MycoData

BACKGROUND: Currently, the use of mushrooms as functional foods, nutraceuticals or phytopharmaceuticals source has risen. In contrast, the possible cellular cytotoxicity and immunostimulatory activity of Pleurotus eryngii (DC.

OncologyImmune supportLiver supportRespiratory

High relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Food & function

Antrodia camphorata induces G(1) cell-cycle arrest in human premyelocytic leukemia (HL-60) cells and suppresses tumor growth in athymic nude mice.

Antrodia camphorata is a well-known medicinal mushroom in Taiwan. The broth from a fermented culture of Antrodia camphorata (AC) has been shown to induce apoptosis in cultured human premyelocytic leukemia (HL-60) cells..

OncologyEnergy & fatigue

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Biotechnology and applied biochemistry

Biosorption and biotransformation of fluoranthene by the white-rot fungus Pleurotus eryngii F032.

Major concern about the presence of fluoranthene, which consists of four fused benzene rings, in the environment has been raised in the past few years due to its toxic, mutagenic, and persistent organic pollutant properties..

Metabolic health

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Changes in chemical components and cytotoxicity at different maturity stages of Pleurotus eryngii fruiting body.

The present study investigated the changes of the chemical components and cytotoxicity potency at 5 developmental stages of Pleurotus eryngii fruiting body. The carbohydrate and protein contents increased along the maturity of fruiting body while fat content decreased..

OncologyImmune support

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Food & function

Chemical composition of Pleurotus eryngii polysaccharides and their inhibitory effects on high-fructose diet-induced insulin resistance and oxidative stress in mice.

High intake of dietary fructose exerts a number of adverse metabolic effects. The present study investigates the preventive effects of Pleurotus eryngii polysaccharides (PEP), which showed powerful antioxidant activity in vitro, on insulin resistance and oxidative stress in mice fed a high-fructose diet..

Immune supportMetabolic healthLiver support

High relevance

Cordyceps · 2014 · Research Support, Non U.S. Gov'T · Journal of microbiology (Seoul, Korea)

Comparative phylogenetic relationships and genetic structure of the caterpillar fungus Ophiocordyceps sinensis and its host insects inferred from multiple gene sequences.

Ophiocordyceps sinensis (Ascomycota: Ophiocordycipitaceae) is a native fungal parasite of Hepialidae caterpillars and one of the most economically important medicinal caterpillar fungi in China. However, little is known about the phylogenetic and evolutionary relationships between O.

Energy & fatigue

High relevance

King Oyster · 2014 · Comparative Study · Journal of oleo science

Comparison of Agitake (Pleurotus eryngii var. ferulae) Volatile Components with Characteristic Odors Extracted by Hydrodistillation and Solvent-assisted Flavor Evaporation

The chemical composition of volatile oil from agitake (Pleurotus eryngii var. ferulae) was established for the first time using gas chromatography (GC) and GC-mass spectrometry..

High relevance

Cordyceps · 2014 · Research Support, Non U.S. Gov'T · Nutrients

Cordyceps militaris extract protects human dermal fibroblasts against oxidative stress-induced apoptosis and premature senescence.

Oxidative stress induced by reactive oxygen species (ROS) is the major cause of degenerative disorders including aging and disease. In this study, we investigated whether Cordyceps militaris extract (CME) has in vitro protective effects on hydrogen peroxide-induced oxidative stress in human dermal fibroblasts (HDFs)..

OncologyEnergy & fatigueSkin & hydration

High relevance

Shiitake · 2014 · Brief Report · Mycobiology

Determination of Glucan Contents in the Fruiting Bodies and Mycelia of Lentinula edodes Cultivars.

Shiitake mushrooms (Lentinula edodes) containing β-glucans may be beneficial for human health; they have been used in the treatment of cancer, hypertension, and high cholesterol levels..

OncologyMetabolic health

High relevance

Almond Mushroom · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Drying effects on the antioxidant properties of polysaccharides obtained from Agaricus blazei Murrill.

Three polysaccharides (ABMP-F, ABMP-V, ABMP-A) were obtained from Agaricus blazei Murrill via methods such as freeze drying, vacuum drying and air drying, respectively..

