the insect-pathogenic fungus Cordyceps militaris. The assembled iflavirus genome has 10,119 nucleotides, with a 3'-polyadenylated tail, and it encodes a polyprotein composed of 3,004 amino acids..

Respiratory

High relevance

Maitake · 2015 · Research Support, Non U.S. Gov'T · Food & function

Hypoglycemic effects of Grifola frondosa (Maitake) polysaccharides F2 and F3 through improvement of insulin resistance in diabetic rats.

Our laboratory has previously demonstrated that Grifola frondosa polysaccharides (GFPs) showed hypoglycemic effects. This study aimed to investigate which polysaccharide-enriched fractions of GFPs were the main active constituents, and to disclose their hypoglycemic mechanism..

Immune supportMetabolic healthLiver support

High relevance

Wood Ear · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Hypolipidemic and Hepatic Steatosis Preventing Activities of the Wood Ear Medicinal Mushroom Auricularia auricula-judae (Higher Basidiomycetes) Ethanol Extract In Vivo and In Vitro.

Obesity, a rapidly growing threat to human health worldwide, is responsible for a large proportion of the total burden of disease. Therefore, obesity control could be a vital scheme to prevent many diseases..

OncologyMetabolic healthLiver support

High relevance

Shiitake · 2015 · Brief Report · Mycobiology

Identification of Single Nucleotide Polymorphism Markers in the Laccase Gene of Shiitake Mushrooms (Lentinula edodes).

We identified single nucleotide polymorphism (SNP) markers in the laccase gene to establish a line-diagnostic system for shiitake mushrooms. A total of 89 fungal isolates representing four lines, including Korean registered, Korean wild type, Chinese, and Japanese lines, were analyzed..

High relevance

King Oyster · 2015 · Research Support, Non U.S. Gov'T · Asian Pacific journal of cancer prevention: APJCP

Inhibition of Azoxymethane-induced Colorectal Aberrant Crypt Foci in Mice Fed a High-fat Diet by Pleurotus eryngii (Eringi) and Hypsizygus marmoreus (Bunashimeji).

Obesity markedly increases the risk of colorectal cancer. Recently, the preventive effects of edible mushrooms on triglyceride elevation and visceral fat accumulation have been reported..

OncologyMetabolic healthGut & microbiomeLiver support

High relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Lion's Mane, Hericium erinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) Medicinal Mushrooms Stimulate Neurite Outgrowth in Dissociated Cells of Brain, Spinal Cord, and Retina: An In Vitro Study.

Neurodegenerative disease is defined as a deterioration of the nervous system in the intellectual and cognitive capabilities. Statistics show that more than 80-90 million individuals age 65 and above in 2050 may be affected by neurodegenerative conditions like Alzheimer's and Parkinson's disease..

Cognition & nerves

High relevance

King Oyster · 2015 · Research Support, Non U.S. Gov'T · ACS applied materials & interfaces

MicroRNA Replacing Oncogenic Klf4 and c-Myc for Generating iPS Cells via Cationized Pleurotus eryngii Polysaccharide-based Nanotransfection.

Induced pluripotent stem cells (iPSCs), resulting from the forced expression of cocktails out of transcription factors, such as Oct4, Sox2, Klf4, and c-Myc (OSKM), has shown tremendous potential in regenerative medicine..

Immune support

High relevance

Turkey Tail · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Mycochemical Investigation of the Turkey Tail Medicinal Mushroom Trametes versicolor (Higher Basidiomycetes): A Potential Application of the Isolated Compounds in Documented Pharmacological Studies.

The purpose of this study was to elucidate the chemical properties of the n-hexane, chloroform, and ethyl acetate extracts of the fruiting body of the medicinal mushroom Trametes versicolor..

Metabolic health

High relevance

King Oyster · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Notes on a New Productive Strain of King Oyster Mushroom, Pleurotus eryngii (Higher Basidiomycetes), a Prized Italian Culinary-Medicinal Mushroom.

In this paper, the authors provide data on a culinary-medicinal, host-specific variety of P. eryngii species-complex that is known in Italy as "cardoncello".

High relevance

Reishi · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Optimization of the Yield of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes), Cultivated on a Sunflower Seed Hull Substrate Produced in Argentina: Effect of Olive Oil and Copper.

Sunflower seed hulls were used as the main component of a solid substrate for the cultivation of the lingzhi or reishi medicinal mushroom Ganoderma lucidum. This study evaluated the effects of supplementing the substrate with olive oil and copper (II) on the mushroom production (MP) parameters and fruiting body total….

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Protective Efficacy of the Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes), from India in Neuronal Hippocampal Cells against Hypoxia.

This study demonstrated the protective efficiency of extracts of the Indian variety of Ophiocordyceps sinensis (=Cordyceps sinensis) (CSEs) in HT22 (murine hippocampal) cells under hypoxic conditions..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Molecular medicine reports

Purification of polysaccharides from Cordyceps militaris and their anti‑hypoxic effect.

Acute mountain sickness, one of the most common altitude diseases, causes lung and brain injury. The present study aimed to investigate the anti‑hypoxic effect of purified polysaccharides extracted from Cordyceps militaris..

Immune supportCognition & nervesRespiratory

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Journal of invertebrate pathology

Quantitative real-time PCR (qPCR)--based tool for detection and quantification of Cordyceps militaris in soil.

A quantitative real-time PCR using a primer pair CM2946F/CM3160R was developed for specific detection and quantification of Cordyceps militaris from soil. Standard curves were obtained for genomic DNA and DNA extracts from autoclaved soil with a certain dose of C.