Immune support

High relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · TheScientificWorldJournal

Effect of Antrodia camphorata on inflammatory arterial thrombosis-mediated platelet activation: the pivotal role of protein kinase C.

Antrodia camphorata is a rare Taiwanese medicinal mushroom. Antrodia camphorata extract has been reported to exhibit antioxidant, anti-inflammation, antimetastasis, and anticancer activities and plays a role in liver fibrosis, vasorelaxation, and immunomodulation..

OncologyImmune supportMetabolic healthLiver support

High relevance

Cordyceps · 2014 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL/6J mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps species which is well-known as 'winter worm summer grass' has long been used as tonics and stimulants to enhance energy, exhibiting a potential for energy metabolism. Clinical trials have suggested their beneficial effect on lipid metabolic disorders such as hyperlipidemia..

Energy & fatigueMetabolic healthLiver support

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Climacteric: the journal of the International Menopause Society

Effect of the ethanol extract of Pleurotus eryngii on bone metabolism in ovariectomized rats.

OBJECTIVE: Postmenopausal bone loss and the possible progression to osteoporosis are a major health concern. Mushrooms have been recognized as functional foods.

High relevance

Almond Mushroom · 2014 · Comparative Study · Biological trace element research

Effects of selenium-enriched Agaricus blazei Murill on liver metabolic dysfunction in mice, a comparison with selenium-deficient Agaricus blazei Murill and sodium selenite.

In the present study, we investigated the effects of Se-enriched Agaricus blazei Murill (Se-AbM) on liver injury in mice induced by acute alcohol administration. Mice received ethanol (5 g/kg body weight (BW)) by gavage every 12 h for a total of 3 doses.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Zhu Ling · 2014 · Research Support, Non U.S. Gov'T · International journal of molecular sciences

ESTs analysis of putative genes engaged in Polyporus umbellatus sclerotial development.

Polyporus umbellatus is one of the most widely used and precious medicinal fungi and the underground sclerotia are known to be with great medicinal value. However, the molecular mechanisms involved in sclerotial development are poorly understood..

High relevance

Cordyceps · 2014 · Research Support, Non U.S. Gov'T · International journal of oncology

Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells.

Angiogenesis is essential for tumor development and metastasis. Among several angiogenic factors, vascular endothelial growth factor receptor (VEGF) is important for tumor-derived angiogenesis and commonly overexpressed in solid tumors..

Oncology

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Bioscience, biotechnology, and biochemistry

Gene cloning and biochemical characterization of eryngase, a serine aminopeptidase of Pleurotus eryngii belonging to the family S9 peptidases.

Pleurotus eryngii serine aminopeptidase that has peptide bond formation activity, redesignated as eryngase, was cloned and expressed. Eryngase has a family S9 peptidase unit in the C-terminal region having a catalytic triad of Ser, Asp, and His..

High relevance

Cordyceps · 2014 · Research Support, Non U.S. Gov'T · PloS one

Genetic diversity and distribution patterns of host insects of Caterpillar Fungus Ophiocordyceps sinensis in the Qinghai-Tibet Plateau.

The caterpillar fungus Ophiocordyceps sinensis is one of the most valuable medicinal fungi in the world, and it requires host insects in family Hepialidae (Lepidoptera) to complete its life cycle. However, the genetic diversity and phylogeographic structures of the host insects remain to be explored..

High relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · BioMed research international

Hypolipidemic and antioxidant activity of enoki mushrooms (Flammulina velutipes).

According to the literatures, Flammulina velutipes contains biologically active components such as dietary fiber, polysaccharide, and mycosterol, whose effects in reducing blood sugar, blood pressure, and cholesterol have been proven..

Immune supportMetabolic healthLiver support

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · PloS one

Identification and functional analysis of pheromone and receptor genes in the B3 mating locus of Pleurotus eryngii.

Pleurotus eryngii has recently become a major cultivated mushroom; it uses tetrapolar heterothallism as a part of its reproductive process. Sexual development progresses only when the A and B mating types are compatible..

High relevance

Cordyceps · 2014 · Research Support, Non U.S. Gov'T · Natural product communications

Identification of nucleosides and nucleobases from cultured Cordyceps militaris.

Four nucleosides and seven nucleobases were isolated from the BuOH subfraction of the extract of cultured Cordyceps militaris; one of them, 6-acetylpurine (1) is a new natural compound. The structure of I was determined on the basis of HR-ESI-MS, and I D and 2D NMR spectroscopic analysis..

High relevance

Shiitake · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Identification of potent odorants in a novel nonalcoholic beverage produced by fermentation of wort with shiitake (Lentinula edodes).

Novel refreshments with pleasant flavors were developed by fermentation of wort with basidiomycetes. Among 31 screened fungi, shiitake (Lentinula edodes) produced the most pleasant flavor.

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Immunopotentiation of Pleurotus eryngii (DC. ex Fr.) Quel.

ETHNOPHARMACOLOGICAL RELEVANCE: Pleurotus eryngii (DC. ex Fr.) Quel has been collected from the wild, cultivated and used in traditional medicines to treat various disorders and diseases since antiquity..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Cordyceps · 2014 · Research Support, Non U.S. Gov'T · PloS one

Impact of climate change on potential distribution of Chinese caterpillar fungus (Ophiocordyceps sinensis) in Nepal Himalaya.

Climate change has already impacted ecosystems and species and substantial impacts of climate change in the future are expected. Species distribution modeling is widely used to map the current potential distribution of species as well as to model the impact of future climate change on distribution of species..

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Enzyme and microbial technology

Improvement of hydrogen peroxide stability of Pleurotus eryngii versatile ligninolytic peroxidase by rational protein engineering.

Peroxide tolerant versatile peroxidases are required for industrial applications. In this study, rational protein engineering was performed to improve the oxidative stability of Pleurotus eryngii versatile ligninolytic peroxidase..

High relevance

Shiitake · 2014 · Research Support, Non U.S. Gov'T · Biotechnology letters

Increased mycelial biomass production by Lentinula edodes intermittently illuminated by green light emitting diodes.

Fungi possess a range of light receptors to regulate metabolism and differentiation. To study the effect of light on Lentinula edodes (the shiitake mushroom), mycelial cultures were exposed to blue, green, and red fluorescent lights and light-emitting diodes, as well as green laser light..

High relevance

Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · BioMed research international

Inhibitory effect on in vitro LDL oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom).

Oxidation of low-density lipoprotein (LDL) has been strongly suggested as the key factor in the pathogenesis of atherosclerosis. Mushrooms have been implicated in having preventive effects against chronic diseases due especially to their antioxidant properties..

Metabolic health

High relevance

Shiitake · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Lentinan degradation in the Lentinula edodes fruiting body during postharvest preservation is reduced by downregulation of the exo-β-1,3-glucanase EXG2.

Lentinan from Lentinula edodes fruiting bodies (shiitake mushrooms) is a valuable β-glucan for medical purposes based on its anticancer activity and immunomodulating activity. However, lentinan content in fruiting bodies decreases after harvesting and storage due to an increase in glucanase activity..

OncologyImmune support

High relevance

Snow Fungus · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Molecular cloning and function characterization of a new macrophage-activating protein from Tremella fuciformis.

Silver ear mushroom ( Tremella fuciformis ) is an edible fungus with health benefits. In this study, we purified a new T.

Immune support

High relevance

Cordyceps · 2014 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Mycelial fermentation characteristics and anti-fatigue activities of a Chinese caterpillar fungus, Ophiocordyceps sinensis strain Cs-HK1 (Ascomycetes).

Mycelial fermentation of an Ophiocordyceps sinensis strain Cs-HK1 was carried out in various volumes of stirred-tank fermenters from 1.6-L and 15-L laboratory scale to 2000-L industrial scale. The mycelial growth in most fermenters had a higher rate, due probably to more efficient oxygen supply, than in shake-flasks..

Energy & fatigue

High relevance

Shiitake · 2014 · Research Support, Non U.S. Gov'T · Food chemistry

Occurrence of inorganic arsenic in edible Shiitake (Lentinula edodes) products.

The present study reports arsenic speciation analysis in edible Shiitake (Lentinula edodes) products. The study focused on the extraction, and accurate quantification of inorganic arsenic (iAs), the most toxic form of arsenic, which was selectively separated and determined using anion exchange LC-ICPMS..