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Journal of industrial microbiology & biotechnology

Rhf1 gene is involved in the fruiting body production of Cordyceps militaris fungus.

Cordyceps militaris is an important medicinal fungus. Commercialization of this fungus needs to improve the fruiting body production by molecular engineering.

High relevance

King Oyster · 2015 · Research Support, Non U.S. Gov'T · Plant foods for human nutrition (Dordrecht, Netherlands)

Structure Identification of Triterpene from the Mushroom Pleurotus eryngii with Inhibitory Effects Against Breast Cancer.

Breast cancer is the leading cause of death among women, with approximately 1 million diagnoses annually. Triterpenoids, which have cancer preventive or anti-tumour efficacy towards various tumour cells, may play a role in breast cancer prevention..

Oncology

High relevance

Maitake · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Submerged-Culture Mycelia and Broth of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes) Alleviate Type 2 Diabetes-Induced Alterations in Immunocytic Function.

Type 2 Diabetes mellitus (T2DM), a disease with impaired glucose, protein and lipid metabolism, low-grade chronic inflammation, and immune dysfunction, is a global public health crisis. We previously demonstrated that Grifola frondosa has bioactivities in improving glycemic responses in diabetic rats..

OncologyImmune supportMetabolic health

High relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium erinaceus (Higher Basidiomycetes) and Its Protective Effects on Aβ-Triggered Neurotoxicity in PC12 Cells.

Hericium erinaceus possesses multiple medicinal values. To date, however, there have been few studies of the systemic screening of H.

Cognition & nerves

High relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages.

Chronic low-grade inflammation in the adipose tissue accompanying obesity is thought to be an underlying driver of metabolic diseases. In this study, we aimed to investigate the efficacy of Hericium erinaceus on adipose tissue inflammation.

OncologyImmune supportMetabolic health

High relevance

Almond Mushroom · 2015 · Research Support, Non U.S. Gov'T · Journal of medicinal food

The polar high molecular weight fraction of the Agaricus blazei Murill extract, AndoSan™, reduces the activity of the tumor-associated protease, legumain, in RAW 264.7 cells.

AndoSan™ is an extract of Agaricus blazei Murill (AbM; 82.4%), Hericium erinaceum (14.7%), and Grifola frondosa (2.9%). The main ingredient of AndoSan, AbM, is rich in different forms of β-glucans..

OncologyImmune supportMetabolic health

High relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

[Determination of inorganic elements in Antrodia camphorata powder by ICP-MS].

OBJECTIVE: To establish a method for simultaneous analysis of 22 inorganic elements in Antrodia camphorata powder by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Additionally, inorganic elements of Ganoderma lucidum had been detected and compared..

Gut & microbiome

High relevance

Chaga · 2014 · English Abstract · Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

[Prevention of Inonotus obliquus polysaccharides for high power microwave radiation induced testicular injury in rats: an experimental research].

OBJECTIVE: To investigate the effect of Inonotus obliquus polysaccharides on testicular injury induced by exposure to high power microwave (HPM) in rats. METHODS: A total of 30 male Wistar rats were randomly divided into 5 groups, i.e., the normal control group, the microwave radiation model group, the treatment….

Immune supportEnergy & fatigueMetabolic health

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Fungal biology

A halotolerant type A feruloyl esterase from Pleurotus eryngii.

An extracellular feruloyl esterase (PeFaeA) from the culture supernatant of Pleurotus eryngii was purified to homogeneity using cation exchange, hydrophobic interaction, and size exclusion chromatography..

High relevance

Maitake · 2014 · Research Support, Non U.S. Gov'T · Glycoconjugate journal

A polysaccharide from Grifola frondosa relieves insulin resistance of HepG2 cell by Akt-GSK-3 pathway.

Grifola frondosa is an important fungal research resource. However, there was little report about hyperglycemic activity of Grifola frondosa polysaccharide on insulin resistance in vitro..

Immune supportMetabolic health

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Fungal biology

A reappraisal of the Pleurotus eryngii complex - new species and taxonomic combinations based on the application of a polyphasic approach, and an identification key to Pleurotus taxa associated with Apiaceae plants.

The Pleurotus eryngii species-complex comprises choice edible mushrooms growing on roots and lower stem residues of Apiaceae (umbellifers) plants. Material deriving from extensive sampling was studied by mating compatibility, morphological and ecological criteria, and through analysis of ITS1-5.8S-ITS2 and IGS1 rRNA….

High relevance

Almond Mushroom · 2014 · Research Support, Non U.S. Gov'T · Molecules (Basel, Switzerland)

Agaricus blazei hot water extract shows anti quorum sensing activity in the nosocomial human pathogen Pseudomonas aeruginosa.

The edible mushroom Agaricus blazei Murill is known to induce protective immunomodulatory action against a variety of infectious diseases. In the present study we report potential anti-quorum sensing properties of A.

Immune supportEnergy & fatigue

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Antioxidant activity of polysaccharide extracted from Pleurotus eryngii using response surface methodology.

Ultrasonic technology was applied for polysaccharide extraction from the fruiting bodies of P. Eryngii, and response surface methodology (RSM) was used to optimize the effects of processing parameters on polysaccharide extraction yield..

Immune supportEnergy & fatigue

High relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

Antioxidant and immunomodulatory activities of a polysaccharide from Flammulina velutipes.

OBJECTIVE: To evaluate the antioxidant and immunomodulatory activities of a unique polysaccharide from the medicinal fungus Flammulina velutipes in vitro. METHODS: Using water extraction and alcohol precipitation, crude polysaccharides were obtained..

OncologyImmune supportEnergy & fatigue