High relevance

Cordyceps · 2014 · Research Support, Non U.S. Gov'T · TheScientificWorldJournal

Optimization of large-scale culture conditions for the production of cordycepin with Cordyceps militaris by liquid static culture.

Cordycepin is one of the most important bioactive compounds produced by species of Cordyceps sensu lato, but it is hard to produce large amounts of this substance in industrial production..

High relevance

Cordyceps · 2014 · Research Support, Non U.S. Gov'T · Molecules (Basel, Switzerland)

Optimization of ultrasonic-assisted extraction of cordycepin from Cordyceps militaris using orthogonal experimental design.

This study reports on the optimization of the extraction conditions of cordycepin from Cordyceps militaris by using ultrasonication. For this purpose, the orthogonal experimental design was used to investigate the effects of factors on the ultrasonic-assisted extraction (UAE)..

High relevance

Oyster Mushroom · 2014 · Brief Report · Mycobiology

Overproduction of Laccase by the White-Rot Fungus Pleurotus ostreatus Using Apple Pomace as Inducer.

Laccase activity of Pleurotus ostreatus is significantly increased by the addition of apple pomace. Among various conditions, the best concentration of apple pomace and cultivation time for the production of laccase by P.

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Fungal biology

Potential of a white-rot fungus Pleurotus eryngii F032 for degradation and transformation of fluorene.

The white-rot fungus Pleurotus eryngii F032 showed the capability to degrade a three fused-ring aromatic hydrocarbons fluorene. The elimination of fluorene through sorption was also investigated.

Metabolic health

High relevance

Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · International journal of molecular sciences

Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine.

Hericium erinaceus, an edible mushroom, has been demonstrated to potentiate the effects of numerous biological activities. The aim of this study was to investigate whether H..

OncologyImmune supportCognition & nerves

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Purification, characterization and antitumor activity of polysaccharides from Pleurotus eryngii residue.

A novel water-soluble polysaccharide from Pleurotus eryngii residue was isolated and further purified by DEAE cellulose-52 chromatography and Sephadex G-100 size-exclusion chromatography to yield PEPE-1, PEPE-2 and PEPE-3. Molecular weights were determined by high-performance size-exclusion chromatography (HPSEC)..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2014 · Research Support, Non U.S. Gov'T · BioMed research international

Studies on the antidiabetic activities of Cordyceps militaris extract in diet-streptozotocin-induced diabetic Sprague-Dawley rats.

Due to substantial morbidity and high complications, diabetes mellitus is considered as the third "killer" in the world. A search for alternative antidiabetic drugs from herbs or fungi is highly demanded..

Metabolic healthLiver support

High relevance

Chaga · 2014 · Research Support, Non U.S. Gov'T · Phytochemistry

Terpenoids with alpha-glucosidase inhibitory activity from the submerged culture of Inonotus obliquus.

Lanostane-type triterpenoids, inotolactones A and B, a drimane-type sesquiterpenoid, inotolactone C, and five known terpenoids 6β-hydroxy-trans-dihydroconfertifolin, inotodiol, 3β,22-dihydroxyanosta-7,9(11),24-triene, 3β-hydroxycinnamolide, and 17-hydroxy-ent-atisan-19-oic acid, were isolated from the submerged….

Metabolic health

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

The excreted polysaccharide of Pleurotus eryngii inhibits the foam-cell formation via down-regulation of CD36.

Previous study has verified the polysaccharide from the fruiting body of Pleurotus eryngii (PEPE) is capable of decreasing the lipid content in both of cell-line and mouse model. However, little is known about underlying mechanisms and whether this bioactive polysaccharide exists in submerged culture..

Immune supportMetabolic healthGut & microbiome

High relevance

Shiitake · 2014 · Research Support, Non U.S. Gov'T · Gene

The genetic structure of the A mating-type locus of Lentinula edodes.

The Shiitake mushroom, Lentinula edodes (Berk.) Pegler is a tetrapolar basidiomycete with two unlinked mating-type loci, commonly called the A and B loci. Identifying the mating-types in shiitake is important for enhancing the breeding and cultivation of this economically-important edible mushroom..

Energy & fatigue

High relevance

Almond Mushroom · 2014 · Research Support, Non U.S. Gov'T · BioMed research international

The protective effect of Agaricus blazei Murrill, submerged culture using the optimized medium composition, on alcohol-induced liver injury.

Agaricus blazei Murrill (ABM), an edible mushroom native to Brazil, is widely used for nonprescript and medicinal purposes. Alcohol liver disease (ALD) is considered as a leading cause for a liver injury in modern dietary life, which can be developed by a prolonged or large intake of alcohol..

Immune supportMetabolic healthLiver support

High relevance

Lion's Mane · 2013 · Research Support, Non U.S. Gov'T · BMC complementary and alternative medicine

Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats.

BACKGROUND: Hericium erinaceus, as a commonly used medicine or food, has attracted much attention due to its health effects when used as a home remedy for some diseases..

Metabolic healthLiver support

High relevance

King Oyster · 2013 · Research Support, Non U.S. Gov'T · Food chemistry

Antioxidant properties of different edible mushroom species and increased bioconversion efficiency of Pleurotus eryngii using locally available casing materials.

Total phenolics, radical scavenging activity (RSA) on DPPH, ascorbic acid content and chelating activity on Fe(2+) of Pleurotus citrinopileatus, Pleurotus djamor, Pleurotus eryngii, Pleurotus flabellatus, Pleurotus florida, Pleurotus ostreatus, Pleurotus sajor-caju and Hypsizygus ulmarius have been evaluated..

High relevance

King Oyster · 2013 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Antioxidant properties of fruiting bodies, mycelia, and fermented products of the culinary-medicinal king oyster mushroom, Pleurotus eryngii (higher Basidiomycetes), with high ergothioneine content.

The culinary-medicinal king oyster mushroom Pleurotus eryngii is known to contain ergothioneine, and its products, including fruiting bodies, mycelia, and solid-state fermented products (adlay and buckwheat), were prepared to study their antioxidant properties..

High relevance

Chaga · 2013 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Aqueous extract from a Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), prevents herpes simplex virus entry through inhibition of viral-induced membrane fusion.

Chaga medicinal mushroom, Inonotus obliquus, a popular prescription in traditional medicine in Europe and Asia, was used to reduce inflammation in the nasopharynx and to facilitate breathing. The aqueous extract from I..

OncologyImmune supportRespiratory

High relevance

King Oyster · 2013 · Research Support, Non U.S. Gov'T · Journal of lipid research

Binding of a pleurotolysin ortholog from Pleurotus eryngii to sphingomyelin and cholesterol-rich membrane domains.

A mixture of sphingomyelin (SM) and cholesterol (Chol) exhibits a characteristic lipid raft domain of the cell membranes that provides a platform to which various signal molecules as well as virus and bacterial proteins are recruited..

Cognition & nervesMetabolic healthRespiratory

High relevance

Maitake · 2013 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Characterization of a novel maitake (Grifola frondosa) protein that activates natural killer and dendritic cells and enhances antitumor immunity in mice.

Grifola frondosa, also known as maitake, is a culinary mushroom with immune-enhancing and antitumor effects. Numerous studies have investigated the activity of maitake polysaccharide extracts, but studies of maitake proteins are scarce.

OncologyImmune support

High relevance

King Oyster · 2013 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Characterization of polysaccharides with marked inhibitory effect on lipid accumulation in Pleurotus eryngii.

Mushrooms have a great potential for the production of useful bioactive metabolites. To explore the bioactive compounds from edible mushrooms for interfering with the development of macrophage-derived foam cells, which is recognized as the hallmark of early atherosclerosis, eight types of mushrooms polysaccharides had….

Immune supportMetabolic health

High relevance

King Oyster · 2013 · Research Support, Non U.S. Gov'T · Fitoterapia

Chemical constituents from the rice fermented with the edible mushroom Pleurotus eryngii and their quinone oxidoreductase 1 inducing effect.

The fruiting bodies or mycelia of mushrooms have been used as food and food-flavoring material for centuries due to their nutritional and medicinal values and the diversity of their bioactive components..